Patents by Inventor Mahavir Yadav

Mahavir Yadav has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of making a plasminogen activator polypeptide with clot-specific streptokinase activity
    Patent number: 8143027
    Abstract: The present invention provides polynucleotides encoding clot-specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of plasminogen activation by these proteins are distinct from those of natural streptokinase, in that there is a temporary delay or lag in the initial rate of catalytic conversion of plasminogen to plasmin. Also disclosed are processes for preparing the proteins.
    Type: Grant
    Filed: July 23, 2007
    Date of Patent: March 27, 2012
    Assignee: Council of Scientific & Industrial Research of Rafi Marg
    Inventors: Girish Sahni, Rajesh Kumar, Chiati Roy, Kammara Rajagopal, Deepak Nihalani, Vasudha Sundaram, Mahavir Yadav
  • Polynucleotides Encoding Proteins with Clot-Specific Streptokinase Activity
    Publication number: 20080171362
    Abstract: The present invention provides polynucleotides encoding clot-specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of plasminogen activation by these proteins are distinct from those of natural streptokinase, in that there is a temporary delay or lag in the initial rate of catalytic conversion of plasminogen to plasmin. Also disclosed are processes for preparing the proteins.
    Type: Application
    Filed: July 23, 2007
    Publication date: July 17, 2008
    Inventors: Girish Sahni, Rajesh Kumar, Chiati Roy, Kammara Rajagopal, Deepak Nihalani, Vasudha Sundaram, Mahavir Yadav
  • Novel clot-specific steptokinase proteins possessing altered plasminogen activation-characteristics and a process for the preparation of said proteins
    Publication number: 20070287660
    Abstract: Clot-specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of plasminogen activation by these proteins are distinct from those of natural streptokinase, in that there is a temporary delay or lag in the initial rate of catalytic conversion of plasminogen to plasmin. Also disclosed are processes for preparing the proteins.
    Type: Application
    Filed: November 29, 2006
    Publication date: December 13, 2007
    Inventors: Girish Sahai, Rajesh Kumar, Chaiti Roy, Kammara Rajagopal, Deepak Nihalani, Vasudha Sundaram, Mahavir Yadav
  • Nucleic acid molecules encoding clot-specific streptokinase fusion proteins possessing altered plasminogen activation characteristics
    Patent number: 7250503
    Abstract: The present invention provides polynucleotides encoding clot-specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of plasminogen activation by these proteins are distinct from those of natural streptokinase, in that there is a temporary delay or lag in the initial rate of catalytic conversion of plasminogen to plasmin. Also disclosed are processes for preparing the proteins.
    Type: Grant
    Filed: July 31, 2003
    Date of Patent: July 31, 2007
    Assignee: Council of Scientific and Industrial Research
    Inventors: Girish Sahni, Rajesh Kumar, Chaiti Roy, Kammara Rajagopal, Deepak Nihalani, Vasudha Sundaram, Mahavir Yadav
  • Clot-specific streptokinase proteins possessing altered plasminogen activation characteristics and a process for their preparation
    Patent number: 7163817
    Abstract: The invention disclosed herein provides clot specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of plasminogen activation by these proteins are distinct from those of natural streptokinase, in that there is a temporary delay or lag in the initial rate of catalytic conversion of plasminogen to plasmin. Also disclosed are processes for preparing the proteins.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: January 16, 2007
    Inventors: Girish Sahni, Rajesh Kumar, Chaiti Roy, Kammara Rajagopal, Deepak Nihalani, Vasudha Sundaram, Mahavir Yadav
  • Novel clot-specific streptokinase proteins possessing altered plasminogen activation characteristics and a process for the preparation of said protein
    Publication number: 20050260598
    Abstract: Clot-specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of plasminogen activation by these proteins are distinct from those of natural streptokinase, in that there is a temporary delay or lag in the initial rate of catalytic conversion of plasminogen to plasmin. Also disclosed are processes for preparing the proteins.
    Type: Application
    Filed: July 31, 2003
    Publication date: November 24, 2005
    Inventors: Girish Sahni, Rajesh Kumar, Chaiti Roy, Kammara Rajagopal, Deepak Nihalani, Vasudha Sundaram, Mahavir Yadav
  • Novel clot-specific steptokinase proteins possessing altered plasminogen activation characteristics and a process for the preparation of said proteins
    Publication number: 20030059921
    Abstract: Clot-specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of plasminogen activation by these proteins are distinct from those of natural streptokinase, in that there is a temporary delay or lag in the initial rate of catalytic conversion of plasminogen to plasmin. Also disclosed are processes for preparing the proteins.
    Type: Application
    Filed: August 27, 2001
    Publication date: March 27, 2003
    Applicant: Council of Scientific and Industrial Research of Rafi Marg, a New Delhi, India corporation
    Inventors: Girish Sahni, Rajesh Kumar, Chaiti Roy, Kammara Rajagopal, Deepak Nihalani, Vasudha Sundaram, Mahavir Yadav