Patents by Inventor Ludwig Ross

Ludwig Ross has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230401458
    Abstract: An artificial intelligence (AI) system classifies a document by a document type and determines redlining for the document based on the classified document type. The AI system may use machine learning to classify the document, where the AI system trains a machine-learned model using training documents of respective types. After determining the document type of a target document, the AI system compares the target document against one or more templates of the classified document type to determine edited or unedited portions of the target document. The AI system can modify an unedited portion of the target document using a predetermined edit associated with a template. The modified document target document may be displayed at a client device such that the edits (e.g., the modified unedited portion and existing edits in the target document) are visually distinct from one another.
    Type: Application
    Filed: June 8, 2022
    Publication date: December 14, 2023
    Inventors: Michael Ludwig Ross, Alexander Dylan Sugar, Gurinder Singh Sangha
  • Publication number: 20230072925
    Abstract: An artificial intelligence (AI) system accesses training text documents and parses the training text documents to extract training edits. The AI system forms a set of training data that includes the training text documents and the training edits. The AI system trains an AI model based on at least the set of training data. The AI system may also use a reference model, a general model, and/or user input to generate the AI model. In some embodiments, the training text documents are associated with a type of transaction and the AI model is specific to the type of transaction. The AI system applies the AI model to a target text document to generate target edits. The AI system further modifies the target text document to include the target edits and transmits the modified target text document to a client device.
    Type: Application
    Filed: September 7, 2021
    Publication date: March 9, 2023
    Inventors: Michael Ludwig Ross, Alexander Dylan Sugar, Gurinder Singh Sangha
  • Patent number: 10961246
    Abstract: The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein fluorine-18 is covalently linked to the glutamate portion of a folate or derivative thereof, a method of their preparation, as well as their use in diagnosis and monitoring of therapy of cancer and inflammatory and autoimmune diseases.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: March 30, 2021
    Assignee: MERCK & CIE
    Inventors: Roger Schibli, Rudolf Moser, Cristina Magdalena Muller, Simon Mensah Ametamey, Tobias Ludwig Ross, Viola Groehn
  • Patent number: 10377756
    Abstract: The present invention is directed towards a new method of synthesis of 18F-folate radiopharmaceuticals, wherein fluorine-18 is attached to a pteroate (or folate) or derivative thereof, through direct radiolabeling with 18[F]fluoride, as well as 18F-folate radiopharmaceuticals obtained by such method of synthesis and their use in diagnosis and monitoring of cancer therapy and therapy of inflammatory and autoimmune diseases.
    Type: Grant
    Filed: July 13, 2015
    Date of Patent: August 13, 2019
    Assignee: MERCK & CIE
    Inventors: Simon Mensah Ametamey, Rudolf Moser, Tobias Ludwig Ross, Phoebe Lam, Viola Groehn
  • Publication number: 20180072734
    Abstract: The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein fluorine-18 is covalently linked to the glutamate portion of a folate or derivative thereof, a method of their preparation, as well as their use in diagnosis and monitoring of therapy of cancer and inflammatory and autoimmune diseases.
    Type: Application
    Filed: September 21, 2017
    Publication date: March 15, 2018
    Applicant: MERCK & CIE
    Inventors: Roger SCHIBLI, Rudolf MOSER, Cristina Magdalena MULLER, Simon Mensah AMETAMEY, Tobias Ludwig ROSS, Viola GROEHN
  • Patent number: 9771368
    Abstract: The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein the fluorine-18 is covalently linked to the aminobenzoyl moiety, which connects the condensed pyrimidine heterocycle to the amino acid portion within folate structures, as well as their precursors and their non-radioactive references, a method of their preparation, as well as their use in diagnosis of a cell or population of cells expressing a folate-receptor and monitoring of cancer and inflammatory and autoimmune diseases and therapy thereof.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: September 26, 2017
    Assignee: MERCK & CIE
    Inventors: Simon Mensah Ametamey, Rudolf Moser, Tobias Ludwig Ross, Viola Groehn
  • Publication number: 20160159802
    Abstract: The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein the fluorine-18 is covalently linked to the aminobenzoyl moiety, which connects the condensed pyrimidine heterocycle to the amino acid portion within folate structures, as well as their precursors and their non-radioactive references, a method of their preparation, as well as their use in diagnosis of a cell or population of cells expressing a folate-receptor and monitoring of cancer and inflammatory and autoimmune diseases and therapy thereof.
    Type: Application
    Filed: February 12, 2016
    Publication date: June 9, 2016
    Applicant: MERCK & CIE
    Inventors: Simon Mensah AMETAMEY, Rudolf MOSER, Tobais Ludwig ROSS, Viola GROEHN
  • Patent number: 9315506
    Abstract: The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein the fluorine-18 is covalently linked to the aminobenzoyl moiety, which connects the condensed pyrimidine heterocycle to the amino acid portion within folate structures, as well as their precursors and their non-radioactive references, a method of their preparation, as well as their use in diagnosis of a cell or population of cells expressing a folate-receptor and monitoring of cancer and inflammatory and autoimmune diseases and therapy thereof.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: April 19, 2016
    Assignee: MERCK & CIE
    Inventors: Simon Mensah Ametamey, Rudolf Moser, Tobias Ludwig Ross, Viola Groehn
  • Publication number: 20150315189
    Abstract: The present invention is directed towards a new method of synthesis of 18F-folate radiopharmaceuticals, wherein fluorine-18 is attached to a pteroate (or folate) or derivative thereof, through direct radiolabeling with 18[F]fluoride, as well as 18F-folate radiopharmaceuticals obtained by such method of synthesis and their use in diagnosis and monitoring of cancer therapy and therapy of inflammatory and autoimmune diseases.
    Type: Application
    Filed: July 13, 2015
    Publication date: November 5, 2015
    Applicant: MERCK & CIE
    Inventors: Simon Mensah AMETAMEY, Rudolf MOSER, Tobias Ludwig ROSS, Phoebe LAM, Viola GROEHN
  • Patent number: 9069134
    Abstract: An optical assembly, which is in particular in the form of a splitter component with a so-called splitter forming a passive optical component, is produced particularly inexpensively. In a first step a plurality of splitters are produced on a common wafer by forming a corresponding conductor track pattern. In a second step optical fibers are coupled simultaneously to the connection sides of the individual splitters with the aid of a connection carrier. Then, in a third step the individual splitters with the connection carriers connected thereto are separated form one another. Only one common coupling operation for a large number of splitters is required. The splitters may then be connected to form a splitter cascade.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: June 30, 2015
    Assignee: Leoni Kabel Holding GmbH
    Inventors: Ludwig Ross, Stefan Kufner, Maria Kufner, Wolfgang Foss, Marco Bock, Frank Baetz
  • Patent number: 8344140
    Abstract: The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein fluorine-18 is covalently linked through a triazole- or tetrazole linker to a folate or derivative thereof, a method of their preparation, as well as their use in diagnosis and monitoring of therapy of cancer and inflammatory and autoimmune diseases.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: January 1, 2013
    Assignee: Merck Eprova AG
    Inventors: Simon Mensah Ametamey, Rudolf Moser, Tobias Ludwig Ross, Thomas Leighton Mindt, Viola Groehn
  • Publication number: 20120237161
    Abstract: An optical assembly, which is in particular in the form of a splitter component with a so-called splitter forming a passive optical component, is produced particularly inexpensively. In a first step a plurality of splitters are produced on a common wafer by forming a corresponding conductor track pattern. In a second step optical fibers are coupled simultaneously to the connection sides of the individual splitters with the aid of a connection carrier. Then, in a third step the individual splitters with the connection carriers connected thereto are separated form one another. Only one common coupling operation for a large number of splitters is required. The splitters may then be connected to form a splitter cascade.
    Type: Application
    Filed: May 16, 2012
    Publication date: September 20, 2012
    Applicant: LEONI KABEL HOLDING GMBH
    Inventors: LUDWIG ROSS, STEFAN KUFNER, MARIA KUFNER, WOLFGANG FOSS, MARCO BOCK, FRANK BAETZ
  • Publication number: 20110286921
    Abstract: The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein fluorine-18 is covalently linked to the glutamate portion of a folate or derivative thereof, a method of their preparation, as well as their use in diagnosis and monitoring of therapy of cancer and inflammatory and autoimmune diseases.
    Type: Application
    Filed: October 12, 2009
    Publication date: November 24, 2011
    Applicant: MERCK & CIE
    Inventors: Roger Schibli, Rudolf Moser, Cristina Magdalena Muller, Simon Mensah Ametamey, Tobias Ludwig Ross, Viola Groehn
  • Publication number: 20100111863
    Abstract: The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein fluorine-18 is covalently linked through a triazole- or tetrazole linker to a folate or derivative thereof, a method of their preparation, as well as their use in diagnosis and monitoring of therapy of cancer and inflammatory and autoimmune diseases.
    Type: Application
    Filed: April 11, 2008
    Publication date: May 6, 2010
    Applicant: Merck Eprova AG
    Inventors: Simon Mensah Ametamey, Rudolf Moser, Tobias Ludwig Ross, Thomas Leighton Mindt, Viola Groehn
  • Publication number: 20100111864
    Abstract: The present invention is directed towards a new method of synthesis of 18F-folate radiopharmaceuticals, wherein fluorine-18 is attached to a pteroate (or folate) or derivative thereof, through direct radiolabeling with 18[F]fluoride, as well as 18F-folate radiopharmaceuticals obtained by such method of synthesis and their use in diagnosis and monitoring of cancer therapy and therapy of inflammatory and autoimmune diseases.
    Type: Application
    Filed: April 11, 2008
    Publication date: May 6, 2010
    Applicant: MERCK EPROVA AG
    Inventors: Simon Mensah Ametamey, Rudolf Moser, Tobias Ludwig Ross, Phoebe Lam, Viola Groehn
  • Publication number: 20100056533
    Abstract: The present invention is directed towards new 18F-folate radio-pharmaceuticals, wherein the fluorine-18 is covalently linked to the aminobenzoyl moiety, which connects the condensed pyrimidine heterocycle to the amino acid portion within folate structures, as well as their precursors and their non-radioactive references, a method of their preparation, as well as their use in diagnosis of a cell or population of cells expressing a folate-receptor and monitoring of cancer and inflammatory and autoimmune diseases and therapy thereof.
    Type: Application
    Filed: April 11, 2008
    Publication date: March 4, 2010
    Applicant: Merck Eprova AG
    Inventors: Simon Mensah Ametamey, Rudolf Moser, Tobias Ludwig Ross, Viola Groehn
  • Patent number: 5114453
    Abstract: A method of production of mono- or multimodal lightwave guides from special substrate glasses of the glass system SiO.sub.2 -B.sub.2 O.sub.3 -Al.sub.2 O.sub.3 - K.sub.2 O-F.sup.-, with partial exchange of the Li.sup.+, Na.sup.+, and/or K.sup.+ ions present in the glass against Cs.sup.+ ions, the substrate glasses having the following compositions (in mol.-%): SiO.sub.2 45-72, B.sub.2 O.sub.3 8-25, Al.sub.2 O.sub.3 1-25, Li.sub.2 O 0-1, Na.sub.2 O 0-2, K.sub.2 O 6-18, MO 0-1 (MO= MgO, CaO, SrO, BaO, ZnO, PbO), in which a portion of the O.sup.- ions present in the glass are replaced by 1-15 mol % F.sup.- ions.
    Type: Grant
    Filed: November 27, 1990
    Date of Patent: May 19, 1992
    Assignee: Schott Glaswerke
    Inventors: Ludwig Ross, Werner Schumann
  • Patent number: 5004707
    Abstract: Production of mono- or multimodal lightwave guides from special substrate glasses of the glass system SiO.sub.2 --B.sub.2 O.sub.3 --Al.sub.2 O.sub.3 -- K.sub.2 O--F.sup.-, with partial exchange of the Li.sup.+, Na.sup.+, and/or K.sup.+ ions present in the glass against Cs.sup.+ ions, the substrate glasses having the following compositions (in mol.-%): SiO.sub.2 45-72, B.sub.2 O.sub.3 8-25, Al.sub.2 O.sub.3 1-25, Li.sub.2 O 0-1, Na.sub.2 O 0-2, K.sub.2 O 6-18, MO 0-1 (MO=MgO, CaO, SrO, BaO, ZnO, PbO), in which a portion of the O.sup.- ions present in the glass are replaced by 1-15 mol % F.sup.- ions.
    Type: Grant
    Filed: November 16, 1989
    Date of Patent: April 2, 1991
    Assignee: Schott Glaswerke
    Inventors: Ludwig Ross, Werener Schumann
  • Patent number: 4824809
    Abstract: A new, CdO-and ThO.sub.2 -free optical glass with refractive indices of 1.73-1.78 and Abbe numbers of 30-34 and with particularly good devitrification stability comprises (in weight %):______________________________________ SiO.sub.2 12-20, B.sub.2 O.sub.3 10-18, PbO 50-60 Al.sub.2 O.sub.3 2-7, ZnO 0-4, ZrO.sub.2 0.5-3 La.sub.2 O.sub.3 2-10, Cs.sub.2 O 0-5, M.sub.2 O 0-1 (M.sub.2 O.dbd. Na.sub.2 O, K.sub.2 O, Li.sub.2 O) TiO.sub.2 0-5 with the SiO.sub.2 /B.sub.2 O.sub.3 -ratio being about 1.0 to ______________________________________ 1.5.
    Type: Grant
    Filed: December 28, 1987
    Date of Patent: April 25, 1989
    Assignee: Schott Glaswerke
    Inventors: Danuta Grabowski, Ludwig Ross
  • Patent number: 4814299
    Abstract: An optical glass, n.sub.d .gtoreq.1.60 and v.sub.d .gtoreq.58, having a high chemical stability as well as resistance to phase separation and crystallization, comprises in percent by weight:______________________________________ SiO.sub.2 21.5-27.0; B.sub.2 O.sub.3 23.5-30.0 SrO 16.0-24.0; La.sub.2 O.sub.3 10.0-20; Al.sub.2 O.sub.3 1.5-5.0; BaO 5.0-14.0; ZrO.sub.2 0-4.0; Li.sub.2 O 0.5-5.0; Na.sub.2 O 0.8-2.5; K.sub.2 O 0-2.0.
    Type: Grant
    Filed: July 2, 1987
    Date of Patent: March 21, 1989
    Assignee: Schott Glaswerke
    Inventors: Ludwig Ross, Volkmar Geiler