Patents by Inventor M. Robert Leanna
M. Robert Leanna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7538105Abstract: Compounds having the formula are hepatitis C(HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C(HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.Type: GrantFiled: April 4, 2008Date of Patent: May 26, 2009Assignee: Abbott LaboratoriesInventors: Douglas K. Hutchinson, John R. Bellettini, David A. Betebenner, Richard D. Bishop, Thomas B. Borchardt, Todd D. Bosse, Russell D. Cink, Charles A. Flentge, Bradley D. Gates, Brian E. Green, Mira M. Hinman, Peggy P. Huang, Larry L. Klein, Allan C. Krueger, Daniel P. Larson, M. Robert Leanna, Dachun Liu, Darold L. Madigan, Keith F. McDaniel, John T. Randolph, Todd W. Rockway, Teresa A. Rosenberg, Kent D. Stewart, Vincent S. Stoll, Rolf Wagner, Ming C. Yeung
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Publication number: 20080193413Abstract: Compounds having the formula are hepatitis C(HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C(HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.Type: ApplicationFiled: April 4, 2008Publication date: August 14, 2008Applicant: ABBOTT LABORATORIESInventors: Douglas K. Hutchinson, John R. Bellettini, David A. Betebenner, Richard D. Bishop, Thomas B. Borchardt, Todd D. Bosse, Russell D. Cink, Charles A. Flentge, Bradley D. Gates, Brian E. Green, Mira M. Hinman, Peggy P. Huang, Larry L. Klein, Allan C. Krueger, Daniel P. Larson, M. Robert Leanna, Dachun Liu, Darold L. Madigan, Keith F. McDaniel, John T. Randolph, Todd W. Rockway, Teresa A. Rosenberg, Kent D. Stewart, Vincent S. Stoll, Rolf Wagner, Ming C. Yeung
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Patent number: 7378414Abstract: Compounds having the formula are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.Type: GrantFiled: August 24, 2004Date of Patent: May 27, 2008Assignee: Abbott LaboratoriesInventors: Douglas K. Hutchinson, John R. Bellettini, David A. Betebenner, Richard D. Bishop, Thomas B. Borchardt, Todd D. Bosse, Russell D. Cink, Charles A. Flentge, Bradley D. Gates, Brian E. Green, Mira M. Hinman, Peggy P. Huang, Larry L. Klein, Allan C. Krueger, Daniel P. Larson, M. Robert Leanna, Dachun Liu, Darold L. Madigan, Keith F. McDaniel, John T. Randolph, Todd W. Rockway, Teresa A. Rosenberg, Kent D. Stewart, Vincent S. Stoll, Rolf Wagner, Ming C. Yeung
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Patent number: 7189849Abstract: Novel processes towards the synthesis of the antiviral valomaciclovir stearate in which an esterified guanine acetal is reduced to the corresponding alcohol, reacted with an activated amino acid and N-deprotected. The esterified guanine acetal is prepared from a 9-guanine derivative bearing an acyclic hydroxymethylbutylacetal. The processes are amendable to one-pot reactions.Type: GrantFiled: May 18, 2005Date of Patent: March 13, 2007Assignee: Medivir ABInventors: M. Robert Leanna, Michael Rasmussen, Steven M. Hannick, Jien-Heh J. Tien, Kirill A. Lukin, Zhenping Tian, Sou-Jen Chang, Cynthia B. Curty, Bikshandarkoil A. Narayanan, John Bellettini, Bhadra Shelat, Tiffany Spitz
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Patent number: 6878844Abstract: Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a —C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: December 9, 2002Date of Patent: April 12, 2005Assignee: Medivir ABInventors: M. Robert Leanna, Michael Rasmussen, Howard Morton, Zhenping Tian, Daniel Plata, Bradley D. Gates, Bikshandarkoil A. Narayanan
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Publication number: 20040248910Abstract: Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of the formula: 1Type: ApplicationFiled: June 17, 2004Publication date: December 9, 2004Applicant: Medivir ABInventors: M. Robert Leanna, Steven M. Hannick, Michael Rasmussen, Jien-Heh J. Tien, Lakshmi Bhagavatula, Pulla Reddy Singam, Bradley D. Gates, Lawrence Kolaczkowski, Ramesh R. Patel, Greg Wayne, Greg Lannoye, Weijiang Zhang, Zhenping Tian, Kirill A. Lukin, Bikshandarkoil A. Narayanan, David A. Riley, Howard Morton, Sou-Jen Chang, Cynthia B. Curty, Daniel Plata, John Bellettini, Bhadra Shelat, Tiffany Spitz, Cheng-Xi Yang
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Publication number: 20040132749Abstract: Methods and novel intermediates for the preparation of and the treatment with acyclic nucleoside derivatives of the formula: 1Type: ApplicationFiled: December 19, 2003Publication date: July 8, 2004Applicant: Medivir ABInventors: Per Engelhardt, Marita Hogberg, Nils-Gunnar Johansson, Xiao-Xiong Zhou, Bjorn Lindborg, M. Robert Leanna, Michael Rasmussen
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Publication number: 20040024214Abstract: Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of the formula: 1Type: ApplicationFiled: December 9, 2002Publication date: February 5, 2004Applicant: Medivir ABInventors: M. Robert Leanna, Michael Rasmussen, Howard Morton, Zhenping Tian, Daniel Plata, Bradley D. Gates, Bikshandarkoil A. Narayanan
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Patent number: 6613936Abstract: Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a —C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: October 18, 2000Date of Patent: September 2, 2003Assignee: Medivir ABInventors: M. Robert Leanna, Steven M. Hannick, Michael Rasmussen, Howard Morton, Daniel Plata
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Patent number: 6576763Abstract: Compounds of the Formula I where one of R1 and R2 is —C(O)CH(CH(CH3)2)NH2 or —C(O)CH(CH(CH3)CH2CH3)NH2; the other of R1 and R2 is —C(═O)C3-C21 saturated or monounsaturated, optionally substituted alkyl; and R3 is OH or H; and pharmaceutically acceptable salts thereof have utility as enhanced bioavailability antivirals against herpes and retroviral infections.Type: GrantFiled: April 17, 2000Date of Patent: June 10, 2003Assignee: Medivir ABInventors: Per Engelhardt, Marita Hogberg, Nils-Gunnar Johansson, Xiao-Xiong Zhou, Bjorn Lindborg, M. Robert Leanna, Michael Rasmussen
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Patent number: 6184376Abstract: Methods and novel intermediates of the formula: wherein R6 and R7 are lower alkyl or benzyl or R6 and R7 taken together are —CH2CH2—, —CH2CH2CH2— or —CH2CH2CH2CH2CH2—, R8 is C1-C21 alkyl or a C2-C21 monounsaturated alkenyl, which may optionally be substituted with substitution substituents independently selected from the group consisting of hydroxy, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkoxy C1-C6 alkyl, C1-C6 alkanoyl, amino, halo, cyano, azido, oxo, mercapto and nitro, and R9 is an alcohol protecting group. The intermediates are useful for the preparation of acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a —C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: August 6, 1998Date of Patent: February 6, 2001Assignee: Mediver ABInventors: M. Robert Leanna, Steven M. Hannick, Michael Rasmussen, Jien-Heh J. Tien, Lakshmi Bhagavatula, Pulla Reddy Singam, Bradley D. Gates, Lawrence Kolaczkowski, Ramesh R. Patel, Greg Wayne, Greg Lannoye, Weijiang Zhang, Zhenping Tian, Kirill A. Lukin, Bikshandarkoil A. Narayanan, David A. Riley, Howard Morton, Sou-Jen Chang, Cynthia B. Curty, Daniel Plata, John Bellettini, Bhadra Shelat, Tiffany Spitz, Cheng-Xi Yang
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Patent number: 5712400Abstract: A process for the preparation of 5-hydroxymethylthiazole comprises reacting a compound of the formula, ##STR1## with a carboxylic acid salt (optimally in the presence of a quaternary ammonium salt) and hydrolyzing the resulting ester. Subsequent dechlorination gives 5-hydroxymethylthiazole.Type: GrantFiled: May 22, 1996Date of Patent: January 27, 1998Assignee: Abbott LaboratoriesInventors: M. Robert Leanna, Howard E. Morton, Michael S. Allen
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Patent number: 5625092Abstract: Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of the formula: ##STR1## wherein R.sub.6 and R.sub.7 are each hydrogen or R.sub.6 and R.sub.7 are independently selected from ##STR2## wherein R.sub.a and R.sub.b are independently selected from hydrogen, loweralkyl and phenyl and R.sub.c, R.sub.d and R.sub.e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; orR.sub.6 is as defined above and R.sub.7 is R.sub.7a OC(O)-- wherein R.sub.7a is loweralkyl or benzyl; orR.sub.6 and R.sub.7 taken together with the nitrogen atom to which they are bonded are ##STR4## wherein R.sub.f, R.sub.g, R.sub.h and R.sub.i are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl and R.sub.Type: GrantFiled: April 10, 1995Date of Patent: April 29, 1997Assignee: Abbott LaboratoriesInventors: Timothy L. Stuk, Michael S. Allen, Anthony R. Haight, Francis A. J. Kerdesky, Denton C. Langridge, M. Robert Leanna, Linda M. Lijewski, Laura Melcher, Howard E. Morton, Daniel W. Norbeck, Daniel S. Reno, Timothy A. Robbins, David Scarpetti, Hing L. Sham, Thomas J. Sowin, Jien-Heh J. Tien, Chen Zhao
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Patent number: 5616776Abstract: Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of the formula: ##STR1## wherein R.sub.6 and R.sub.7 are each hydrogen or R.sub.6 and R.sub.7 are independently selected from ##STR2## wherein R.sub.a and R.sub.b are independently selected from hydrogen, loweralkyl and phenyl and R.sub.c, R.sub.d and R.sub.e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; orR.sub.6 is as defined above and R.sub.7 is R.sub.7a OC(O)-- wherein R.sub.7a is loweralkyl or benzyl; orR.sub.6 and R.sub.7 taken together with the nitrogen atom to which they are bonded are ##STR4## wherein R.sub.f, R.sub.g, R.sub.h and R.sub.i are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl and R.sub.Type: GrantFiled: April 7, 1995Date of Patent: April 1, 1997Assignee: Abbott LaboratoriesInventors: Timothy L. Stuk, Anthony R. Haight, Francis A. J. Kerdesky, M. Robert Leanna, Howard E. Morton, Timothy A. Robbins, David Scarpetti, Jien-Heh J. Tien
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Patent number: 5559245Abstract: New intermediates, and processes therefor, provide an efficient method for deriving 4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles, which are themselves intermediates to useful CNS agents, from the Kornfeld-Woodward ketone and like compounds. Preferred embodiments provide means for the preparation of substantially pure enantiomers of the desired 4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indole.Type: GrantFiled: September 12, 1995Date of Patent: September 24, 1996Assignee: Eli Lilly and CompanyInventors: Thomas J. Kress, M. Robert Leanna, Michael J. Martinelli, Barry C. Peterson
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Patent number: 5543552Abstract: Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of the formula: ##STR1## wherein R.sub.6 and R.sub.7 are each hydrogen or R.sub.6 and R.sub.7 are independently selected from ##STR2## wherein R.sub.a and R.sub.b are independently selected from hydrogen, loweralkyl and phenyl and R.sub.c, R.sub.d and R.sub.e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; orR.sub.6 is as defined above and R.sub.7 is R.sub.7a OC(O)- wherein R.sub.7a is loweralkyl or benzyl; orR.sub.6 and R.sub.7 taken together with the nitrogen atom to which they are bonded are ##STR4## wherein R.sub.f, R.sub.g, R.sub.h and R.sub.i are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl and R.sub.Type: GrantFiled: April 10, 1995Date of Patent: August 6, 1996Assignee: Abbott LaboratoriesInventors: Timothy L. Stuk, Michael S. Allen, Anthony R. Haight, M. Robert Leanna, Linda M. Lijewski, Laura Melcher, Howard E. Morton, Daniel S. Reno, Hing L. Sham, Thomas J. Sowin
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Patent number: 5543551Abstract: Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of the formula: ##STR1## wherein R.sub.6 and R.sub.7 are each hydrogen or R.sub.6 and R.sub.7 are independently selected from ##STR2## wherein R.sub.a and R.sub.b are independently selected from hydrogen, loweralkyl and phenyl and R.sub.c, R.sub.d and R.sub.e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; orR.sub.6 is as defined above and R.sub.7 is R.sub.7a OC(O)-- wherein R.sub.7a is loweralkyl or benzyl; orR.sub.6 and R.sub.7 taken together with the nitrogen atom to which they are bonded are ##STR4## wherein R.sub.f, R.sub.g, R.sub.h and R.sub.i are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl and R.sub.Type: GrantFiled: April 10, 1995Date of Patent: August 6, 1996Assignee: Abbott LaboratoriesInventors: Timothy L. Stuk, Michael S. Allen, Anthony R. Haight, Francis A. Kerdesky, Denton C. Langridge, M. Robert Leanna, Linda M. Lijewski, Laura Melcher, Howard E. Morton, Daniel W. Norbeck, Daniel S. Reno, Timothy A. Robbins, Hing L. Sham, Thomas J. Sowin, Jien-heh J. Tien, Chen Zhao, David Scarpetti
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Patent number: 5541328Abstract: A substantially pure compound of formula: ##STR1## wherein R.sub.6 and R.sub.7 are independently selected from ##STR2## wherein R.sub.a and R.sub.b are independently selected from hydrogen, loweralkyl and phenyl and R.sub.c, R.sub.d and R.sub.e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; orR.sub.6 is as defined above and R.sub.7 is R.sub.7a OC(O)-- wherein R.sub.7a is loweralkyl; orR.sub.6 and R.sub.7 taken together with the nitrogen atom to which they are bonded are ##STR4## wherein R.sub.f, R.sub.g, R.sub.h and R.sub.l are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl; andR.sub.g is hydrogen, loweralkyl or benzyl; or an acid addition salt thereof.Type: GrantFiled: April 3, 1995Date of Patent: July 30, 1996Assignee: Abbott LaboratoriesInventors: Timothy L. Stuk, Michael S. Allen, Anthony R. Haight, Francis A. Kerdesky, Denton C. Langridge, M. Robert Leanna, Linda M. Lijewski, Laura Melcher, Howard E. Morton, Daniel W. Norbeck, Daniel S. Reno, Timothy A. Robbins, Hing L. Sham, Thomas J. Sowin, Jien-Heh J. Tien, Chen Zhao, David Scarpetti
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Patent number: 5491253Abstract: Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of the formula: ##STR1## wherein R.sub.6 and R.sub.7 are each hydrogen or R.sub.6 and R.sub.7 are independently selected from ##STR2## wherein R.sub.a and R.sub.b are independently selected from hydrogen, loweralkyl and phenyl and R.sub.c, R.sub.d and R.sub.e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; orR.sub.6 is as defined above and R.sub.7 is R.sub.7a OC(O)--wherein R.sub.7a is loweralkyl or benzyl; orR.sub.6 and R.sub.7 taken together with the nitrogen atom to which they are bonded are ##STR4## wherein R.sub.f, R.sub.g, R.sub.h and R.sub.i are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl and R.sub.Type: GrantFiled: July 27, 1994Date of Patent: February 13, 1996Assignee: Abbott LaboratoriesInventors: Timothy L. Stuk, Michael S. Allen, Anthony R. Haight, Francis A. Kerdesky, Denton C. Langridge, M. Robert Leanna, Linda M. Lijewski, Laura Melcher, Howard E. Morton, Daniel W. Norbeck, Daniel S. Reno, Timothy A. Robbins, David Scarpetti, Hing L. Sham, Thomas J. Sowin, Jien-Heh J. Tien, Chen Zhao
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Patent number: 5275950Abstract: Intermediates and a process for their preparation are disclosed which are useful for the preparation of a renin inhibiting compound of the formula: ##STR1## wherein R is a nitrogen-containing heterocycle which is bonded via a nitrogen atom to the sulfonyl group, R.sub.6 is hydrogen, alkoxy, halogen or loweralkyl, R.sub.7 is loweralkyl having 2 to 7 carbon atoms, and R.sub.8 is loweralkyl, cycloalkyl, or aryl or a pharmaceutically acceptable acid addition salt thereof.Type: GrantFiled: February 10, 1993Date of Patent: January 4, 1994Assignee: Abbott LaboratoriesInventors: Daniel A. Dickman, Bruce W. Horrom, Chi-Nung W. Hsiao, M. Robert Leanna, Hormoz Mazdiyasni, Howard E. Morton, Thomas M. Zydowsky, William R. Baker, Stephen L. Condon