Abstract: A method for applying adhesive on a wrapping band of a smoking article includes moving the band along a feed direction, the band has a longitudinal direction of extension, opposing first and second surfaces, a first plurality of portions having a first thickness and a second plurality of portions having a second thickness greater than the first thickness, the portions of the first and second pluralities being disposed alternately along the direction of extension. A nozzle having a delivery end, and the band are moved towards/away from each other between a first position, where the delivery end and the second surface are at a first distance which is less than or equal to the second thickness, and a second position, where the delivery end and the second surface are at a second distance greater than the second thickness. An adhesive is delivered on the first surface through the nozzle.

Abstract: The invention discloses synergistic compositions stimulating the expression of Sirtuin comprising combinations of a first component selected from berberine and tyrosol with a second component selected from selected from quercetin, tyrosol, catechin and ferulic acid.

Abstract: The present invention relates to ophthalmic preparations in the form of eyedrops based on BDNF (Brain-Derived Neurotrophic Factor). Said preparations can be administered topically to the intact eye surface, and are useful in the prevention and treatment of neurodegenerative disorders of the retina, optic nerve, lateral geniculate body and visual cortex, in order to prevent reduction of visual capacity and restore the normal visual function.

Abstract: The present invention relates to ophthalmic preparations in the form of eyedrops based on PACAP (Pituitary Adenylate Cyclase Activating Polypeptide) which restore the normal visual function in retinal dystrophy/retinopathy and optic neuropathy, with special reference to glaucoma. Said preparations can be administered topically to the intact eye surface, and are useful in the treatment of various forms of retinal dystrophy/retinopathy and optic neuropathy, such as glaucoma.

Abstract: Said preparations can be administered topically to the intact eye surface, and are useful in the prevention and treatment of neurodegenerative disorders of the retina, optic nerve, lateral geniculate body and visual cortex, in order to prevent reduction of visual capacity and restore the normal visual function.