Abstract: A method and apparatus for incubating a liquid reagent with target spots on a microarray substrate. A deformable cover is placed over the surface of the microarray substrate having the target spots with the liquid reagent between the microarray substrate and the deformable cover, and a device is used to apply a force to the deformable cover.

Abstract: A method and apparatus for incubating a liquid reagent with target spots on a microarray substrate. A deformable cover is placed over the surface of the microarray substrate having the target spots with the liquid reagent between the microarray substrate and the deformable cover, and a device is used to apply a force to the deformable cover.

Abstract: The disclosed spotting instrument includes one or more sensors that are mechanically fixed to the instrument's printhead. The sensors enable the instrument to detect whether a substrate is mounted in a particular holder of the instrument's substrate station prior to attempting to print spots onto that substrate. Similarly, the sensors enable the instrument to detect whether a reservoir is mounted in a particular holder of the instrument's well station prior to attempting to collect a sample of target material from that reservoir. The sensors also enable the instrument to read bar code labels affixed to substrates or reservoirs mounted in the instrument.

Abstract: The disclosed spotting instrument includes one or more sensors that are mechanically fixed to the instrument's printhead. The sensors enable the instrument to detect whether a substrate is mounted in a particular holder of the instrument's substrate station prior to attempting to print spots onto that substrate. Similarly, the sensors enable the instrument to detect whether a reservoir is mounted in a particular holder of the instrument's well station prior to attempting to collect a sample of target material from that reservoir. The sensors also enable the instrument to read bar code labels affixed to substrates or reservoirs mounted in the instrument.

Abstract: In a scanner system (10) in which two scanners (14 and 16) deflect light from a laser (12) in orthogonal directions along a cylindrical object surface (18), the light from the laser is focused by a combination of an image-forming lens (24) disposed between the laser (12) and the first scanner (14) and a negative field-flattening lens (28) disposed between the two scanners (14 and 16) so as to compensate the effective focal length for the change in light-path length that results from deflection by the first scanner (14).

Abstract: A resonant scanner control system controls a laser source using a pixel clock which uses a voltage controlled oscillator (VCO) and a phase detector to track continuously throughout the entire scan cycle the pixel-to-pixel and cycle-to-cycle operations of the scanner. The clock includes a VCO which changes frequency in a linear manner in response to changes in a frequency-control voltage applied to it. The VCO includes a negative feedback loop which consists of a frequency-to-voltage converter, which converts the VCO output to a related voltage, and a summing/integrating circuit, which compares this voltage with the frequency-control voltage which is produced in response to pixel related control signals and then integrates the difference. The integrated signal drives the VCO, which produces in response an output signal whose frequency varies linearly with variations in the pixel-related frequency-control signal.

Abstract: A dynamically resonant system including a linearly movable element having a neutral position and a range of excursion centered on the neutral position, a spring-like element for urging the movable element toward the neutral position, the resonant system having a natural resonant frequency dependent on the spring characteristics of the spring-like element, the spring-like element having a temperature sensitive member that causes the spring characteristics to vary with temperature of the member.