Patents by Inventor Lutz Muller

Lutz Muller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4526784
    Abstract: The invention relates to animo-cyclitol derivatives of Formula (I) and their individual anomers. Also included in the invention are processes for the manufacture of said amino-cyclitol derivatives and their individual anomers, compositions containing said amino-cyclitol derivatives or anomers; and methods for the use of said derivatives and anomers for the treatment of diabetes, adiposity or hyperlipaemia.
    Type: Grant
    Filed: April 19, 1982
    Date of Patent: July 2, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Fred R. Heiker, Lutz Muller, Walter Puls, Hilmar Bischoff
  • Patent number: 4407809
    Abstract: The invention relates to 3,4,5-trihydroxypiperidine compound of Formula (I) as methods for the preparation of said compounds. Also included in the invention are compositions containing said piperidine compounds and methods for the use of said piperidine compounds and compositions. The invention further includes veterinary compositions containing said piperidine compounds and their use in animal nutrition.The piperidine compounds of Formula (I) are useful as agents against prediabetes, gastritis, constipation, infections of the gastro-intestinal tract, meteorism, flatulence, caries, arteriosclerosis and hypertension and in particular against diabetes, hyperlipaemia and adiposity, and also in animal nutrition for influencing the meat/fat ratio in favor of the meat content.
    Type: Grant
    Filed: February 5, 1981
    Date of Patent: October 4, 1983
    Assignee: Bayer Aktiengesellschaft
    Inventors: Bodo Junge, Jurgen Stoltefuss, Lutz Muller, Hans-Peter Krause, Rudiger Sitt
  • Patent number: 4348402
    Abstract: The invention relates to .alpha.-hydroxyalkyl-3,4,5-trihydroxypiperidines defined by Formula (I), infra, and pharmaceutical compositions and medicaments containing said compounds. Also included in the invention are methods for the use of said compounds, compositions and medicaments as inhibitors of .alpha.-glucoside hydrolases; and intermediates for the compounds of said Formula (I).
    Type: Grant
    Filed: October 2, 1980
    Date of Patent: September 7, 1982
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gunther Kinast, Lutz Muller, Rudiger Sitt, Walter Puls
  • Patent number: 4312872
    Abstract: The invention relates to 1-alka-2,4-dienyl-2-hydroxymethyl-3,4,5-trihydroxypiperidine compounds which are, inter alia, potent inhibitors for .alpha.- glucoside hydrolases and effect lipid absorption. Also included in the invention are methods for the manufacture of the said compounds, compositions containing said compounds and methods for the use of said compounds and compositions.
    Type: Grant
    Filed: June 11, 1980
    Date of Patent: January 26, 1982
    Assignee: Bayer Aktiengesellschaft
    Inventors: Bodo Junge, Lutz Muller, Rudiger Sitt, Gunter Thomas, Hans P. Krause, Walter Puls
  • Patent number: 4307194
    Abstract: According to the present invention inhibitors for glycoside hydrolases, and in particular glucosidase inhibitors especially saccharase inhibitors, which are active in the digestive tract are formed by culturing organisms of the family Bacillaceae, particularly by strains of the genus Bacillus.It has also been found that certain strains of organisms of the family Bacillaceae, especially strains DSM 7, DSM 704 and DSM 675 produce the antibiotic known as 1-desoxynojirimycin. The invention therefore provides a method of producing 1-desoxynojirimycin which comprises culturing a 1-desoxynojirimycin producing organism of the genus Bacillus. Inhibitors for glycoside hydrolases and the invention includes methods for producing such inhibitors, pharmaceutical compositions containing the inhibitors and methods of treatment involving the use of the inhibitors.
    Type: Grant
    Filed: December 6, 1977
    Date of Patent: December 22, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventors: Werner Frommer, Lutz Muller, Delf Schmidt, Walter Puls, Hans-Peter Krause, Ulrich Heber
  • Patent number: 4293551
    Abstract: The invention relates to N-amino-3,4,5-trihydroxypiperidines, methods for their production, compositions containing said compounds. Also included are methods for the use of said compounds and compositions.
    Type: Grant
    Filed: July 17, 1979
    Date of Patent: October 6, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gunther Kinast, Lutz Muller, Walter Puls, Rudiger Sitt
  • Patent number: 4278683
    Abstract: The invention relates to 3,4,5-trihydroxypiperidines, processes for their producion, compositions containing them and methods for the use of said 3,4,5-trihydroxypiperidines and compositions containing them. The compounds and compositions of the invention are useful, inter alia, for their saccharase inhibiting activity in warm-blooded animals as well as their ability to improve feed utilization in warm-blooded and cold-blooded animals.
    Type: Grant
    Filed: August 30, 1979
    Date of Patent: July 14, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jurgen Stoltefuss, Lutz Muller, Walter Puls, Rudiger Sitt
  • Patent number: 4260622
    Abstract: The invention includes certain 3,4,5-trihydroxypiperidine compounds, methods for their preparation, compositions containing said 3,4,5-trihydroxypiperidine compounds and methods for the use of said compounds and compositions.The subject matter of the invention is useful against diabetes, hyperlipaemia and adiposity as well as in animal nutrition.
    Type: Grant
    Filed: September 20, 1979
    Date of Patent: April 7, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventors: Bodo Junge, Hans P. Krause, Lutz Muller, Walter Puls
  • Patent number: 4233439
    Abstract: Glucopyranosido-1,6-mannitol, represented by the formula: ##STR1## and a process for its preparation are provided. The glucopyranosido-1,6-mannitol is obtained by catalytically hydrogenating neutral aqueous solutions of isomaltulose and cooling the hydrogenated solution.In a second embodiment of the invention the use of the glucopyranosido-1,6-mannitol as a sugar substitute, sweetener for food or beverages, and sweetened food composition is provided.
    Type: Grant
    Filed: March 16, 1979
    Date of Patent: November 11, 1980
    Assignee: Suddeutsche Zucker-Aktiengesellschaft
    Inventors: Hubert Schiweck, Georg Steinle, Lutz Muller, Wolfgang Gau, Mohammad Munir
  • Patent number: 4175123
    Abstract: The present invention provides amino-sugar derivatives of the general formula ##STR1## in which n and m independently of each other represent an integer from 0 to 8 and the sum n+m has a value of 0 to 8, andX designates a group --OR, --SH, --SR, --NH.sub.2, --NHR or NRR.sub.1,in whichR designates an alkyl, alkenyl, cycloalkyl, aralkyl, aryl or heterocyclic radical, which can be substituted, andR.sub.1 designates an alkyl, cycloalkyl, aralkyl or aryl radical, which can be substituted, orR and R.sub.1 together with the nitrogen atom to which they are bonded, form a heterocyclic ring.It has been found that the compounds of the formula (II) are highly active inhibitors for glycoside hydrolases of the digestive tract.Also included in the invention are methods of preparing the amino-sugar derivatives of the invention, compositions containing said amino-sugar derivatives and methods for the use of said amino-sugar derivatives and compositions containing them.
    Type: Grant
    Filed: December 15, 1977
    Date of Patent: November 20, 1979
    Assignee: Bayer Aktiengesellschaft
    Inventors: Bodo Junge, Hans-Peter Krause, Lutz Muller, Walter Puls, Jurgen Stoltefuss
  • Patent number: 4117173
    Abstract: Glucopyranosido-1,6-mannitol, represented by the formula: ##STR1## and a process for its preparation are provided. The glucopyranosido-1,6-mannitol is obtained by catalytically hydrogenating neutral aqueous solutions of isomaltulose and cooling the hydrogenated solution.In a second embodiment of the invention the use of the glucopyranosido-1,6-mannitol as a sugar substitute, sweetener for food or beverages, and sweetened food composition is provided.
    Type: Grant
    Filed: May 3, 1976
    Date of Patent: September 26, 1978
    Assignee: Suddeutsche Zucker-Aktiengesellschaft
    Inventors: Hubert Schiweck, Georg Steinle, Lutz Muller, Wolfgang Gau, Mohammad Munir
  • Patent number: 4062950
    Abstract: New amino sugars which are glucopyranosyl and oligoglucosidyl derivatives of 4,6-bisdesoxy-4-(4,5,6-trihydroxy-3-hydroxymethylcyclohex-2-en-1-ylamin o)-.alpha.-D-glucopyranose inhibit glycoside hydrolases of the digestive tract. The compounds, of which O-{4,6-bisdesoxy-4-[1S-(1,4,6/5)-4,5,6-trihydroxy-3-hydroxymethylcyclohex- 2-en-1-ylamino]-.alpha.-D-glucopyranosyl}-(1.fwdarw.4)-O-.alpha.-D-glucopyr anosyl-(1.fwdarw.4)-D-glucopyranose is a representative embodiment, demonstrate both saccharase and amylase inhibiting properties.
    Type: Grant
    Filed: February 2, 1976
    Date of Patent: December 13, 1977
    Assignee: Bayer Aktiengesellschaft
    Inventors: Werner Frommer, Bodo Junge, Uwe Keup, Lutz Muller, Walter Puls, Delf Schmidt