Abstract: Diffusion and infusion resistant implantable devices and methods for reducing pulsatile pressure are provided. The implantable device includes a balloon implantable within a blood vessel of a patient, e.g., the pulmonary artery. The balloon is injected with a fluid mixture comprising a constituent fluid(s) and a diffusion-resistant gas to provide optimal balloon volume and limit fluid diffusion throughout multiple cardiac cycles. The fluid mixture may be pressurized such that the balloon is transitionable between an expanded state and a collapsed state responsive to pressure fluctuations in the blood vessel.

Abstract: Diffusion and infusion resistant implantable devices and methods for reducing pulsatile pressure are provided. The implantable device includes a balloon implantable within a blood vessel of a patient, e.g., the pulmonary artery. The balloon is injected with a fluid mixture comprising a constituent fluid(s) and a diffusion-resistant gas to provide optimal balloon volume and limit fluid diffusion throughout multiple cardiac cycles. The fluid mixture may be pressurized such that the balloon is transitionable between an expanded state and a collapsed state responsive to pressure fluctuations in the blood vessel.

Abstract: An implantable device for reducing pulsatile pressure within a blood vessel is described herein, for example to treat pulmonary hypertension. The implantable device may include a fluid reservoir, a compliant member (e.g., a balloon), and a conduit coupled to the fluid reservoir and the compliant member. Advanced designs for anchoring the compliant member in the blood vessel are described. In addition, enhanced reservoir, conduit, and balloon designs, as well as methods for implanting/using the same, are provided.

Abstract: Diffusion and infusion resistant implantable devices and methods for reducing pulsatile pressure are provided. The implantable device includes a balloon implantable within a blood vessel of a patient, e.g., the pulmonary artery. The balloon is injected with a fluid mixture comprising a constituent fluid(s) and a diffusion-resistant gas to provide optimal balloon volume and limit fluid diffusion throughout multiple cardiac cycles. The fluid mixture may be pressurized such that the balloon is transitionable between an expanded state and a collapsed state responsive to pressure fluctuations in the blood vessel.

Abstract: Diffusion and infusion resistant implantable devices and methods for reducing pulsatile pressure are provided. The implantable device includes a balloon implantable within a blood vessel of a patient, e.g., the pulmonary artery. The balloon is injected with a fluid mixture comprising a constituent fluid(s) and a diffusion-resistant gas to provide optimal balloon volume and limit fluid diffusion throughout multiple cardiac cycles. The fluid mixture may be pressurized such that the balloon is transitionable between an expanded state and a collapsed state responsive to pressure fluctuations in the blood vessel.

Abstract: An anchor for an electrical lead or other elongate medical instrument can include an anchor body. The anchor body can define an instrument passageway. The instrument passageway can extend from a first end of the anchor body to a second end of the anchor body. The anchor body can define one or more suture holes in the anchor body. A clamp can be included in or coupled to the anchor body. The clamp can include a first clamping flange and a second clamping flange. The first clamping flange and the second clamping flange can project laterally from the clamp. The clamp can include a clamping cavity extending about the instrument passageway. The clamp can be arranged to close such that changing a distance between the first clamping flange and the second clamping flange causes a dimension of the clamping cavity to decrease and hold the instrument within the instrument passageway.

Abstract: Endocardial pressure measurement devices, systems and methods for the effective treatment of congestive heart failure and its underlying causes, in addition to other clinical applications.

Abstract: An implantable sensor device, such as a pressure monitor, is implanted in the left ventricle (LV), in other heart chambers, or elsewhere, from which it wirelessly communicates pressure information to a remote communication device. The sensor device can be implanted using a placement catheter, an endoscope, or a laparoscope. The device can be secured entirely within the LV or heart wall, such as by using a corkscrew, a helical anchor, a harpoon, a threaded member, a hook, a barb, a fastener, a suture, or a mesh or coating for receiving fibrous tissue growth. The implantable sensor device provides less invasive chronic measurements of left ventricular blood pressure or other physical parameters. The wireless communication techniques include radio-telemetry, inductive coupling, passive transponders, and using the body as a conductor (referred to as “intracorporeal conductive communication” or a “personal area network”). Data from the receiver is downloadable into a computer for analysis or display.

Abstract: Endocardial pressure measurement devices, systems and methods for the effective treatment of congestive heart failure and its underlying causes, in addition to other clinical applications.