Abstract: Patients diagnosed with a cancer harboring an IDH-1 mutation can be treated by the administration of a therapeutically effective amount of a pharmaceutical composition comprising Compound 1, a selective inhibitor of 2-HG production from mIDH-1 enzymes including the R132 mutations R132C, R132H, R132L, R132G, and R132S.

Abstract: Patients diagnosed with a cancer harboring an IDH-1 mutation can be treated by the administration of a therapeutically effective amount of a pharmaceutical composition comprising Compound 1, a selective inhibitor of 2-HG production from mIDH-1 enzymes including the R132 mutations R132C, R132H, R132L, R132G, and R132S.

Abstract: Molded articles are prepared from propylene-ethylene copolymers and exhibiting improved clarity and strength properties. Articles prepared include bottles and other thin-walled articles. The articles are prepared using an isotactic propylene-ethylene random copolymer resin having an ethylene content of from about 0.5 to about 3 percent by total weight of copolymer, with a xylene solubles content of less than about 1.5 percent. The injection molded article may exhibit less than about 20 percent haze, as determined by ASTM D1003, at a thickness of about 0.08 inch (2.03 mm). Articles may also be prepared from similar copolymers having an ethylene content greater than about 3 percent by total weight of copolymer, with a xylene solubles content of less than about 4 percent by total weight of copolymer. These articles may exhibit less than about 13 percent haze, as determined by ASTM D1003, at a thickness of about 0.08 inch (2.03 mm).

Abstract: A composition that may be useful for thermoforming and blow molding applications comprises a metallocene catalyzed propylene-ethylene random copolymer having an ethylene content of from about 0.1 to about 1.5 weight percent based on the copolymer, and exhibits a flexural modulus of at least about 1,100 MPa, a haze of less than about 40 percent, a melt flow of from about 1.0 dg/min to about 3.0 dg/min, and a xylene solubles content from about 0.2 weight percent to about 1.0 weight percent based on the copolymer. A process for preparing the copolymer and articles prepared therefrom are also disclosed. The composition's properties may make it particularly desirable for applications such as bottles, syringes and containers such as those used for food and medical purposes.

Abstract: Alicyclic carboxylates, such as alicyclic norbonane sodium dicarboxylate, may be used in relatively small amounts as crystallization nucleating agents for foamed polypropylene. The alicyclic carboxylates give improved cell structures at lower proportions than conventional crystallization nucleating agents. The use of alicyclic carboxylate crystallization nucleating agents together with conventional nucleating agents may help give lower density polypropylene foams across a broader melt temperature range.

Abstract: A polypropylene composition comprises an isotactic polypropylene homopolymer resin that is suitable to form an injected molded article exhibiting less than about 60% haze, as determined by ASTM D1003, at a thickness of 0.05 inch without clarity-enhancing agents. The polypropylene composition has particular application to injection molded articles and may have a melt flow rate of from about 0.1 g/10 min to about 150 g/10 min as determined by ASTM D-1238, Procedure B. The resin may be prepared using a metallocene catalyst, and the composition may include clarity-enhancing agents for even greater clarity improvements.

Abstract: Syndiotactic polypropylene blends having a unique set of mechanical properties may be prepared by blending syndiotactic polypropylene with a high molecular weight mineral oil, an ultra low density polyethylene, or both. The syndiotactic polypropylene blends of the present invention have been found to have reduced flexural modulus, reduced haze, improved impact strength and shorter injection molding cycle times. It has been determined that the addition of about 5 to about 10 percent high molecular weight mineral oil to a syndiotactic polypropylene can decrease flexural modulus values by about 25 to about 30 percent. Moreover, the addition of up to about 10 percent mineral oil to the syndiotactic polypropylene material does not show signs of bleeding or impair clarity, in fact, percent haze values are slightly improved with the addition of mineral oil.