Abstract: A handle base bracket has a first handle receiving section and a fastener opening that extends through the first handle receiving section. In a fully assembled state the outboard surface of the handle base bracket overlays a portion of an inboard surface of a door panel. A first fastener member extends through the first handle opening and into the fastener opening. A head portion overlays a portion of the outboard surface of the door panel adjacent to the first handle opening. A metallic bracket has a main section fixedly attached to the handle base bracket. First and second side flanges of the metallic bracket extend toward the inboard surface of the door panel. An operation handle has a grip portion outboard of the door panel and a protrusion extending into the first handle receiving section of the handle base bracket.

Abstract: The present disclosure relates generally to immunoglobulin-related compositions (e.g., multi-specific antibodies or antigen binding fragments thereof) that can bind to the GPA33 protein. The multi-specific antibodies of the present technology are useful in methods for detecting and treating a GPA33-associated cancer in a subject in need thereof.

Abstract: A vehicle body structure includes a reinforcement member, a latch mechanism and a secondary reinforcement portion. The reinforcement member is installed to an inner door panel of a door structure and extends from a forward area of the door structure to a rearward area of the door structure. The latch mechanism is installed to the rearward area of the inner door panel and is positioned such that a section of a rearward portion of the reinforcement member is outboard and level with a portion of the latch mechanism. The secondary reinforcement portion is fixedly attached to a central area of the reinforcement member spaced apart from a forward area of the inner door panel. In response to an impact event where force is directed to a central area of the door structure, the reinforcement member deforms and contacts the latch mechanism retaining the latch mechanism in the latching orientation.

Abstract: The present invention relates to vaccine compositions comprising lipid antigens, antibodies targeting lipid antigens, pharmaceutical compositions comprising such and their use in diagnosing, monitoring, treating, and preventing infectious disease, such as Lyme disease. In one aspect, administered is a therapeutically effective amount of a vaccine composition comprising a lipid antigen, an antibody or fragment thereof binding a lipid antigen, and/or a pharmaceutical composition comprising an antibody or fragment thereof binding a lipid antigen. Other aspects are described.

Abstract: The present invention inter alia relates to the use of phosphotidylserine or pathogenic sugar targeted therapeutics for the management and treatment of microbial infections, including Zika, Dengue, West Nile, Ebola, H1N1, enteroviruses, Leishmaniasis, Malaria and Coronaviruses SARS-COV. In an aspect, the invention concerns a fusion construct comprising an Ig-Fc domain or other protein scaffold, such as albumin, and a peptide, protein, or antibody fragment binding to phosphatidylserine and/or a peptide or protein binding to and/or recognizing a PAMP expressed by a microbe. Other aspects are described.

Abstract: A door structure is moveable to and from of a closed orientation covering a door opening and an open orientation exposing the door opening of a vehicle. The door structure has an inner door panel with an interior latch handle attachment area and an attenuation slot adjacent to the interior latch handle attachment area. The attenuation slot is defined between a first slot edge and a second slot edge. The interior latch handle is installed to the interior latch handle attachment area. A portion of the interior latch handle is located adjacent to the first slot edge of the attenuation slot. In response to an impact event proximate a central area of the door structure, the door structure and the interior latch handle attachment area deform such that the first slot edge and the interior latch handle move relative to the second slot edge of the attenuation slot.

Abstract: The present technology relates to the use of protein conjugates including a self-assembly and disassembly (SADA) polypeptide and a GD2-specific antigen binding domain for preventing or mitigating off-target tissue toxicity, such as brain, kidney, and/or myeloid damage, in a subject undergoing targeted alpha radioimmunotherapy. Also disclosed herein are pretargeted radioimmunotherapy (PRIT) methods that improve the durability of the anti-GD2-SADA conjugate anti-tumor response in vivo.

Abstract: The present disclosure relates generally to immunoglobulin-related compositions (e.g., antibodies or antigen binding fragments thereof) that can bind to the CD3 protein. The antibodies of the present technology are useful in methods for detecting and treating cancer or a CD3 -associated pathology in a subject in need thereof.

Abstract: A vehicle body structure includes a door, a latch mechanism and a secondary reinforcement member (an attenuation member). The door has an inner door panel and a reinforcement member installed thereto the inner door panel. The latch mechanism is installed the inner door panel such that in a latching orientation the latch mechanism retains the door in the closed orientation and in a release orientation the door can move to the open orientation. A rearward portion of the reinforcement member is outboard and level with a portion of the latch mechanism. The secondary reinforcement member is fixedly attached to a central area of the reinforcement member spaced apart from the rearward area of the inner door panel and spaced apart from a forward area of the inner door panel. In response to an impact event, the reinforcement member deforms and contacts the latch mechanism preventing movement of the latch mechanism.

Abstract: The present invention relates to compositions and methods employing conjugates that include a self-assembly and disassembly (SADA) polypeptide and a binding domain. The present invention encompasses the recognition that conjugates with a SADA polypeptide have certain improved biological properties. SADA-conjugates are described, along with uses thereof (e.g., as therapeutic or diagnostic agents) and methods of manufacture.

Abstract: A retainer is disclosed that is configured to receive at least one elongated member in a vehicle. The retainer includes a body and first and second receptacles that are supported by the body. The first receptacle defines a first channel that is configured to receive a first elongated member (e.g., a cable, a wire, a rod, etc.) and includes a first finger that extends towards the second receptacle. The second receptacle defines a second channel that is configured to receive a second elongated member (e.g., a cable, a wire, a rod, etc.) and includes a second finger that extends towards the first receptacle. In certain embodiments, the first finger and the second finger may be formed as discrete structures so as not to interfere with flexure of the first receptacle and the second receptacle during insertion and removal of the first elongated member and the second elongated member.

Abstract: A door structure is moveable to and from of a closed orientation covering a door opening and an open orientation exposing the door opening of a vehicle. The door structure has an inner door panel with an interior latch handle attachment area and an attenuation slot adjacent to the interior latch handle attachment area. The attenuation slot is defined between a first slot edge and a second slot edge. The interior latch handle is installed to the interior latch handle attachment area. A portion of the interior latch handle is located adjacent to the first slot edge of the attenuation slot. In response to an impact event proximate a central area of the door structure, the door structure and the interior latch handle attachment area deform such that the first slot edge and the interior latch handle move relative to the second slot edge of the attenuation slot.

Abstract: A vehicle body structure, comprising: a door structure having an inner door panel and a reinforcement member installed to the inner door panel, the reinforcement member extending from a forward area of the door structure to a rearward area of the door structure, the door structure being movable to and from each of a closed orientation and an open orientation when installed to a vehicle; a latch mechanism installed to the rearward area of the inner door panel, the latch mechanism being configured such that in a latching orientation the latch mechanism retains the door structure in the closed orientation and in a release orientation the door structure can move to the open orientation, the latch mechanism being positioned such that at least a section of a rearward portion of the reinforcement member is outboard and level with a portion of the latch mechanism; and a secondary reinforcement portion fixedly attached to a central area of the reinforcement member spaced apart from a forward area of the inner door

Abstract: A vehicle body structure includes a door, a latch mechanism and a secondary reinforcement member (an attenuation member). The door has an inner door panel and a reinforcement member installed thereto the inner door panel. The latch mechanism is installed the inner door panel such that in a latching orientation the latch mechanism retains the door in the closed orientation and in a release orientation the door can move to the open orientation. A rearward portion of the reinforcement member is outboard and level with a portion of the latch mechanism. The secondary reinforcement member is fixedly attached to a central area of the reinforcement member spaced apart from the rearward area of the inner door panel and spaced apart from a forward area of the inner door panel. In response to an impact event, the reinforcement member deforms and contacts the latch mechanism preventing movement of the latch mechanism.

Abstract: The present invention relates to compositions and methods employing conjugates that include a self-assembly and disassembly (SADA) polypeptide and a binding domain. The present invention encompasses the recognition that conjugates with a SADA polypeptide have certain improved biological properties. SADA-conjugates are described, along with uses thereof (e.g., as therapeutic or diagnostic agents) and methods of manufacture.

Abstract: A vehicle door assembly includes a door structure, an interior latch handle a panel and an interference member. The interior latch handle is installed to an inboard area of an inner door panel of the door structure. The interior latch handle has a housing and a release lever supported to the housing for pivotal movement. The panel is fixed to the inner door panel. The interference member is fixed to the panel and extends toward the release lever. With the door structure in a non-deformed state the interference member is spaced apart from the release lever. With the door structure in a deformed state in response to an impact event proximate a central area of the door structure, the panel can deformed and moves the interference member toward one end of the release lever preventing movement of the release lever to an door opening orientation.

Abstract: An outer door panel and an inner door panel are fixed to one another defining a cavity therebetween. A door handle assembly is fixedly attached to the outer door panel, with at least a portion of the door handle assembly overlaying an inboard surface of the outer door panel within the cavity. An inboard portion of the door handle assembly has a connection structure. An upwardly extending bracket within the cavity is fixed to an upper end and a lower end of at least one of the inner door panel or the outer door panel. The upwardly extending bracket is spaced apart from the door handle assembly. A vibration absorbing member has a first end fixed to the connection structure of the door handle assembly and a second end attached to the upwardly extending bracket at a location spaced apart from upper and lower ends of the upwardly extending bracket.

Abstract: The present disclosure relates generally to immunoglobulin-related compositions (e.g., antibodies or antigen binding fragments thereof) that can bind to the CDS 3 protein. The antibodies of the present technology are useful in methods for detecting and treating Alzheimer's disease or a CDS 3-associated cancer in a subject in need thereof.

Abstract: The present disclosure relates generally to immunoglobulin-related compositions (e.g., antibodies or antigen binding fragments thereof) that can bind to the CD 19 protein. The antibodies of the present technology are useful in methods for detecting and treating a CD 19- associated autoimmune disease or a CD19-associated cancer in a subject in need thereof.

Abstract: The present disclosure relates generally to immunoglobulin-related compositions (e.g., antibodies or antigen binding fragments thereof) that can bind to the CD22 protein. The antibodies of the present technology are useful in methods for detecting and treating a CD22-associated cancer, a CD22-associated autoimmune disease, or a CD22-associated allergy in a subject in need thereof.