Abstract: Systems and methods for delivering active ingredients, such as pharmaceutically active ingredients, to substrates are described herein. The active ingredients are delivered as fluids to a fluiddispensing device for the creation of one or more drops for deposition onto substrates such as for the creation of microdoses. The invention further includes microdoses made by such processes.

Abstract: Systems and methods for delivering active ingredients, such as pharmaceutically active ingredients, to substrates are described herein. The active ingredients are delivered as fluids to a fluid-dispensing device for the creation of one or more drops for deposition onto substrates such as for the creation of microdoses. The invention further includes microdoses made by such processes.

Abstract: A method for the synthesis of alkyl ?-carboxy(hydroxyethyl) polysaccharides is described. The method includes methylating or ethylating a polysaccharide or providing a methylated or ethylated polysaccharide, hydroxyethylating the methylated or ethylated polysaccharide, and oxidizing the hydroxyethylated polysaccharide to form the ?-carboxy(hydroxyethyl) polysaccharide. A method for the synthesis of oxidized polysaccharides is also described. The method includes hydroxypropylating a polysaccharide and oxidizing the hydroxypropylated polysaccharides. A method for the production of a solid capable of forming a hydrogel is also described. The method includes combining a first solution comprising an oxidized oligo(hydroxypropyl) polysaccharide bearing one or more ketone groups with a second solution comprising an amine substituted polysaccharide to form a third solution, and removing solvent from the third solution to form the solid, or adding an additional solvent to the third solution to precipitate the solid.

Abstract: A method for the synthesis of alkyl ?-carboxy(hydroxyethyl) polysaccharides is described. The method includes methylating or ethylating a polysaccharide or providing a methylated or ethylated polysaccharide, hydroxyethylating the methylated or ethylated polysaccharide, and oxidizing the hydroxyethylated polysaccharide to form the ?-carboxy(hydroxyethyl) polysaccharide. A method for the synthesis of oxidized polysaccharides is also described. The method includes hydroxypropylating a polysaccharide and oxidizing the hydroxypropylated polysaccharides. A method for the production of a solid capable of forming a hydrogel is also described. The method includes combining a first solution comprising an oxidized oligo(hydroxypropyl) polysaccharide bearing one or more ketone groups with a second solution comprising an amine substituted polysaccharide to form a third solution, and removing solvent from the third solution to form the solid, or adding an additional solvent to the third solution to precipitate the solid.

Abstract: The present disclosure relates to novel thiamine-organic acid salt, and the method of making the novel thiamine-organic acid salt.

Abstract: The present disclosure relates to novel thiamine-organic acid salt, and the method of making the novel thiamine-organic acid salt.

Abstract: The present disclosure relates to a novel method of inhibiting sugar crystallization and/or sugar crystal growth with at least one glycoside as the sugar crystallization and/or sugar crystal growth inhibitor, and novel compositions comprising amorphous sugar and at least one glycoside as the sugar crystallization and/or sugar crystal growth inhibitor.

Abstract: Systems and methods for delivering active ingredients, such as pharmaceutically active ingredients, to substrates are described herein. The active ingredients are delivered as fluids to a fluid-dispensing device for the creation of one or more drops for deposition onto substrates such as for the creation of microdoses. The invention further includes microdoses made by such processes.

Abstract: An apparatus and method for performing volume scanning of a sample comprised of chiral materials disposed in a matrix of non-chiral materials is disclosed. A laser is raster scanned in a plane of the volume such that the intensity of energy in the focal region is sufficient to generate second harmonic (SHG) energy. This energy is detected and may be processed into three dimensional images of the volume. The raster pattern is repeatedly stepped over an area of the sample so as to produce three dimensional images of time-dependent processes.

Abstract: An apparatus and method for performing volume scanning of a sample comprised of chiral materials disposed in a matrix of non-chiral materials is disclosed. A laser is raster scanned in a plane of the volume such that the intensity of energy in the focal region is sufficient to generate second harmonic (SHG) energy. This energy is detected and may be processed into three dimensional images of the volume. The raster pattern is repeatedly stepped over an area of the sample so as to produce three dimensional images of time-dependent processes.