Patents by Inventor Mahesh Gadakar

Mahesh Gadakar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of fluticasone propionate
    Patent number: 8344168
    Abstract: The present invention relates to a process for the preparation of steroidal 17?-carboxylic thioates. More particularly the present invention relates to a convenient and efficient synthesis of steroidal 17?-carboxylic thioates, such as fluticasone propionate I, using soluble mixed fluorides to introduce fluorine by displacing an appropriate leaving group X in compounds II resulting in selective and controlled fluorination. The present invention also relates to intermediates II and their preparation.
    Type: Grant
    Filed: December 8, 2008
    Date of Patent: January 1, 2013
    Assignee: Generics (UK) Limited
    Inventors: Vinayak G. Gore, Mahesh Gadakar, K. Pokharkar, V. Wakchure
  • NOVEL PROCESS AND INTERMEDIATES
    Publication number: 20090177001
    Abstract: The present invention relates to a process for the preparation of steroidal 17?-carboxylic thioates. More particularly the present invention relates to a convenient and efficient synthesis of steroidal 17?-carboxylic thioates, such as fluticasone propionate I, using soluble mixed fluorides to introduce fluorine by displacing an appropriate leaving group X in compounds II resulting in selective and controlled fluorination. The present invention also relates to intermediates II and their preparation.
    Type: Application
    Filed: December 8, 2008
    Publication date: July 9, 2009
    Inventors: Vinayak G. Gore, Mahesh Gadakar, K. Pokharkar, V. Wakchure
  • Process for preparing enantiomerically pure alpha phenyl-alpha (6,7-dihydro-4h-thieno[3,2-c]pyridin-5-yl)-acetic acid derivatives
    Publication number: 20050049415
    Abstract: A process for preparing a substantially enantiomerically pure compound of formula (IV), or a pharmaceutically acceptable salt thereof wherein: R is hydrogen or a Cl alkyl group and X, Y and Z are any atom or group, comprising a step of isolating a substantially enantiomerically pure compound of formula (V) wherein: R3 is CN or C(O)NR1R2 and R1 and R2 are each independently hydrogen or a C1-C4 alkyl group, or, together with the nitrogen in the C(O)NR1R2 group, form a ring that includes 2-6 carbon atoms, from a racemate of formula (V) and converting the substantially enantiomerically pure compound of formula (V) into a substantially enantiomerically pure compound of formula (IV).
    Type: Application
    Filed: October 28, 2002
    Publication date: March 3, 2005
    Inventors: Ramakrishna Arul, Rawat Ajaysingh, Mahesh Gadakar, Abhinay Pise, Rajesh Rao, Jayaraman Raman