Patents by Inventor Lynne Apone

Lynne Apone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fragmentation of DNA
    Publication number: 20230257808
    Abstract: Provided herein is a polymerase-free enzyme mix (FRAG) for fragmenting double-stranded DNA. In some embodiments the enzyme mix may comprise a double-stranded DNA nickase and at least one of a DNA ligase capable of sealing a nick within a DNA, and a single-strand specific DNA nuclease. Methods for fragmenting double-stranded DNA are also provided.
    Type: Application
    Filed: April 24, 2023
    Publication date: August 17, 2023
    Applicant: New England Biolabs, Inc.
    Inventors: Lynne Apone, Brittany S. Sexton, Margaret Heider, Louise JS Williams, Eileen T. Dimalanta
  • Fragmentation of DNA
    Patent number: 11667968
    Abstract: Provided herein is a polymerase-free enzyme mix (FRAG) for fragmenting double-stranded DNA. In some embodiments the enzyme mix may comprise a double-stranded DNA nickase and at least one of a DNA ligase capable of sealing a nick within a DNA, and a single-strand specific DNA nuclease. Methods for fragmenting double-stranded DNA are also provided.
    Type: Grant
    Filed: April 8, 2022
    Date of Patent: June 6, 2023
    Assignee: New England Biolabs, Inc.
    Inventors: Lynne Apone, Brittany S. Sexton, Margaret Heider, Louise J S Williams, Eileen T. Dimalanta
  • Fragmentation of DNA
    Publication number: 20220380840
    Abstract: Provided herein is a polymerase-free enzyme mix (FRAG) for fragmenting double-stranded DNA. In some embodiments the enzyme mix may comprise a double-stranded DNA nickase and at least one of a DNA ligase capable of sealing a nick within a DNA, and a single-strand specific DNA nuclease. Methods for fragmenting double-stranded DNA are also provided.
    Type: Application
    Filed: April 8, 2022
    Publication date: December 1, 2022
    Applicant: New England Biolabs, Inc.
    Inventors: Lynne Apone, Brittany S. Sexton, Margaret Heider, Louise JS Williams, Eileen T. Dimalanta
  • Compositions, methods and related uses for cleaving modified DNA
    Patent number: 8969061
    Abstract: Compositions, methods and a kit are described relating to a novel family of enzymes which preferentially bind to a hydroxymethylated cytosine or a glucosylated hydroxymethylated cytosine and cleave double-stranded DNA at a defined distance 3? of the recognition site to produce a cleavage fragment with a 1-3 base overhang.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: March 3, 2015
    Assignee: New England Biolabs, Inc.
    Inventors: Zhenyu Zhu, Yu Zheng, Shengxi Guan, Hua Wang, Aine Quimby, Penghua Zhang, Lynne Apone
  • Compositions, Methods and Related Uses for Cleaving Modified DNA
    Publication number: 20120301881
    Abstract: Compositions, methods and a kit are described relating to a novel family of enzymes which preferentially bind to a hydroxymethylated cytosine or a glucosylated hydroxymethylated cytosine and cleave double-stranded DNA at a defined distance 3? of the recognition site to produce a cleavage fragment with a 1-3 base overhang.
    Type: Application
    Filed: January 20, 2011
    Publication date: November 29, 2012
    Applicant: NEW ENGLAND BIOLABS, INC.
    Inventors: Zhenyu Zhu, Yu Zheng, Shengxi Guan, Hua Wang, Aine Quimby, Penghua Zhang, Lynne Apone