Abstract: Disclosed herein are mutant Plasmodium-species parasites that are genetically attenuated (GAP). They retain the ability to infect a host and invade host hepatocytes but subsequently their development is completely arrested within the liver stage of Plasmodium development and the parasites do not reach the blood stage of development. Vaccines and pharmaceutical compositions comprising genetically attenuated Plasmodium sporozoites as well as methods of using the same are likewise provided.

Abstract: A sludge flow monitoring system and method measures volume of sludge pumped by a positive displacement pump through a pipeline by determining a fill percentage during each pumping cycle. The start and end of each piston stroke are identified by hydraulic system sensors. The fill percentage is determined based upon a first summation of periodic piston speed command values from the start of a pumping stroke to the end of a pumping stroke, and a second summation of periodic piston speed command values from a poppet valve opening indicating output flow from the pump to the end of the pumping stroke.

Abstract: Disclosed herein are mutant Plasmodium-species parasites that are genetically attenuated (GAP). They retain the ability to infect a host and invade host hepatocytes but subsequently their development is completely arrested within the liver stage of Plasmodium development and the parasites do not reach the blood stage of development. Vaccines and pharmaceutical compositions comprising genetically attenuated Plasmodium sporozoites as well as methods of using the same are likewise provided.

Abstract: Disclosed herein are mutant Plasmodium-species parasites that are genetically attenuated (GAP). They retain the ability to infect a host and invade host hepatocytes but subsequently their development is completely arrested within the liver stage of Plasmodium development and the parasites do not reach the blood stage of development. Vaccines and pharmaceutical compositions comprising genetically attenuated Plasmodium sporozoites as well as methods of using the same are likewise provided.

Abstract: The present invention relates to anti-thymidine phosphorylase compounds. These compounds are derivatives of 4-hydroxybenzohydarzide or generally Schiff bases of hydrazones. The invention evaluates a series of Schiff bases of hydrazones against thymidine phosphorylase, and identified significant inhibitors of thymidine phosphorylase enzyme during in vitro studies.

Abstract: The invention provides a method and system for automatically detecting semantic errors in a text. In order to detect the semantic errors in the text, the method generates a first set of features and a second set of features corresponding to each word in the text. A first set of features corresponds to statistical features of a word and a second set of features for a word corresponds to the features generated for a plurality of words surrounding the word in the text using matrix factorization techniques. The method, then, combines a first set of features and a second set of features to generate a third set of features corresponding to each word in the text. Thereafter, the method utilizes an Artificial Neural Network (ANN) model to detect semantic validity of each word based on a corresponding third set of features.

Abstract: Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of diseases and disorders, such as learning, cognitive activities, and analgesia, particularly in alleviating and/or reducing neuropathic pain. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.

Abstract: Various audio encoders and methods of using the same are disclosed. In one aspect, an apparatus is provided that includes an audio encoder and an audio encoder mode selector. The audio encoder mode selector is operable to analyze video data and adjust an encoding mode of the audio encoder based on the analyzed video data.

Abstract: A high speed voltage mode sensing is provided for a digital multibit non-volatile memory integrated system. An embodiment has a local source follower stage followed by a high speed common source stage. Another embodiment has a local source follower stage followed by a high speed source follower stage. Another embodiment has a common source stage followed by a source follower. An auto zeroing scheme is used. A capacitor sensing scheme is used. Multilevel parallel operation is described.

Abstract: Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of diseases and disorders, such as learning, cognitive activities, and analgesia, particularly in alleviating and/or reducing neuropathic pain. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.

Abstract: One embodiment of the invention relates to treating diseases associated with increased urease enzyme activity comprising administering an effective amount of a compound selected from a group consisting of 28 thiazoles Schiff bases. Kinetic studies were performed on ten (10) of the most active compounds.

Abstract: The invention discloses creatine derivatives that are represented by Formula (I), Formula (II), and Formula (III); wherein Z is a functional group; Y is a mitochondrial targeting agent, a cationic ammonium group, or a polypeptide containing at least one positively charged amino acid residue; each R1 is independently hydrogen, alkyl, or a phosphate group; R2 a linker; R3 is a spacer group; R4 is hydrogen, alkyl, aryl, or heterocyclic; or R4 and R1, or R4 and R3, together with the nitrogen atoms to which they are attached form a heterocyclic ring, and W is hydrogen or alkyl.

Abstract: Two thiourea derivatives N-(3-chlorophenyl)-N?-(3,4-difluorophenyl)thiourea and N-(3-chlorophenyl)-N-(3-methoxyphenyl)-thiourea are reported as treatment of multidrug resistance infections from Staphylococcus aureus.

Abstract: The invention relates to methods of inhibiting the protein glycation process and the associated formation of Advanced Glycation End products (AGEs) in hyperglycemia by administering 6-Nitrobenzimidazole derivatives. These derivatives were found to be effective not merely against the formation of AGE, but they can inhibit the action of AGEs at post-receptor levels.

Abstract: A wireless power transfer system including a transmitting antenna with a first conductive helix wound about a first helical axis, and a first ground plane positioned adjacent to and angled orthogonally with the first helical axis. The wireless power transfer system additionally includes a receiving antenna with a second conductive helix wound about a second helical axis, and a second ground plane positioned adjacent to and angled orthogonally with the second helical axis. Furthermore, the wireless power transfer system further includes a conductive material connecting the first ground plane to the second ground plane.

Abstract: A hierarchically layered group of domain-specific enhanced enterprise ontologies where each domain layer is connected to the immediate domain layer below through a layer policy/control/context translation ontology. Security controls discovery and a mapping ontology is semantically integrated to domain meta models in each layer and a corresponding security controls knowledge base.

Abstract: A sludge flow monitoring system and method measures volume of sludge pumped by a positive displacement pump through a pipeline by determining a fill percentage during each pumping cycle. The start and end of each piston stroke are identified by hydraulic system sensors. The fill percentage is determined based upon a first summation of periodic piston speed command values from the start of a pumping stroke to the end of a pumping stroke, and a second summation of periodic piston speed command values from a poppet valve opening indicating output flow from the pump to the end of the pumping stroke.

Abstract: At least one attribute type associated with an individual in a first record of a first database and one or more similar attribute types in record(s) of other second database(s) are located. The attribute types compared. Based on the comparison, a first weighted score for the first record and another weighted score for each other records are computed. The weighted score indicates a likelihood the particular attribute type is associated with a same individual as other attribute type(s) located in other record(s) and further accounts for a time delta between measurements of the attribute types. Confidence score outputs for the records are also computed. The confidence score output of a record is based on all weighted scores of that record and indicates a likelihood that record is associated with the same individual. At least one database is updated based on at least one of the confidence score outputs.

Abstract: A system and method to enforce read-write partitioning in an N-way, set associative cache may limit a number of ways allocated for storing modified data in a set to a value W and limit a number of ways holding read data to a value R. The cache may be configured where N=R+W. Furthermore, a number of ways storing prefetched read data may be limited to RP, while a number of ways storing prefetched modified data may be limited to WP. The values for W, R, WP, and/or RP may be determined using a prediction method to estimate cache miss rates for different values for W, R, WP, and/or RP and selecting values corresponding to a desired cache miss rate, and so allowing for selective application of the read-write partitioning.

Abstract: One embodiment of the invention relates to treating diseases associated with increased urease enzyme activity comprising administering an effective amount of a compound selected from a group consisting of 28 thiazoles Schiff bases. Kinetic studies were performed on ten (10) of the most active compounds.