Abstract: Methods and materials for the cryopreservation of cellularised scaffolds used for therapeutic or pharmacological testing purposes that provide a cultured scaffold on which cells have been seeded, equilibrate the cellularised scaffold with a cryopreservative composition comprising culture medium and between 5 and 30% of a cryoprotectant such as DMSO, freeze the equilibrated cellularised scaffold by reducing the temperature continuously by about ?1° C./minute to about ?80° C., and store the frozen cellularised scaffold at a temperature of between ?135° C. and ?198° C.

Abstract: The present invention relates generally to methods and materials for use in the production of implants, particularly luminal tissue implants, where the implants are engineered by seeding of an acellular scaffold or matrix with muscle cell precursors and fibroblasts, for example injection seeding using particular ratios of cells. The present invention provides methods for producing tissue engineered constructs for implantation into a subject which can utilise novel seeding processes described herein for improved cell engraftment and differentiation. In addition, the invention describes methods for treating an individual by implantation of the engineered constructs or tissues of the invention.

Abstract: A drilling machine has a drilling tool, a rotary, a main engine that actuates a high-pressure pump, a hydraulic motor, actuated by the high-pressure pump and connected to the rotary at least one pressure sensor disposed in a discharge pipe. The fluid flows from the high-pressure pump to the hydraulic motor. An adjustment valve is disposed in a discharge pipe such that the fluid flows from a low-pressure circuit to the hydraulic motor in order to adjust the cylinder capacity of the hydraulic motor according to the pressure measured by the pressure sensor when the tool is unloaded.

Abstract: The present invention relates generally to methods and materials for use in the production of implants, particularly luminal tissue implants, where the implants are engineered by seeding of an acellular scaffold or matrix with muscle cell precursors and fibroblasts, for example injection seeding using particular ratios of cells. The present invention provides methods for producing tissue engineered constructs for implantation into a subject which can utilise novel seeding processes described herein for improved cell engraftment and differentiation. In addition, the invention describes methods for treating an individual by implantation of the engineered constructs or tissues of the invention.

Abstract: A driving head for telescopic drill rods has a frame, a cylindrical collar rotatably coupled with said frame, and provided at least with one internal surface comprising at least one driving rack adapted to be coupled with corresponding driven racks of telescopic drill rods, and actuation means to drive said cylindrical collar into rotation, said driving rack being coupled with said cylindrical collar by means of removable connection means. A machine provided with said driving head is also disclosed.

Abstract: A drilling machine includes a drilling tool, a rotary, a main engine that actuates a high-pressure pump, a hydraulic motor, with variable cylinder capacity, actuated by the high-pressure pump and connected to the rotary, at least one pressure sensor disposed in a discharge pipe wherein the fluid flows from the high-pressure pump to the hydraulic motor, and an adjustment valve disposed in a discharge pipe wherein the fluid flows from a low-pressure circuit to the hydraulic motor in order to adjust the cylinder capacity of the hydraulic motor according to the pressure measured by the pressure sensor when the tool is unloaded.

Abstract: A driving head for telescopic drill rods has a frame, a cylindrical collar rotatably coupled with said frame, and provided at least with one internal surface comprising at least one driving rack adapted to be coupled with corresponding driven racks of telescopic drill rods, and actual Oil means to drive said cylindrical collar into rotation, said driving rack being coupled with said cylindrical collar by means of removable connection means. A machine provided with said driving head is also disclosed.