Abstract: The present invention relates to the field of skin rejuvenation. Specifically, the present invention provides compositions and methods for promoting skin rejuvenation using a toll-like receptor 3 (TLR3) agonist and retinoic acid or derivatives thereof. In a specific embodiment, a method for treating wrinkles in a subject comprises the steps of (a) administering to the area of the subject comprising a wrinkle a composition comprising an effective amount of retinoic acid or a derivative thereof; and administering to the area of the subject comprising a wrinkle a composition comprising an effective amount of a TLR3 agonist.

Abstract: The present invention relates to the field of caspase inhibition. More specifically, the present invention provides compositions and methods utilizing caspase inhibitors to enhance injury repair and to treat bacterial and viral infections. In a specific embodiment, a method for treating a bacterial infection and skin lesions in a patient comprises the step of administering to the patient an effective amount of a caspase inhibitor.

Abstract: The present invention relates to the field of caspase inhibition. More specifically, the present invention provides compositions and methods utilizing caspase inhibitors to enhance injury repair and to treat bacterial and viral infections. In a specific embodiment, a method for treating a bacterial infection and skin lesions in a patient comprises the step of administering to the patient an effective amount of a caspase inhibitor.

Abstract: Prodrugs of itaconic acid and 1- and 4-methyl itaconic acid and their use for treating a disease, disorder, or condition associated with inflammation are disclosed.

Abstract: Methods for the use of prodrugs of itaconic acid and 1- and 4-methyl itaconic acid for inducing hair growth and treating an inflammatory, or immune activation (adaptive or innate), skin condition or other condition associated with hair loss are disclosed.

Abstract: The present invention relates to the field of skin rejuvenation. Specifically, the present invention provides compositions and methods for promoting skin rejuvenation using a toll-like receptor 3 (TLR3) agonist and retinoic acid or derivatives thereof. In a specific embodiment, a method for treating wrinkles in a subject comprises the steps of (a) administering to the area of the subject comprising a wrinkle a composition comprising an effective amount of retinoic acid or a derivative thereof; and administering to the area of the subject comprising a wrinkle a composition comprising an effective amount of a TLR3 agonist.

Abstract: This invention provides methods of treating androgenetic alopecia (AGA), acne, rosacea, prostate cancer, and benign prostatic hypertrophy (BPH), comprising the step of contacting a subject with a compound or composition capable of decreasing prostaglandin D2 (PGD2) level or activity, a downstream signaling or receptor pathway thereof, or prostaglandin D2 synthase level or activity; methods of stimulating hair growth, comprising the step of contacting a subject with a compound or composition capable of increasing or decreasing the activity or level of a target gene of the present invention, or with a protein product of the target gene or an analogue or mimetic thereof; and methods of testing for AGA and evaluating therapeutic methods thereof, comprising measuring PGD2 levels.

Abstract: A topical composition includes a nanoemulsion of a plurality of hydrophobic particles having a hydrophilic coating therein. The hydrophobic particles are derived from the same or different hydrophobic material and each hydrophobic particle has a melting point below the melting point of the respective hydrophobic material. The hydrophobic particles comprise a mean particle size of less than about 10 nm, and the nanoemulsion further includes one or more pharmaceutically active agents.

Abstract: A gas turbine engine system includes a fuel delivery circuit configured to convey fuel, a combustion chamber configured to combust the fuel, and a flexible hose that fluidly connects the fuel delivery circuit to the combustion chamber. The flexible hose includes a combustion chamber connector portion attached to the combustion chamber, a fuel delivery circuit connector portion attached to the fuel delivery circuit, and a central flexible portion connecting the first connector portion to the second connector portion. The central flexible portion is made of a flexible material. In addition, the fuel delivery circuit connector portion includes a pivotal assembly with an adjustable end that is pivotal relative to a central longitudinal axis of the central flexible portion of the flexible hose when the central flexible portion is in a straight condition.

Abstract: This invention provides methods of treating androgenetic alopecia (AGA), acne, rosacea, prostate cancer, and benign prostatic hypertrophy (BPH), comprising the step of contacting a subject with a compound or composition capable of decreasing prostaglandin D2 (PGD2) level or activity, a downstream signaling or receptor pathway thereof, or prostaglandin D2 synthase level or activity; methods of stimulating hair growth, comprising the step of contacting a subject with a compound or composition capable of increasing or decreasing the activity or level of a target gene of the present invention, or with a protein product of the target gene or an analogue or mimetic thereof; and methods of testing for AGA and evaluating therapeutic methods thereof, comprising measuring PGD2 levels.

Abstract: A gas turbine engine system includes a fuel delivery circuit configured to convey fuel, a combustion chamber configured to combust the fuel, and a flexible hose that fluidly connects the fuel delivery circuit to the combustion chamber. The flexible hose includes a combustion chamber connector portion attached to the combustion chamber, a fuel delivery circuit connector portion attached to the fuel delivery circuit, and a central flexible portion connecting the first connector portion to the second connector portion. The central flexible portion is made of a flexible material. In addition, the fuel delivery circuit connector portion includes a pivotal assembly with an adjustable end that is pivotal relative to a central longitudinal axis of the central flexible portion of the flexible hose when the central flexible portion is in a straight condition.

Abstract: This invention provides methods of treating androgenetic alopecia (AGA), acne, rosacea, prostate cancer, and benign prostatic hypertrophy (BPH), comprising the step of contacting a subject with a compound or composition capable of decreasing prostaglandin D2 (PGD2) level or activity, a downstream signaling or receptor pathway thereof, or prostaglandin D2 synthase level or activity; methods of stimulating hair growth, comprising the step of contacting a subject with a compound or composition capable of increasing or decreasing the activity or level of a target gene of the present invention, or with a protein product of the target gene or an analog or mimetic thereof; and methods of testing for AGA and evaluating therapeutic methods thereof, comprising measuring PGD2 levels.

Abstract: This invention provides methods of treating androgenetic alopecia (AGA), acne, rosacea, prostate cancer, and benign prostatic hypertrophy (BPH), comprising the step of contacting a subject with a compound or composition capable of decreasing prostaglandin D2 (PGD2) level or activity, a downstream signaling or receptor pathway thereof, or prostaglandin D2 synthase level or activity; methods of stimulating hair growth, comprising the step of contacting a subject with a compound or composition capable of increasing or decreasing the activity or level of a target gene of the present invention, or with a protein product of the target gene or an analogue or mimetic thereof; and methods of testing for AGA and evaluating therapeutic methods thereof, comprising measuring PGD2 levels.

Abstract: This invention provides methods of treating androgenetic alopecia (AGA), acne, rosacea, prostate cancer, and benign prostatic hypertrophy (BPH), comprising the step of contacting a subject with a compound or composition capable of decreasing prostaglandin D2 (PGD2) level or activity, a downstream signaling or receptor pathway thereof, or prostaglandin D2 synthase level or activity; methods of stimulating hair growth, comprising the step of contacting a subject with a compound or composition capable of increasing or decreasing the activity or level of a target gene of the present invention, or with a protein product of the target gene or an analog or mimetic thereof; and methods of testing for AGA and evaluating therapeutic methods thereof, comprising measuring PGD2 levels.

Abstract: A method and system for evaluating child development activities for a preschool child. The evaluation may include scoring activities to be performed by or with the child based on a target age for the preschool child. The assessment of the preschool child's abilities and behaviors may be compared with expected levels of performance represented by development milestones. The system may include a non-transitory computer-readable medium that, when executed by a processor, will perform the method.

Abstract: The invention relates to compositions and methods for regulating hair growth. Specifically, the invention relates to regulating hair growth by regulating the activity one of the prostaglandin D2 (PGD2) receptors, DP-2 (GPR44). Compositions and methods for regulating hair growth include inhibiting hair growth by administering a DP-2 agonist, or stimulating hair growth by administering a DP-2 antagonist.

Abstract: A method of detecting a skin condition may include employing a multiband hyperspectral sensor to obtain multi-spectral data, employing the multi-spectral data to map constitutive skin parameters to corresponding spectral signatures via a forward model that enables generation of a set of samples including a plurality of parameters mapped to a plurality of spectral signatures, utilizing the set of samples to employ machine learning to generate an inverse model to enable mapping of a spectral signature of skin of a patient to corresponding skin parameters, estimating constitutive skin parameters of the skin of the patient based on the inverse model, and determining a distribution of the constitutive parameters for one or more skin locations.

Abstract: An embodiment in accordance with the present invention provides a device for performing a skin biopsy that includes a generally curved blade to cut the skin at a predetermined depth disposed within or an integral part of a blade holder assembly. The blade holder assembly has an outer surface and the generally curved blade is coupled to the outer surface of the blade holder assembly. The device also includes a housing having an outer wall and said outer wall defining an interior space within the housing, such that the blade holder assembly and generally curved blade are disposed substantially within the inner space of the housing. The device also includes a handle coupled to the blade holder assembly and configured to rotate the blade holder assembly and in turn the generally curved blade within the inner space of the housing to perform the skin biopsy or removal of skin conditions.

Abstract: A method of detecting a skin condition may include employing a multiband hyperspectral sensor to obtain multi-spectral data, employing the multi-spectral data to map constitutive skin parameters to corresponding spectral signatures via a forward model that enables generation of a set of samples including a plurality of parameters mapped to a plurality of spectral signatures, utilizing the set of samples to employ machine learning to generate an inverse model to enable mapping of a spectral signature of skin of a patient to corresponding skin parameters, estimatingconstitutive skin parameters of the skin of the patient based on the inverse model, and determining a distribution of the constitutive parameters for one or more skin locations.

Abstract: This invention provides methods of treating androgenetic alopecia (AGA), acne, rosacea, prostate cancer, and benign prostatic hypertrophy (BPH), comprising the step of contacting a subject with a compound or composition capable of decreasing prostaglandin D2 (PGD2) level or activity, a downstream signaling or receptor pathway thereof, or prostaglandin D2 synthase level or activity; methods of stimulating hair growth, comprising the step of contacting a subject with a compound or composition capable of increasing or decreasing the activity or level of a target gene of the present invention, or with a protein product of the target gene or an analogue or mimetic thereof; and methods of testing for AGA and evaluating therapeutic methods thereof, comprising measuring PGD2 levels.