Patents by Inventor Louise J. Lucast

Louise J. Lucast has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutant Proteinase with Reduced Self-Cleavage Activity and Method of Purification
    Publication number: 20150152403
    Abstract: The present invention provides a mutant 27 kDa NIa proteinase having reduced self-cleavage activity relative to the self-cleavage activity of its wild-type proteinase. The mutant has the same substrate cleavage activity as the wild-type proteinase but is more stable than the wild-type proteinase. The present invention also provides a method of obtaining large quantities of active 27 kDa NIa proteinase for use as a tool for purification of other proteins.
    Type: Application
    Filed: December 11, 2014
    Publication date: June 4, 2015
    Inventors: Jennifer A. Doudna, Louise J. Lucast, Robert T. Batey
  • Mutant proteinase with reduced self-cleavage activity and method of purification
    Patent number: 8969062
    Abstract: The present invention provides a mutant 27 kDa NIa proteinase having reduced self-cleavage activity relative to the self-cleavage activity of its wild-type proteinase. The mutant has the same substrate cleavage activity as the wild-type proteinase but is more stable than the wild-type proteinase. The present invention also provides a method of obtaining large quantities of active 27 kDa NIa proteinase for use as a tool for purification of other proteins.
    Type: Grant
    Filed: May 21, 2013
    Date of Patent: March 3, 2015
    Assignee: Yale University
    Inventors: Jennifer A. Doudna, Louise J. Lucast, Robert T. Batey
  • MUTANT PROTEINASE WITH REDUCED SELF-CLEAVAGE ACTIVITY AND METHOD OF PURIFICATION
    Publication number: 20130337503
    Abstract: The present invention provides a mutant 27 kDa NIa proteinase having reduced self-cleavage activity relative to the self-cleavage activity of its wild-type proteinase. The mutant has the same substrate cleavage activity as the wild-type proteinase but is more stable than the wild-type proteinase. The present invention also provides a method of obtaining large quantities of active 27 kDa NIa proteinase for use as a tool for purification of other proteins.
    Type: Application
    Filed: May 21, 2013
    Publication date: December 19, 2013
    Applicant: YALE UNIVERSITY
    Inventors: Jennifer A. DOUDNA, Louise J. Lucast, Robert T. Batey
  • Mutant proteinase with reduced self-cleavage activity and method of purification
    Patent number: 8470575
    Abstract: The present invention provides a mutant 27 kDa NIa proteinase having reduced self-cleavage activity relative to the self-cleavage activity of its wild-type proteinase. The mutant has the same substrate cleavage activity as the wild-type proteinase but is more stable than the wild-type proteinase. The present invention also provides a method of obtaining large quantities of active 27 kDa NIa proteinase for use as a tool for purification of other proteins.
    Type: Grant
    Filed: May 29, 2012
    Date of Patent: June 25, 2013
    Assignee: Yale University
    Inventors: Jennifer A. Doudna, Louise J. Lucast, Robert T. Batey
  • MUTANT PROTEINASE WITH REDUCED SELF-CLEAVAGE ACTIVITY AND METHOD OF PURIFICATION
    Publication number: 20120252096
    Abstract: The present invention provides a mutant 27 kDa NIa proteinase having reduced self-cleavage activity relative to the self-cleavage activity of its wild-type proteinase. The mutant has the same substrate cleavage activity as the wild-type proteinase but is more stable than the wild-type proteinase. The present invention also provides a method of obtaining large quantities of active 27 kDa NIa proteinase for use as a tool for purification of other proteins.
    Type: Application
    Filed: May 29, 2012
    Publication date: October 4, 2012
    Applicant: Yale University
    Inventors: Jennifer A. DOUDNA, Louise J. Lucast, Robert T. Batey
  • Mutant proteinase with reduced self-cleavage activity and method of purification
    Patent number: 8206968
    Abstract: The present invention provides a mutant 27 kDa NIa proteinase having reduced self-cleavage activity relative to the self-cleavage activity of its wild-type proteinase. The mutant has the same substrate cleavage activity as the wild-type proteinase but is more stable than the wild-type proteinase. The present invention also provides a method of obtaining large quantities of active 27 kDa NIa proteinase for use as a tool for purification of other proteins.
    Type: Grant
    Filed: August 1, 2008
    Date of Patent: June 26, 2012
    Assignee: Yale University
    Inventors: Jennifer A. Doudna, Louise J. Lucast, Robert T. Batey
  • Mutant proteinase with reduced self-cleavage activity and method of purification
    Patent number: 7494786
    Abstract: The present invention provides a mutant 27 kDa NIa proteinase having reduce self-cleavage activity relative to the self-cleavage activity of its wild-type proteinase. The mutant the same substrate cleavage activity as the wild-type proteinase but is more stable than the wild-type proteinase. The present invention also provides a method of obtaining large quantities of active 27 kDa NIa proteinase for use as a tool for purification of other proteins.
    Type: Grant
    Filed: June 11, 2001
    Date of Patent: February 24, 2009
    Assignee: Yale University
    Inventors: Jennifer A. Doudna, Louise J. Lucast, Robert T. Batey
  • MUTANT PROTEINASE WITH REDUCED SELF-CLEAVAGE ACTIVITY AND METHOD OF PURIFICATION
    Publication number: 20080318273
    Abstract: The present invention provides a mutant 27 kDa NIa proteinase having reduced self-cleavage activity relative to the self-cleavage activity of its wild-type proteinase. The mutant has the same substrate cleavage activity as the wild-type proteinase but is more stable than the wild-type proteinase. The present invention also provides a method of obtaining large quantities of active 27 kDa NIa proteinase for use as a tool for purification of other proteins.
    Type: Application
    Filed: August 1, 2008
    Publication date: December 25, 2008
    Inventors: Jennifer A. DOUDNA, Louise J. Lucast, Robert T. Batey
  • Mutant proteinase with reduced self-cleavage activity and method of purification
    Publication number: 20040072179
    Abstract: The present invention provides a mutant 27 kDa NIa proteinase having reduce self-cleavage activity relative to the self-cleavage activity of its wild-type proteinase. The mutant the same substrate cleavage activity as the wild-type proteinase but is more stable than the wild-type proteinase. The present invention also provides a method of obtaining large quantities of active 27 kDa NIa proteinase for use as a tool for purification of other proteins.
    Type: Application
    Filed: October 9, 2003
    Publication date: April 15, 2004
    Inventors: Jennifer A. Doudna, Louise J. Lucast, Robert T. Batey