Patents by Inventor Mae Joanne Rosok

Mae Joanne Rosok has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for inhibiting immunoglobulin-induced toxicity resulting from the use of immunoglobulins in therapy and in vivo diagnosis
    Patent number: 7247302
    Abstract: The present invention provides a method for inhibiting immunoglobulin-induced toxicity resulting from immunotherapy in a subject comprising administering an immunoglobulin or Ig fusion protein molecule to the subject, the immunoglobulin molecule having a variable region and a constant region, the immunoglobulin molecule being modified prior to administration by inactivation of at least a portion of the constant region.
    Type: Grant
    Filed: August 1, 1997
    Date of Patent: July 24, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Mae Joanne Rosok, Dale E. Yelton
  • Mutant BR96 antibodies reactive with human carcinomas
    Patent number: 5792456
    Abstract: The present invention provides mutant BR96 polypeptides having a variable region comprising an amino acid sequence derived from the variable region of BR96.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 11, 1998
    Assignee: Bristol-Myers Squibb Company
    Inventors: Dale Yelton, Scott Glaser, William Huse, Mae Joanne Rosok
  • Mutant BR96 antibodies reactive with human carcinomas
    Patent number: 5728821
    Abstract: The present invention provides mutant BR96 polypeptides (and nucleotide sequences encoding them) having a variable region comprising an amino acid sequence derived from the variable region of BR96.
    Type: Grant
    Filed: August 4, 1994
    Date of Patent: March 17, 1998
    Assignee: Bristol-Myers Squibb Company
    Inventors: Dale Yelton, Scott Glaser, William Huse, Mae Joanne Rosok
  • Diagnostic test for Pseudomonas aeruginosa infections
    Patent number: 5716829
    Abstract: Methods and reagents are provided for a novel immunodiagnostic test for the presence of P. aeruginosa in a biological sample. Monoclonal antibodies are employed which bind to an outer membrane protein antigen, which may be exposed by a solubilizing reagent. The antibody binds substantially all strains of P. aeruginosa. No cross-reactivity with other species of Pseudomonas or with other clinically significant gram-negative or gram-positive species is observed. Conjugating the monoclonal antibody of the invention with a fluorescent label provides for a rapid and sensitive direct immunofluorescent test for P. aeruginosa.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: February 10, 1998
    Assignee: Genetic Systems Corporation
    Inventors: Mae Joanne Rosok, Mark E. Lostrom, Richard P. Darveau