Patents by Inventor Lyle Bowman
Lyle Bowman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240050446Abstract: The present invention relates to a method of treating blepharitis comprising administering to the affected eye of a subject an effective amount of an active ingredient in an ophthalmically acceptable vehicle for a sufficient period of time to treat blepharitis. The active ingredient comprises a glucocorticoid in an ophthalmically acceptable vehicle, such as DuraSite® 2. Additionally, the present invention discloses a kit that includes: (a) a composition comprising about 0.1% by weight dexamethasone in an ophthalmically acceptable vehicle and, optionally, (b) instructions for using the composition for the treatment of blepharitis.Type: ApplicationFiled: February 24, 2022Publication date: February 15, 2024Applicant: SUN PHARMACEUTICAL INDUSTRIES LIMITEDInventor: Lyle BOWMAN
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Patent number: 10722517Abstract: In certain embodiments the present invention provides methods useful in the treatment of glioma, such as glioblastoma, such methods comprising administering to a subject in need thereof a CSF-IR inhibitor together with one or more additional active agents such as IGF-IR inhibitors, PI3K inhibitors, IL4 inhibitors, NFAT inhibitors, and/or Stat6 inhibitors. In certain embodiments the present invention provides pharmaceutical compositions comprising a CSF-IR inhibitor together with one or more of such additional active agents.Type: GrantFiled: May 9, 2016Date of Patent: July 28, 2020Inventors: Daniela Francis Quail, Johanna Alexandra Joyce, Robert Lyle Bowman
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Patent number: 10201548Abstract: A method of treating blepharitis includes administering to the affected eye of a subject an effective amount of an active ingredient in an ophthalmically acceptable vehicle for a sufficient period of time to treat blepharitis. The active ingredient consists essentially of a glucocorticoid in an ophthalmically acceptable vehicle that includes an aqueous polymer suspension that when mixed with tear fluid provides a sustained release of said active ingredient. The aqueous polymer suspension includes a carboxyl-containing polymer having less than about 5% by weight cross-linking agent and has a viscosity in a range from about 1,000 to about 30,000 centipoises. A kit includes: (a) a composition comprising about 0.1% by weight dexamethasone in this ophthalmically acceptable vehicle and (b) instructions for using the composition of (a) for the treatment of blepharitis.Type: GrantFiled: March 6, 2009Date of Patent: February 12, 2019Assignee: SUN PHARMA GLOBAL FZEInventors: Lyle Bowman, Kamran Hosseini
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Publication number: 20180125852Abstract: In certain embodiments the present invention provides methods useful in the treatment of glioma, such as glioblastoma, such methods comprising administering to a subject in need thereof a CSF-IR inhibitor together with one or more additional active agents such as IGF-IR inhibitors, PI3K inhibitors, IL4 inhibitors, NFAT inhibitors, and/or Stat6 inhibitors. In certain embodiments the present invention provides pharmaceutical compositions comprising a CSF-IR inhibitor together with one or more of such additional active agents.Type: ApplicationFiled: May 9, 2016Publication date: May 10, 2018Inventors: Daniela Francis Quail, Johanna Alexandra Joyce, Robert Lyle Bowman
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Patent number: 8778999Abstract: The disclosure provides compositions and systems for topical ophthalmic application, which include an aqueous mixture of bromfenac and flowable mucoadhesive polymer, for treating inflammation and inflammatory conditions of the eye.Type: GrantFiled: March 5, 2009Date of Patent: July 15, 2014Assignee: Insite Vision IncorporatedInventors: Kamran Hosseini, Lyle Bowman, Erwin C. Si, Stephen Pham
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Patent number: 8695850Abstract: A tip arrangement for a bottle used for dispensing viscous liquid, such as drops of medicine, is provided. Embodiments include a tip insert having an insert body and a piercing point at a lower end of the insert body, for piercing a top surface of the bottle and for retaining the tip insert on the top surface of the bottle after piercing. A passage extends from a distal end of the piercing point, through the insert body, to an opposing upper surface of the insert body. A dispensing tip at the insert body upper surface communicates with the passage for precisely forming drops of the liquid from the bottle.Type: GrantFiled: March 6, 2009Date of Patent: April 15, 2014Assignee: Insite Vision IncorporatedInventors: Lyle Bowman, Surendra Patel
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Patent number: 8501800Abstract: An ophthalmically acceptable vehicle includes an aqueous suspension having a first viscosity. The suspension includes about 0.1% to about 6.5% by weight of a carboxyl-containing polymer prepared by polymerizing one or more carboxyl-containing monoethylenically unsaturated monomers and less than about 5% by weight of a cross-linking agent. The polymer has average particle size of not more than about 50 ?m in equivalent spherical diameter. The vehicle includes a second polymer that allows the carboxyl-containing polymer to remain suspended. Upon contact with tear fluid, the vehicle gels to a second viscosity which is greater than the first viscosity. A method of administering a medicament to the eye of a subject includes applying a composition that includes this ophthalmically acceptable vehicle and a medicament contained for treatment of a disease or disorder for which ophthalmic delivery is indicated. The medicament is released from the vehicle in a sustained release manner.Type: GrantFiled: March 5, 2009Date of Patent: August 6, 2013Assignee: Insite Vision IncorporatedInventors: Lyle Bowman, Stephen Pham
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Patent number: 8361492Abstract: Electrospun fibers are utilized to improve the mechanical characteristics of a contact lens reducing the weight and mechanical strength of the polymers from which the lenses are typically formed. Electrospun fibers are also utilized as a drug delivery system, both through direct use in the eye and by inclusion of the fibers in a contact lens. The fibers are loaded with therapeutic drugs by a variety of methods and processed by coating and cross-linking the fibers.Type: GrantFiled: June 24, 2009Date of Patent: January 29, 2013Assignee: Ocugenics, LLCInventors: Shachar Tauber, Randall Fuerst, Keela Davis, Lyle Bowman, Gary Wnek, Joseph J. Bango, Jr.
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Publication number: 20130023575Abstract: The disclosure provides ophthalmic compositions, systems and methods for the treatment of ocular surface allergies. More particularly the present invention relates to compositions of bromfenac for the treatment of the signs and symptoms of ocular surface allergies due to seasonal allergies.Type: ApplicationFiled: July 22, 2011Publication date: January 24, 2013Inventors: Kamran Hosseini, Lyle Bowman
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Patent number: 8083347Abstract: Electrospun fibers are utilized to improve the mechanical characteristics of a contact lens reducing the weight and mechanical strength of the polymers from which the lenses are typically formed. Electrospun fibers are also utilized as a drug delivery system, both through direct use in the eye and by inclusion of the fibers in a contact lens. The fibers are loaded with therapeutic drugs by a variety of methods and processed by coating and cross-linking the fibers.Type: GrantFiled: April 1, 2009Date of Patent: December 27, 2011Assignee: Ocugenics, LLCInventors: Joseph J. Bango, Jr., Lyle Bowman, Gary Wnek, Shachar Tauber, Randall Fuerst
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Publication number: 20100305054Abstract: The present invention relates to formulations of concentrated azalide antibiotics and methods for making and using them. Specifically, the invention relates to a method of treating an infection comprising administering to a patient in need thereof, an effective amount of a concentrated aqueous azalide antibiotic formulation made according to the method comprising dissolving an azalide antibiotic in an aqueous solution comprising a strong acid. The invention also relates to methods for making concentrated aqueous azalide antibiotic formulations for use in pulmonary infection, a nasopharyngeal infection, an otic infection, an ocular infection, a dermal or a vaginal infection. The invention also relates to concentrated aqueous azalide antibiotic formulations made by dissolving an azalide antibiotic in an aqueous solution comprising a strong acid.Type: ApplicationFiled: August 12, 2010Publication date: December 2, 2010Applicant: INSITE VISION INCORPORATEDInventors: Lyle Bowman, S. Kumar Chandrasekaran, Roy Duane Archibald, Stephen Pham, David Mufson
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Patent number: 7795231Abstract: The present invention relates to formulations of concentrated azalide antibiotics and methods for making and using them. Specifically, the invention relates to a method of treating an infection comprising administering to a patient in need thereof, an effective amount of a concentrated aqueous azalide antibiotic formulation made according to the method comprising dissolving an azalide antibiotic in an aqueous solution comprising a strong acid. The invention also relates to methods for making concentrated aqueous azalide antibiotic formulations for use in pulmonary infection, a nasopharyngeal infection, an otic infection, an ocular infection, a dermal or a vaginal infection. The invention also relates to concentrated aqueous azalide antibiotic formulations made by dissolving an azalide antibiotic in an aqueous solution comprising a strong acid.Type: GrantFiled: October 4, 2007Date of Patent: September 14, 2010Assignee: Insite Vision IncorporatedInventors: Lyle Bowman, S. Kumar Chandrasekaran, Roy Duane Archibald, Stephen Pham, David Mufson
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Publication number: 20100227842Abstract: A method of treating blepharitis includes administering to the affected eye of a subject an effective amount of an active ingredient in an ophthalmically acceptable vehicle for a sufficient period of time to treat blepharitis. The active ingredient consists essentially of a glucocorticoid in an ophthalmically acceptable vehicle that includes an aqueous polymer suspension that when mixed with tear fluid provides a sustained release of said active ingredient. The aqueous polymer suspension includes a carboxyl-containing polymer having less than about 5% by weight cross-linking agent and has a viscosity in a range from about 1,000 to about 30,000 centipoises. A kit includes: (a) a composition comprising about 0.1% by weight dexamethasone in this ophthalmically acceptable vehicle and (b) instructions for using the composition of (a) for the treatment of blepharitis.Type: ApplicationFiled: March 6, 2009Publication date: September 9, 2010Inventors: Lyle Bowman, Kamran Hosseini
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Publication number: 20100224657Abstract: A tip arrangement for a bottle used for dispensing viscous liquid, such as drops of medicine, is provided. Embodiments include a tip insert having an insert body and a piercing point at a lower end of the insert body, for piercing a top surface of the bottle and for retaining the tip insert on the top surface of the bottle after piercing. A passage extends from a distal end of the piercing point, through the insert body, to an opposing upper surface of the insert body. A dispensing tip at the insert body upper surface communicates with the passage for precisely forming drops of the liquid from the bottle.Type: ApplicationFiled: March 6, 2009Publication date: September 9, 2010Inventor: Lyle Bowman
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Publication number: 20100226997Abstract: An ophthalmically acceptable vehicle includes an aqueous suspension having a first viscosity. The suspension includes about 0.1% to about 6.5% by weight of a carboxyl-containing polymer prepared by polymerizing one or more carboxyl-containing monoethylenically unsaturated monomers and less than about 5% by weight of a cross-linking agent. The polymer has average particle size of not more than about 50 ?m in equivalent spherical diameter. The vehicle includes a second polymer that allows the carboxyl-containing polymer to remain suspended. Upon contact with tear fluid, the vehicle gels to a second viscosity which is greater than the first viscosity. A method of administering a medicament to the eye of a subject includes applying a composition that includes this ophthalmically acceptable vehicle and a medicament contained for treatment of a disease or disorder for which ophthalmic delivery is indicated. The medicament is released from the vehicle in a sustained release manner.Type: ApplicationFiled: March 5, 2009Publication date: September 9, 2010Inventors: Lyle Bowman, Stephen Pham
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Publication number: 20090269392Abstract: Electrospun fibers are utilized to improve the mechanical characteristics of a contact lens reducing the weight and mechanical strength of the polymers from which the lenses are typically formed. Electrospun fibers are also utilized as a drug delivery system, both through direct use in the eye and by inclusion of the fibers in a contact lens. The fibers are loaded with therapeutic drugs by a variety of methods and processed by coating and cross-linking the fibers.Type: ApplicationFiled: June 24, 2009Publication date: October 29, 2009Inventors: Shachar Tauber, Randall Fuerst, Keela Davis, Lyle Bowman, Gary Wnek, Joseph J. Bango, JR.
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Publication number: 20090269391Abstract: Electrospun fibers are utilized to improve the mechanical characteristics of a contact lens reducing the weight and mechanical strength of the polymers from which the lenses are typically formed. Electrospun fibers are also utilized as a drug delivery system, both through direct use in the eye and by inclusion of the fibers in a contact lens. The fibers are loaded with therapeutic drugs by a variety of methods and processed by coating and cross-linking the fibers.Type: ApplicationFiled: April 1, 2009Publication date: October 29, 2009Applicant: OCUGENICS, L.L.C.Inventors: Joseph J. Bango, JR., Lyle Bowman, Gary Wnek, Shachar Tauber, Randall Fuerst
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Publication number: 20090093449Abstract: The present invention relates to formulations of concentrated azalide antibiotics and methods for making and using them. Specifically, the invention relates to a method of treating an infection comprising administering to a patient in need thereof, an effective amount of a concentrated aqueous azalide antibiotic formulation made according to the method comprising dissolving an azalide antibiotic in an aqueous solution comprising a strong acid. The invention also relates to methods for making concentrated aqueous azalide antibiotic formulations for use in pulmonary infection, a nasopharyngeal infection, an otic infection, an ocular infection, a dermal or a vaginal infection. The invention also relates to concentrated aqueous azalide antibiotic formulations made by dissolving an azalide antibiotic in an aqueous solution comprising a strong acid.Type: ApplicationFiled: October 4, 2007Publication date: April 9, 2009Inventors: Lyle Bowman, S. Kumar Chandrasekaran, Roy Duane Archibald, Stephen Pham, David Mufson
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Publication number: 20080103103Abstract: The invention provides compositions and methods of treating an ocular condition by administering to an eye of a patient having an ocular condition an effective amount of a catechin or polyphenol. The compositions and methods can be used to treat ocular conditions such as ocular infection, ocular inflammation, ocular cancer or benign eye tumors.Type: ApplicationFiled: October 30, 2006Publication date: May 1, 2008Inventors: Bahram Memarzadeh, Lyle Bowman
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Publication number: 20070233021Abstract: A drop dispenser has a substantially conical sleeve member with a narrow upper end and a wide lower end. Centrally located at the apex of the upper end of the sleeve member is an aperture which has an inner diameter and is circumscribed by a raised ridge. The aperture and the ridge form a nozzle. The interior space of the substantially conical sleeve member forms a substantially conical chamber between the narrow upper end and wide lower end of the sleeve member. The nozzle is in liquid communication with the chamber through the aperture. The drop dispenser may have external threads at the lower end of the sleeve member for engaging a cap having a protuberance centrally located at its internal top end for hermetically engaging the aperture of the nozzle when the cap fully engages the sleeve member.Type: ApplicationFiled: April 3, 2006Publication date: October 4, 2007Inventors: Patrick Poisson, Lyle Bowman