Patents by Inventor Mahdokht Masaeli
Mahdokht Masaeli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240149267Abstract: Systems and methods in accordance with various embodiments of the invention are capable of rapid analysis and classification of cellular samples based on cytomorphological properties. In several embodiments, cells suspended in a fluid medium are passed through a microfluidic channel, where they are focused to a single stream line and imaged continuously. In a number of embodiments, the microfluidic channel establishes flow that enables individual cells to each be imaged at multiple angles in a short amount of time. A pattern recognition system can analyze the data captured from high-speed images of cells flowing through this system and classify target cells. In this way, the automated platform creates new possibilities for a wide range of research and clinical applications such as (but not limited to) point of care services.Type: ApplicationFiled: August 11, 2023Publication date: May 9, 2024Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Mahdokht Masaeli, Euan A. Ashley
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Publication number: 20240153289Abstract: The present disclosure provides systems and methods for classifying and sorting a cell. The method can comprise processing image data of cells to generate a cell morphology map comprising a plurality of morphologically-distinct clusters corresponding to different types or states of the cells. The method can comprise using a classifier to automatically classify a cellular image sample based on its proximity, correlation, or commonality with one or more of the morphologically-distinct clusters.Type: ApplicationFiled: February 17, 2022Publication date: May 9, 2024Applicant: DEEPCELL, INC.Inventors: Mahdokht Masaeli, Mahyar Salek
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Publication number: 20240102986Abstract: The present disclosure provides systems and methods for sorting a cell. The system may comprise a flow channel configured to transport a cell through the channel. The system may comprise an imaging device configured to capture an image of the cell from a plurality of different angles as the cell is transported through the flow channel. The system may comprise a processor configured to analyze the image using a deep learning algorithm to enable sorting of the cell.Type: ApplicationFiled: September 29, 2023Publication date: March 28, 2024Inventors: Mahdokht MASAELI, Mahyar SALEK, Hou-Pu CHOU, Soroush KAHKESHANI, Prashast KHANDELWAL, Syed Tariq SHAFAAT
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Patent number: 11815507Abstract: The present disclosure provides systems and methods for sorting a cell. The system may comprise a flow channel configured to transport a cell through the channel. The system may comprise an imaging device configured to capture an image of the cell from a plurality of different angles as the cell is transported through the flow channel. The system may comprise a processor configured to analyze the image using a deep learning algorithm to enable sorting of the cell.Type: GrantFiled: February 11, 2021Date of Patent: November 14, 2023Assignee: Deepcell, Inc.Inventors: Mahdokht Masaeli, Mahyar Salek, Hou-Pu Chou, Soroush Kahkeshani, Prashast Khandelwal, Syed Tariq Shafaat
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Publication number: 20220081672Abstract: The present disclosure provides systems and methods for sorting a cell. The system may comprise a flow channel configured to transport a cell through the channel. The system may comprise an imaging device configured to capture an image of the cell from a plurality of different angles as the cell is transported through the flow channel. The system may comprise a processor configured to analyze the image using a deep learning algorithm to enable sorting of the cell.Type: ApplicationFiled: April 26, 2021Publication date: March 17, 2022Inventors: Mahdokht MASAELI, Mahyar SALEK, Hou-Pu CHOU, Soroush KAHKESHANI
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Publication number: 20210405022Abstract: The present disclosure provides systems and methods for sorting a cell. The system may comprise a flow channel configured to transport a cell through the channel. The system may comprise an imaging device configured to capture an image of the cell from a plurality of different angles as the cell is transported through the flow channel. The system may comprise a processor configured to analyze the image using a deep learning algorithm to enable sorting of the cell.Type: ApplicationFiled: February 11, 2021Publication date: December 30, 2021Inventors: Mahdokht MASAELI, Mahyar SALEK, Hou-Pu CHOU, Soroush KAHKESHANI, Prashast KHANDELWAL, Syed Tariq SHAFAAT
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Publication number: 20210245158Abstract: Systems and methods in accordance with various embodiments of the invention are capable of rapid analysis and classification of cellular samples based on cytomorphological properties. In several embodiments, cells suspended in a fluid medium are passed through a microfluidic channel, where they are focused to a single stream line and imaged continuously. In a number of embodiments, the microfluidic channel establishes flow that enables individual cells to each be imaged at multiple angles in a short amount of time. A pattern recognition system can analyze the data captured from high-speed images of cells flowing through this system and classify target cells. In this way, the automated platform creates new possibilities for a wide range of research and clinical applications such as (but not limited to) point of care services.Type: ApplicationFiled: November 23, 2020Publication date: August 12, 2021Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Mahdokht Masaeli, Euan A. Ashley
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Patent number: 11015165Abstract: The present disclosure provides systems and methods for sorting a cell. The system may comprise a flow channel configured to transport a cell through the channel. The system may comprise an imaging device configured to capture an image of the cell from a plurality of different angles as the cell is transported through the flow channel. The system may comprise a processor configured to analyze the image using a deep learning algorithm to enable sorting of the cell.Type: GrantFiled: October 15, 2020Date of Patent: May 25, 2021Assignee: Deepcell, Inc.Inventors: Mahdokht Masaeli, Mahyar Salek, Hou-Pu Chou, Soroush Kahkeshani
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Publication number: 20210032588Abstract: The present disclosure provides systems and methods for sorting a cell. The system may comprise a flow channel configured to transport a cell through the channel. The system may comprise an imaging device configured to capture an image of the cell from a plurality of different angles as the cell is transported through the flow channel. The system may comprise a processor configured to analyze the image using a deep learning algorithm to enable sorting of the cell.Type: ApplicationFiled: October 15, 2020Publication date: February 4, 2021Applicant: Deepcell, Inc.Inventors: Mahdokht MASAELI, Mahyar SALEK, Hou-Pu CHOU, Soroush KAHKESHANI
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Patent number: 10843196Abstract: Systems and methods in accordance with various embodiments of the invention are capable of rapid analysis and classification of cellular samples based on cytomorphological properties. In several embodiments, cells suspended in a fluid medium are passed through a microfluidic channel, where they are focused to a single stream line and imaged continuously. In a number of embodiments, the microfluidic channel establishes flow that enables individual cells to each be imaged at multiple angles in a short amount of time. A pattern recognition system can analyze the data captured from high-speed images of cells flowing through this system and classify target cells. In this way, the automated platform creates new possibilities for a wide range of research and clinical applications such as (but not limited to) point of care services.Type: GrantFiled: May 19, 2017Date of Patent: November 24, 2020Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Mahdokht Masaeli, Euan A. Ashley
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Patent number: 10808219Abstract: The present disclosure provides systems and methods for sorting a cell. The system may comprise a flow channel configured to transport a cell through the channel. The system may comprise an imaging device configured to capture an image of the cell from a plurality of different angles as the cell is transported through the flow channel. The system may comprise a processor configured to analyze the image using a deep learning algorithm to enable sorting of the cell.Type: GrantFiled: April 3, 2020Date of Patent: October 20, 2020Assignee: Deepcell, Inc.Inventors: Mahdokht Masaeli, Mahyar Salek, Hou-Pu Chou, Soroush Kahkeshani
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Publication number: 20200231927Abstract: The present disclosure provides systems and methods for sorting a cell. The system may comprise a flow channel configured to transport a cell through the channel. The system may comprise an imaging device configured to capture an image of the cell from a plurality of different angles as the cell is transported through the flow channel.Type: ApplicationFiled: April 3, 2020Publication date: July 23, 2020Inventors: Mahdokht MASAELI, Mahyar SALEK, Hou-Pu CHOU, Soroush KAHKESHANI
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Patent number: 10611995Abstract: The present disclosure provides systems and methods for sorting a cell. The system may comprise a flow channel configured to transport a cell through the channel. The system may comprise an imaging device configured to capture an image of the cell from a plurality of different angles as the cell is transported through the flow channel. The system may comprise a processor configured to analyze the image using a deep learning algorithm to enable sorting of the cell.Type: GrantFiled: November 16, 2018Date of Patent: April 7, 2020Assignee: Deepcell, Inc.Inventors: Mahdokht Masaeli, Mahyar Salek, Hou-Pu Chou, Soroush Kahkeshani
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Publication number: 20200056142Abstract: The present disclosure provides systems and methods for sorting a cell. The system may comprise a flow channel configured to transport a cell through the channel. The system may comprise an imaging device configured to capture an image of the cell from a plurality of different angles as the cell is transported through the flow channel. The system may comprise a processor configured to analyze the image using a deep learning algorithm to enable sorting of the cell.Type: ApplicationFiled: November 16, 2018Publication date: February 20, 2020Inventors: Mahdokht Masaeli, Mahyar Salek, Houpu Chou, Soroush Kahkeshani
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Patent number: 10502674Abstract: A system and method for the label-free analysis of cells includes a purification device configured to receive a heterogeneous population of cells, the purification device temporarily trapping therein a subpopulation of cells from the heterogeneous population of cells and a cell analysis device positioned downstream of the purification device and configured to measure one or more cellular parameters including cell count, measured cell size, and/or cell morphology. In an alternative embodiment, the subpopulation of cells is analyzed while they are trapped within the purification device.Type: GrantFiled: June 26, 2015Date of Patent: December 10, 2019Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Dino Di Carlo, Derek Go, Mahdokht Masaeli, Elodie Sollier
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Publication number: 20170333903Abstract: Systems and methods in accordance with various embodiments of the invention are capable of rapid analysis and classification of cellular samples based on cytomorphological properties. In several embodiments, cells suspended in a fluid medium are passed through a microfluidic channel, where they are focused to a single stream line and imaged continuously. In a number of embodiments, the microfluidic channel establishes flow that enables individual cells to each be imaged at multiple angles in a short amount of time. A pattern recognition system can analyze the data captured from high-speed images of cells flowing through this system and classify target cells. In this way, the automated platform creates new possibilities for a wide range of research and clinical applications such as (but not limited to) point of care services.Type: ApplicationFiled: May 22, 2017Publication date: November 23, 2017Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Mahdokht Masaeli, Mahyar Salek, Euan A. Ashley
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Publication number: 20170333902Abstract: Systems and methods in accordance with various embodiments of the invention are capable of rapid analysis and classification of cellular samples based on cytomorphological properties. In several embodiments, cells suspended in a fluid medium are passed through a microfluidic channel, where they are focused to a single stream line and imaged continuously. In a number of embodiments, the microfluidic channel establishes flow that enables individual cells to each be imaged at multiple angles in a short amount of time. A pattern recognition system can analyze the data captured from high-speed images of cells flowing through this system and classify target cells. In this way, the automated platform creates new possibilities for a wide range of research and clinical applications such as (but not limited to) point of care services.Type: ApplicationFiled: May 19, 2017Publication date: November 23, 2017Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Mahdokht Masaeli, Euan A. Ashley
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Publication number: 20170248512Abstract: A system and method for the label-free analysis of cells includes a purification device configured to receive a heterogeneous population of cells, the purification device temporarily trapping therein a subpopulation of cells from the heterogeneous population of cells and a cell analysis device positioned downstream of the purification device and configured to measure one or more cellular parameters including cell count, measured cell size, and/or cell morphology. In an alternative embodiment, the subpopulation of cells is analyzed while they are trapped within the purification device.Type: ApplicationFiled: June 26, 2015Publication date: August 31, 2017Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Dino Di Carlo, Derek Go, Mahdokht Masaeli, Elodie Sollier
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Patent number: 9333510Abstract: A particle sorting system includes an inlet and an inertial focusing microchannel disposed in a substrate and having a downstream expanding region at a distal end, wherein the inlet is connected to an upstream end of the microchannel. A source of different shaped particles is connected to the inlet, wherein the source of different shaped particles are configured for continuous introduction into the inlet. A plurality of outlets is connected to the microchannel at the downstream expanding region. Fluidic resistors are located in the respective outlets. Different resistances may be used in the outlets to capture enriched fractions of particles having particular particle shape(s).Type: GrantFiled: September 27, 2012Date of Patent: May 10, 2016Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Dino Di Carlo, Mahdokht Masaeli, Elodie Sollier
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Publication number: 20140224710Abstract: A particle sorting system includes an inlet and an inertial focusing microchannel disposed in a substrate and having a downstream expanding region at a distal end, wherein the inlet is connected to an upstream end of the microchannel. A source of different shaped particles is connected to the inlet, wherein the source of different shaped particles are configured for continuous introduction into the inlet. A plurality of outlets is connected to the microchannel at the downstream expanding region. Fluidic resistors are located in the respective outlets. Different resistances may be used in the outlets to capture enriched fractions of particles having particular particle shape(s).Type: ApplicationFiled: September 27, 2012Publication date: August 14, 2014Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Dino Di Carlo, Mahdokht Masaeli, Elodie Sollier