Patents by Inventor Lunzhi Dai

Lunzhi Dai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • REAGENTS AND METHODS FOR DETECTING PROTEIN LYSINE LACTYLATION
    Publication number: 20220091129
    Abstract: The invention provides an isolated peptide comprising a lactylated lysine and a specific affinity reagent that specifically binds to a lactylated lysine in a peptide. Also provided are a method for detecting a lactylated lysine in a protein or a fragment thereof using the affinity reagent and a method for isolating the affinity reagent.
    Type: Application
    Filed: December 19, 2019
    Publication date: March 24, 2022
    Applicant: Jingjie PTM Biolab (Hangzhou) Co., Inc
    Inventors: Yingming ZHAO, Di Zhang, Lunzhi DAI
  • REAGENTS AND METHODS FOR DETECTING PROTEIN LYSINE 2-HYDROXYISOBUTYRYLATION
    Publication number: 20220091134
    Abstract: The invention provides an isolated peptide comprising a lysine 2-hydroxyisobutyrylation site, a lysine 2-hydroxyisobutyrylation specific affinity reagent that specifically binds to the peptide, and a method for detecting protein lysine 2-hydroxyisobutyrylation in a sample using the reagent.
    Type: Application
    Filed: November 15, 2021
    Publication date: March 24, 2022
    Applicant: PTM Biolab Inc.
    Inventors: Yingming ZHAO, Lunzhi DAI
  • Reagents and methods for detecting protein lysine 2-hydroxyisobutyrylation
    Patent number: 11204353
    Abstract: The invention provides an isolated peptide comprising a lysine 2-hydroxyisobutyrylation site, a lysine 2-hydroxyisobutyrylation specific affinity reagent that specifically binds to the peptide, and a method for detecting protein lysine 2-hydroxyisobutyrylation in a sample using the reagent.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: December 21, 2021
    Assignee: PTM Biolab Inc.
    Inventors: Yingming Zhao, Lunzhi Dai
  • Detection and Quantitation Method for Proteomics of Post-Translational Modifications
    Publication number: 20200033361
    Abstract: The present disclosure relates to the technical field of comparative proteomics, in particular to a detection and quantitation method for proteomics of post-translational modifications. With this method, the protein samples to be studied and internal standards are labeled with isobaric tandem mass tags, and tandem mass spectrometry analysis is carried out for the labeled peptide mixture, wherein the internal standard is a peptide mixture rich in post-translational modifications to be detected. Through this method, the signal of peptides containing the post-translational modifications to be detected can be amplified under the situation that mass spectrometer sensitivity is unchanged, and enrichment of the post-translational modification peptides is not needed. The probability of detecting the peptides containing the post-translational modifications to be detected by mass spectrometer and being selected for subsequent MS/MS analysis is increased.
    Type: Application
    Filed: September 19, 2019
    Publication date: January 30, 2020
    Applicant: Sichuan University
    Inventor: Lunzhi DAI
  • REAGENTS AND METHODS FOR DETECTING PROTEIN LYSINE 2-HYDROXYISOBUTYRYLATION
    Publication number: 20190145986
    Abstract: The invention provides an isolated peptide comprising a lysine 2-hydroxyisobutyrylation site, a lysine 2-hydroxyisobutyrylation specific affinity reagent that specifically binds to the peptide, and a method for detecting protein lysine 2-hydroxyisobutyrylation in a sample using the reagent.
    Type: Application
    Filed: January 18, 2019
    Publication date: May 16, 2019
    Applicant: PTM BIO LLC
    Inventors: Yingming ZHAO, Lunzhi DAI
  • REAGENTS AND METHODS FOR DETECTING PROTEIN LYSINE 2-HYDROXYISOBUTYRYLATION
    Publication number: 20150018224
    Abstract: The invention provides an isolated peptide comprising a lysine 2-hydroxyisobutyrylation site, a lysine 2-hydroxyisobutyrylation specific affinity reagent that specifically binds to the peptide, and a method for detecting protein lysine 2-hydroxyisobutyrylation in a sample using the reagent.
    Type: Application
    Filed: July 15, 2013
    Publication date: January 15, 2015
    Inventors: Yingming ZHAO, Lunzhi Dai