Patents by Inventor Lowell L. Wood
Lowell L. Wood has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210205444Abstract: Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.Type: ApplicationFiled: January 7, 2021Publication date: July 8, 2021Inventors: Ana Jaklenec, William Gates, Philip A. Welkhoff, Boris Nikolic, Lowell L. Wood, JR., Robert S. Langer, Thanh Duc Nguyen, Stephany Yi Tzeng, James J. Norman, Kevin McHugh
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Publication number: 20210177750Abstract: Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.Type: ApplicationFiled: February 12, 2021Publication date: June 17, 2021Applicants: Massachusetts Institute of Technology, The Brigham and Womens's Hospital, Inc.Inventors: Andrew Bellinger, Shiyi Zhang, Carlo Giovanni Traverso, Robert S. Langer, Stacey Mo, Tyler Grant, Mousa Jafari, Dean Liang Glettig, Angela DiCiccio, Lowell L. Wood, JR., Philip A. Eckhoff
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Publication number: 20210146042Abstract: Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with chemical blocking agents are disclosed. Methods and systems for reversing effects of chemical blocking agents and/or for producing substantially permanent conduction block are also disclosed.Type: ApplicationFiled: October 28, 2020Publication date: May 20, 2021Inventors: Ralph G. Dacey, JR., Gregory J. Della Rocca, Colin P. Derdeyn, Joshua L. Dowling, Eleanor V. Goodall, Roderick A. Hyde, Muriel Y. Ishikawa, Jordin T. Kare, Eric C. Leuthardt, Nathan P. Myhrvold, Michael A. Smith, Lowell L. Wood, Victoria Y. H. Wood, Gregory J. Zipfel
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Patent number: 11012552Abstract: An apparatus, device, methods, computer program product, and system are described that make a determination that a wireless device is in proximity to at least one secondary wireless device, and determine an aggregate user interface on the wireless device based on the determination.Type: GrantFiled: May 2, 2020Date of Patent: May 18, 2021Assignee: Uber Technologies, Inc.Inventors: Edward K. Y. Jung, Royce A. Levien, Robert W. Lord, Mark A. Malamud, John D. Rinaldo, Jr., Lowell L. Wood, Jr.
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Publication number: 20210128460Abstract: Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.Type: ApplicationFiled: December 18, 2020Publication date: May 6, 2021Applicants: Massachusetts Institute of Technology, The Brigham and Women't Hospital, Inc.Inventors: Andrew Bellinger, Shiyi Zhang, Carlo Giovanni Traverso, Robert S. Langer, Stacy Mo, Tyler Grant, Mousa Jafari, Dean Liang Glettig, Angela DiCiccio, Lowell L. Wood, JR., Philip A. Eckhoff
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Patent number: 10987048Abstract: The present disclosure relates to systems, methods, and devices that may be used to incentivize inhaler use.Type: GrantFiled: August 13, 2014Date of Patent: April 27, 2021Assignee: Elwha LLCInventors: Jesse R. Cheatham, III, Roderick A. Hyde, Robert C. Petroski, Lowell L. Wood, Jr., Victoria Y. H. Wood
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Publication number: 20210113460Abstract: Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.Type: ApplicationFiled: December 18, 2020Publication date: April 22, 2021Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Andrew Bellinger, Shiyi Zhang, Carlo Giovanni Traverso, Robert S. Langer, Stacy Mo, Tyler Grant, Mousa Jafari, Dean Liang Glettig, Angela DiCiccio, Lowell L. Wood, JR., Philip A. Eckhoff
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Publication number: 20210106493Abstract: An embodiment of a system for treating sleep apnea includes a collar, pump, motor, sensor, memory, and controller, which is configured to store, in the memory, information related to sleep-apnea events or sleep-apnea treatment, experienced by the subject. For example, the controller can obtain, and store in the memory, information related to sleep-apnea events, and the controller, or another computing system, can correlate this information with the subject's lifestyle choices, and can recommend lifestyle changes to improve the subject's sleep apnea. Furthermore, the controller can obtain and store, in the memory, information related to usage and settings of the sleep-apnea system, and the controller, or another computing system, can correlate this information with the subject's wellbeing, and can recommend changes in the usage or the settings of the sleep-apnea system that can improve the subject's wellbeing.Type: ApplicationFiled: September 22, 2020Publication date: April 15, 2021Applicant: Somne LLCInventors: Roderick A. Hyde, Kenneth G. Caldeira, Gary L. McKnight, Lowell L. Wood, JR., Dennis J. Rivet, Katherine A. Sharadin, Michael A. Smith
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Publication number: 20210093564Abstract: Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.Type: ApplicationFiled: June 11, 2020Publication date: April 1, 2021Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Andrew Bellinger, Shiyi Zhang, Carlo Giovanni Traverso, Robert S. Langer, Stacy Mo, Tyler Grant, Mousa Jafari, Dean Liang Glettig, Angela DiCiccio, Lowell L. Wood, Philip A. Eckhoff
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Patent number: 10960073Abstract: Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.Type: GrantFiled: May 2, 2019Date of Patent: March 30, 2021Assignees: TOKITAE LLC, MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Ana Jaklenec, William Gates, Philip A. Welkhoff, Boris Nikolic, Lowell L. Wood, Jr., Robert S. Langer, Thanh Duc Nguyen, Stephany Yi Tzeng, James J. Norman, Kevin McHugh
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Publication number: 20210086172Abstract: The present disclosure relates to methods and devices that may be used to separate components from one or more samples.Type: ApplicationFiled: August 27, 2020Publication date: March 25, 2021Applicant: Inflammatix, Inc.Inventors: Edward K.Y. Jung, Eric C. Leuthardt, Royce A. Levien, Robert W. Lord, Mark A. Malamud, John D. Rinaldo, JR., Lowell L. Wood, JR.
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Patent number: 10941971Abstract: Portage storage containers including controlled evaporative cooling systems are described herein. In some embodiments, a portable container including an integral controlled evaporative cooling system includes: a storage region, an evaporative region adjacent to the storage region, a desiccant region adjacent to the outside of the container, and an insulation region positioned between the evaporative region and the desiccant region. A vapor conduit with an attached vapor control unit has a first end within the evaporative region and a second end within the desiccant region. In some embodiments, the controlled evaporative cooling systems are positioned in a radial configuration within the portable container.Type: GrantFiled: March 24, 2017Date of Patent: March 9, 2021Assignee: Tokitae LLCInventors: Fong Li Chou, Philip A. Welkhoff, Lawrence Morgan Fowler, Shieng Liu, Peter K. Maier-Laxhuber, Nels R. Peterson, Ivan Poleshchuk, Ralf W. Schmidt, Clarence T. Tegreene, Lowell L. Wood, Jr., Reiner M. Wörz, David J. Yager
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Publication number: 20210018680Abstract: According to various embodiments, an array of elements forms an artificially-structured material. The artificially-structured material can also include an array of tuning mechanisms included as part of the array of elements that are configured to change material properties of the artificially-structured material on a per-element basis. The tuning mechanisms can change the material properties of the artificially-structured material by changing operational properties of the elements in the array of elements on a per-element basis based on one or a combination of stimuli detected by sensors included in the array of tuning mechanisms, programmable circuit modules included as part of the array of tuning mechanisms, data stored at individual data stores included as part of the array of tuning mechanisms, and communications transmitted through interconnects included as part of the array of elements.Type: ApplicationFiled: September 28, 2020Publication date: January 21, 2021Inventors: Daniel Arnitz, Patrick Bowen, Seyedmohammadreza Faghih Imani, Joseph Hagerty, Roderick A. Hyde, Edward K.Y. Jung, Guy S. Lipworth, Nathan P. Myhrvold, David R. Smith, Clarence T. Tegreene, Yaroslav A. Urzhumov, Lowell L. Wood, JR.
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Patent number: 10874577Abstract: An embodiment of a system for treating sleep apnea includes a collar, pump, motor, sensor, memory, and controller, which is configured to store, in the memory, information related to sleep-apnea events or sleep-apnea treatment, experienced by the subject. For example, the controller can obtain, and store in the memory, information related to sleep-apnea events, and the controller, or another computing system, can correlate this information with the subject's lifestyle choices, and can recommend lifestyle changes to improve the subject's sleep apnea. Furthermore, the controller can obtain and store, in the memory, information related to usage and settings of the sleep-apnea system, and the controller, or another computing system, can correlate this information with the subject's wellbeing, and can recommend changes in the usage or the settings of the sleep-apnea system that can improve the subject's wellbeing.Type: GrantFiled: January 13, 2017Date of Patent: December 29, 2020Assignee: Somne LLCInventors: Roderick A. Hyde, Kenneth G. Caldeira, Gary L. McKnight, Lowell L. Wood, Jr., Dennis J. Rivet, Katherine A. Sharadin, Michael A. Smith
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Patent number: 10875525Abstract: Techniques for ability enhancement are described. In some embodiments, devices and systems located in a transportation network share threat information with one another, in order to enhance a user's ability to operate or function in a transportation-related context. In one embodiment, a process in a vehicle receives threat information from a remote device, the threat information based on information about objects or conditions proximate to the remote device. The process then determines that the threat information is relevant to the safe operation of the vehicle. Then, the process modifies operation of the vehicle based on the threat information, such as by presenting a message to the operator of the vehicle and/or controlling the vehicle itself.Type: GrantFiled: August 5, 2015Date of Patent: December 29, 2020Assignee: Microsoft Technology Licensing LLCInventors: Richard T. Lord, Robert W. Lord, Nathan P. Myhrvold, Clarence T. Tegreene, Roderick A. Hyde, Lowell L. Wood, Muriel Y. Ishikawa, Victoria Y. H. Wood, Charles Whitmer, Paramvir Bahl, Douglas C. Burger, Ranveer Chandra, William H. Gates, III, Pablos Holman, Jordin T. Kare, Craig J. Mundie, Tim Paek, Desney S. Tan, Lin Zhong, Matthew G. Dyor
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Publication number: 20200399398Abstract: Devices, compositions, and methods are described which provide a tubular nanostructure or a composite tubular nanostructure targeted to a lipid bilayer membrane. The tubular nanostructure includes a hydrophobic surface region flanked by two hydrophilic surface regions. The tubular nanostructure is configured to interact with a lipid bilayer membrane and form a pore in the lipid bilayer membrane. The tubular nanostructure may be targeted by including at least one ligand configured to bind to one or more cognates on the lipid bilayer membrane of a target cell.Type: ApplicationFiled: June 15, 2020Publication date: December 24, 2020Inventors: Mahalaxmi Gita Bangera, Ed Harlow, Roderick A. Hyde, Muriel Y. Ishikawa, Edward K.Y. Jung, Eric C. Leuthardt, Nathan P. Myhrvold, Dennis J. Rivet, Elizabeth A. Sweeney, Clarence T. Tegreene, Lowell L. Wood, JR., Victoria Y.H. Wood
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Publication number: 20200384198Abstract: Methods, computer program products, and systems are described that include measuring at least one effect of a combined bioactive agent and artificial sensory experience on an individual and/or modifying at least one of the bioactive agent or the artificial sensory experience at least partially based on the at least one effect.Type: ApplicationFiled: August 6, 2020Publication date: December 10, 2020Inventors: Roderick A. Hyde, Muriel Y. Ishikawa, Eric C. Leuthardt, Royce A. Levien, Robert W. Lord, Mark A. Malamud, Elizabeth A. Sweeney, Lowell L. Wood, JR., Victoria Y.H. Wood
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Patent number: 10853819Abstract: Configuration technologies for apportioning resources and communicating indications of potential or actual incentives based on one or more measurements or other objective indications that therapeutic components have been administered to an individual, other attributes of the therapeutic components or the individual, or other such determinants. Techniques for apportioning resources cost-effectively (between providers and other parties, e.g.) and for facilitating or handling implementations thereof or output therefrom.Type: GrantFiled: April 14, 2011Date of Patent: December 1, 2020Assignee: Elwha LLCInventors: Eun Young Hwang, Roderick A. Hyde, Muriel Y. Ishikawa, Jordin T. Kare, Dennis J. Rivet, Elizabeth A. Sweeney, Clarence T. Tegreene, Lowell L. Wood, Jr., Victoria Y.H. Wood
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Patent number: 10849853Abstract: Residence devices as well as their related methods of manufacture and use are generally provided. In some embodiments, a residence device includes a plurality of self-assembling structures that assemble in vivo to form an aggregate structure. Each structure of the plurality of structures includes a first side and a first attachment point that attaches to a second attachment point on another structure of the plurality of structures. The aggregate structure may be sized and shaped to maintain an in vivo position relative to an internal orifice of a subject. The attachment between the first and second attachment points may degrade after a period of time.Type: GrantFiled: June 11, 2015Date of Patent: December 1, 2020Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Andrew Bellinger, Shiyi Zhang, Carlo Giovanni Traverso, Robert S. Langer, Stacy Mo, Jiaqi Lin, Angela DiCiccio, Dean Liang Glettig, Lowell L. Wood, Jr., Philip A. Eckhoff
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Patent number: 10839965Abstract: A nuclear fission reactor, flow control assembly, methods therefor and a flow control assembly system. The flow control assembly is coupled to a nuclear fission module capable of producing a traveling burn wave at a location relative to the nuclear fission module. The flow control assembly controls flow of a fluid in response to the location relative to the nuclear fission module. The flow control assembly comprises a flow regulator subassembly configured to be operated according to an operating parameter associated with the nuclear fission module. In addition, the flow regulator subassembly is reconfigurable according to a predetermined input to the flow regulator subassembly. Moreover, the flow control assembly comprises a carriage subassembly coupled to the flow regulator subassembly for adjusting the flow regulator subassembly to vary fluid flow into the nuclear fission module.Type: GrantFiled: May 2, 2017Date of Patent: November 17, 2020Assignee: TERRAPOWER, LLCInventors: Charles E. Ahlfeld, Roderick A. Hyde, Muriel Y. Ishikawa, David G. McAlees, Jon D. McWhirter, Nathan P. Myhrvold, Ashok Odedra, Clarence T. Tegreene, Thomas A. Weaver, Charles Whitmer, Victoria Y. H. Wood, Lowell L. Wood, Jr., George B. Zimmerman