Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.

Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.

Abstract: The present disclosure provides methods for inducing neoepitope-specific CD8+ T cells in an individual or for inducing trafficking of neoepitope-specific CD8+ T cells to a tumor in an individual using an RNA vaccine or using an RNA vaccine in combination with a PD-1 axis binding antagonist. Also provided herein are PD-1 axis binding antagonists and RNA vaccines that include one or more polynucleotides encoding one or more neoepitopes resulting from cancer-specific somatic mutations present in a tumor specimen obtained from the individual for use in methods of inducing neoepitope-specific CD8+ T cells in an individual or for inducing trafficking of neoepitope-specific CD8+ T cells to a tumor in an individual.

Abstract: A machine learning (ML) operating mode is selected for a camera. A physical orientation of a housing of a camera is determined. In response to determining the orientation, an operating mode from a set of operating modes is selected. The set of operating modes includes at least a ML inference mode and a ML training mode. Based on the selected operating mode, images obtained by an image capturing unit are processed. In the ML inference mode, a ML controller applies a ML model to the images to infer or predict characteristics of the image (e.g., detecting objects within the images). In the ML training mode, the ML controller is configured to cause a ML model to be trained using images captured by the image capturing unit, either local to the camera or on a remotely located computing device.

Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.

Abstract: A machine learning (ML) operating mode is selected for a camera. A physical orientation of a housing of a camera is determined. In response to determining the orientation, an operating mode from a set of operating modes is selected. The set of operating modes includes at least a ML inference mode and a ML training mode. Based on the selected operating mode, images obtained by an image capturing unit are processed. In the ML inference mode, a ML controller applies a ML model to the images to infer or predict characteristics of the image (e.g., detecting objects within the images). In the ML training mode, the ML controller is configured to cause a ML model to be trained using images captured by the image capturing unit, either local to the camera or on a remotely located computing device.

Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.

Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.

Abstract: The present disclosure provides methods of identifying a disease-specific immunogenic peptide through a series of selection steps. Immunogenic epitopes identified by methods of the present disclosure are applicable for use in peptide-based immunotherapy, preferably cancer therapy. Furthermore, the methods of the present disclosure may be performed in a high-throughput manner and serve as a means of personalized vaccine development and therapy. Also provided are compositions of immunogenic peptides as well as methods of treatment comprising said compositions.

Abstract: The present disclosure provides methods of identifying a disease-specific immunogenic peptide through a series of selection steps. Immunogenic epitopes identified by methods of the present disclosure are applicable for use in peptide-based immunotherapy, preferably cancer therapy. Furthermore, the methods of the present disclosure may be performed in a high-throughput manner and serve as a means of personalized vaccine development and therapy. Also provided are compositions of immunogenic peptides as well as methods of treatment comprising said compositions.

Abstract: The embodiments of the disclosure include methods and apparatus that allow dynamic configuration of discontinuous reception (DRX) mode based on conditions associated with device use. For example, a device may be operating in a first mode of DRX having short and long DRX cycles that provide a level of user experience that is balanced with a level of power conservation. During operation, changing conditions of device use may indicate that the first configuration of the DRX may be changed to a second configuration by removing the short DRX cycle to conserve power without affecting the user's experience. For example, a user may move out of proximity of the device and may not be affected by a slower speed of data downloading. Based on the changed conditions of device use, the DRX may be changed to operate in a second configuration that may download data slower but consumes less power.

Abstract: Adjustable device settings is described herein. In one or more implementations, a client device is configured with device settings that are compatible with multiple different geographical locations. The client device attaches to a wireless network via a wireless radio of the client device, and receives location information from the attached wireless network. The client device determines a current geographical location of the client device based at least in part on the location information received from the wireless network, and adjusts the device settings of the client device to conform to location-specific settings of the current geographical location.

Abstract: A computing device may include an accessory radio that facilitates point-to-point wireless connectivity between the computing device and one or more accessory devices. The accessory radio may periodically broadcast its presence to the one or more accessory devices while operating in an active state. The accessory radio may transition from the active state to a sleep state after a period of inactivity. The computing device may also include a general purpose radio that may facilitate general wireless connectivity between the computing device and other devices. The general purpose radio may listen for any messages that are intended for the accessory radio while the accessory radio is in the sleep state. The general purpose radio may activate the accessory radio in response to the general purpose radio receiving a message, while the accessory radio is in the sleep state, that satisfies at least one activation condition.

Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.

Abstract: A computing device may include an accessory radio that facilitates point-to-point wireless connectivity between the computing device and one or more accessory devices. The accessory radio may periodically broadcast its presence to the one or more accessory devices while operating in an active state. The accessory radio may transition from the active state to a sleep state after a period of inactivity. The computing device may also include a general purpose radio that may facilitate general wireless connectivity between the computing device and other devices. The general purpose radio may listen for any messages that are intended for the accessory radio while the accessory radio is in the sleep state. The general purpose radio may activate the accessory radio in response to the general purpose radio receiving a message, while the accessory radio is in the sleep state, that satisfies at least one activation condition.

Abstract: Adjustable device settings is described herein. In one or more implementations, a client device is configured with device settings that are compatible with multiple different geographical locations. The client device attaches to a wireless network via a wireless radio of the client device, and receives location information from the attached wireless network. The client device determines a current geographical location of the client device based at least in part on the location information received from the wireless network, and adjusts the device settings of the client device to conform to location-specific settings of the current geographical location.

Abstract: Examples of the disclosure enable packet data access to be managed. In some examples, a device is coupled to a wireless network using a first access point name (APN). The wireless network includes a first packet data network (PDN) corresponding to the first APN and a second PDN. A request to couple the device to the wireless network using a second APN corresponding to the second PDN is received. When the device is configured to use a single PDN, a first instruction associated with decoupling the device from the wireless network is transmitted to the first PDN, and a second instruction associated with coupling the device to the wireless network using the second APN is transmitted to the second PDN. Aspects of the disclosure enable controlling or restricting packet data access to manage network resources.

Abstract: The embodiments of the disclosure include methods and apparatus that provide back-off procedures for avoiding device/network resource depletion in bad network conditions. A device user may selectively enable an auxiliary back-off procedure that extends the time between network service requests. For example, the auxiliary back-off procedure may be used if the device determines an attach request is unsuccessful when a reject message is received from the network and the reject message indicates a reject cause for which the device has no defined back-off to follow. The auxiliary back-off procedure may be also be used if the device determines that a service request is unsuccessful when the service request is ignored, i.e. no response is received from the network, or, when a service request reject is received from the network and the reject message indicates a reject cause for which the device has no defined back-off to follow.

Abstract: Adjustable device settings is described herein. In one or more implementations, a client device is configured with device settings that are compatible with multiple different geographical locations. The client device attaches to a wireless network via a wireless radio of the client device, and receives location information from the attached wireless network. The client device determines a current geographical location of the client device based at least in part on the location information received from the wireless network, and adjusts the device settings of the client device to conform to location-specific settings of the current geographical location.

Abstract: Adjustable device settings is described herein. In one or more implementations, a client device is configured with device settings that are compatible with multiple different geographical locations. The client device attaches to a wireless network via a wireless radio of the client device, and receives location information from the attached wireless network. The client device determines a current geographical location of the client device based at least in part on the location information received from the wireless network, and adjusts the device settings of the client device to conform to location-specific settings of the current geographical location.