Abstract: Techniques pertaining to channeling state information (CSI) pre-processing are described. A user equipment (UE) that is in wireless communication with a base station node extracts eigenvectors (EVs) from CSI acquired by the UE. The UE generates pre-processed CSI for compression by a machine-learning (ML)-based encoder of the UE into CSI feedback for the base station node by at least performing one or more of a phase discontinuity compensation (PDC), a one-step polarization separation with re-ordering, or a two-step polarization separation that includes separation based on polarization type and separation by position on the EVs.

Abstract: In an aspect of the disclosure, a method, a computer-readable medium, and an apparatus are provided. The apparatus may be a UE. In certain configurations, the UE receives a message having Demodulation Reference Signal (DMRS) switching bits that indicate which DMRS pattern is being used of either of a first DMRS pattern or a second DMRS pattern. The UE determines the DMRS pattern being used from the DMRS switching bits. The UE applies the determined DMRS pattern being used to processing of uplink and downlink channels.

Abstract: The present invention provides processes for preparing a prostacyclin analogue of Formula I or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.

Abstract: The present invention provides processes for preparing a prostacyclin analog of Formula I or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.

Abstract: Embodiments presented herein provide techniques for dynamically generating synthetic test data used to test a web service. In one embodiment, a service description language document defining a web service may include a test interface definition. The test interface definition specifies rules for generating the synthetic data to use when testing API interfaces exposed by the web service, e.g., to generate synthetic data needed carry out load and performance testing. Including rules for generating test data in the service description language document provides a centralized and authoritative source for both building and testing the web service.

Abstract: The present invention provides amine salts of the prostacyclin analogue of Formula I and processes for generating these amine salts.

Abstract: The present invention provides processes for preparing a prostacyclin analogue of Formula I or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.

Abstract: The present invention provides amine salts of the prostacyclin analogue of Formula I and processes for generating these amine salts.

Abstract: The present invention provides processes for preparing a prostacyclin analog of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.

Abstract: The present invention provides amine salts of the prostacyclin analogue of Formula I and processes for generating these amine salts.

Abstract: The present invention provides processes for preparing a prostacyclin analogue of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.

Abstract: The present invention provides amine salts of the prostacyclin analogue of Formula I and processes for generating these amine salts.

Abstract: The present invention provides processes for preparing a prostacyclin analogue of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.