Abstract: Methods of assaying a breath sample from a subject for the presence of one or more PFAS are provided. Embodiments of the methods further include providing a composite score that can be used to determine if the subject has been exposed to PFAS and to monitor changes in PFAS exposure over time in the subject. In certain embodiments, a machine learning model may be used to determine if a subject has been exposed to one or more PFAS.

Abstract: Methods of assaying a breath sample from a subject for the presence of one or more toxins or toxin associated compounds are provided. In some embodiments, the one or more toxins or toxin associated compounds includes trichloroethylene (TCE) and/or one or more metabolites thereof. Embodiments of the methods further include providing a toxin exposure assessment that can be used to determine if the subject has been exposed to a toxin and to monitor changes in toxin exposure over time in the subject. In certain embodiments, a machine learning model may be used to determine if a subject has been exposed to one or more toxins.

Abstract: Methods and devices for handling a fluid and delivering the fluid to the eye. The device has a vibrating element with a plurality of openings through which a fluid is ejected when the vibrated. An enclosure defines a chamber which holds a single application of the fluid. The enclosure may be biased against the vibrating element with a spring load developed in whole or part by the resilient structure of the enclosure. The chamber may be substantially empty after the single application.

Abstract: An apparatus for closing a surgical incision comprises left and right base panels, a plurality of closure components, and a plurality of left and right axial supports coupled to the respective base panels. The closure components couple the left and right base panels to each other laterally and have left and right ends coupled to the respective base panels. The closure components are positioned laterally across the left and right panels, the left axial supports are disposed between pairs of left closure component ends, the right axial supports are disposed between pairs of right closure component ends, and the left and right axial supports are offset from one another such that a serpentine arrangement of consecutive closure components and axial supports is formed. The apparatus can be made of antimicrobial materials or materials impregnated with antimicrobial agents. A flexible adhesive cover can be provided over the apparatus when in use.

Abstract: Described herein are inserts for reducing sloshing in a bottle. The insert may be integrally formed in an outer shell of the bottle or removably insertable into the outer shell. The insert may include an elongate body extending between a first end opposite a second end; and an aperture defined by the elongate body and extending longitudinally through the elongate body between the first and second ends. The elongate body has an uncompressed state when removed from an outer shell and a compressed state when positioned in the outer shell. A diameter of the elongate body in the compressed state is less than or equal to a smallest diameter of the liquid retention compartment. The insert has a durometer between about 40 A and about 70 A. A volume of the insert is less than about 10% of a volume defined by the outer shell. The insert includes a compressible mesh material.

Abstract: Described herein are inserts for reducing sloshing in a bottle. The insert may be integrally formed in an outer shell of the bottle or removably insertable into the outer shell. The insert may include an elongate body extending between a first end opposite a second end; and an aperture defined by the elongate body and extending longitudinally through the elongate body between the first and second ends. The elongate body has an uncompressed state when removed from an outer shell and a compressed state when positioned in the outer shell. A diameter of the elongate body in the compressed state is less than or equal to a smallest diameter of the liquid retention compartment. The insert has a durometer between about 40 A and about 70 A. A volume of the insert is less than about 10% of a volume defined by the outer shell. The insert includes a compressible mesh material.

Abstract: A system for deploying an implant cut from a biological tissue into an eye of a patient including a delivery device and a nose cone assembly, a tubular shaft projecting from the distal end region of the nose cone and comprising a lumen. Related devices, systems, and methods are provided.

Abstract: An apparatus for closing a surgical incision comprises left and right base panels, a plurality of closure components, and a plurality of left and right axial supports coupled to the respective base panels. The closure components couple the left and right base panels to each other laterally and have left and right ends coupled to the respective base panels. The closure components are positioned laterally across the left and right panels, the left axial supports are disposed between pairs of left closure component ends, the right axial supports are disposed between pairs of right closure component ends, and the left and right axial supports are offset from one another such that a serpentine arrangement of consecutive closure components and axial supports is formed. The apparatus can be made of antimicrobial materials or materials impregnated with antimicrobial agents. A flexible adhesive cover can be provided over the apparatus when in use.

Abstract: The present disclosure provides methods and devices for delivering pilocarpine to the eye. In certain aspects, the disclosure provides method for delivering a composition comprising pilocarpine to an eye of a subject in need thereof as a micro-dose stream of droplets. In certain embodiments, the method treats or alleviates one or more symptoms of presbyopia, in particular presbyopia in adults 40 years of age or older, in the subject in need thereof. In certain embodiments, the present disclosure utilizes relatively high concentrations of pilocarpine in the solution to be administered and as a single active agent.

Abstract: Devices, systems, and methods are disclosed for measuring, capturing, and modifying the motion of a body, for providing visual comparisons, metrics of comparison, and for generating motion standards. The motion standards may be generated during motion capture and may be used as references for comparing amongst other motion standards or captured motions. Comparisons may generally be used for training and improving upon motions, such as athletic related motions, rehabilitation related motions, and the like. In certain embodiments data capture is done primarily by sensor units worn on a body which communicate amongst each other and are supplemented by probabilistic relationships and models which infer or modify motion not captured by sensor units, which when paired with a secondary processing unit analyzes the data and provides a means of comparing and modifying a captured motion, and which stores or relays such data to a tertiary device, such as a remote database.

Abstract: Described herein are inserts for reducing sloshing in a bottle. The insert may be integrally formed in an outer shell of the bottle or removably insertable into the outer shell. The insert may include an elongate body extending between a first end opposite a second end; and an aperture defined by the elongate body and extending longitudinally through the elongate body between the first and second ends. The elongate body has an uncompressed state when removed from an outer shell and a compressed state when positioned in the outer shell. A diameter of the elongate body in the compressed state is less than or equal to a smallest diameter of the liquid retention compartment. The insert has a durometer between about 40 A and about 70 A. A volume of the insert is less than about 10% of a volume defined by the outer shell. The insert includes a compressible mesh material.

Abstract: A delivery system is disclosed which can be used to deliver an ocular implant into a target location within the eye via an ab interno procedure. In some embodiments, the implant can provide fluid communication between the anterior chamber and the suprachoroidal or supraciliary space while in an implanted state. The delivery system can include a proximal handle component and a distal delivery component. In addition, the proximal handle component can include an actuator to control the release of the implant from the delivery component into the target location in the eye.

Abstract: Disclosed herein are multiple embodiments of anti-sloshing liquid-retaining bottles. Embodiments include anti-sloshing liquid-retaining bottles that comprise an internal bladder configured to expand in volumetric proportion to the liquid expelled from the liquid containing bottle thereby eliminating air and, by extension, space in which the water could slosh. Anti-sloshing liquid-retaining bottles disclosed herein can rely on various mechanisms for volumetrically expanding the bladder against liquid retained in the bottle, mechanisms include pneumatic modulation of the bladder using a regulator configured to introduce pressure from a high pressure reservoir to inflate or expand the bladder and valves to release the pressure and deflate the bladder, as well as mechanisms for spring actuation to expand or inflate the bladder. Additional embodiments of anti-sloshing liquid-retaining bottles include bottles comprising wave breakers for passively preventing sloshing by dampening the motion.

Abstract: The present disclosure provides methods and devices which improve upon prior art methods and devices for delivering atropine to the eye. In certain aspects, the disclosure provides method for delivering a composition comprising atropine to an eye of a subject in need thereof as a micro-dose stream of droplets. The method generally includes, (a) generating a micro-dose stream of droplets including the composition comprising atropine via a piezoelectric droplet delivery device, wherein the micro-dose stream of droplets has an average ejected droplet diameter greater than 15 microns; and (b) delivering the micro-dose stream of droplets to the eye of said subject. In certain embodiments, the method treats myopia, in particular progressive myopia (nearsightedness) in adults and children, in the subject in need thereof.

Abstract: Devices, systems, and methods for treating damaged or diseased valves are disclosed. A representative embodiment includes an elongated shaft having a longitudinal axis, a proximal portion, and a distal portion, and a dissection arm at the distal portion. The dissection arm can have a longitudinal axis and be moveable between a low-profile state and a deployed state. In the deployed state, a portion of the arm can flex outwardly away from the longitudinal axis of the shaft. The arm is configured to be deployed within a space within a vessel wall such that, as the arm moves from the low-profile state to the deployed state, the arm pushes against vessel wall tissue at a periphery of the space, thereby separating tissue at the periphery to form a dissection pocket having a predetermined shape.

Abstract: Methods and devices for handling a fluid and delivering the fluid to the eye. The device has a vibrating element with a plurality of openings through which a fluid is ejected when the vibrated. An enclosure defines a chamber which holds a single application of the fluid. The enclosure may be biased against the vibrating element with a spring load developed in whole or part by the resilient structure of the enclosure. The chamber may be substantially empty after the single application.

Abstract: An apparatus for closing a surgical incision comprises left and right base panels, a plurality of closure components, and a plurality of left and right axial supports coupled to the respective base panels. The closure components couple the left and right base panels to each other laterally and have left and right ends coupled to the respective base panels. The closure components are positioned laterally across the left and right panels, the left axial supports are disposed between pairs of left closure component ends, the right axial supports are disposed between pairs of right closure component ends, and the left and right axial supports are offset from one another such that a serpentine arrangement of consecutive closure components and axial supports is formed. The apparatus can be made of antimicrobial materials or materials impregnated with antimicrobial agents. A flexible adhesive cover can be provided over the apparatus when in use.

Abstract: A hand-held aspiration device is provided which has a relatively small suction volume along a suction path to improve responsiveness of the aspiration device when the device is activated. The device may be manually powered and may be provided without electronic controls. The device has a suction path which may be purged into a disposal enclosure to reduce the volume of material under the influence of the suction pressure during the procedure. The suction source may also be part of the hand-held unit to further reduce the suction path and suction volume.

Abstract: Devices, systems, and methods for treating damaged or diseased valves are disclosed. A representative embodiment includes an elongated shaft having a longitudinal axis, a proximal portion, and a distal portion, and a dissection arm at the distal portion. The dissection arm can have a longitudinal axis and be moveable between a low-profile state and a deployed state. In the deployed state, a portion of the arm can flex outwardly away from the longitudinal axis of the shaft. The arm is configured to be deployed within a space within a vessel wall such that, as the arm moves from the low-profile state to the deployed state, the arm pushes against vessel wall tissue at a periphery of the space, thereby separating tissue at the periphery to form a dissection pocket having a predetermined shape.

Abstract: Provided herewith is a needle for delivering dermal filler thread to a wrinkle in a patient. The needle can also be used to deliver the thread to a patient for the purposes of facial contouring. The needle comprises a coupler for attaching the thread to the needle and also a trocar to ease delivery through the skin.