Abstract: A semiconductor module includes: a stacked substrate; a semiconductor element arranged on an upper surface of the first circuit board; a metal wiring board including a first bonding portion bonded to an upper surface of the semiconductor element with a bonding material; and a sealing resin that seals the stacked substrate, the semiconductor element, and the metal wiring board. The first bonding portion includes a plate-shaped portion having an upper surface and a lower surface. The metal wiring board has a first standing portion standing up from one end of the first bonding portion, and a second standing portion standing up from the other end of the first bonding portion. The first standing portion constitutes a part of a wiring path through which a main current flows. The second standing portion constitutes a non-wiring path through which the main current does not flow.

Abstract: A medicament comprising (I) brexpiprazole or a pharmaceutically acceptable salt thereof, and (II) nalmefene or a pharmaceutically acceptable salt thereof in combination, wherein brexpiprazole or a pharmaceutically acceptable salt thereof, and nalmefene or a pharmaceutically acceptable salt thereof are contained in a single preparation, or a pharmaceutical composition containing brexpiprazole or a pharmaceutically acceptable salt thereof and a pharmaceutical composition containing nalmefene or a pharmaceutically acceptable salt thereof are formulated for use in combination. The medicament is used for the prophylaxis or treatment of a substance-related disorder, preferably an alcohol-related disorder.

Abstract: The present invention relates to a prophylactic and/or therapeutic agent for behavioral and psychological symptoms associated with neurodegenerative disease or impulsive symptoms associated with mental disease, which contains 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one or a salt thereof as an active ingredient.

Abstract: A medicament comprising (I) brexpiprazole or a pharmaceutically acceptable salt thereof, and (II) nalmefene or a pharmaceutically acceptable salt thereof in combination, wherein brexpiprazole or a pharmaceutically acceptable salt thereof, and nalmefene or a pharmaceutically acceptable salt thereof are contained in a single preparation, or a pharmaceutical composition containing brexpiprazole or a pharmaceutically acceptable salt thereof and a pharmaceutical composition containing nalmefene or a pharmaceutically acceptable salt thereof are formulated for use in combination. The medicament is used for the prophylaxis or treatment of a substance-related disorder, preferably an alcohol-related disorder.

Abstract: The spark plug includes: an insulator having an axial hole formed along an axial line; and a metal terminal provided on a rear side of the axial hole of the insulator. The metal terminal has, at a rear end portion thereof, a bottom surface facing rearward and a projection projecting rearward from an outer edge of the bottom surface, and a mark is provided to at least a part of the bottom surface. The Vickers hardness of the projection is 100 HV or higher. A rear end surface of the projection is positioned on a rear side with respect to a rear end of the mark. An area of the rear end surface is 3 mm2 or greater.

Abstract: The spark plug includes: an insulator having an axial hole formed along an axial line; and a metal terminal provided on a rear side of the axial hole of the insulator. The metal terminal has, at a rear end portion thereof, a bottom surface facing rearward and a projection projecting rearward from an outer edge of the bottom surface, and a mark is provided to at least a part of the bottom surface. The Vickers hardness of the projection is 100 HV or higher. A rear end surface of the projection is positioned on a rear side with respect to a rear end of the mark. An area of the rear end surface is 3 mm2 or greater.

Abstract: The present invention relates to a prophylactic and/or therapeutic agent for behavioral and psychological symptoms associated with neurodegenerative disease or impulsive symptoms associated with mental disease, which contains 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one or a salt thereof as an active ingredient.

Abstract: A medicament comprising (I) brexpiprazole or a pharmaceutically acceptable salt thereof, and (II) nalmefene or a pharmaceutically acceptable salt thereof in combination, wherein brexpiprazole or a pharmaceutically acceptable salt thereof, and nalmefene or a pharmaceutically acceptable salt thereof are contained in a single preparation, or a pharmaceutical composition containing brexpiprazole or a pharmaceutically acceptable salt thereof and a pharmaceutical composition containing nalmefene or a pharmaceutically acceptable salt thereof are formulated for use in combination. The medicament is used for the prophylaxis or treatment of a substance-related disorder, preferably an alcohol-related disorder.

Abstract: The present invention relates to a prophylactic and/or therapeutic agent for behavioral and psychological symptoms associated with neurodegenerative disease or impulsive symptoms associated with mental disease, which contains 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one or a salt thereof as an active ingredient.

Abstract: A medicament comprising (I) brexpiprazole or a pharmaceutically acceptable salt thereof, and (II) nalmefene or a pharmaceutically acceptable salt thereof in combination, wherein brexpiprazole or a pharmaceutically acceptable salt thereof, and nalmefene or a pharmaceutically acceptable salt thereof are contained in a single preparation, or a pharmaceutical composition containing brexpiprazole or a pharmaceutically acceptable salt thereof and a pharmaceutical composition containing nalmefene or a pharmaceutically acceptable salt thereof are formulated for use in combination. The medicament is used for the prophylaxis or treatment of a substance-related disorder, preferably an alcohol-related disorder.

Abstract: A spark plug includes: a metal shell including a tool engagement portion and having a through hole; an insulator disposed in the through hole of the metal shell; and a metal terminal including: a trunk portion disposed in an axial hole of the insulator; a flange portion having a larger diameter than the trunk portion; and a head portion having a smaller diameter than the flange portion. A minimum thickness of an exposed portion of the insulator is equal to or less than 2.5 mm. A diameter difference between the maximum outer diameter of the head portion and the maximum outer diameter of the tool engagement portion is equal to or less than 9 mm, or a diameter difference between the maximum outer diameter of the exposed portion and the maximum outer diameter of the head portion is equal to or less than 2.3 mm.

Abstract: A spark plug includes: a metal shell including a tool engagement portion and having a through hole; an insulator disposed in the through hole of the metal shell; and a metal terminal including: a trunk portion disposed in an axial hole of the insulator; a flange portion having a larger diameter than the trunk portion; and a head portion having a smaller diameter than the flange portion. A minimum thickness of an exposed portion of the insulator is equal to or less than 2.5 mm. A diameter difference between the maximum outer diameter of the head portion and the maximum outer diameter of the tool engagement portion is equal to or less than 9 mm, or a diameter difference between the maximum outer diameter of the exposed portion and the maximum outer diameter of the head portion is equal to or less than 2.3 mm.

Abstract: The present invention relates to a prophylactic and/or therapeutic agent for behavioral and psychological symptoms associated with neurodegenerative disease or impulsive symptoms associated with mental disease, which contains 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one or a salt thereof as an active ingredient.

Abstract: An ignition plug having a ceramic insulator with an axial bore, a metallic shell provided around the ceramic insulator, and a terminal electrode having a leg portion inserted into a rear end portion of the axial bore and a head portion projecting from the rear end of the ceramic insulator, wherein the length L of a portion of the ceramic insulator projecting from the rear end of the metallic shell is not less than 28 mm but not greater than 34 mm. The thickness t of the thinnest portion of the ceramic insulator is 1.0 mm or greater within a region which extends 5.5 mm from the rear end of the ceramic insulator toward the forward end side with respect to the direction of the axis.

Abstract: An ignition plug having a ceramic insulator with an axial bore, a metallic shell provided around the ceramic insulator, and a terminal electrode having a leg portion inserted into a rear end portion of the axial bore and a head portion projecting from the rear end of the ceramic insulator, wherein the length L of a portion of the ceramic insulator projecting from the rear end of the metallic shell is not less than 28 mm but not greater than 34 mm. The thickness t of the thinnest portion of the ceramic insulator is 1.0 mm or greater within a region which extends 5.5 mm from the rear end of the ceramic insulator toward the forward end side with respect to the direction of the axis.

Abstract: A spark plug includes a ceramic insulator having a tapered rear end stepped portion whose diameter decreases from front to rear and a metal shell having a crimp portion which crimps the rear end stepped portion from the rear end. An area defined by an outer edge of the rear end stepped portion and an inner edge of the crimp portion is 5-25 mm2 when the spark plug is projected on a plane perpendicular to an axial line. An angle formed by a tapered surface of the rear end stepped portion and a plane perpendicular to the axial line is 20-60 degrees. A distance along the axial line from a front end of a proximal portion of the crimp portion to a frontmost position of a contact portion between an inner surface of the crimp and the rear end stepped portion is 0.4-1.8 mm.

Abstract: A spark plug comprised of an insulator having a stepped portion on an outer circumferential portion thereof, the stepped portion tapering frontward in the direction of the axis of the spark plug, an annular sheet packing and a metallic shell having a taper portion provided on an inner circumferential portion thereof and tapering frontward in the direction of the axis of the spark plug, the metallic shell holding the insulator through a rear end portion thereof being crimped, the stepped portion being seated on the taper portion via the sheet packing, and the taper portion having a groove therein.

Abstract: A spark plug (1) includes an insulator (2) and a metal shell (3), including a middle section (41) positioned between a collar section (16) and a tool engaging section (19). The middle section (41) has a bulged section (42), a first slender section (43) and a second slender section (44) that is the most slender at a portion positioned further to the leading end side than the bulged section (42). In a cross-section including the axis CL1, when the distance between both slender sections (43) and (44) along the axis CL1 is F (mm) and the bulged amount to the inside in diametrical direction of a most bulged section (42M) with respect to an imaginary line that connects a portion that is positioned furthest to the inside in diametrical direction of both slender sections 43 and 44 is G (mm), the relationship 0.00<G/F?0.18 is satisfied.

Abstract: A spark plug including a center electrode; an insulator; and a metal shell, the metal shell including: a tool engaging section; a body section; and a groove section formed between the tool engaging section and the body section, and having bulges which bulge in an outer peripheral direction and in an inner peripheral direction. When a portion of the groove section having a largest outer diameter is a first section, a thinnest portion from the first section to the body section is a second section, and a portion having a thickness that is the same as that of the first section is a third section, a relation between a thickness A of the second section and a radius of curvature R of an outer surface of the metal shell that continues from the second section to the third section satisfies R×A?0.20 mm2.

Abstract: A spark plug includes a ceramic insulator having a tapered rear end stepped portion whose diameter decreases from front to rear and a metal shell having a crimp portion which crimps the rear end stepped portion from the rear end. An area defined by an outer edge of the rear end stepped portion and an inner edge of the crimp portion is 5-25 mm2 when the spark plug is projected on a plane perpendicular to an axial line. An angle formed by a tapered surface of the rear end stepped portion and a plane perpendicular to the axial line is 20-60 degrees. A distance along the axial line from a front end of a proximal portion of the crimp portion to a frontmost position of a contact portion between an inner surface of the crimp and the rear end stepped portion is 0.4-1.8 mm.