Abstract: Contamination Control System includes a housing having a cartridge input-output port and an application input-output port The cartridge is coupleable to the cartridge input-output port and of a size to completely fit in an interior of the housing. A dual isolation interface is provided between cartridge and housing so that each entity may be separately isolated at the fluid interface. The isolation interface is resiliently engageable to make the fluid path open and close. The cartridge has a body physically defining a multi-region interior chamber, the chamber in fluid communication with an input and an output and defining a fluid flow path therebetween larger than any dimension of the body.