Abstract: Described herein are devices and methods for identifying the existence of an oral condition in a subject.

Abstract: Generally regarded as safe (GRAS) dyes can be used as photosensitizing dyes in oral compositions to provide anti-bacterial and anti-inflammatory efficacy. Embodiments include oral care compositions including photosensitizing dyes, methods of making the compositions, methods of using the compositions, and kits containing the compositions and light emitting devices.

Abstract: Generally regarded as safe (GRAS) dyes can be used as photosensitizing dyes in oral compositions to provide anti-bacterial and anti-inflammatory efficacy. Embodiments include oral care compositions including photosensitizing dyes, methods of making the compositions, methods of using the compositions, and kits containing the compositions and light emitting devices.

Abstract: Generally regarded as safe (GRAS) dyes can be used as photosensitizing dyes in oral compositions to provide anti-bacterial and anti-inflammatory efficacy. Embodiments include oral care compositions including photosensitizing dyes, methods of making the compositions, methods of using the compositions, and kits containing the compositions and light emitting devices.

Abstract: An oral care implement includes a collection system for oral fluids. Some embodiments of the implement may include an oral care region having a wearable oral member having a thickness that is reduced during use, a reservoir for retaining an oral fluid, a receiver coupled to the oral member for receiving an oral fluid, and a fluid pathway in communication with the receiver to provide the oral fluid to the reservoir.

Abstract: An oral care implement includes a collection system for oral fluids. Some embodiments of the implement may include an oral care region having a wearable oral member having a thickness that is reduced during use, a reservoir for retaining an oral fluid, a receiver coupled to the oral member for receiving an oral fluid, and a fluid pathway in communication with the receiver to provide the oral fluid to the reservoir.

Abstract: Relative quantification of metabolites by Electrospray Ionization Mass Spectrometry (ESI-MS) requiring a mechanism for simultaneous analysis of multiple analytes in two or more samples. Labeling reagents that are reactive to particular compound classes and differ only in their isotopic compositions facilitate relative quantification. Heavy and light isotopic forms of methylacetimidate were synthesized and used as labeling reagents for quantification of amine-containing molecules. Heavy and light isotopic forms of formaldehyde and cholamine were also synthesized and used independently as labeling reagents for quantification of amine-containing and carboxylic acid-containing molecules, such as found in biological samples. The labeled end-products are positively charged under normal acidic conditions involving conventional Liquid Chromatography Mass Spectrometry (LC/MS) applications.

Abstract: A fluid dispensing oral care implement with fluid delivery system. The implement includes a storage member containing a fluid. A channel formed of one or more wicking or capillary members extends through at least a portion of the oral care implement to deliver fluid(s) through one or more fluid outlets via capillary action. In one embodiment, the fluid outlet is comprised of a wicking or capillary material and is disposed in the head of the implement. In some embodiments, the implement may include a valve and a specially configured storage cap. A variety of fluids can be administered for therapeutic, hygienic, and/or other benefits, such as fresh breath, tooth whitening, tooth sensitivity, plaque and/or tartar control, or producing sensations of heat, cool, or tingling.

Abstract: A fluid delivery system usable in an oral care implement and a reservoir containing a flowable substance. A capillary channel formed of one or more wicking or capillary members extends through at least a portion of the oral care implement to deliver flowable substance(s) through one or more outlets via capillary action. In one embodiment, the rate of fluid flow through the capillary channel is different in at least a first flow section than in a second flow section. In another embodiment, the rate of flow between flow sections of the wicking member is different than in at least one of the flow sections. A variety of flowable substances can be administered for therapeutic, hygienic, and/or other benefits, such as fresh breath, tooth whitening, tooth sensitivity, plaque and/or tartar control, or producing sensations of heat, cool, or tingling.

Abstract: Relative quantification of metabolites by Electrospray Ionization Mass Spectrometry (ESI-MS) requiring a mechanism for simultaneous analysis of multiple analytes in two or more samples. Labeling reagents that are reactive to particular compound classes and differ only in their isotopic kit facilitating relative quantification and providing tangible evidence for the existence of specific functional groups. Heavy and light isotopic forms of methylacetimidate were synthesized and used as labeling reagents for quantification of amine-containing molecules, such as biological samples. Heavy and light isotopic forms of formaldehyde and cholamine were also synthesized and used independently as labeling reagents for quantification of amine-containing and carboxylic acid-containing molecules, such as found in biological samples. Advantageously, the labeled end-products are positively charged under normal acidic conditions involving conventional Liquid Chromatography Mass Spectrometry (LC/MS) applications.

Abstract: An oral care implement includes a collection system for oral fluids. Some embodiments of the implement may include an oral care region having a wearable oral member having a thickness that is reduced during use, a reservoir for retaining an oral fluid, a receiver coupled to the oral member for receiving an oral fluid, and a fluid pathway in communication with the receiver to provide the oral fluid to the reservoir.

Abstract: Relative quantification of metabolites by Electrospray Ionization Mass Spectrometry (ESI-MS) requiring a mechanism for simultaneous analysis of multiple analytes in two or more samples. Labeling reagents that are reactive to particular compound classes and differ only in their isotopic kit facilitating relative quantification and providing tangible evidence for the existence of specific functional groups. Heavy and light isotopic forms of methylacetimidate were synthesized and used as labeling reagents for quantification of amine-containing molecules, such as biological samples. Heavy and light isotopic forms of formaldehyde and cholamine were also synthesized and used independently as labeling reagents for quantification of amine-containing and carboxylic acid-containing molecules, such as found in biological samples. Advantageously, the labeled end-products are positively charged under normal acidic conditions involving conventional Liquid Chromatography Mass Spectrometry (LC/MS) applications.