Patents by Inventor Lyle M. Rode
Lyle M. Rode has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20080118472Abstract: Methods for increasing the resistance to rumen inactivation of a cultured Gram positive bacteria strain useful for gastrointestinal delivery of bioactive compounds to ruminants, which includes the steps of growing a culture of the bacteria strain through at least one passage in a growth medium containing an amount of lysozyme effective to induce the growth of bacterial cell walls resistant to protozoal predation; and recovering the bacteria strain from the lysozyme-containing medium. Rumen-bypass feed supplements produced by the inventive method are also disclosed, as well as methods for supplementing the diet of a ruminant with the rumen bypass feed supplements and an in vitro method for evaluating the resistance of Gram positive bacteria strains to rumen inactivation in vivo.Type: ApplicationFiled: December 6, 2005Publication date: May 22, 2008Applicant: Sage Biosciences Inc.Inventors: Lyle M. Rode, C. James Newbold
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Patent number: 6814988Abstract: A method of supplying a ruminant with its nutritional requirements for methionine is provided wherein a hydroxy analogue of methionine that is available for absorption by a ruminant is administered to the ruminant. Preferably, the, ruminant is administered an isopropyl ester of a hydroxy analogue of methionine, wherein at least 40% of the isopropyl ester of the hydroxy analogue of methionine is available for absorption by the cow.Type: GrantFiled: November 16, 2001Date of Patent: November 9, 2004Assignee: Novus International, Inc.Inventors: Christopher D. Knight, Karen M. Koenig, Lyle M. Rode, Michael J. Vandenberg, Mercedes Vazquez-Anon
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Publication number: 20020058085Abstract: A process for formulating a ruminant food ration in which the methionine needs of the ruminant are determined, a plurality of natural or synthetic feed ingredients and the nutrient composition of each of said ingredients are identified wherein one of said ingredients is 2-hydroxy-4-(methylthio)butanoic acid or a salt, amide or ester thereof, and a ration is formulated from the identified feed ingredients to meet the determined methionine needs of the ruminant which comprises one or more grains, a hydroxy analog of methionine, and optionally a bypass fat wherein (i) the hydroxy analog of methionine is selected from the group consisting of 2-hydroxy-4-(methylthio)butanoic acid and the salts, amides and esters thereof, (ii) the hydroxy analog of methionine is added separately from any bypass fat which is included in the ration, and (iii) the ration is formulated on the basis that at least 20% of the hydroxy analog of methionine is assumed to be available for absorption by the ruminant.Type: ApplicationFiled: November 16, 2001Publication date: May 16, 2002Inventors: Christopher D. Knight, Karen M. Koenig, Lyle M. Rode, Michael J. Vandenberg, Mercedes Vazquez-Anon
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Patent number: 6319525Abstract: A process for formulating a ruminant food ration in which the methionine needs of the ruminant are determined, a plurality of natural or synthetic feed ingredients and the nutrient composition of each of said ingredients are identified wherein one of said ingredients is 2-hydroxy-4-(methylthio)butanoic acid or a salt, amide or ester thereof, and a ration is formulated from the identified feed ingredients to meet the determined methionine needs of the ruminant which comprises one or more grains, a hydroxy analog of methionine, and optionally a bypass fat wherein (i) the hydroxy analog of methionine is selected from the group consisting of 2-hydroxy-4-(methylthio)butanoic acid and the salts, amides and esters thereof, (ii) the hydroxy analog of methionine is added separately from any bypass fat which is included in the ration, and (iii) the ration is formulated on the basis that at least 20% of the hydroxy analog of methionine is assumed to be available for absorption by the ruminant.Type: GrantFiled: October 26, 2000Date of Patent: November 20, 2001Assignee: Novus International, Inc.Inventors: Christopher D. Knight, Karen M. Koenig, Lyle M. Rode, Michael J. Vandenberg, Mercedes Vazquez-Anon
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Patent number: 6183786Abstract: A process for formulating a ruminant food ration in which the methionine needs of the ruminant are determined, a plurality of natural or synthetic feed ingredients and the nutrient composition of each of said ingredients are identified wherein one of said ingredients is 2-hydroxy-4-(methylthio)butanoic acid or a salt, amide or ester thereof, and a ration is formulated from the identified feed ingredients to meet the determined methionine needs of the ruminant which comprises one or more grains, a hydroxy analog of methionine, and optionally a bypass fat wherein (i) the hydroxy analog of methionine is selected from the group consisting of 2-hydroxy-4-(methylthio)butanoic acid and the salts, amides and esters thereof, (ii) the hydroxy analog of methionine is added separately from any bypass fat which is included in the ration, and (iii) the ration is formulated on the basis that at least 20% of the hydroxy analog of methionine is assumed to be available for absorption by the ruminant.Type: GrantFiled: June 15, 1999Date of Patent: February 6, 2001Assignee: Novus International, Inc.Inventors: Christopher D. Knight, Karen M. Koenig, Lyle M. Rode, Michael J. Vandenberg, Mercedes Vazquez-Anon
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Patent number: 6017563Abstract: A process for formulating a ruminant food ration in which the methionine needs of the ruminant are determined, a plurality of natural or synthetic feed ingredients and the nutrient composition of each of the ingredients are identified wherein one of the ingredients is 2-hydroxy-4-(methylthio)butanoic acid or a salt, amide or ester thereof, and a ration is formulated from the identified feed ingredients to meet the determined methionine needs of the ruminant which comprises one or more grains, a hydroxy analog of methionine, and optionally a bypass fat wherein (i) the hydroxy analog of methionine is selected from the group consisting of 2-hydroxy-4-(methylthio)butanoic acid and the salts, amides and esters thereof, (ii) the hydroxy analog of methionine is added separately from any bypass fat which is included in the ration, and (iii) the ration is formulated on the basis that at least 20% of the hydroxy analog of methionine is assumed to be available for absorption by the ruminant.Type: GrantFiled: July 25, 1997Date of Patent: January 25, 2000Assignee: Novus International, Inc.Inventors: Christopher D. Knight, Karen M. Koenig, Lyle M. Rode, Michael J. Vandenberg, Mercedes Vazquez-Anon
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Patent number: 5871773Abstract: A method for supplementing the amino acid levels in ruminants is provided where rumen-protected amino acids, particularly lysine and/or methionine, are used to supplement ruminant feed.Type: GrantFiled: August 14, 1995Date of Patent: February 16, 1999Assignee: Ajinomoto Co., Inc.Inventors: Lyle M. Rode, William E. Julien, Hiroyuki Sato, Takeshi Fujieda, Hiroyuki Suzuki
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Patent number: 5720970Abstract: A method for supplementing the amino acid levels in ruminants is provided where rumen-protected amino acids, particularly lysine and/or methionine, are used to supplement ruminant feed.Type: GrantFiled: April 21, 1995Date of Patent: February 24, 1998Assignee: Ajinomoto Co., Inc.Inventors: Lyle M. Rode, William E. Julien, Hiroyuki Sato, Takeshi Fujieda, Hiroyuki Suzuki