Patents by Inventor Mack Flinspach

Mack Flinspach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GIP RECEPTOR AGONIST PEPTIDE COMPOUNDS AND USES THEREOF
    Publication number: 20220135638
    Abstract: The present disclosure provides GIP receptor agonist peptide compounds having an activating action on GIP receptors and use of the GIP receptor agonist peptide as a medicament for the treatment and/or prevention of diabetes, obesity, emesis, or a symptom or condition associated with diabetes, obesity, or emesis. Specifically, a GIP receptor agonist peptide containing a sequence represented by the formula (I) or a salt thereof, and a medicament comprising the same are provided. Formula I: P1-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12-A13-A14-A15-A16-A17-A18-A19-A20-A21-A22-A23-A24-A25-A26-A27-A28-A29-A30-A341-A32-A33-A34-A35-A36-A37-A38-A39-A40-A41-P2 (SEQ ID NO: 4), or a salt thereof, wherein each symbol is as defined herein, with the proviso that the GIP receptor agonist peptide does not have an amino acid sequence as provided in SEQ ID NOs: 4-569 disclosed in PCT/JP2018/013540.
    Type: Application
    Filed: September 24, 2019
    Publication date: May 5, 2022
    Inventors: Hiroshi IMOTO, Mari ADACHI, Yoko KANEMATSU, Taiji ASAMI, Ayumu NIIDA, Naoki NISHIZAWA, Derek Cecil COLE, Mack FLINSPACH, Nick SCORAH, Abhijit Suresh BHAT
  • PROTOXIN-II VARIANTS AND METHODS OF USE THEREOF
    Publication number: 20220054590
    Abstract: The present invention relates to Protoxin-II variants, polynucleotides encoding them, and methods of making and using the foregoing.
    Type: Application
    Filed: August 9, 2021
    Publication date: February 24, 2022
    Inventors: Mack FLINSPACH, Alan WICKENDEN, Ross FELLOWS, Qinghao XU, Andrew PIEKARZ
  • GIP RECEPTOR AGONIST PEPTIDE COMPOUNDS AND USES THEREOF
    Publication number: 20220016215
    Abstract: The present disclosure provides GIF receptor agonist peptide compounds having an activating action on GIF receptors and use of the GIF receptor agonist peptide as a medicament for the treatment and/or prevention of emesis. Specifically, a GIF receptor agonist peptide containing a sequence represented by the formula (I) or a salt thereof, and a medicament comprising the same are N provided. Formula (I) P1-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12-A13-A14-A15-A16-A17-A18-A19-A20-A21-A22-A23-A24-A25-A26-A27-A28-A29-A30-A31-A32-A33-A34-A35-A36-A37-A38-A39-A40-A41-A42-P2, wherein each symbol is as defined herein, with the proviso that the GIF receptor agonist peptide is not native human GIF having an amino acid sequence as set forth in SEQ ID NO: 1.
    Type: Application
    Filed: September 24, 2019
    Publication date: January 20, 2022
    Inventors: Shiro TAKEKAWA, Tomoko MORIMOTO, Minoru MARUYAMA, Hiroaki NAGAI, Akira TANAKA, Hisanori MATSUI, Atsuko OBINATA, Derek Cecil COLE, Mack FLINSPACH, Nick SCORAH, Abhijit Suresh BHAT
  • PROTOXIN-II VARIANTS AND METHODS OF USE
    Publication number: 20210363204
    Abstract: The present invention relates to Protoxin-II variants, polynucleotides encoding them, and methods of making and using the foregoing.
    Type: Application
    Filed: May 3, 2021
    Publication date: November 25, 2021
    Inventors: Mack FLINSPACH, Alan WICKENDEN
  • Protoxin-II variants and methods of use
    Patent number: 11083776
    Abstract: The present invention relates to Protoxin-II variants, polynucleotides encoding them, and methods of making and using the foregoing.
    Type: Grant
    Filed: November 4, 2019
    Date of Patent: August 10, 2021
    Assignee: JANSSEN BIOTECH, INC.
    Inventors: Mack Flinspach, Alan Wickenden, Ross Fellows, Qinghao Xu, Andrew Piekarz
  • Protoxin-II variants and methods of use
    Patent number: 10995125
    Abstract: The present invention relates to Protoxin-II variants, polynucleotides encoding them, and methods of making and using the foregoing.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: May 4, 2021
    Assignee: JANSSEN BIOTECH, INC.
    Inventors: Mack Flinspach, Alan Wickenden
  • Protoxin-II variants and methods of use
    Patent number: 10975129
    Abstract: The present invention relates to Protoxin-II variants, polynucleotides encoding them, and methods of making and using the foregoing.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: April 13, 2021
    Assignee: JANSSEN BIOTECH, INC.
    Inventors: Mack Flinspach, Alan Wickenden, Ross Fellows, Robert Neff, Yi Liu, Rebecca Hagan, Qinghao Xu
  • PROTOXIN-II VARIANTS AND METHODS OF USE
    Publication number: 20200054712
    Abstract: The present invention relates to Protoxin-II variants, polynucleotides encoding them, and methods of making and using the foregoing.
    Type: Application
    Filed: November 4, 2019
    Publication date: February 20, 2020
    Inventors: Mack FLINSPACH, Alan WICKENDEN, Ross FELLOWS, Qinghao XU, Andrew PIEKARZ
  • PROTOXIN-II VARIANTS AND METHODS OF USE
    Publication number: 20200048316
    Abstract: The present invention relates to Protoxin-II variants, polynucleotides encoding them, and methods of making and using the foregoing.
    Type: Application
    Filed: April 17, 2017
    Publication date: February 13, 2020
    Inventors: Mack Flinspach, Alan Wickenden, Ross Fellows, Robert Neff, Yi Liu, Rebecca Hagan, Qinghao Xu
  • Protoxin-II variants and methods of use
    Patent number: 10463714
    Abstract: The present invention relates to Protoxin-II variants, polynucleotides encoding them, and methods of making and using the foregoing.
    Type: Grant
    Filed: April 4, 2016
    Date of Patent: November 5, 2019
    Assignee: JANSSEN BIOTECH, INC.
    Inventors: Mack Flinspach, Alan Wickenden, Ross Fellows, Qinghao Xu, Andrew Piekarz
  • Huwentoxin-IV variants and methods of use
    Patent number: 10414808
    Abstract: The present invention relates to Huwentoxin-IV variants, polynucleotides encoding them, methods of making and using the foregoing, and methods of alleviating pain with peptide inhibitors of Nav1.7.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: September 17, 2019
    Assignee: JANSSEN BIOTECH, INC.
    Inventors: William Eckert, Mack Flinspach, Michael Hunter, Yi Liu, Robert Neff, Alan Wickenden, Alan Gibbs
  • PROTOXIN-II VARIANTS AND METHODS OF USE
    Publication number: 20170334959
    Abstract: The present invention relates to Protoxin-II variants, polynucleotides encoding them, and methods of making and using the foregoing.
    Type: Application
    Filed: May 1, 2017
    Publication date: November 23, 2017
    Inventors: Mack FLINSPACH, Alan WICKENDEN
  • Protoxin-II variants and methods of use
    Patent number: 9624280
    Abstract: The present invention relates to Protoxin-II variants, polynucleotides encoding them, and methods of making and using the foregoing.
    Type: Grant
    Filed: October 3, 2014
    Date of Patent: April 18, 2017
    Assignee: JANSSEN BIOTECH, INC.
    Inventors: Mack Flinspach, Alan Wickenden, Ross Fellows, Robert Neff, Yi Liu, Rebecca Hagan, Qinghao Xu
  • PROTOXIN-II VARIANTS AND METHODS OF USE
    Publication number: 20160287666
    Abstract: The present invention relates to Protoxin-II variants, polynucleotides encoding them, and methods of making and using the foregoing.
    Type: Application
    Filed: April 4, 2016
    Publication date: October 6, 2016
    Inventors: Mack Flinspach, Alan Wickenden, Ross Fellows, Qinghao XU, Andrew Piekarz
  • PROTOXIN-II VARIANTS AND METHODS OF USE
    Publication number: 20160257726
    Abstract: The present invention relates to Protoxin-II variants, polynucleotides encoding them, and methods of making and using the foregoing.
    Type: Application
    Filed: March 3, 2016
    Publication date: September 8, 2016
    Inventors: Mack FLINSPACH, Alan WICKENDEN
  • Huwentoxin-IV variants and methods of use
    Patent number: 9102751
    Abstract: The present invention relates to Huwentoxin-IV variants, polynucleotides encoding them, and methods of making and using the foregoing.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: August 11, 2015
    Assignee: JANSSEN BIOTECH, INC.
    Inventors: Mack Flinspach, Michael Hunter, Yi Liu, Robert Neff, Alan Wickenden, Alan Gibbs
  • PROTOXIN -II VARIANTS AND METHODS OF USE
    Publication number: 20150099705
    Abstract: The present invention relates to Protoxin-II variants, polynucleotides encoding them, and methods of making and using the foregoing.
    Type: Application
    Filed: October 3, 2014
    Publication date: April 9, 2015
    Inventors: Mack FLINSPACH, Alan Wickenden, Ross Fellows, Robert Neff, Yi Liu, Rebecca Hagan, Qinghao Xu
  • HUWENTOXIN-IV VARIANTS AND METHODS OF USE
    Publication number: 20150087596
    Abstract: The present invention relates to Huwentoxin-IV variants, polynucleotides encoding them, methods of making and using the foregoing, and methods of alleviating pain with peptide inhibitors of Nav1.7.
    Type: Application
    Filed: March 15, 2013
    Publication date: March 26, 2015
    Inventors: William Eckert, Mack Flinspach, Michael Hunter, Yi Liu, Robert Neff, Alan Wickenden, Alan Gibbs
  • HUWENTOXIN-IV VARIANTS AND METHODS OF USE
    Publication number: 20130310324
    Abstract: The present invention relates to Huwentoxin-IV variants, polynucleotides encoding them, and methods of making and using the foregoing.
    Type: Application
    Filed: March 15, 2013
    Publication date: November 21, 2013
    Applicant: JANSSEN BIOTECH, INC.
    Inventors: Mack Flinspach, Michael Hunter, Yi Liu, Robert Neff, Alan Wickenden, Alan Gibbs
  • Selective inhibition of neuronal nitric oxide synthase
    Patent number: 7056945
    Abstract: Compositions, prodrugs and methods for inhibiting neural Nitric Oxide Synthase (nNOS). By inhibiting nNOS, the compounds, prodrugs and methods of the presnet invention are useable to treat or prevent disorders in human or veterinary patients that are caused, mediated or agrevated by Nitric Oxide within the body.
    Type: Grant
    Filed: June 17, 2003
    Date of Patent: June 6, 2006
    Assignee: The Regents of the University of California
    Inventors: Thomas Poulos, Huiying Li, Mack Flinspach