Patents by Inventor Luca Francesco Raveglia
Luca Francesco Raveglia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9580416Abstract: Disclosed herein are compounds that inhibit Bruton's tyrosine kinase (Btk) having the structure of Formula (B): Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.Type: GrantFiled: July 2, 2015Date of Patent: February 28, 2017Assignee: PHARMACYCLICS LLCInventors: Wei Chen, Longcheng Wang, Shunqi Yan, David J. Loury, Zhaozhong J. Jia, Leah Lynn Frye, Jeremy Robert Greenwood, Mee Yoo Shelley, Gordana Babic Atallah, Riccardo Zanaletti, Maria Pia Catalani, Luca Francesco Raveglia
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Publication number: 20160002225Abstract: Disclosed herein are compounds that inhibit Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition, reversible inhibitors of Btk are also described. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.Type: ApplicationFiled: July 2, 2015Publication date: January 7, 2016Inventors: Wei CHEN, Longcheng WANG, Shunqi YAN, David J. LOURY, Zhaozhong J. JIA, Leah Lynn FRYE, Jeremy Robert GREENWOOD, Mee Yoo SHELLEY, Gordana Babic ATALLAH, Riccardo ZANALETTI, Maria Pia CATALANI, Luca Francesco RAVEGLIA
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Patent number: 8063039Abstract: A method for treating pain, migraine, inflammation, gastrointestinal tract disorders, disorders of the genito-urinary tract, ophthalmic diseases or obesity in a subject, the method including administering to the subject an effective amount of a compound of a general formula, specific examples of which include 3-(4-Butyloxy-benzylamino)-pyrrolidin-2-one, 3-[4-(4-trifluorobutyloxy)-benzylamino]-pyrrolidin-2-one, 3-(4-Pentyloxy-benzylamino)-pyrrolidin-2-one, 3-[4-(5-trifluoropentyloxy)-benzylamino]-pyrrolidin-2-one, and 3-(4-Phenylethyl-benzylamino)-pyrrolidin-2-one.Type: GrantFiled: November 2, 2009Date of Patent: November 22, 2011Assignee: Newron Pharmaceuticals S.p.A.Inventors: Florian Thaler, Cibele Maria Sabido David, Sara Maestroni, Luca Francesco Raveglia, Patricia Salvati
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Patent number: 7968592Abstract: 3-aminopyrrolidone compounds and pharmaceutically acceptable salts thereof that are active as sodium and/or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases.Type: GrantFiled: November 16, 2004Date of Patent: June 28, 2011Assignee: Newron Pharmaceuticals S.p.A.Inventors: Florian Thaler, Cibele Maria Sabido David, Sara Maestroni, Luca Francesco Raveglia, Patricia Salvati
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Publication number: 20100048665Abstract: 3-aminopyrrolidone compounds and pharmaceutically acceptable salts thereof that are active as sodium and/or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases.Type: ApplicationFiled: November 2, 2009Publication date: February 25, 2010Applicant: NEWRON PHARMACEUTICALS S.p.A.,Inventors: Florian THALER, Cibele Maria Sabido David, Sara Maestroni, Luca Francesco Raveglia, Patricia Salvati
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Patent number: 7482458Abstract: NK3 receptor antagonists of formula (I): are useful in treating inter alia pulmonary disorders, CNS disorders and neurodegenerative disorders.Type: GrantFiled: March 21, 2006Date of Patent: January 27, 2009Assignee: SmithKline Beecham Farmaceutica S.p.A.Inventors: Carlo Farina, Giuseppe Arnaldo Maria Giardina, Mario Grugni, Luca Francesco Raveglia
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Patent number: 6780875Abstract: A compound, or a solvate or a salt thereof, of formula (I): wherein, Ar is an optionally substituted aryl or a C5-7 cycloalkdienyl group, or an optionally substituted C5-7 cycloalkyl group, or an optionally substituted single or fused ring aromatic heterocyclic group; R is hydrogen, linear or branched C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkylalkyl; R1 represents hydrogen or up to three optional substituents selected from the list consisting of: C1-6 alkyl, C1-6 alkenyl, aryl, C1-6 alkoxy, hydroxy, halogen, nitro, cyano, carboxy, carboxamido, sulphonamido, C1-6 alkoxycarbonyl, trifluoromethyl, acyloxy, amino or mono- and di-C1-6 alkylamino, R2 represents a moiety —(CH2)n—NYY2 wherein n is an integer in the range of from 1 to 9, Y1 and Y2 are independently selected from C1-6-alkyl; C1-6 alkyl substituted with hydroxy, alkoxy, C1-6 alkylamino or bis (C1-6 alkyl) amino; C3-6 cycloalkyl; C4-6 azacycloalkyl; C1-6-alkenyl; aryl or aryl-C1-6-alkyl or Y1 and Y2 together with the nitType: GrantFiled: February 5, 2003Date of Patent: August 24, 2004Assignees: SmithKline Beecham S.p.A., SmithKline Beecham Laboratories PharmaceutiquesInventors: Carlo Farina, Giuseppe Giardina, Mario Grugni, Marcel Morvan, Guy Marguerite Marie GĂ©rard Nadler, Luca Francesco Raveglia
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Publication number: 20040116469Abstract: A compound, or a solvate or a salt thereof, of formula (I): wherein, Ar is an optionally substituted aryl or a C5-7 cycloalkdienyl group, or a C5-7 cycloalkyl group or an optionally substituted single or fused ring aromatic heterocyclic group; R is C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkylalkyl, optionally substituted phenyl or phenyl C1-6 alkyl, an optionally substituted five-membered heteroaromatic ring comprising up to four heteroatoms selected from O and N, hydroxy C1-6 alkyl, amino C1-6 alkyl, C1-6 alkylaminoalkyl, di C1-6 alkylaminoalkyl, C1-6 acylaminoalkyl, C1-6 alkoxyalkyl, C1-6 alkylcarbonyl, carboxy, C1-6 alkoxycarbonyl, C1-6 alkoxycarbonyl C1-6 alkyl, aminocarbonyl, C1-6 alkylaminocarbonyl, di C1-6 alkylaminocarbonyl, halogeno C1-6 alkyl; or R is a group —(CH2)p— wherein p is 2 or 3 which group forms a ring with a carbon atom of Ar, R1 represents hydrogen or up to four optional substituents selected from the list consisting of: C1-6 alkyl, C1-6 alkenyl, aryl, C1-6 alkoxy, hydroxy, hType: ApplicationFiled: November 25, 2003Publication date: June 17, 2004Applicant: SmithKline Beecham SpAInventors: Giuseppe Arnaldo Maria Giardina, Mario Grugni, Davide Graziani, Luca Francesco Raveglia
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Patent number: 6743804Abstract: The present invention relates to a novel use, in particular a novel pharmaceutical use for a series of quinoline derivatives.Type: GrantFiled: May 7, 2002Date of Patent: June 1, 2004Assignee: SmithKline Beecham S p.A.Inventors: Giuseppe Arnaldo Maria Giardina, Carlo Farina, Mario Grugni, Luca Francesco Raveglia
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Patent number: 6696457Abstract: Heterocycle condensed morphinoid derivatives of formula (I) have therapeutic utility as analgesics, in collagen disease, as anti-allergic and anti-inflammatory agents, brain cell protectants, in gastritis, diarrhoea, cardiovascular and respiratory diseases, cough, mental illness, epilepsy, for the preservation of organs during transplant operations, and for the treatment of those pathological conditions which customarily can be treated with agonists of the delta opioid receptor.Type: GrantFiled: April 2, 2002Date of Patent: February 24, 2004Assignees: SmithKline Beecham p.l.c., SmithKline Beecham S.p.A.Inventors: Stephen Edward Clarke, Giulio Dondio, Luca Francesco Raveglia, Silvano Ronzoni
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Publication number: 20030236281Abstract: NK3 receptor antagonists of formula (I): 1Type: ApplicationFiled: May 29, 2001Publication date: December 25, 2003Inventors: Carlo Farina, Giuseppe Arnaldo Maria Giardina, Mario Grugni, Luca Francesco Raveglia
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Publication number: 20030212101Abstract: A compound, or a solvate or a salt thereof, of formula (I): 1Type: ApplicationFiled: February 5, 2003Publication date: November 13, 2003Applicant: SmithKline Beecham S.p.A.Inventors: Carlo Farina, Giuseppe Giardina, Mario Grugni, Marcel Morvan, Guy Marguerite Marie Gerard Nadler, Luca Francesco Raveglia
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Publication number: 20030195204Abstract: The present invention relates to a novel use, in particular a novel pharmaceutical use for a series of quinoline derivatives.Type: ApplicationFiled: May 7, 2002Publication date: October 16, 2003Applicant: SmithKline Beecham S.p.A.Inventors: Giuseppe Arnaldo Maria Giardina, Carlo Farina, Mario Grugni, Luca Francesco Raveglia
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Patent number: 6613770Abstract: A compound, or a solvate or a salt thereof, of formula (I): wherein R is linear or branched alkyl; R1 represents hydrogen or up to four optional substituents selected from the list consisting of: C1-6 alkyl, C1-6 alkenyl, aryl, C1-6 alkoxy, hydroxy, halogen, nitro, cyano, carboxy, carboxamido, sulphonamido, C1-6 alkoxycarbonyl, trifluoromethyl, acyloxy, phthalimido, amino or mono- and di-C1-6 alkylamino; R2 represents a moiety —(CH2)n—NY1Y2 wherein n is an integer in the range of from 1 to 9, Y1 and Y2 are independently selected from hydrogen; C1-6-alkyl; C1-6 alkyl substituted with hydroxy, C1-6 alkylamino or bis (C1-6 alkyl) amino; C1-6-alkenyl; aryl or aryl-C1-6-alkyl or Y1 and Y2 together with the nitrogen atom to which they are attached represent an optionally substituted N-linked single or fused ring heterocyclic group; R3 is branched or linear C1-6 alkyl, C3-7 cycloalkyl, C4-7 cycloalkylalkyl, optionally substituted aryl, or an optionally substituted single or fused rinType: GrantFiled: September 28, 2001Date of Patent: September 2, 2003Assignees: SmithKline Beecham S.p.A., SmithKline Beecham Laboratoires PhamaceutiquesInventors: Carlo Farina, Giuseppe Giardina, Mario Grugni, Guy Marguerite Marie Gerard Nadler, Luca Francesco Raveglia
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Patent number: 6608083Abstract: NK3 receptor antagonists of formula (I): in which: Ar is an optionally substituted phenyl group, or a naphthyl or C5-7 cycloalkdienyl group, or an optionally substituted single or fused ring heterocyclic group, having aromatic character, containing from 5 to 12 ring atoms and comprising up to four hetero-atoms in the or each ring selected from S, O, N; R is linear or branched C1-8 alkyl, C3-7 cycloalkyl, C4-7 cycloalkylalkyl, an optionally substituted phenyl group or a phenyl C1-6 alkyl group, an optionally substituted five-membered heteroaromatic ring comprising up to four heteroatoms selected from O and N, hydroxy C1-6 alkyl, amino C1-6 alkyl, C1-6 alkylaminoalkyl, di C1-6 alkylaminoalkyl, C1-6 acylaminoalkyl, C1-6 alkoxyalkyl, C1-6 alkylcarbonyl, carboxy, C1-6 alkoxyxcarbonyl, C1-6 alkoxycarbonyl C1-6 alkyl, aminocarbonyl, C1-6 alkylaminocarbonyl, di C1-6 alkylaminocarbonyl, halogeno C1-6 alkyl; or is a group —(CH2)p— when cyclized onto Ar, where p is 2 or 3; R1 and R2, whiType: GrantFiled: May 25, 1995Date of Patent: August 19, 2003Assignee: SmithKline Beecham Farmaceutici S.p.AInventors: Carlo Farina, Giuseppe Arnaldo Maria Giardina, Mario Grugni, Luca Francesco Raveglia
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Publication number: 20030004183Abstract: A compound, or a solvate or a salt thereof of formula (I), wherein, Ar is an optionally substituted aryl or a C5-7cycloalkdienyl group, or a C5-7cycloalkyl group or an optionally substituted single or fused ring aromatic heterocyclic group; R is C1-6alkyl, C3-7cycloalkyl, C3-7cycloalkylalkyl, optionally substituted phenyl or phenylC1-6alkyl, an optionally substituted five-membered heteroaromatic ring comprising up to four heteroatoms selected from O and N, hydroxy C1-6alkyl, amino C1-6 alkyl, C1-6alkylaminoalkyl, di C1-6alkylaminoalkyl, C1-6acylaminoalkyl, C1-6alkoxyalkyl, C1-6alkylcarbonyl, carboxy, C1-6alkoxycarbonyl, C1-6alkoxycarbonylC1-6alkyl, aminocarbonyl, C1-6alkylaminocarbonyl, di C1-6alkylaminocarbonyl, halogenoC1-6alkyl; or R is a group —(CH2)p— wherein p is 2 or 3 which group forms a ring with a carbon atom of Ar; R1 represents hydrogen or up to four optional substituents selected from the list consisting of, C1-6alkyl, C1-6alkenyl, aryl, C1-6alkoxy, hydroxy, halogen, nitro, cyano, carType: ApplicationFiled: January 16, 2002Publication date: January 2, 2003Inventors: Giuseppe Arnaldo Maria Giardina, Mario Grugni, Davide Graziani, Luca Francesco Raveglia
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Publication number: 20020156097Abstract: A compound of formula (I) or a solvate thereof, characterized in that salt comprises a compound of formula (I) in anionic form and a salting cation; a process for preparing such a compound, a pharmaceutical composition containing such a compound and the use of such a compound in medicine.Type: ApplicationFiled: June 12, 2002Publication date: October 24, 2002Applicant: SmithKline Beecham S.p.A.Inventors: Giuseppe Arnaldo Maria-Giardina, Carlo Farina, Mario Grugni, Luca Francesco Raveglia
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Patent number: 6432977Abstract: A compound of formula (I) or a solvate thereof, characterized in that salt comprises a compound of formula (I) in anionic form and a salting cation; a process from preparing such a compound, a pharmaceutical composition containing such a compound and the use of such a compound in medicine.Type: GrantFiled: November 6, 2001Date of Patent: August 13, 2002Assignee: SmithKline Beecham S.p.A.Inventors: Giuseppe Arnaldo Maria Giardina, Carlo Farina, M. Grugni, Luca Francesco Raveglia
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Publication number: 20020077335Abstract: A compound of formula (I) or a solvate thereof, characterized in that salt comprises a compound of formula (I) in anionic form and a salting cation; a process for preparing such a compound, a pharmaceutical composition containing such a compound and the use of such a compound in medicine.Type: ApplicationFiled: November 6, 2001Publication date: June 20, 2002Applicant: SmithKline Beecham S.p.A.Inventors: Giuseppe Arnaldo Giardina, Carlo Farina, M. Grugni, Luca Francesco Raveglia
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Publication number: 20020068827Abstract: A compound of formula (I): 1Type: ApplicationFiled: November 26, 2001Publication date: June 6, 2002Applicant: SmithKline Beecham S.p.A.Inventors: Giuseppe Arnaldo Maria Giardina, Mario Grugni, Luca Francesco Raveglia, Carlo Farina