Abstract: A transdermal drug delivery apparatus includes a receptacle having a housing and a microneedle assembly mounted to the housing. The apparatus includes a reservoir for being mounted to the receptacle. The reservoir has an interior for containing fluid for being supplied to the microneedle assembly. The apparatus is adapted so that, when the apparatus is assembled, the reservoir is configured to move relative to the microneedle assembly along a path from an outer position to an inner position. The reservoir is closer to the microneedle assembly in the inner position than in the outer position. In the outer position, the reservoir is out of fluid communication with the microneedle assembly, and in the inner position, the reservoir is in fluid communication with the microneedle assembly. The apparatus also includes a plurality of connector parts spaced apart from one another along the path.

Abstract: A uniformity control membrane can be securely engaged against an upstream side of a microneedle array and configured so that resistance to flow through the uniformity control membrane is substantially greater than the resistance to flow through the microneedle array. These differences in flow resistance can facilitate uniform administration of a liquid formulation into the patient's skin across a broad area and at a relatively low pressure, such as by way of capillary action. The administration of the liquid formulation into the patient's skin across the broad area can result from the liquid formulation being administered by way of at least a majority of the microneedles of the microneedle array.

Abstract: A transdermal drug delivery device is disclosed that may comprise a housing including an upper housing portion and a lower housing portion. The lower housing portion may define a bottom surface including skin attachment means for releasably attaching the lower housing portion to skin of a user. The upper housing portion may at least partially surround a central region of the device. The device may also include a microneedle assembly and a reservoir disposed within the central region. The reservoir may be in fluid communication with the microneedle assembly. Additionally, the device may include a pushing element disposed above the microneedle assembly within the central region. The pushing element may be configured to provide a continuous bilateral force having a downward component transmitted through the microneedle assembly and an upward component transmitted through the skin attachment means.

Abstract: A transdermal drug delivery apparatus includes a housing for being fastened to a user, a microneedle assembly for being engaged against the skin of the user, a first force provider for providing a first force for forcing the microneedle assembly outwardly from the housing and against the skin, a reservoir movably carried by the housing for containing the fluid and for being in fluid communication with the microneedle assembly, and a second force provider for providing a second force for causing at least some of the fluid to flow from the reservoir to the microneedle assembly after the reservoir has moved into fluid communication with the microneedle assembly.

Abstract: A cartridge, which may be suitable for use as a portion of a transdermal drug delivery apparatus, may include a body at least partially defining an interior for containing fluid for being delivered by the transdermal drug delivery apparatus. The body may also at least partially define first and second openings to the interior of the body, wherein the first and second openings are respectively proximate opposite first and second ends of the body. The cartridge may also include a self-sealing member at least partially closing the first opening, and a movable member at least partially closing the second opening, wherein at least a portion of the movable member is for being urged into the interior of the body for increasing pressure within the interior of the body.

Abstract: A transdermal drug delivery device is disclosed that may comprise a housing including an upper housing portion and a lower housing portion. The lower housing portion may define a bottom surface including skin attachment means for releasably attaching the lower housing portion to skin of a user. The upper housing portion may at least partially surround a central region of the device. The device may also include a microneedle assembly and a reservoir disposed within the central region. The reservoir may be in fluid communication with the microneedle assembly. Additionally, the device may include a pushing element disposed above the microneedle assembly within the central region. The pushing element may be configured to provide a continuous bilateral force having a downward component transmitted through the microneedle assembly and an upward component transmitted through the skin attachment means.

Abstract: A cartridge, which may be suitable for use as a portion of a transdermal drug delivery apparatus, may include a body at least partially defining an interior for containing fluid for being delivered by the transdermal drug delivery apparatus. The body may also at least partially define first and second openings to the interior of the body, wherein the first and second openings are respectively proximate opposite first and second ends of the body. The cartridge may also include a self-sealing member at least partially closing the first opening, and a movable member at least partially closing the second opening, wherein at least a portion of the movable member is for being urged into the interior of the body for increasing pressure within the interior of the body.

Abstract: A light curing impression system comprising a light emitting tray that precisely distributes an optimal amount of curing light energy to internal, external and extra oral portions of the dental arch to cure impression material. The light curing impression system generally includes an LED light source, a light emitting impression tray, an activation module and impression material.

Abstract: A light curing dental system comprising a light emitting tray that precisely distributes an optimal amount of curing light energy to internal, external and extra oral portions of the dental arch to cure a dental material. The light curing dental system generally includes a light source, a light emitting dental tray, an activation module and a photocurable dental material.

Abstract: A drug delivery device is disclosed that may include a skin penetrating assembly having a support defining an upper surface and a lower surface. The skin penetrating assembly may also include a plurality of skin penetrating members extending outwardly from the lower surface. Each skin penetrating member may define a channel for receiving a drug formulation. In addition, the device may include a reservoir positioned adjacent to the upper surface of the support for initially retaining the drug formulation. The reservoir may include a top surface and a bottom surface and may define a plurality of passages extending between the top and bottom surfaces. The passages may be configured such that the drug formulation is retained within the passages against gravity.

Abstract: A packaged feminine care absorbent article has an absorbent article with an absorbent structure and a shell. The absorbent structure is configured for disposition adjacent a female wearer's vaginal region. The shell is configured for supporting the absorbent structure at the vaginal region. The shell has a body-facing surface and a garment-facing surface. The body-facing surface has an adhesive thereon for adhering the shell directly to the wearer. The absorbent structure is attached directly to the garment-facing surface. The absorbent article is configurable between a packaged configuration and a use configuration. The absorbent structure is folded longitudinally about at least one transverse fold line and transversely about at least one longitudinal fold line in the packaged configuration. A portion of the shell overlies a portion of the absorbent structure in the packaged configuration.

Abstract: Leak location devices and methods of using leak location devices that can be used in conjunction with negative pressure wound therapy systems are disclosed. In some embodiments, a leak location device can include a microphone for detecting sound pressure produced by a leak. Detected sound pressure can be compared to a threshold, which can correspond to background or ambient sound pressure. Background or ambient sound pressure can correspond to sound produced by a negative pressure source. The leak detection device can include a display configured to visually depict the detected sound, and a light source which creates a visual depiction of the coverage angle of the microphone.

Abstract: A transdermal drug delivery apparatus includes a housing for being fastened to a user, a microneedle assembly for being engaged against the skin of the user, a first force provider for providing a first force for forcing the microneedle assembly outwardly from the housing and against the skin, a reservoir movably carried by the housing for containing the fluid and for being in fluid communication with the microneedle assembly, and a second force provider for providing a second force for causing at least some of the fluid to flow from the reservoir to the microneedle assembly after the reservoir has moved into fluid communication with the microneedle assembly.

Abstract: Leak location devices and methods of using leak location devices that can be used in conjunction with negative pressure wound therapy systems are disclosed. In some embodiments, a leak location device can include a microphone for detecting sound pressure produced by a leak. Detected sound pressure can be compared to a threshold, which can correspond to background or ambient sound pressure. Background or ambient sound pressure can correspond to sound produced by a negative pressure source. The leak detection device can include a display configured to visually depict the detected sound, and a light source which creates a visual depiction of the coverage angle of the microphone.

Abstract: A controller, which may be used in a transdermal drug delivery apparatus, includes a housing, a pushing mechanism mounted for moving relative to the housing, a force provider positioned between the housing and the pushing mechanism for moving the pushing mechanism relative to the housing, and a latching mechanism for selectively restricting and allowing relative movement between the housing and the pushing mechanism. The pushing mechanism may be configured for pushing against a reservoir of the transdermal drug delivery apparatus. The latching mechanism may include flexible arms extending between the opposite ends of the latching mechanism, and the latching mechanism may be configured so that the arms release the pushing mechanism in response to the opposite ends being forced toward one another.

Abstract: A receptacle, which may be suitable for use as a portion of a transdermal drug delivery apparatus, may include a housing for being fastened to the user, a force provider that is elastic, at least one deformable component, and a microneedle assembly movably mounted to the housing for moving inwardly and outwardly relative to the housing. The force provider may be positioned between the housing and the microneedle assembly for forcing the microneedle assembly outwardly relative to the housing and against the skin of the user. The at least one deformable component may be connected between the microneedle assembly and the housing for both allowing relative movement between the microneedle assembly and the housing, and at least partially restricting the microneedle assembly from falling away from the housing.

Abstract: A cartridge, which may be suitable for use as a portion of a transdermal drug delivery apparatus, may include a body at least partially defining an interior for containing fluid for being delivered by the transdermal drug delivery apparatus. The body may also at least partially define first and second openings to the interior of the body, wherein the first and second openings are respectively proximate opposite first and second ends of the body. The cartridge may also include a self-sealing member at least partially closing the first opening, and a movable member at least partially closing the second opening, wherein at least a portion of the movable member is for being urged into the interior of the body for increasing pressure within the interior of the body.

Abstract: A transdermal drug delivery device is disclosed that may comprise a housing including an upper housing portion and a lower housing portion. The lower housing portion may define a bottom surface including skin attachment means for releaseably attaching the lower housing portion to skin of a user. The upper housing portion may at least partially surround a central region of the device. The device may also include a microneedle assembly and a reservoir disposed within the central region. The reservoir may be in fluid communication with the microneedle assembly. Additionally, the device may include a pushing element disposed above the microneedle assembly within the central region. The pushing element may be configured to provide a continuous bilateral force having a downward component transmitted through the microneedle assembly and an upward component transmitted through the skin attachment means.

Abstract: A drug delivery device is disclosed that may include a skin penetrating assembly having a support defining an upper surface and a lower surface. The skin penetrating assembly may also include a plurality of skin penetrating members extending outwardly from the lower surface. Each skin penetrating member may define a channel for receiving a drug formulation. In addition, the device may include a reservoir positioned adjacent to the upper surface of the support for initially retaining the drug formulation. The reservoir may include a top surface and a bottom surface and may define a plurality of passages extending between the top and bottom surfaces. The passages may be configured such that the drug formulation is retained within the passages against gravity.