Patents by Inventor Luke Anthony O'Neill

Luke Anthony O'Neill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of preterm labor with toll-like receptor 9 antagonists
    Patent number: 8933011
    Abstract: The invention provides a method for treating or preventing preterm labor in pregnant female subjects. The method comprises the step of administering a therapeutically effective amount of a Toll-like Receptor 9 antagonist sufficient to prevent the activation of Toll-like Receptor 9 by fetal DNA. The invention further provides compositions comprising a Toll-like Receptor 9 antagonist for use in the methods of the invention. The compositions and methods of the present invention enhance gestation and therefore improve neonatal morbidity and mortality.
    Type: Grant
    Filed: September 24, 2009
    Date of Patent: January 13, 2015
    Assignees: The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin, The Coombe Lying-In Hospital
    Inventors: Luke Anthony O'Neill, John O'Leary, Sean Daly, Andrea Scharfe Nugent
  • Assays for determining compounds which modulate TRAM phosphorylation
    Patent number: 8221992
    Abstract: Disclosed are assays for the determination and quantification of the phosphorylation of TRAM (Trif-related adaptor molecule). TRAM is rapidly phosphorylated upon LPS stimulation by protein kinase C epsilon (PKC?) and that this phosphorylation is vital for TRAM to function normally. Assays suitable for detecting the state of phosphorylation of TRAM have utility in identifying compounds which have activity in modulating TRAM. Further disclosed are compounds which have utility in modulating the phosphorylation of TRAM to modulate signalling mediating by the Toll Like Receptor 4 (TLR4) receptor.
    Type: Grant
    Filed: April 3, 2006
    Date of Patent: July 17, 2012
    Assignee: Opsona Therapeutics Limited
    Inventors: Luke Anthony O'Neill, Anne McGettrick
  • COMPOSITION AND METHOD FOR TREATMENT OF PRETERM LABOR
    Publication number: 20110236392
    Abstract: The invention provides a method for treating or preventing preterm labor in pregnant female subjects. The method comprises the step of administering a therapeutically effective amount of a Toll-like Receptor 9 antagonist sufficient to prevent the activation of Toll-like Receptor 9 by fetal DNA. The invention further provides compositions comprising a Toll-like Receptor 9 antagonist for use in the methods of the invention. Said compositions and methods enhance gestation and therefore improve neonatal morbidity and mortality.
    Type: Application
    Filed: September 24, 2009
    Publication date: September 29, 2011
    Inventors: Luke Anthony O'Neill, John O'Leary, Sean Daly, Andrea Scharfe Nugent
  • Compounds and Methods for the Modulation of Toll-Like Receptor Function
    Publication number: 20100330067
    Abstract: The present invention relates to compositions and methods for use in the treatment of conditions such as septicaemia and septic shock. The invention further provides compositions and methods for the suppression Toll-like Receptor 4 mediated activation of the immune system. The invention further provides screening assays to identify compounds which have utility in the foregoing compositions and methods.
    Type: Application
    Filed: October 18, 2007
    Publication date: December 30, 2010
    Applicant: The Provost ,Fellows and Scholars oftheCollegeof theHolyandUndividedTrinityof Queen ElizabethNearDu
    Inventors: Luke Anthony O'Neill, Susan Carpenter, Aisling Dunne
  • ASSAYS FOR DETERMINING COMPOUNDS WHICH MODULATE TRAM PHOSPHORYLATION
    Publication number: 20090123482
    Abstract: Disclosed are assays for the determination and quantification of the phosphorylation of TRAM (Trif-related adaptor molecule). TRAM is rapidly phosphorylated upon LPS stimulation by protein kinase C epsilon (PKC?) and that this phosphorylation is vital for TRAM to function normally. Assays suitable for detecting the state of phosphorylation of TRAM have utility in identifying compounds which have activity in modulating TRAM. Further disclosed are compounds which have utility in modulating the phosphorylation of TRAM to modulate signalling mediating by the Toll Like Receptor 4 (TLR4) receptor.
    Type: Application
    Filed: April 3, 2006
    Publication date: May 14, 2009
    Inventors: Luke Anthony O'Neill, Anne McGettrick