Patents by Inventor Lucas O. Tiziani
Lucas O. Tiziani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11185794Abstract: Described are a fraction collector and a method of fraction collection for a liquid chromatography system. The method includes diverting a liquid chromatography system flow from a waste channel to a collection tube at a start of a fraction collection window and collecting the system flow dispensed from the collection tube during the fraction collection window. At the end of the window, the system flow is diverted to the waste channel and a flow of a wash solvent is provided to the collection tube to dispense liquid remaining in the collection tube at the end of the window from the collection tube. The method can increase the amount of the collected fraction and can reduce or eliminate cross-contamination of a subsequently collected fraction. The method is useful for analytical scale applications where the collected fractions may have volumes defined by a limited number of drops dispensed from the collection tube.Type: GrantFiled: February 26, 2015Date of Patent: November 30, 2021Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: Joshua A. Burnett, James Usowicz, Marc Lemelin, Lucas O. Tiziani, John Lamoureux, Aaron Lebeau
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Patent number: 10183238Abstract: A method includes passing a mobile phase fluid flow comprising liquefied CO2 through a separation column; then introducing a makeup fluid flow into the mobile phase fluid flow to form a mixed fluid flow; and then splitting the mixed fluid flow.Type: GrantFiled: March 5, 2013Date of Patent: January 22, 2019Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: Michael R. Jackson, James E. Usowicz, Lucas O. Tiziani, Joseph A. Jarrell, Douglas P. Wittmer
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Patent number: 10175209Abstract: Apparatus and method measure the flow rate of fluid for use in calibrating fraction collection in a chromatography system. An injector inserts a detectable substance into a flow of fluid. A first detector, disposed in a path of the flow of liquid with the substance, produces a signal in response to detecting the substance in the flow of fluid. A second detector, disposed downstream from the first detector in the path of the flow of fluid with the substance, produces a signal in response to detecting the substance in the flow of fluid. A computing system receives each signal produced by the first and second detectors upon detecting the substance in the flow of fluid, and computes a volumetric flow rate of the flow of fluid based on a time interval between the signals and a volume of the path between the first and second detectors.Type: GrantFiled: November 2, 2015Date of Patent: January 8, 2019Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: Joshua A. Burnett, James Usowicz, Marc Lemelin, Lucas O. Tiziani, Aaron Lebeau
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Patent number: 10001463Abstract: Described is a dispensing needle for a fraction collector. The dispensing needle includes a conduit having a fluid channel to conduct a chromatographic flow, an interior wall that defines the fluid channel, an exterior surface and an endface through which the chromatographic flow is dispensed. The dispensing needle also includes a coating of a hydrocarbon material or a fluorocarbon material that is bonded to the endface. The coating is also bonded to at least a portion of the exterior surface that is adjacent to the endface and at least a portion of the interior wall that is adjacent to the endface. The coating operates to reduce a droplet volume of a liquid dispensed from the endface that may remain at the tip of the dispensing needle. Consequently, the concentration variation in a collected fraction due to a missing droplet or extra droplet is reduced.Type: GrantFiled: August 30, 2017Date of Patent: June 19, 2018Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: Theodore A. Dourdeville, Joshua A. Burnett, James E. Usowicz, Marc E. Lemelin, Lucas O. Tiziani
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Publication number: 20170363590Abstract: Described is a dispensing needle for a fraction collector. The dispensing needle includes a conduit having a fluid channel to conduct a chromatographic flow, an interior wall that defines the fluid channel, an exterior surface and an endface through which the chromatographic flow is dispensed. The dispensing needle also includes a coating of a hydrocarbon material or a fluorocarbon material that is bonded to the endface. The coating is also bonded to at least a portion of the exterior surface that is adjacent to the endface and at least a portion of the interior wall that is adjacent to the endface. The coating operates to reduce a droplet volume of a liquid dispensed from the endface that may remain at the tip of the dispensing needle. Consequently, the concentration variation in a collected fraction due to a missing droplet or extra droplet is reduced.Type: ApplicationFiled: August 30, 2017Publication date: December 21, 2017Inventors: Theodore A. Dourdeville, Joshua A. Burnett, James E. Usowicz, Marc E. Lemelin, Lucas O. Tiziani
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Patent number: 9791423Abstract: Described is a dispensing needle for a fraction collector. The dispensing needle includes a conduit having a fluid channel to conduct a chromatographic flow, an interior wall that defines the fluid channel, an exterior surface and an endface through which the chromatographic flow is dispensed. The dispensing needle also includes a coating of a hydrocarbon material or a fluorocarbon material that is bonded to the endface. The coating is also bonded to at least a portion of the exterior surface that is adjacent to the endface and at least a portion of the interior wall that is adjacent to the endface. The coating operates to reduce a droplet volume of a liquid dispensed from the endface that may remain at the tip of the dispensing needle. Consequently, the concentration variation in a collected fraction due to a missing droplet or extra droplet is reduced.Type: GrantFiled: February 26, 2015Date of Patent: October 17, 2017Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: Theodore Dourdeville, Joshua A. Burnett, James Usowicz, Marc Lemelin, Lucas O. Tiziani
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Publication number: 20160131617Abstract: Apparatus and method measure the flow rate of fluid for use in calibrating fraction collection in a chromatography system. An injector inserts a detectable substance into a flow of fluid. A first detector, disposed in a path of the flow of liquid with the substance, produces a signal in response to detecting the substance in the flow of fluid. A second detector, disposed downstream from the first detector in the path of the flow of fluid with the substance, produces a signal in response to detecting the substance in the flow of fluid. A computing system receives each signal produced by the first and second detectors upon detecting the substance in the flow of fluid, and computes a volumetric flow rate of the flow of fluid based on a time interval between the signals and a volume of the path between the first and second detectors.Type: ApplicationFiled: November 2, 2015Publication date: May 12, 2016Inventors: Joshua A. Burnett, James Usowicz, Marc Lemelin, Lucas O. Tiziani, Aaron Lebeau
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Publication number: 20150246296Abstract: Described are a fraction collector and a method of fraction collection for a liquid chromatography system. The method includes diverting a liquid chromatography system flow from a waste channel to a collection tube at a start of a fraction collection window and collecting the system flow dispensed from the collection tube during the fraction collection window. At the end of the window, the system flow is diverted to the waste channel and a flow of a wash solvent is provided to the collection tube to dispense liquid remaining in the collection tube at the end of the window from the collection tube. The method can increase the amount of the collected fraction and can reduce or eliminate cross-contamination of a subsequently collected fraction. The method is useful for analytical scale applications where the collected fractions may have volumes defined by a limited number of drops dispensed from the collection tube.Type: ApplicationFiled: February 26, 2015Publication date: September 3, 2015Inventors: Joshua A. Burnett, James Usowicz, Marc Lemelin, Lucas O. Tiziani, John Lamoureux, Aaron Lebeau
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Publication number: 20150247830Abstract: Described is a dispensing needle for a fraction collector. The dispensing needle includes a conduit having a fluid channel to conduct a chromatographic flow, an interior wall that defines the fluid channel, an exterior surface and an endface through which the chromatographic flow is dispensed. The dispensing needle also includes a coating of a hydrocarbon material or a fluorocarbon material that is bonded to the endface. The coating is also bonded to at least a portion of the exterior surface that is adjacent to the endface and at least a portion of the interior wall that is adjacent to the endface. The coating operates to reduce a droplet volume of a liquid dispensed from the endface that may remain at the tip of the dispensing needle. Consequently, the concentration variation in a collected fraction due to a missing droplet or extra droplet is reduced.Type: ApplicationFiled: February 26, 2015Publication date: September 3, 2015Inventors: Theodore Dourdeville, Joshua A. Burnett, James Usowicz, Marc Lemelin, Lucas O. Tiziani
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Publication number: 20150246351Abstract: Described is a dispensing needle for a fraction collector. The dispensing needle includes a conduit having a fluid channel to conduct a chromatographic system flow. The dispensing needle also includes a needle tip that has a fluid channel and an endface. The fluid channel of the needle tip is disposed at a dispensing end of the conduit and has a cross-sectional area that is less than a cross-sectional area of the fluid channel of the conduit. The fluid channels are in communication and enable a liquid chromatography system flow at a first velocity in the conduit to be dispensed at the endface of the needle tip at a second velocity that is greater than the first velocity. Advantageously, any droplets that may form at the endface of the needle tip are reduced in volume and therefore concentration variations for collected fractions are reduced.Type: ApplicationFiled: February 26, 2015Publication date: September 3, 2015Inventors: Joshua A. Burnett, James Usowicz, Marc Lemelin, Lucas O. Tiziani
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Publication number: 20150021265Abstract: A method includes passing a mobile phase fluid flow comprising liquefied CO2 through a separation column; then introducing a makeup fluid flow into the mobile phase fluid flow to form a mixed fluid flow; and then splitting the mixed fluid flow.Type: ApplicationFiled: March 5, 2013Publication date: January 22, 2015Applicant: WATERS TECHNOLOGIES CORPORATIONInventors: Michael R. Jackson, James E. Usowicz, Lucas O. Tiziani, Joseph A. Jarrell, Douglas P. Wittmer