Patents by Inventor Lowell D. Markley

Lowell D. Markley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10913737
    Abstract: Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to imidazopyridine compounds, synthesis thereof, and methods of using same. Disclosed herein are various imidazo[1,2-a]pyhdine compounds and methods of using the novel compounds to treat or prevent tuberculosis in a subject or to inhibit fungal growth on plant species. Other embodiments include methods of synthesizing imidazo[1,2-a]pyridine compounds, such as the disclosed imidazo[1,2-a]pyridine compounds.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: February 9, 2021
    Assignee: UNIVERSITY OF NOTRE DAME DU LAC
    Inventors: Marvin J. Miller, Garrett C. Moraski, Lowell D. Markley, George E. Davis
  • Publication number: 20180354944
    Abstract: Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to imidazopyridine compounds, synthesis thereof, and methods of using same. Disclosed herein are various imidazo[1,2-a]pyhdine compounds and methods of using the novel compounds to treat or prevent tuberculosis in a subject or to inhibit fungal growth on plant species. Other embodiments include methods of synthesizing imidazo [1,2-a]pyridine compounds, such as the disclosed imidazo[1,2-a]pyridine compounds.
    Type: Application
    Filed: February 5, 2018
    Publication date: December 13, 2018
    Applicant: UNIVERSITY OF NOTRE DAME DU LAC
    Inventors: Marvin J. MILLER, Garrett C. MORASKI, Lowell D. MARKLEY, George E. DAVIS
  • Patent number: 9908876
    Abstract: Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to imidazopyridine compounds, synthesis thereof, and methods of using same. Disclosed herein are various imidazo[1,2-a]pyhdine compounds and methods of using the novel compounds to treat or prevent tuberculosis in a subject or to inhibit fungal growth on plant species. Other embodiments include methods of synthesizing imidazo[1,2-a]pyridine compounds, such as the disclosed imidazo[1,2-a]pyridine compounds.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: March 6, 2018
    Assignee: UNIVERSITY OF NOTRE DAME DU LAC
    Inventors: Marvin J. Miller, Garrett C. Moraski, Lowell D. Markley, George E. Davis
  • Publication number: 20160318925
    Abstract: Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to imidazopyridine compounds, synthesis thereof, and methods of using same. Disclosed herein are various imidazo[1,2-a]pyhdine compounds and methods of using the novel compounds to treat or prevent tuberculosis in a subject or to inhibit fungal growth on plant species. Other embodiments include methods of synthesizing imidazo[1,2-a]pyridine compounds, such as the disclosed imidazo[1,2-a]pyridine compounds.
    Type: Application
    Filed: February 29, 2016
    Publication date: November 3, 2016
    Applicant: UNIVERSITY OF NOTRE DAME DU LAC
    Inventors: Marvin J. MILLER, Garrett C. MORASKI, Lowell D. MARKLEY, George E. DAVIS
  • Patent number: 9309238
    Abstract: Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to imidazopyridine compounds, synthesis thereof, and methods of using same. Disclosed herein are various imidazo[1,2-a]pyhdine compounds and methods of using the novel compounds to treat or prevent tuberculosis in a subject or to inhibit fungal growth on plant species. Other embodiments include methods of synthesizing imidazo[1,2-a]pyridine compounds, such as the disclosed imidazo[1,2-a]pyridine compounds.
    Type: Grant
    Filed: November 5, 2010
    Date of Patent: April 12, 2016
    Assignee: UNIVERSITY OF NOTRE DAME DU LAC
    Inventors: Marvin J. Miller, Garrett C. Moraski, Lowell D. Markley, George E. Davis
  • Publication number: 20120220457
    Abstract: Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to imidazopyridine compounds, synthesis thereof, and methods of using same. Disclosed herein are various imidazo[1,2-a]pyhdine compounds and methods of using the novel compounds to treat or prevent tuberculosis in a subject or to inhibit fungal growth on plant species. Other embodiments include methods of synthesizing imidazo [1,2- a]pyridine compounds, such as the disclosed imidazo[1,2-a]pyridine compounds.
    Type: Application
    Filed: November 5, 2010
    Publication date: August 30, 2012
    Applicants: Dow AgroSciences LLC, University of Notre Dame du Lac
    Inventors: Marvin J. Miller, Garrett C. Moraski, Lowell D. Markley, George E. Davis
  • Patent number: 5780465
    Abstract: 4-Substituted 5-polycyclylpyrimidine compounds in which the 5-substituent is polycyclic and is attached to the pyrimidine moiety through an aliphatic carbon atom, such as 5-(2,2-dimethylindan-1-yl)-4-methylthiopyrimidine, were prepared and found to possess excellent herbicidal activity. The compounds are especially useful for the control of undesirable vegetation in paddy rice.
    Type: Grant
    Filed: April 3, 1997
    Date of Patent: July 14, 1998
    Assignee: Dow AgroSciences LLC
    Inventors: Lowell D. Markley, Kim E. Arndt, Patricia G. Ray, Terry W. Balko, Erik N. K. Cressman, David G. Ouse, Johnny L. Jackson, Jacob Secor
  • Patent number: 5399542
    Abstract: The present disclosure is directed to substituted cyclohexanedione compounds, the preparation of said compounds, compositions containing said compounds and the use of said compositions in the selective pre- and postemergent kill and control of grassy weeds in the presence of various broad-leafed and grassy crop plants.
    Type: Grant
    Filed: December 20, 1993
    Date of Patent: March 21, 1995
    Assignee: DowElanco
    Inventors: Christopher T. Hamilton, Lowell D. Markley, Todd C. Geselius
  • Patent number: 5013352
    Abstract: The present disclosure is directed to substituted cyclohexanedione compounds, the preparation of said compounds, compositions containing said compounds and the use of said compositions in the selective pre- and postemergent kill and control of grassy weeds in the presence of various crop plants.
    Type: Grant
    Filed: March 30, 1990
    Date of Patent: May 7, 1991
    Assignee: DowElanco
    Inventors: Lowell D. Markley, Christopher T. Hamilton, Beth A. Swisher, Jacob Secor
  • Patent number: 5006159
    Abstract: The present disclosure is directed to substituted cyclohexanedione compounds, the preparation of said compounds, compositions containing said compounds and the use of said compositions in the selective pre- and postemergent kill and control of grassy weeds in the presence of various crop plants.
    Type: Grant
    Filed: March 30, 1990
    Date of Patent: April 9, 1991
    Assignee: DowElanco
    Inventors: Lowell D. Markley, Christopher T. Hamilton, Beth A. Swisher, Jacob Secor
  • Patent number: 4983211
    Abstract: The present disclosure is directed to substituted cyclohexanedione compounds, the preparation of said compounds, compositions containing said compounds and the use of said compositions in the selective pre- and postemergent kill and control of grassy weeds in the presence of various crop plants.
    Type: Grant
    Filed: March 30, 1990
    Date of Patent: January 8, 1991
    Assignee: DowElanco
    Inventors: Lowell D. Markley, Christopher T. Hamilton, Beth A. Swisher, Jacob Secor
  • Patent number: 4935436
    Abstract: Substituted triazole compounds, their preparation, compositions containing said compounds and the use of said compositions to control fungal infections in plants are disclosed.
    Type: Grant
    Filed: January 23, 1989
    Date of Patent: June 19, 1990
    Assignee: The Dow Chemical Company
    Inventors: Lowell D. Markley, Richard B. Rogers, Neil V. Kirby, John W. Liebeschuetz, Peter F. S. Street
  • Patent number: 4927833
    Abstract: Substituted azole compounds especially substituted imidazole and triazole compounds, their preparation, compositions containing said compounds and the use of said compositions to control fungal infections in plants are disclosed.
    Type: Grant
    Filed: January 23, 1989
    Date of Patent: May 22, 1990
    Assignee: The Dow Chemical Company
    Inventors: Neil V. Kirby, Peter F. S. Street, Lowell D. Markley
  • Patent number: 4824475
    Abstract: The herbicidal action of a herbicidal triazine upon weeds is enchanced upon also applying to the weeds a second herbicidal component, a butyl or pentyl glycol sulfonate or glycol sulfamate having 3, 5 or 3 substituted phenyl in the 2-position of the butyl or pentyl chain. The glycol sulfonate or sulfamate also adds its own herbicidal action to increase effectiveness.Both components are applied simultaneously as a novel composition which may also contain crop oil or crop oil concentrate. Application is made post-emergently before weeds reach about the 8 leaf stage. Advantageously, in an additional step, triazine alone or in combination with at least some of the sulfonate or sulfamate is also applied at planting or very early postemergently prior to the treatment described.
    Type: Grant
    Filed: September 16, 1985
    Date of Patent: April 25, 1989
    Assignee: The Dow Chemical Company
    Inventors: Lowell D. Markley, Paul S. Zorner
  • Patent number: 4505929
    Abstract: Novel compounds exhibiting antiviral activity are disclosed, such compounds are represented by the formula: ##STR1## wherein m represents the integer 0, 1 or 2; R represents trihalomethyl, alkyl or phenyl; R.sub.1 represents hydrogen, bromo, chloro, fluoro, cyano, nitro, amino, alkyl, alkoxy or trifluoromethyl; R.sub.2 represents hydroxyl, bromo, chloro, fluoro, cyano, acetyl, benzoyl, substituted benzoyl, alkyl, alkoxy, substituted alkoxy, benzyl, substituted benzyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, or the radical --O(CH.sub.2).sub.n R.sub.4 wherein n represents the integer 1, 2 or 3 and R.sub.4 represents cyano or dialkylamino; R.sub.3 represents hydrogen, hydroxyl, bromo, chloro, fluoro, cyano, acetyl, benzoyl, substituted benzoyl, alkyl, alkoxy, substituted alkoxy, benzyl, substituted benzyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, or the radical --O(CH.sub.2).sub.n R.sub.
    Type: Grant
    Filed: August 16, 1982
    Date of Patent: March 19, 1985
    Assignee: The Dow Chemical Company
    Inventors: Lowell D. Markley, Yulan C. Tong, Steven G. Wood
  • Patent number: 4474602
    Abstract: Substituted pyridyl compounds, e.g. 2,6-dichloro-4(2-(2,2,2-trichloroethyl)oxiranyl) pyridine; herbicidal compositions containing such compounds and method for the control of undesired vegetation using these compositions.
    Type: Grant
    Filed: January 19, 1982
    Date of Patent: October 2, 1984
    Assignee: The Dow Chemical Company
    Inventors: Lowell D. Markley, John M. Soper
  • Patent number: 4371537
    Abstract: Sulfur-substituted phenoxypyridines having antiviral activity are disclosed. Methods of using the sulfur-substituted phenoxypyridines to employ their antiviral activity are also disclosed as well as pharmaceutically-acceptable compositions thereof.
    Type: Grant
    Filed: August 13, 1981
    Date of Patent: February 1, 1983
    Assignee: The Dow Chemical Company
    Inventors: Lowell D. Markley, Yulan C. Tong, Steven G. Wood
  • Patent number: 4349568
    Abstract: Novel compounds exhibiting antiviral activity are disclosed, such compounds are represented by the formula: ##STR1## wherein m represents the integer 0, 1 or 2; R represents trihalomethyl, alkyl or phenyl; R.sub.1 represents hydrogen, bromo, chloro, fluoro, cyano, nitro, amino, alkyl, alkoxy or trifluoromethyl; R.sub.2 represents hydroxyl, bromo, chloro, fluoro, cyano, acetyl, benzoyl, substituted benzoyl, alkyl, alkoxy, substituted alkoxy, benzyl, substituted benzyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, or the radical --O(CH.sub.2).sub.n R.sub.4 wherein n represents the integer 1, 2 or 3 and R.sub.4 represents cyano or dialkylamino; R.sub.3 represents hydrogen, hydroxyl, bromo, chloro, fluoro, cyano, acetyl, benzoyl, substituted benzoyl, alkyl, alkoxy, substituted alkoxy, benzyl, substituted benzyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, or the radical --O(CH.sub.2).sub.n R.sub.
    Type: Grant
    Filed: June 12, 1980
    Date of Patent: September 14, 1982
    Assignee: The Dow Chemical Company
    Inventors: Lowell D. Markley, Yulan C. Tong, Steven G. Wood
  • Patent number: 4332820
    Abstract: Substituted benzonitriles having antiviral activity are disclosed. Methods of use based on the antiviral activity of the compounds are also disclosed, as well as compositions which comprise a carrier in combination with a suitable antiviral active compound.
    Type: Grant
    Filed: December 29, 1980
    Date of Patent: June 1, 1982
    Assignee: The Dow Chemical Company
    Inventor: Lowell D. Markley
  • Patent number: 4254144
    Abstract: Substituted benzonitriles are disclosed having the formula ##STR1## wherein X represents O or S; R.sub.1 represents bromo, chloro, fluoro, phenoxy, loweralkylthio, loweralkylsulfinyl, loweralkylsulfonyl, loweralkylaminosulfonyl, diloweralkylaminosulfonyl or benzoyl; and R.sub.2 represents hydrogen, bromo, chloro or fluoro with the proviso that R.sub.2 is hydrogen when R.sub.1 is a substituent other than bromo, chloro or fluoro. The compounds of the invention exhibit antiviral activity. Methods of use based on the antiviral activity of the compounds are also disclosed, as well as compositions which comprise a carrier in combination with a suitable antiviral active compound.
    Type: Grant
    Filed: January 25, 1980
    Date of Patent: March 3, 1981
    Assignee: The Dow Chemical Company
    Inventor: Lowell D. Markley