Patents by Inventor Luigi Mapelli

Luigi Mapelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210137899
    Abstract: The present invention provides a pharmaceutical composition comprising taste-masked immediate release microcapsules which comprise fexofenadine and a water-insoluble polymer coating. These microcapsules and the pharmaceutical compositions comprising them have suitable drug content and desirable pharmaceutical properties, including a quick dissolution rate of fexofenadine combined with a taste masking effect.
    Type: Application
    Filed: January 21, 2021
    Publication date: May 13, 2021
    Inventors: Luigi MAPELLI, Flavio Fabiani, Luigi Boltri, Paolo Gatti, Mauro Serratoni, Roberto Cassanmagnago
  • Publication number: 20210046015
    Abstract: The present invention is directed to pharmaceutical compositions and dosage forms comprising TPR beads, wherein said TPR beads comprise a solid dispersion of at least one active pharmaceutical ingredient in at least one solubility-enhancing polymer, and a TPR coating comprising a water insoluble polymer and an enteric polymer, wherein the active pharmaceutical ingredient comprises a weakly basic active pharmaceutical ingredient having a solubility of not more than 100 ?g/mL at pH 6.8.
    Type: Application
    Filed: November 2, 2020
    Publication date: February 18, 2021
    Inventors: Gopi M. VENKATESH, Luigi BOLTRI, Italo COLOMBO, Jin-Wang LAI, Flavio FABIANI, Luigi MAPELLI
  • Patent number: 10864166
    Abstract: The present invention is directed to pharmaceutical compositions and dosage forms comprising TPR beads, wherein said TPR beads comprise a solid dispersion of at least one active pharmaceutical ingredient in at least one solubility-enhancing polymer, and a TPR coating comprising a water insoluble polymer and an enteric polymer, wherein the active pharmaceutical ingredient comprises a weakly basic active pharmaceutical ingredient having a solubility of not more than 100 ?g/mL at pH 6.8.
    Type: Grant
    Filed: June 6, 2013
    Date of Patent: December 15, 2020
    Assignee: Adare Pharmaceuticals, Inc.
    Inventors: Gopi Venkatesh, Luigi Boltri, Italo Colombo, Jin-Wang Lai, Flavio Fabiani, Luigi Mapelli
  • Publication number: 20200316042
    Abstract: The present invention provides a pharmaceutical composition comprising taste-masked immediate release microcapsules which comprise fexofenadine and a water-insoluble polymer coating. These microcapsules and the pharmaceutical compositions comprising them have suitable drug content and desirable pharmaceutical properties, including a quick dissolution rate of fexofenadine combined with a taste masking effect.
    Type: Application
    Filed: June 23, 2020
    Publication date: October 8, 2020
    Inventors: Luigi MAPELLI, Flavio FABIANI, Luigi BOLTRI, Paolo GATTI, Mauro SERRATONI, Roberto CASSANMAGNAGO
  • Patent number: 10729682
    Abstract: The present invention provides a pharmaceutical composition comprising taste-masked immediate release microcapsules which comprise fexofenadine and a water-insoluble polymer coating. These microcapsules and the pharmaceutical compositions comprising them have suitable drug content and desirable pharmaceutical properties, including a quick dissolution rate of fexofenadine combined with a taste masking effect.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: August 4, 2020
    Assignee: Adare Pharmaceuticals S.R.L.
    Inventors: Luigi Mapelli, Flavio Fabiani, Luigi Boltri, Paolo Gatti, Mauro Serratoni, Roberto Cassanmagnago
  • Publication number: 20190076414
    Abstract: The present invention provides a pharmaceutical composition comprising taste-masked immediate release microcapsules which comprise fexofenadine and a water-insoluble polymer coating. These microcapsules and the pharmaceutical compositions comprising them have suitable drug content and desirable pharmaceutical properties, including a quick dissolution rate of fexofenadine combined with a taste masking effect.
    Type: Application
    Filed: November 9, 2018
    Publication date: March 14, 2019
    Inventors: Luigi Mapelli, Flavio FABIANI, Luigi BOLTRI, Paolo GATTI, Mauro SERRATONI, Roberto CASSANMAGNAGO
  • Patent number: 10206882
    Abstract: Compositions of the present invention, comprising at least one digestive enzyme (e.g., pancrelipase) are useful for treating or preventing disorders associated with digestive enzyme deficiencies. The compositions of the present invention can comprise a plurality of coated particles, each of which is comprised of a core coated with an enteric coating comprising at least one enteric polymer and 4-10% of at least one alkalinizing agent, or have moisture contents of about 3% or less, water activities of about 0.6 or less, or exhibit a loss of activity of no more than about 15% after six months of accelerated stability testing.
    Type: Grant
    Filed: October 2, 2013
    Date of Patent: February 19, 2019
    Assignee: ALLERGAN PHARMACEUTICALS INTERNATIONAL LIMITED
    Inventors: Giovanni Ortenzi, Marco Marconi, Luigi Mapelli
  • Patent number: 10166220
    Abstract: The present invention provides a pharmaceutical composition comprising taste-masked immediate release microcapsules which comprise fexofenadine and a water-insoluble polymer coating. These microcapsules and the pharmaceutical compositions comprising them have suitable drug content and desirable pharmaceutical properties, including a quick dissolution rate of fexofenadine combined with a taste masking effect.
    Type: Grant
    Filed: December 2, 2015
    Date of Patent: January 1, 2019
    Assignee: ADARE PHARMACEUTICALS S.R.L.
    Inventors: Luigi Mapelli, Flavio Fabiani, Luigi Boltri, Paolo Gatti, Mauro Serratoni, Roberto Cassanmagnago
  • Patent number: 9850671
    Abstract: Vehicle to project concrete, including a truck provided with a main motor to move the truck using a movement unit, a unit to project the concrete equipped with a pumping device configured to feed the concrete along a pipe, where the vehicle includes a unit to generate and feed electric energy configured to selectively feed one or more of either the movement unit of the truck, the concrete projection unit and the pumping device.
    Type: Grant
    Filed: November 23, 2015
    Date of Patent: December 26, 2017
    Assignee: CIFA SPA
    Inventors: Ferdinando Luigi Mapelli, Davide Tarsitano, Federico Cheli, Nicola Pirri, Ulrich Delogu, Paolo Sala
  • Publication number: 20160145880
    Abstract: Vehicle to project concrete, including a truck provided with a main motor to move the truck using a movement unit, a unit to project the concrete equipped with a pumping device configured to feed the concrete along a pipe, where the vehicle includes a unit to generate and feed electric energy configured to selectively feed one or more of either the movement unit of the truck, the concrete projection unit and the pumping device.
    Type: Application
    Filed: November 23, 2015
    Publication date: May 26, 2016
    Inventors: Ferdinando Luigi MAPELLI, Davide TARSITANO, Federico CHELI, Nicola PIRRI, Ulrich DELOGU, Paolo SALA
  • Publication number: 20160081991
    Abstract: The present invention provides a pharmaceutical composition comprising taste-masked immediate release microcapsules which comprise fexofenadine and a water-insoluble polymer coating. These microcapsules and the pharmaceutical compositions comprising them have suitable drug content and desirable pharmaceutical properties, including a quick dissolution rate of fexofenadine combined with a taste masking effect.
    Type: Application
    Filed: December 2, 2015
    Publication date: March 24, 2016
    Inventors: Luigi Mapelli, Flavio FABIANI, Luigi BOLTRI, Paolo GATTI, Mauro SERRATONI, Roberto CASSANMAGNAGO
  • Patent number: 9233105
    Abstract: The present invention provides a pharmaceutical composition comprising taste-masked immediate release microcapsules which comprise fexofenadine and a water-insoluble polymer coating. These microcapsules and the pharmaceutical compositions comprising them have suitable drug content and desirable pharmaceutical properties, including a quick dissolution rate of fexofenadine combined with a taste masking effect.
    Type: Grant
    Filed: October 9, 2013
    Date of Patent: January 12, 2016
    Assignee: Adare Pharmaceuticals S.R.L.
    Inventors: Luigi Mapelli, Flavio Fabiani, Luigi Boltri, Paolo Gatti, Mauro Serratoni, Roberto Cassanmagnago
  • Publication number: 20140170212
    Abstract: Compositions of the present invention, comprising at least one digestive enzyme (e.g., pancrelipase) are useful for treating or preventing disorders associated with digestive enzyme deficiencies. The compositions of the present invention can comprise a plurality of coated particles, each of which is comprised of a core coated with an enteric coating comprising at least one enteric polymer and 4-10% of at least one alkalinizing agent, or have moisture contents of about 3% or less, water activities of about 0.6 or less, or exhibit a loss of activity of no more than about 15% after six months of accelerated stability testing.
    Type: Application
    Filed: October 2, 2013
    Publication date: June 19, 2014
    Applicant: APTALIS PHARMA LTD
    Inventors: Giovanni ORTENZI, Marco Marconi, Luigi Mapelli
  • Publication number: 20140141091
    Abstract: The present invention provides a pharmaceutical composition comprising taste-masked immediate release microcapsules which comprise fexofenadine and a water-insoluble polymer coating. These microcapsules and the pharmaceutical compositions comprising them have suitable drug content and desirable pharmaceutical properties, including a quick dissolution rate of fexofenadine combined with a taste masking effect.
    Type: Application
    Filed: October 9, 2013
    Publication date: May 22, 2014
    Applicant: APTALIS PHARMA LIMITED
    Inventors: Luigi Mapelli, Flavio Fabiani, Luigi Boltri, Paolo Gatti, Mauro Serratoni, Roberto Cassanmagnago
  • Patent number: 8722096
    Abstract: Lipoic acid pellets are described, obtained from inert cores externally coated with lipoic acid. The so obtained active cores are coated with a first layer of insulating polymeric material and then with a polymeric coat that is insoluble at the gastric pH. Pellet are then formulated pharmaceutically, for instance in jelly capsules or controlled release capsules or as oral suspensions, dispersible powders, sachets, etc.
    Type: Grant
    Filed: May 25, 2007
    Date of Patent: May 13, 2014
    Assignees: Aptalis Pharma Limited, Laboratorio Chimico Internazionale S.p.A.
    Inventors: Luigi Boltri, Flavio Fabiani, Luigi Mapelli, Annibale Salvi, Paolo Magri', Antonio Nardi, Flavio Villani
  • Publication number: 20140127307
    Abstract: The present invention relates to a small particle size composition comprising pancreatin containing digestive enzymes for use in patients in need, including pediatric, geriatric, and adult patients, particularly those patients with dysphagia or wherein enteral administration using such composition would be suitable. In addition, the invention is directed to the composition as particles, such as micropellets or microgranules having a high potency, high useable yield and at least 10%-90% of 400-800 ?m. Furthermore, the composition optionally has an improved enteric coating and concomitant improved stability and enzyme activity compared to conventional prepared enterically coated pancreatic enzyme particles.
    Type: Application
    Filed: November 2, 2012
    Publication date: May 8, 2014
    Applicant: APTALIS PHARMA LIMITED
    Inventors: Gopi M. VENKATESH, Craig Kramer, Flavio Fabiani, Luigi Mapelli, Giovanni Ortenzi, Massimo Latino
  • Publication number: 20140050797
    Abstract: The present invention is directed to pharmaceutical compositions and dosage forms comprising TPR beads, wherein said TPR beads comprise a solid dispersion of at least one active pharmaceutical ingredient in at least one solubility-enhancing polymer, and a TPR coating comprising a water insoluble polymer and an enteric polymer, wherein the active pharmaceutical ingredient comprises a weakly basic active pharmaceutical ingredient having a solubility of not more than 100 ?g/mL at pH 6.8.
    Type: Application
    Filed: June 6, 2013
    Publication date: February 20, 2014
    Inventors: Gopi VENKATESH, Luigi BOLTRI, Italo COLOMBO, Jin-Wang LAI, Flavio FABIANI, Luigi MAPELLI
  • Patent number: 8580313
    Abstract: The present invention provides a pharmaceutical composition comprising taste-masked immediate release microcapsules which comprise fexofenadine and a water-insoluble polymer coating. These microcapsules and the pharmaceutical compositions comprising them have suitable drug content and desirable pharmaceutical properties, including a quick dissolution rate of fexofenadine combined with a taste masking effect.
    Type: Grant
    Filed: December 2, 2010
    Date of Patent: November 12, 2013
    Assignee: Aptalis Pharma Limited
    Inventors: Luigi Mapelli, Flavio Fabiani, Luigi Boltri, Paolo Gatti, Mauro Serratoni, Roberto Cassanmagnago
  • Patent number: 8562980
    Abstract: Compositions of the present invention, comprising at least one digestive enzyme (e.g., pancrelipase) are useful for treating or preventing disorders associated with digestive enzyme deficiencies. The compositions of the present invention can comprise a plurality of coated particles, each of which is comprised of a core coated with an enteric coating comprising at least one enteric polymer and 4-10% of at least one alkalinizing agent, or have moisture contents of about 3% or less, water activities of about 0.6 or less, or exhibit a loss of activity of no more than about 15% after six months of accelerated stability testing.
    Type: Grant
    Filed: February 2, 2011
    Date of Patent: October 22, 2013
    Assignee: Aptalis Pharma Limited
    Inventors: Giovanni Ortenzi, Marco Marconi, Luigi Mapelli
  • Patent number: 8562981
    Abstract: Compositions of the present invention, comprising at least one digestive enzyme (e.g., pancrelipase) are useful for treating or preventing disorders associated with digestive enzyme deficiencies. The compositions of the present invention can comprise a plurality of coated particles, each of which is comprised of a core coated with an enteric coating comprising at least one enteric polymer and 4-10% of at least one alkalinizing agent, or have moisture contents of about 3% or less, water activities of about 0.6 or less, or exhibit a loss of activity of no more than about 15% after six months of accelerated stability testing.
    Type: Grant
    Filed: February 2, 2011
    Date of Patent: October 22, 2013
    Assignee: Aptalis Pharma Limited
    Inventors: Giovanni Ortenzi, Marco Marconi, Luigi Mapelli