Abstract: Various embodiments are described herein for the fabrication enzyme degradable hydrogels useful as payload delivery systems. More particularly, embodiments disclosed herein relate to enzyme-degradable hydrogel systems comprising a crosslinkable polymer, such as a chemically-modified biopolymer, for example, chemically-modified gelatin, the hydrogel formed by a method comprising sequential physical and chemical crosslinking steps, for delivery of various payloads. Enzymes may be selected and administered to tune the release profile of the hydrogel. The payload can be, but not limited to, drugs, markers, cells, or these members encapsulated within another drug delivery such as a nanoparticle, or liposome. The hydrogel system can also be combined with another device such as a contact lens or bandage for wound healing.

Abstract: A contact lens storage case of limited life and predetermined usage to further the safe and effective use of contact lenses by ensuring patient compliance through both limiting case use over a set period of time and discouraging reuse and topping-off of the disinfecting and storage solution. Generally, the self-destruction consists of the case developing a leak in a pre-determined fashion as a result of the change in properties of a material in a limited area of the case following exposure of the case to the storage solution.

Abstract: A contact lens storage case of limited life and predetermined usage to further the safe and effective use of contact lenses by ensuring patient compliance through both limiting case use over a set period of time and discouraging reuse and topping-off of the disinfecting and storage solution. Generally, the self-destruction consists of the case developing a leak in a pre-determined fashion as a result of the change in properties of a material in a limited area of the case following exposure of the case to the storage solution.

Abstract: Novel hyaluronic acid-containing biopolymers are provided which exhibit increased hydrophilicity and reduced protein adsorption. In one aspect, the biopolymer incorporates hyaluronic acid modified to include a linking agent in a molar excess sufficient to yield a degree of HA modification in a range of about 1-5. In another aspect, the biopolymer incorporates unmodified hyaluronic acid.