Abstract: The present disclosure relates to the field of image definition recognition, and discloses a logging image definition recognition method and device, medium and electronic equipment. The method comprises: establishing a logging image sample library comprising a plurality of logging images; acquiring actual definition information corresponding to the respective logging images; acquiring a plurality of definitions corresponding to the respective logging images; determining target weights corresponding to the respective target image definition determination algorithms according to the plurality of definitions and the actual definition information corresponding to the respective logging images; and determining a definition of a target logging image by the respective target image definition determination algorithms and the target weights corresponding to the respective target image definition determination algorithms.

Abstract: Certain embodiments provide a method of performing ophthalmic surgical procedures. The method includes ingesting and preparing pre-operative data and intra-operative data associated with a patient's eye for further processing. In certain embodiments, the method further includes integrating the pre-operative data and intra-operative data to generate context sensitive data for further processing. The method also includes classifying and annotating the pre-operative data, the intra-operative data, and the context sensitive data. The method also includes extracting one or more actionable inferences from the pre-operative data, the intra-operative data, context sensitive data, and the classified and annotated data. The method further includes triggering, based on the one or more actionable inferences, one or more actions on an imaging system or a surgical system.

Abstract: Provided are a preparation method for a CTL cell and an application thereof. The preparation method comprises the following steps of: inducing a CTL cell by using a tumor antigen PAP-GM-CSF sensitized DC cell; and knocking out a PD-1 gene of the CTL cell to obtain a PD-1 knock-out CTL cell. The CTL cell obtained by the preparation method can be used for preparing drugs for treatment of prostate cancer, especially for treating PAP-positive prostate cancer. The CTL cell does not cause CTL cell failure and anergy due to the tumor-expressed PD-L1 after being transfused into the body, thereby producing efficient specific cytotoxic effect on a tumor cell and improving the curative effect and reducing the side effect.

Abstract: In certain embodiments, a system, a computer-implemented method, and computer-readable medium are disclosed for performing integrated analysis of MSI and OCT images to diagnose eye disorders. MSI and OCT are processed using separate input machine learning models to create input feature maps that are input to an intermediate machine learning model. The intermediate machine learning model processes the input feature maps and outputs a final feature map that is processed by one or more output machine learning models that output one or more estimated representations of a pathology of the eye of the patient. A single device captures OCT and non-OCT images using (a) a sensor of a first imaging device that is shared with a second imaging device and/or (b) an optical component for directing light form the retina to the first imaging device or the second imaging device.

Abstract: In certain embodiments, a system, a computer-implemented method, and computer-readable medium are disclosed for performing integrated analysis of MSI and OCT images to diagnose eye disorders. MSI and OCT are processed using separate input machine learning models to create input feature maps that are input to an intermediate machine learning model. The intermediate machine learning model processes the input feature maps and outputs a final feature map that is processed by one or more output machine learning models that output one or more estimated representations of a pathology of the eye of the patient.

Abstract: In certain embodiments, a system, a computer-implemented method, and computer-readable medium are disclosed for light efficient fluorescence imaging. The retina is flashed with broadband light and returned light is imaged after passing through one or more filters, such as notch filers, low-pass filters, and high-pass filters. Images may be captured with a single camera or at least two cameras, one capturing transmitted light from the filter and the other capturing returned light. Images may be combined by subtraction and/or addition to obtain a combined image representing light within a passband whereas no passband filters are used during imaging.

Abstract: In certain embodiments, a system, a computer-implemented method, and computer-readable medium for generating multispectral imaging (MSI) based on performing an analytical MSI operation are described. The analytical MSI operation includes synchronizing a scan of a target by a broadband imaging device with a generation of a plurality of light signals, from a plurality of broadband illumination sources, directed towards the target. A set of spectral information associated with the target is generated, based on the scan of the target with the broadband imaging device. A set of multispectral imaging (MSI) information associated with the target is generated, based on performing an MSI operation using at least the set of spectral information. Ophthalmic information is determined based on the set of MSI information.

Abstract: Particular embodiments disclosed herein provide an alignment guide for aligning a toric IOL during surgery. An image with a reference axis is obtained, such as from a digital microscope, and processed, such as using an autoencoder, to label alignment marks on the IOL and possibly other features of the IOL. The label is processed, such as using a logistic regression model, to estimate an IOL axis of the IOL intersecting the alignment marks. An output image is generated from the image that has superimposed thereon guides to a surgeon, such as a line representing the IOL axis, a rotation direction indicator, and a number or other representation of a difference between the reference axis and the IOL axis. Tracking of features of the IOL may be performed across multiple images to predict the location of features not represented in a particular image.

Abstract: Methods, systems, and devices are disclosed for collecting and transferring naturally-produced sweat containing an analyte to a biosensor and/or biofuel cell to estimate a concentration of the analyte corresponding to the analyte's concentration in blood and/or for producing electricity. In some aspects, a device includes a substrate, a plurality of electrodes disposed on the substrate and operable to detect an analyte in naturally-produced sweat of an individual, and a sweat permeation layer including a hydrogel, wherein the sweat permeation layer is in contact with the plurality of electrodes and configured to transfer the sweat containing the analyte through the sweat permeation layer to reach the plurality of electrodes for detection and/or energy harvesting.

Abstract: In certain embodiments, an ophthalmic system and computer-implemented method for analyzing multiple spectral information to generate ophthalmic information are described. In an exemplary ophthalmic system, multiple spectral information associated with an eye of a patient is captured via an imaging system. A first set of information and a second set of information are extracted from the multiple spectral information. A visualization of the multiple spectral information is generated using the first set of information. The first set of information and the second set of information are evaluated using different deep learning models to generate ophthalmic information. The ophthalmic information is sent to a user for diagnostic evaluation.

Abstract: Compositions, materials, methods, articles of manufacture and devices that pertain to chemical-resistant elastomer binders and flexible, printed, high-performance electrochemical systems based on said binders. The chemical-resistant, flexible elastomer binder can be used in printable, flexible high areal energy density batteries for wearable and flexible electronics and printable, flexible fuel cells. More generally, the disclosed binder material can be used in any printed electrochemical and electronic systems, e.g., supercapacitors, electrochromic cells, sensors, circuit interconnections, organic electrochemical transistors, touch screens, solar cells, etc.

Abstract: The present disclosure provides a process for purifying high-molecular weight bacterial polysaccharides (e.g., cell wall polysaccharides), and polypeptide-polysaccharide conjugates thereof, suitable for use in immunogenic compositions.

Abstract: In certain embodiments, an ophthalmic system and computer-implemented method for performing ophthalmic image registration are described. The ophthalmic image registration includes obtaining a plurality of images of an eye of a user. Within each image of the plurality of images, a segmented region(s) of the eye within the image is determined based on evaluating the image with a neural network(s), and a set of point features of the eye within the segmented region(s) of the eye is determined based on evaluating the image with the neural network(s). A set of transformation information for transforming at least one of the plurality of images is generated based on performing one or more image processing operations on the set of point features within each image of the plurality of images. At least one of the plurality of images is transformed, based on the set of transformation information.

Abstract: Certain embodiments provide a method of performing ophthalmic surgical procedures. The method includes ingesting and preparing pre-operative data and intra-operative data associated with a patient's eye for further processing. In certain embodiments, the method further includes integrating the pre-operative data and intra-operative data to generate context sensitive data for further processing. The method also includes classifying and annotating the pre-operative data, the intra-operative data, and the context sensitive data. The method also includes extracting one or more actionable inferences from the pre-operative data, the intra-operative data, context sensitive data, and the classified and annotated data. The method further includes triggering, based on the one or more actionable inferences, one or more actions on an imaging system or a surgical system.

Abstract: Systems and methods are presented for providing a vision simulation of a patient who has an eye condition. A composite image representing a real-world scene is obtained. The composite image includes multiple image layers, where each image layer represents objects that are at a particular viewing distance in the real-world scene. A first eye model representing the eye optics of the patient is generated. A second eye model representing the eye optics of a viewer is generated. The second eye model is modified by performing a mathematical function. A simulated image representing the vision of the patient is generated by convolving the first eye model and the modified second eye model with the composite image. In some embodiments, a tone mapping algorithm may also be applied to the simulated image to simulate a nighttime scene.

Abstract: Disclosed are compositions, devices, systems and fabrication methods for stretchable composite materials and stretchable electronics devices. In some aspects, an elastic composite material for a stretchable electronics device includes a first material having a particular electrical, mechanical or optical property; and a multi-block copolymer configured to form a hyperelastic binder that creates contact between the first material and the multi-block copolymer, in which the elastic composite material is structured to stretch at least 500% in at least one direction of the material and to exhibit the particular electrical, mechanical or optical property imparted from the first material. In some aspects, the stretchable electronics device includes a stretchable battery, biofuel cell, sensor, supercapacitor or other device able to be mounted to skin, clothing or other surface of a user or object.

Abstract: Certain aspects of the present disclosure provide an ophthalmic imaging device for enhancing images. The device comprises an image capture component configured to generate an image stream comprising a first frame preceding a second frame, both capturing a branch of veins in an eye. The device further comprises an image processor configured to calculate first order statistics for a plurality of blocks for the first frame and to interpolate first order statistics for the first frame based at least in part on the branch of veins. The image processor is also configured to generate a tone mapping function and calculate tone mapping values for individual pixels of the second frame based on the tone mapping function. The image processor is additionally configured to generate an enhanced frame based on the calculated tone mapping values for individual pixels of the second frame to the pixels of the second frame.

Abstract: A system and method for visually enhancing an original image of an eye includes a visualization module. A controller is configured to convert an output of the visualization module to a first pixel cloud in a first color space and map the first pixel cloud to a second pixel cloud in a second color space. The method includes identifying at least one selected zone in the second color space. The controller is configured to move the selected zone from an original location to a modified location in the second color space. The second pixel cloud is updated to obtain a modified second pixel cloud, which is transformed into a third pixel cloud in the first color space. An enhanced image is formed based in part on the modified second pixel cloud and provides selective visual enhancement in the selected zone without affecting contrast in a remainder of the original image.

Abstract: Disclosed are devices, systems, and methods for multi-modal, wearable sensors, including an electrochemical-ultrasonic transducer-based sensor, that can simultaneously detect and monitor one or more bio-analyte markers and one or more physiological markers. In some aspects, a wearable, acoustic-electrochemical sensor device includes a flexible substrate, one or more electrochemical sensors disposed on the flexible substrate, a physiological sensor comprising an array of acoustic transducers disposed on the flexible substrate, wherein the sensor device is operable to simultaneously detect and monitor one or more analyte markers and physiological markers including hemodynamic parameters.

Abstract: Disclosed are compositions, devices, systems and fabrication methods for stretchable composite materials and stretchable electronics devices. In some aspects, an elastic composite material for a stretchable electronics device includes a first material having a particular electrical, mechanical or optical property; and a multi-block copolymer configured to form a hyperelastic binder that creates contact between the first material and the multi-block copolymer, in which the elastic composite material is structured to stretch at least 500% in at least one direction of the material and to exhibit the particular electrical, mechanical or optical property imparted from the first material. In some aspects, the stretchable electronics device includes a stretchable battery, biofuel cell, sensor, supercapacitor or other device able to be mounted to skin, clothing or other surface of a user or object.