Patents by Inventor Luigi Mapelli
Luigi Mapelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210137899Abstract: The present invention provides a pharmaceutical composition comprising taste-masked immediate release microcapsules which comprise fexofenadine and a water-insoluble polymer coating. These microcapsules and the pharmaceutical compositions comprising them have suitable drug content and desirable pharmaceutical properties, including a quick dissolution rate of fexofenadine combined with a taste masking effect.Type: ApplicationFiled: January 21, 2021Publication date: May 13, 2021Inventors: Luigi MAPELLI, Flavio Fabiani, Luigi Boltri, Paolo Gatti, Mauro Serratoni, Roberto Cassanmagnago
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Publication number: 20210046015Abstract: The present invention is directed to pharmaceutical compositions and dosage forms comprising TPR beads, wherein said TPR beads comprise a solid dispersion of at least one active pharmaceutical ingredient in at least one solubility-enhancing polymer, and a TPR coating comprising a water insoluble polymer and an enteric polymer, wherein the active pharmaceutical ingredient comprises a weakly basic active pharmaceutical ingredient having a solubility of not more than 100 ?g/mL at pH 6.8.Type: ApplicationFiled: November 2, 2020Publication date: February 18, 2021Inventors: Gopi M. VENKATESH, Luigi BOLTRI, Italo COLOMBO, Jin-Wang LAI, Flavio FABIANI, Luigi MAPELLI
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Patent number: 10864166Abstract: The present invention is directed to pharmaceutical compositions and dosage forms comprising TPR beads, wherein said TPR beads comprise a solid dispersion of at least one active pharmaceutical ingredient in at least one solubility-enhancing polymer, and a TPR coating comprising a water insoluble polymer and an enteric polymer, wherein the active pharmaceutical ingredient comprises a weakly basic active pharmaceutical ingredient having a solubility of not more than 100 ?g/mL at pH 6.8.Type: GrantFiled: June 6, 2013Date of Patent: December 15, 2020Assignee: Adare Pharmaceuticals, Inc.Inventors: Gopi Venkatesh, Luigi Boltri, Italo Colombo, Jin-Wang Lai, Flavio Fabiani, Luigi Mapelli
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Publication number: 20200316042Abstract: The present invention provides a pharmaceutical composition comprising taste-masked immediate release microcapsules which comprise fexofenadine and a water-insoluble polymer coating. These microcapsules and the pharmaceutical compositions comprising them have suitable drug content and desirable pharmaceutical properties, including a quick dissolution rate of fexofenadine combined with a taste masking effect.Type: ApplicationFiled: June 23, 2020Publication date: October 8, 2020Inventors: Luigi MAPELLI, Flavio FABIANI, Luigi BOLTRI, Paolo GATTI, Mauro SERRATONI, Roberto CASSANMAGNAGO
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Patent number: 10729682Abstract: The present invention provides a pharmaceutical composition comprising taste-masked immediate release microcapsules which comprise fexofenadine and a water-insoluble polymer coating. These microcapsules and the pharmaceutical compositions comprising them have suitable drug content and desirable pharmaceutical properties, including a quick dissolution rate of fexofenadine combined with a taste masking effect.Type: GrantFiled: November 9, 2018Date of Patent: August 4, 2020Assignee: Adare Pharmaceuticals S.R.L.Inventors: Luigi Mapelli, Flavio Fabiani, Luigi Boltri, Paolo Gatti, Mauro Serratoni, Roberto Cassanmagnago
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Publication number: 20190076414Abstract: The present invention provides a pharmaceutical composition comprising taste-masked immediate release microcapsules which comprise fexofenadine and a water-insoluble polymer coating. These microcapsules and the pharmaceutical compositions comprising them have suitable drug content and desirable pharmaceutical properties, including a quick dissolution rate of fexofenadine combined with a taste masking effect.Type: ApplicationFiled: November 9, 2018Publication date: March 14, 2019Inventors: Luigi Mapelli, Flavio FABIANI, Luigi BOLTRI, Paolo GATTI, Mauro SERRATONI, Roberto CASSANMAGNAGO
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Patent number: 10206882Abstract: Compositions of the present invention, comprising at least one digestive enzyme (e.g., pancrelipase) are useful for treating or preventing disorders associated with digestive enzyme deficiencies. The compositions of the present invention can comprise a plurality of coated particles, each of which is comprised of a core coated with an enteric coating comprising at least one enteric polymer and 4-10% of at least one alkalinizing agent, or have moisture contents of about 3% or less, water activities of about 0.6 or less, or exhibit a loss of activity of no more than about 15% after six months of accelerated stability testing.Type: GrantFiled: October 2, 2013Date of Patent: February 19, 2019Assignee: ALLERGAN PHARMACEUTICALS INTERNATIONAL LIMITEDInventors: Giovanni Ortenzi, Marco Marconi, Luigi Mapelli
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Patent number: 10166220Abstract: The present invention provides a pharmaceutical composition comprising taste-masked immediate release microcapsules which comprise fexofenadine and a water-insoluble polymer coating. These microcapsules and the pharmaceutical compositions comprising them have suitable drug content and desirable pharmaceutical properties, including a quick dissolution rate of fexofenadine combined with a taste masking effect.Type: GrantFiled: December 2, 2015Date of Patent: January 1, 2019Assignee: ADARE PHARMACEUTICALS S.R.L.Inventors: Luigi Mapelli, Flavio Fabiani, Luigi Boltri, Paolo Gatti, Mauro Serratoni, Roberto Cassanmagnago
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Patent number: 9850671Abstract: Vehicle to project concrete, including a truck provided with a main motor to move the truck using a movement unit, a unit to project the concrete equipped with a pumping device configured to feed the concrete along a pipe, where the vehicle includes a unit to generate and feed electric energy configured to selectively feed one or more of either the movement unit of the truck, the concrete projection unit and the pumping device.Type: GrantFiled: November 23, 2015Date of Patent: December 26, 2017Assignee: CIFA SPAInventors: Ferdinando Luigi Mapelli, Davide Tarsitano, Federico Cheli, Nicola Pirri, Ulrich Delogu, Paolo Sala
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Publication number: 20160145880Abstract: Vehicle to project concrete, including a truck provided with a main motor to move the truck using a movement unit, a unit to project the concrete equipped with a pumping device configured to feed the concrete along a pipe, where the vehicle includes a unit to generate and feed electric energy configured to selectively feed one or more of either the movement unit of the truck, the concrete projection unit and the pumping device.Type: ApplicationFiled: November 23, 2015Publication date: May 26, 2016Inventors: Ferdinando Luigi MAPELLI, Davide TARSITANO, Federico CHELI, Nicola PIRRI, Ulrich DELOGU, Paolo SALA
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Publication number: 20160081991Abstract: The present invention provides a pharmaceutical composition comprising taste-masked immediate release microcapsules which comprise fexofenadine and a water-insoluble polymer coating. These microcapsules and the pharmaceutical compositions comprising them have suitable drug content and desirable pharmaceutical properties, including a quick dissolution rate of fexofenadine combined with a taste masking effect.Type: ApplicationFiled: December 2, 2015Publication date: March 24, 2016Inventors: Luigi Mapelli, Flavio FABIANI, Luigi BOLTRI, Paolo GATTI, Mauro SERRATONI, Roberto CASSANMAGNAGO
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Patent number: 9233105Abstract: The present invention provides a pharmaceutical composition comprising taste-masked immediate release microcapsules which comprise fexofenadine and a water-insoluble polymer coating. These microcapsules and the pharmaceutical compositions comprising them have suitable drug content and desirable pharmaceutical properties, including a quick dissolution rate of fexofenadine combined with a taste masking effect.Type: GrantFiled: October 9, 2013Date of Patent: January 12, 2016Assignee: Adare Pharmaceuticals S.R.L.Inventors: Luigi Mapelli, Flavio Fabiani, Luigi Boltri, Paolo Gatti, Mauro Serratoni, Roberto Cassanmagnago
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Publication number: 20140170212Abstract: Compositions of the present invention, comprising at least one digestive enzyme (e.g., pancrelipase) are useful for treating or preventing disorders associated with digestive enzyme deficiencies. The compositions of the present invention can comprise a plurality of coated particles, each of which is comprised of a core coated with an enteric coating comprising at least one enteric polymer and 4-10% of at least one alkalinizing agent, or have moisture contents of about 3% or less, water activities of about 0.6 or less, or exhibit a loss of activity of no more than about 15% after six months of accelerated stability testing.Type: ApplicationFiled: October 2, 2013Publication date: June 19, 2014Applicant: APTALIS PHARMA LTDInventors: Giovanni ORTENZI, Marco Marconi, Luigi Mapelli
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Publication number: 20140141091Abstract: The present invention provides a pharmaceutical composition comprising taste-masked immediate release microcapsules which comprise fexofenadine and a water-insoluble polymer coating. These microcapsules and the pharmaceutical compositions comprising them have suitable drug content and desirable pharmaceutical properties, including a quick dissolution rate of fexofenadine combined with a taste masking effect.Type: ApplicationFiled: October 9, 2013Publication date: May 22, 2014Applicant: APTALIS PHARMA LIMITEDInventors: Luigi Mapelli, Flavio Fabiani, Luigi Boltri, Paolo Gatti, Mauro Serratoni, Roberto Cassanmagnago
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Patent number: 8722096Abstract: Lipoic acid pellets are described, obtained from inert cores externally coated with lipoic acid. The so obtained active cores are coated with a first layer of insulating polymeric material and then with a polymeric coat that is insoluble at the gastric pH. Pellet are then formulated pharmaceutically, for instance in jelly capsules or controlled release capsules or as oral suspensions, dispersible powders, sachets, etc.Type: GrantFiled: May 25, 2007Date of Patent: May 13, 2014Assignees: Aptalis Pharma Limited, Laboratorio Chimico Internazionale S.p.A.Inventors: Luigi Boltri, Flavio Fabiani, Luigi Mapelli, Annibale Salvi, Paolo Magri', Antonio Nardi, Flavio Villani
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Publication number: 20140127307Abstract: The present invention relates to a small particle size composition comprising pancreatin containing digestive enzymes for use in patients in need, including pediatric, geriatric, and adult patients, particularly those patients with dysphagia or wherein enteral administration using such composition would be suitable. In addition, the invention is directed to the composition as particles, such as micropellets or microgranules having a high potency, high useable yield and at least 10%-90% of 400-800 ?m. Furthermore, the composition optionally has an improved enteric coating and concomitant improved stability and enzyme activity compared to conventional prepared enterically coated pancreatic enzyme particles.Type: ApplicationFiled: November 2, 2012Publication date: May 8, 2014Applicant: APTALIS PHARMA LIMITEDInventors: Gopi M. VENKATESH, Craig Kramer, Flavio Fabiani, Luigi Mapelli, Giovanni Ortenzi, Massimo Latino
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Publication number: 20140050797Abstract: The present invention is directed to pharmaceutical compositions and dosage forms comprising TPR beads, wherein said TPR beads comprise a solid dispersion of at least one active pharmaceutical ingredient in at least one solubility-enhancing polymer, and a TPR coating comprising a water insoluble polymer and an enteric polymer, wherein the active pharmaceutical ingredient comprises a weakly basic active pharmaceutical ingredient having a solubility of not more than 100 ?g/mL at pH 6.8.Type: ApplicationFiled: June 6, 2013Publication date: February 20, 2014Inventors: Gopi VENKATESH, Luigi BOLTRI, Italo COLOMBO, Jin-Wang LAI, Flavio FABIANI, Luigi MAPELLI
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Patent number: 8580313Abstract: The present invention provides a pharmaceutical composition comprising taste-masked immediate release microcapsules which comprise fexofenadine and a water-insoluble polymer coating. These microcapsules and the pharmaceutical compositions comprising them have suitable drug content and desirable pharmaceutical properties, including a quick dissolution rate of fexofenadine combined with a taste masking effect.Type: GrantFiled: December 2, 2010Date of Patent: November 12, 2013Assignee: Aptalis Pharma LimitedInventors: Luigi Mapelli, Flavio Fabiani, Luigi Boltri, Paolo Gatti, Mauro Serratoni, Roberto Cassanmagnago
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Patent number: 8562980Abstract: Compositions of the present invention, comprising at least one digestive enzyme (e.g., pancrelipase) are useful for treating or preventing disorders associated with digestive enzyme deficiencies. The compositions of the present invention can comprise a plurality of coated particles, each of which is comprised of a core coated with an enteric coating comprising at least one enteric polymer and 4-10% of at least one alkalinizing agent, or have moisture contents of about 3% or less, water activities of about 0.6 or less, or exhibit a loss of activity of no more than about 15% after six months of accelerated stability testing.Type: GrantFiled: February 2, 2011Date of Patent: October 22, 2013Assignee: Aptalis Pharma LimitedInventors: Giovanni Ortenzi, Marco Marconi, Luigi Mapelli
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Patent number: 8562981Abstract: Compositions of the present invention, comprising at least one digestive enzyme (e.g., pancrelipase) are useful for treating or preventing disorders associated with digestive enzyme deficiencies. The compositions of the present invention can comprise a plurality of coated particles, each of which is comprised of a core coated with an enteric coating comprising at least one enteric polymer and 4-10% of at least one alkalinizing agent, or have moisture contents of about 3% or less, water activities of about 0.6 or less, or exhibit a loss of activity of no more than about 15% after six months of accelerated stability testing.Type: GrantFiled: February 2, 2011Date of Patent: October 22, 2013Assignee: Aptalis Pharma LimitedInventors: Giovanni Ortenzi, Marco Marconi, Luigi Mapelli