Patents by Inventor Ludger A. Wessjohann
Ludger A. Wessjohann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230129118Abstract: Phytosphingosine derivatives suitable as adjuvants in immune stimulation, pharmaceutical compositions comprising such compounds and the medical use of the compounds and/or compositions in therapeutic or prophylactic methods of immune stimulation in a subject, and for use in the treatment of a disease, for which stimulation of an immune response in a subject produces a therapeutic benefit. The phytosphingosine derivative may also be used as adjuvants in vaccinating a subject. The phytosphingosine derivative may also be used in stimulating antibody production, stimulating an immune response against infection, stimulating an immune response against a cancer, or preventing and/or treating septic shock. Methods for the manufacture of the derivatives comprising an Ugi-4-component reaction (Ugi-4CR) is also disclosed.Type: ApplicationFiled: June 18, 2021Publication date: April 27, 2023Inventors: Yanira MENDEZ-GOMEZ, Bernhard WESTERMANN, Daniel GARCIA-RIVERA, Aldrin VASCO-VIDAL, Ludger WESSJOHANN, Carlos A. GUZMÁN, Thomas EBENSEN, Kai SCHULZE, Peggy RIESE, Stephanie TRITTEL
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Patent number: 10988786Abstract: The present invention relates to genetically modified enzymes obtained by rational design of the active site binding pocket of the prototypic enzyme 4-hydroxyphenylacetate 3-hydroxylase (4HPA3H) for hydroxylating a 4-hydroxyphenyl compound to yield a 3,4-dihydroxyphenyl compound and to biotechnological methods including in vivo and in vitro methods using said enzymes or catalytically active fragments thereof. Further provided is a method either using a suitable oxidase or hydroxylase further enabling the subsequent site specific methylation of the 3,4-dihydroxyphenyl compound in a coupled enzymatic reaction by providing a suitable O-methyltransferase. Finally, compositions obtainable by the aforementioned methods are disclosed.Type: GrantFiled: September 30, 2016Date of Patent: April 27, 2021Assignees: SYMRISE AG, LEIBNIZ-INSTITUT FÜR PFLANZENBIOCHEMIEInventors: Ludger A. Wessjohann, Susann Herrmann, Martin Dippe, Torsten Geissler, Katrin Geissler, Jakob Peter Ley
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Publication number: 20200360332Abstract: Compound, stereoisomers, enantiomers or diastereomers thereof, physiologically acceptable salts thereof, mixtures of said compound for use in increasing mental capability, and a pharmaceutical composition. The increasing of mental capability is tested in learning experiments with Drosophila melanogaster larvae or older animals, which are raised with standard feed mash or with different concentrations of FSE-20 in the feed mash. In the learning experiment, the animals are each subjected to one of two inverse training regimens and then subjected to a test. In the training, a first scent was presented with the feed reward to the first group, while a second scent was presented alone to the first group. The second group was trained inversely. In the test of the learning experiment, it was subsequently examined whether the larvae of both groups prefer the first scent or the second scent in a selection situation; thus, their learning and memory capability was determined.Type: ApplicationFiled: November 23, 2018Publication date: November 19, 2020Inventors: Birgit Michels, Bertram Gerber, Ludger Wessjohann, Katrin Franke, Stephan Sigrist, Anuradha Bhukel, Oleh Lushchak, Hanna Zwaka, Ruth Bartels, Alexander Dityatev, Inseon Song, Markus Fendt, Volkmar Lessmann, Thomas Endres, Thilo Kaehne
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Patent number: 10435673Abstract: A method is proposed for producing flavonoids, comprising the steps: (a) providing of a transgenic microorganism, containing (i) a first nucleic acid section (A), comprising or consisting of a gene coding for a CYP450 oxidase, (ii) a second nucleic acid section (B), comprising or consisting of a gene coding for a plant O-methyltransferase, and (b) adding of one or more flavanones to the transgenic microorganism, (c) the conversion of the substrate flavanones by the transgenic microorganism to the corresponding flavonoids, and optionally (d) isolating and purifying of the final products.Type: GrantFiled: September 27, 2015Date of Patent: October 8, 2019Assignee: SYMRISE AGInventors: Ludger Wessjohann, Anne-Kathrin Bauer, Jakob Ley, Torsten Geissler, Katrin Geissler
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BIOTECHNOLOGICAL METHODS FOR PROVIDING 3,4-DIHYDROXYPHENYL COMPOUNDS AND METHYLATED VARIANTS THEREOF
Publication number: 20190194707Abstract: The present invention relates to genetically modified enzymes obtained by rational design of the active site binding pocket of the prototypic enzyme 4-hydroxyphenylacetate 3-hydroxylase (4HPA3H) for hydroxylating a 4-hydroxyphenyl compound to yield a 3,4-dihydroxyphenyl compound and to biotechnological methods including in vivo and in vitro methods using said enzymes or catalytically active fragments thereof. Further provided is a method either using a suitable oxidase or hydroxylase further enabling the subsequent site specific methylation of the 3,4-dihydroxyphenyl compound in a coupled enzymatic reaction by providing a suitable O-methyltransferase. Finally, compositions obtainable by the aforementioned methods are disclosed.Type: ApplicationFiled: September 30, 2016Publication date: June 27, 2019Inventors: Ludger A. WESSJOHANN, Susann HERRMANN, Martin DIPPE, Torsten GEISSLER, Katrin GEISSLER, Jakob Peter LEY -
Patent number: 10227620Abstract: The invention relates to providing both fermentative and biotechnological methods for producing 3,4-methylized cinnamic acids, 3,4-methylized cinnamic acid esters, 3,4-dimethoxyphenethylamine, and 4-methylized cinnamic acid amides using a 4?-O-methyltransferase, optionally in combination with further enzymes, wherein the enzymes are selected by means of metabolic engineering and operation have been adapted by targeted optimization, and compositions obtained by means of the method. The invention further relates to vector systems, recombinant microorganisms or fungi, and specific nucleic acid segments and polypeptides.Type: GrantFiled: February 1, 2016Date of Patent: March 12, 2019Assignee: SYMRISE AGInventors: Gerhard Krammer, Jakob Peter Ley, Katrin Geißler, Torsten Geißler, Frauke Gomoll, Peter Welters, Guido Jach, Ludger Wessjohann
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Publication number: 20180228825Abstract: The invention relates to the use of a compound of formula (I), or a composition containing the compound, as glutaminyl cyclase (QC) inhibitor and to methods of preparation.Type: ApplicationFiled: September 15, 2016Publication date: August 16, 2018Applicants: Hochschule Anhalt, Leibniz-Institut Für Pflanzenbiochemie (IPB)Inventors: Stephanie Hielscher-Michael, Carola Griehl, Hans-Ulrich Demuth, Stephan Schilling, Ludger Wessjohann, Norbert Arnold
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Publication number: 20180135029Abstract: A method is proposed for producing flavonoids, comprising the steps: (a) providing of a transgenic microorganism, containing (i) a first nucleic acid section (A), comprising or consisting of a gene coding for a CYP450 oxidase, (ii) a second nucleic acid section (B), comprising or consisting of a gene coding for a plant O-methyltransferase, and (b) adding of one or more flavanones to the transgenic microorganism, (c) the conversion of the substrate flavanones by the transgenic microorganism to the corresponding flavonoids, and optionally (d) isolating and purifying of the final products.Type: ApplicationFiled: September 27, 2015Publication date: May 17, 2018Inventors: Ludger Wessjohann, Anne-Kathrin Bauer, Jakob Ley, Torsten Geissier, Katrin Geissler
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Patent number: 9803180Abstract: The present invention relates to isolated polypeptides that are derived from wildtype Bacillus subtilis S-Adenosylmethionine (SAM) synthase or from a biologically active fragment thereof, wherein said isolated polypeptides comprise an amino acid sequence that, in relation to the amino acid sequence of said wildtype Bacillus subtilis SAM synthase or of the biologically active fragment thereof, comprises at least one amino acid substitution, selected from the group consisting of amino acid substitutions at positions I317 and I105. The present invention further relates to respective isolated nucleic acids, vectors, host cells, uses and methods for the production of SAM derivatives.Type: GrantFiled: September 4, 2014Date of Patent: October 31, 2017Assignee: LEIBNIZ-INSTITUT FÜR PFLANZENBIOCHEMIE STIFTUNG DES ÖFFENTLICHEN RECHTSInventors: Martin Dippe, Wolfgang Brandt, Ludger A. Wessjohann, Hannes Rost, Andrea Porzel
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Publication number: 20170240870Abstract: The present invention relates to isolated polypeptides that are derived from wildtype Bacillus subtilis S-Adenosylmethionine (SAM) synthase or from a biologically active fragment thereof, wherein said isolated polypeptides comprise an amino acid sequence that, in relation to the amino acid sequence of said wildtype Bacillus subtilis SAM synthase or of the biologically active fragment thereof, comprises at least one amino acid substitution, selected from the group consisting of amino acid substitutions at positions I317 and I105. The present invention further relates to respective isolated nucleic acids, vectors, host cells, uses and methods for the production of SAM derivatives.Type: ApplicationFiled: September 4, 2014Publication date: August 24, 2017Inventors: Martin Dippe, Wolfgang Brandt, Ludger A. Wessjohann, Hannes Rost, Andrea Porzel
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Patent number: 9642381Abstract: The invention relates to triterpenes and triterpene glycosides of the formula (I) and/or physiologically acceptable salts thereof, preferably naturally occurring triterpenes and triterpene glycosides from Mycetia balansae and/or physiologically acceptable salts thereof and orally consumable formulations comprising one or a plurality of these triterpenes and triterpene glycosides and/or physiologically acceptable salts thereof. The invention further relates to the use of these triterpenes and triterpene glycosides and/or physiologically acceptable salts thereof, preferably an extract of Mycetia balansae, for generating a sweet impression in an orally consumable formulation or for reinforcing the sweet impression of an orally consumable formulation comprising at least one further, preferably naturally occurring, sweet-tasting substance.Type: GrantFiled: June 1, 2012Date of Patent: May 9, 2017Assignee: Symrise AGInventors: Jakob Ley, Katharina Reichelt, Katja Obst, Ludger Wessjohann, Sabine Wessjohann, Tran Van Sung, The Anh Nguyen, Ngo Van Trai
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Publication number: 20160281118Abstract: The invention relates to providing both fermentative and biotechnological methods for producing 3,4-methylized cinnamic acids, 3,4-methylized cinnamic acid esters, 3,4-dimethoxyphenethylamine, and 4-methylized cinnamic acid amides using a 4?-O-methyltransferase, optionally in combination with further enzymes, wherein the enzymes are selected by means of metabolic engineering and operation have been adapted by targeted optimization, and compositions obtained by means of the method. The invention further relates to vector systems, recombinant microorganisms or fungi, and specific nucleic acid segments and polypeptides.Type: ApplicationFiled: February 1, 2016Publication date: September 29, 2016Inventors: GERHARD KRAMMER, JAKOB PETER LEY, KATRIN GEIßLER, TORSTEN GEIßLER, FRAUKE GOMOLL, PETER WELTERS, GUIDO JACH, LUDGER WESSJOHANN
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Publication number: 20160264946Abstract: The present invention relates to isolated polypeptides that are derived from wildtype Bacillus subtilis S-Adenosylmethionine (SAM) synthase or from a biologically active fragment thereof, wherein said isolated polypeptides comprise an amino acid sequence that, in relation to the amino acid sequence of said wildtype Bacillus subtilis SAM synthase or of the biologically active fragment thereof, comprises at least one amino acid substitution, selected from the group consisting of amino acid substitutions at positions I317 and I105. The present invention further relates to respective isolated nucleic acids, vectors, host cells, uses and methods for the production of SAM derivatives.Type: ApplicationFiled: September 4, 2014Publication date: September 15, 2016Inventors: Martin Dippe, Wolfgang Brandt, Ludger A. Wessjohann, Hannes Rost, Andrea Porzel
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Patent number: 9371358Abstract: The present invention relates to novel tubulysin compounds (tubulysin analogs) as well as pharmaceutical formulations thereof. The present invention further relates to the use of such compounds for medicinal, agricultural, biotool or cosmetic applications. In particular, the novel tubulysin analogs show a cytostatic effect and can therefore be used for the treatment of proliferative disorders. The tertiary amide moiety of the tubulysin analogs (so-called tubugis) according to the present invention is generated by an Ugi-type reaction.Type: GrantFiled: July 18, 2011Date of Patent: June 21, 2016Assignee: Leibniz-Institut Fur PflanzenbiochemieInventors: Ludger A. Wessjohann, Orlando Pando Morejon
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Patent number: 8865863Abstract: The invention relates to a method for producing peptoidic, peptidic and chimeric peptidic-peptoidic dendrimers by multiple iterative multi-component reactions (MCR), in particular Ugi or Passerini multi-component reactions, to compounds produced in this way and to the use thereof.Type: GrantFiled: April 14, 2011Date of Patent: October 21, 2014Assignee: Leibniz-Institut fur PflandzenbiochemieInventors: Ludger A. Wessjohann, Michael Henze, Oliver Kreye, Daniel Garcia Rivera
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Publication number: 20140170083Abstract: The invention relates to triterpenes and triterpene glycosides of the formula (I) and/or physiologically acceptable salts thereof, preferably naturally occurring triterpenes and triterpene glycosides from Mycetia balansae and/or physiologically acceptable salts thereof and orally consumable formulations comprising one or a plurality of these triterpenes and triterpene glycosides and/or physiologically acceptable salts thereof. The invention further relates to the use of these triterpenes and triterpene glycosides and/or physiologically acceptable salts thereof, preferably an extract of Mycetia balansae, for generating a sweet impression in an orally consumable formulation or for reinforcing the sweet impression of an orally consumable formulation comprising at least one further, preferably naturally occurring, sweet-tasting substance.Type: ApplicationFiled: June 1, 2012Publication date: June 19, 2014Applicant: Symrise AGInventors: Jakob Ley, Katharina Reichelt, Katja Obst, Ludger wessjohann, Sabine Wessjohann, Tran Van Sung, The Anh Nguyen, Ngo Van Trai
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Patent number: 8648115Abstract: The present invention relates to the use of compounds of general formula (I) or of a salt thereof as anti-oomycetes and to a method for combating plant pathogens using said compounds.Type: GrantFiled: May 26, 2010Date of Patent: February 11, 2014Assignees: BASF SE, Leibniz-Institute Fuer PflanzenbiochemieInventors: Norbert Arnold, Axel Teichert, Sabine Rosahl, Bernhard Westermann, Ludger Wessjohann, Lennart Eschen-Lippold, Tobias Draeger
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Publication number: 20130217638Abstract: The present invention relates to novel tubulysin compounds (tubulysin analogues) as well as pharmaceutical formulations thereof. The present invention further relates to the use of such compounds for medicinal, agricultural, biotool or cosmetic applications. In particular, the novel tubulysin analogues show a cytostatic effect and can therefore be used for the treatment of proliferative disorders. The tertiary amide moiety of the tubulysin analogues (so-called tubugis) according to the present invention is generated by an Ugi-type reaction.Type: ApplicationFiled: July 18, 2011Publication date: August 22, 2013Applicant: Leibniz-Institut Fur PflanzenbiochemieInventors: Ludger A. Wessjohann, Orlando Pando Morejon
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Publication number: 20130203960Abstract: The invention relates to a method for producing peptoidic, peptidic and chimeric peptidic-peptoidic dendrimers by multiple iterative multi-component reactions (MCR), in particular Ugi or Passerini multi-component reactions, to compounds produced in this way and to the use thereof.Type: ApplicationFiled: April 14, 2011Publication date: August 8, 2013Applicant: LEIBNIZ-INSTITUT FUR PFLANZENBIOCHEMIEInventors: Ludger A. Wessjohann, Michael Henze, Oliver Kreye, Daniel Garcia Rivera
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Publication number: 20120129938Abstract: The present invention relates to the use of compounds of general formula (I) or of a salt thereof as anti-oomycetes and to a method for combating plant pathogens using said compounds.Type: ApplicationFiled: May 26, 2010Publication date: May 24, 2012Inventors: Norbert Arnold, Axel Teichert, Sabine Rosahl, Bernhard Westermann, Ludger Wessjohann, Lennart Eschen-Lippold, Tobias Draeger