Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Abstract: A system includes a computing platform having processing hardware, and a memory storing software code. The processing hardware is configured to execute the software code to receive an image having a plurality of image regions, determine a boundary of each of the image regions to identify a plurality of bounded image regions, and identify, within each of the bounded image regions, one or more image sub-regions to identify a plurality of image sub-regions. The processing hardware is further configured to execute the software code to identify, within each of the bounded image regions, one or more first features, respectively, identify, within each of the image sub-regions, one or more second features, respectively, and provided an annotated image by annotating each of the bounded image regions using the respective first features and annotating each of the image sub-regions using the respective second features.

Abstract: A method for determining a treatment recommendation using a multi-armed bandit (MAB) model can include receiving first patient information, determining, using the MAB model, the treatment recommendation based on the first patient information, wherein the MAB model is trained based on a MAB treatment recommendation determined by the MAB model using second patient information and a clinical treatment recommendation determined according to clinical guidelines based on the second patient information, and providing the treatment recommendation.

Abstract: A system includes a computing device comprising a memory storing instructions configured to cause a processor to receive: purchase data associated with products purchased by a user, online activity data performed by the user and other users and associated with information pertaining to the products, and vendor information comprising retail sales data, after-market sales data, and product availability associated with the products. The processor determines one or more values of the products based on the purchase data, the online activity data, and the vendor information and whether the purchased products correspond to specialty products based on the purchase data, the online activity data, and the values of the products. The processor may then send a notification to the user comprising an offer for insurance for the products in response to determining the products correspond to specialty products.

Abstract: A connector for a flat flexible cable (FFC) has a terminal holder adapted to be mounted to a substrate, and a plurality of terminals arranged within the terminal holder. Each terminal defines a plurality of sharpened tines arranged in a row. A cable holder is slidably arranged on the terminal holder and movable between an insertion position wherein an FFC is free to be inserted into the cable holder, and an installed position wherein the tines of each terminal engage with or penetrate conductors of the FFC arranged within the cable holder for establishing electrical contact therewith.

Abstract: Current cartridge-style mixers due not have the ability to measure mixing performance nor determine the need for maintenance based on performance. Risks of non-homogeneous mixing and insufficient maintenance can exist with cartridge-style mixers. A mixing system comprises a mixing apparatus, a first switch, a magnetic switch, and a controller. The mixing apparatus is configured to receive a cartridge and to mix a material. The mixing apparatus comprises a linear actuator configured to translate the cartridge or plunger in a vertical direction and a spindle configured to rotate a plunger. The first switch is configured to measure a number of strokes per unit of time of operating the linear actuator. The magnetic switch is configured to measure a speed of the spindle. The controller is configured to receive one or more mixing parameters, actuate the spindle and the linear actuator, and actuate a light to indicate if there was sufficient mixing.

Abstract: A zero turning radius mower park brake system includes a park brake pawl on a transmission which engages a park brake to a pair of independently driven traction wheels. A park brake link may be pivotably mounted to the park brake pawl and connected to a left steering lever and a right steering lever. The park brake link may pivot while moving the park brake pawl forward to a park brake engaged position if only one of the steering levers is moved outward from a neutral traction drive position.

Abstract: A method at a client device includes displaying media library information corresponding to a set of media items. The media items include one or more local media items, the one or more local media items including media items stored at the client device, and one or more remote media items, the one or more remote media items including media items stored at a remote system and not at the client device. The method also includes displaying, concurrently with displaying the media library information, affordances identifying the remote media items; detecting user interaction with an affordance identifying a respective remote media item; and in response to detecting the user interaction, initiating a process for downloading a copy of the respective remote media item to the client device for storage at the client device.

Abstract: A work machine can include a machine frame; and a component box holding a plurality of electrical components mounted to a roof of the machine frame; wherein the component box includes a plurality of indicator light sets exposed on an outer surface of the component box, wherein the plurality of indicator light sets are configured to indicate to external personnel a mode of operation of the work machine.

Abstract: A method for locating buried utilities in a utility locator is disclosed. The method may include receiving, at an antenna array for receiving magnetic field signals, a plurality of magnetic field signals at predefined signal frequencies in a predefined frequency suite, generating, in a receiver coupled to an output of the antenna array, a first receiver output signal, generating, in a processing element coupled to the receiver, a first set of data associated with the two or more signal components, and storing, in a non-transitory memory of the locator, the first set of data.

Abstract: Disclosed herein is a bracket connectable to a stator core of an electrical machine. The bracket includes a comb portion having a plurality of teeth arranged in at least one row such that an indentation is defined between each pair of adjacent teeth. Each indentation is sized to receive a portion of a busbar therein. The bracket further includes a tab sized and shaped to be received within a mounting recess defined in the stator core, and an arm extending between the comb portion and the tab such that the comb portion is offset from the tab.

Abstract: A nuclear reactor includes a heat exchanger that transfers thermal energy from a primary reactor coolant to a secondary coolant. The heat exchanger is formed with a hot flow channel, a cold flow channel, and a porous layer between the hot flow channel and the cold flow channel. The porous layer may be thermally insulative to reduce the efficiency of thermal energy transfer from the hot flow channel to the cold flow channel. The porous layer may have a control gas passed therethrough that can be tailored to control the thermal energy transfer through the porous layer. The control gas can be tested for leakage within the heat exchanger. The control gas may also be used to sequester fission or activation products.

Abstract: This disclosure provides a consolidated electric motor stator lamination for multiple enclosure types such that a single stator assembly can be used for different classifications of an electric motor. Each layer of the stator lamination includes external features that, when combined with the external features of the other layers in the lamination, can be adapted to conform the electric motor to one of a plurality of enclosure types. The external features include retaining features for one or more covers, fins, and a profile configured to accept cooling tubes. In various embodiments, a single consolidated stator lamination assembly can be adapted to provide a motor having at least two of an open-drip proof (ODP), a totally enclosed fan cooled (TEFC), or a totally enclosed water cooled (TEWC) enclosure classification.