Patents by Inventor Maier Steve Avendano Amado
Maier Steve Avendano Amado has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11974574Abstract: Provided herein are methods and compositions for modulating the fitness of a host invertebrate (e.g., insect, mollusk, or nematode) by altering interactions between the host and one or more micoorganisms resident in the host. The invention features a composition including a modulating agent (e.g., a polypeptide, nucleic acid, small molecule, or combinations thereof) that can induce changes in the host's microbiota in a manner that modulates (e.g., increases or decreases) host fitness. The modulating agent described herein may modulate the fitness of a variety of invertebrates that are important for agriculture, commerce, and/or public health.Type: GrantFiled: February 23, 2018Date of Patent: May 7, 2024Assignee: Flagship Pioneering Innovations V, Inc.Inventors: Ignacio Martinez, Zachary Garo Armen, Barry Andrew Martin, Maier Steve Avendano Amado
-
Publication number: 20230242867Abstract: The invention provides methods for manufacturing purified preparations of achromosomal dynamic active systems (ADAS), including highly active ADAS. These ADAS provided by the invention can be obtained by a variety of means. Various associated methods of making and using these ADAS are provided.Type: ApplicationFiled: June 17, 2021Publication date: August 3, 2023Applicant: Flagship Pioneering Innovations VI, LLCInventors: Adam Barclay FISHER, Troy Patrick HUBBARD, Caitlin Nicole SPAULDING, Maier Steve AvendaƱo AMADO
-
Patent number: 11690387Abstract: Provided herein are methods and compositions for food and feed applications, e.g., for targeting one or more microorganisms resident in a host insect, the modulation resulting in an increase in the fitness of the host. The invention features a composition that includes a modulating agent (e.g., phage, peptide, small molecule, antibiotic, or combinations thereof) that can alter the host's microbiota in a manner that is beneficial to the host. By promoting favorable microbial levels, microbial activity, microbial metabolism, and/or microbial diversity, the modulating agent described herein may be used to increase the fitness of a variety of insects utilized in human food or animal feed industries.Type: GrantFiled: January 24, 2018Date of Patent: July 4, 2023Assignee: Flagship Pioneering Innovations V, Inc.Inventors: Ignacio Martinez, Zachary Garo Armen, Christine Cezar, Barry Andrew Martin, Maier Steve Avendano Amado
-
Publication number: 20230018839Abstract: Disclosed herein are compositions and methods for increasing the fitness of insects for agriculture or commerce, wherein the composition includes a postbiotic agent (e.g., a short chain fatty acid).Type: ApplicationFiled: September 27, 2022Publication date: January 19, 2023Inventors: Ignacio MARTINEZ, Maier Steve AVENDANO AMADO, Thomas Michael MALVAR, Emily Michelle MALLICK
-
Patent number: 11471433Abstract: Disclosed herein are compositions and methods for increasing the fitness of insects for agriculture or commerce, wherein the composition includes a postbiotic agent (e.g., a short chain fatty acid).Type: GrantFiled: July 31, 2020Date of Patent: October 18, 2022Assignee: Flagship Pioneering Innovations V, Inc.Inventors: Ignacio Martinez, Maier Steve Avendano Amado, Thomas Michael Malvar, Emily Michelle Mallick
-
Publication number: 20220304930Abstract: Disclosed herein are compositions including a plurality of plant messenger packs, (e.g., including a plant extracellular vesicle (EV), or segment, portion, or extract thereof), that are modified to have enhanced cell uptake (e.g., animal plant cell uptake, bacterial cell uptake, or fungal cell uptake), e.g., for use in a variety of agricultural or therapeutic methods.Type: ApplicationFiled: August 24, 2020Publication date: September 29, 2022Inventors: Maria Helena Christine VAN ROOIJEN, Hok Hei TAM, Maier Steve Avendano AMADO, Barry Andrew MARTIN, Ignacio MARTINEZ, Piotr Stanislaw KOWALSKI, Nataliya Vladimirovna NUKOLOVA, Jr., John Patrick CASEY, Jr., Siddharth PATEL, Roman Lvovitch BOGORAD
-
Publication number: 20220273565Abstract: Disclosed herein are compositions including a plurality of plant messenger packs, (e.g., including a plant extracellular vesicle (EV), or segment, portion, or extract thereof), that are modified to have enhanced cell uptake (e.g., animal plant cell uptake, bacterial cell uptake, or fungal cell uptake), e.g., for use in a variety of agricultural or therapeutic methods.Type: ApplicationFiled: July 23, 2021Publication date: September 1, 2022Inventors: Maria Helena Christine VAN ROOIJEN, Hok Hei TAM, Maier Steve AVENDANO AMADO, Barry Andrew MARTIN, Ignacio MARTINEZ, Piotr Stanislaw KOWALSKI, Nataliya Vladimirovna NUKOLOVA, John Patrick CASEY, Jr.
-
Patent number: 11350648Abstract: Provided herein are agents, compositions, and methods for agricultural use, e.g., for altering the level, activity, or metabolism of one or more microorganisms resident in a host nematode or arthropod (e.g., honeybee or silkworm), the alteration resulting in an increase in the fitness of the host. The invention features a composition that includes an agent (e.g., phage, peptide, small molecule, antibiotic, or combinations thereof) that can alter the host's microbiota in a manner that is beneficial to the host. By promoting favorable microbial levels, microbial activity, microbial metabolism, and/or microbial diversity, the agents described herein may be used to increase the fitness of a variety of beneficial nematodes or arthropods, such as bees and silkworms, utilized in agriculture and commerce.Type: GrantFiled: January 24, 2018Date of Patent: June 7, 2022Assignee: Flagship Pioneering Innovations V, Inc.Inventors: Ignacio Martinez, Zachary Garo Armen, Jonathan Friedlander, Christine Cezar, Barry Andrew Martin, Maier Steve Avendano Amado
-
Publication number: 20210360934Abstract: Provided herein are agents, compositions, and methods useful for animal health, e.g., for altering the level, activity, or metabolism of one or more microorganisms resident in a host insect (e.g., arthropod, e.g., insect, e.g., pathogen vector), the alteration resulting in a decrease in the fitness of the host. The invention features a composition that includes an agent (e.g., phage, peptide, small molecule, antibiotic, or combinations thereof) that can alter the host's microbiota in a manner that is detrimental to the host. By disrupting microbial levels, microbial activity, microbial metabolism, or microbial diversity, the agents described herein may be used to decrease the fitness of a variety of insects that carry vector-borne pathogens that cause disease in animals.Type: ApplicationFiled: December 2, 2020Publication date: November 25, 2021Inventors: Ignacio MARTINEZ, Zachary Garo ARMEN, Barry Andrew MARTIN, Maier Steve AVENDANO AMADO
-
Publication number: 20210289794Abstract: The invention comprises methods for decreasing colonization by a bacterium of a gut of a stink bug, the method comprising providing a composition comprising vanillin or an analog thereof; and delivering said composition to an egg from which the stink bug will hatch, whereby colonization by the bacterium within the gut of the stink bug hatched from the egg treated with the composition is decreased relative to a stink bug hatched from an untreated egg. In some embodiments, the decrease in colonization by the bacterium decreases the fitness of the stink bug, e.g., decreases reproductive ability, survival, rate of development, number of eggs, number of hatched eggs, adult emergence rate, body length, body width, body mass, or cuticle thickness. In some embodiments of the methods herein, the bacterial colonization-disrupting agent is an inhibitor of bacterial metabolism. In some embodiments, the bacterial colonization-disrupting agent is a polyhydroxyalkanoate (PHA) synthesis inhibitor.Type: ApplicationFiled: July 25, 2019Publication date: September 23, 2021Inventors: Ignacio MARTINEZ, Maier Steve AVENDANO AMADO, Thomas Michael MALVAR, Rama Krishna SIMHADRI, Yunlong YANG, Adam Javier MARTINEZ
-
Publication number: 20210275635Abstract: Provided herein are methods and compositions useful for human health, e.g., for targeting one or more microorganisms resident in a host insect (e.g., arthropod, e.g., insect, e.g., pathogen vector), the modulation resulting in a decrease in the fitness of the host. The invention features a composition that includes a modulating agent (e.g., phage, peptide, small molecule, antibiotic, or combinations thereof) that can alter the host's microbiota in a manner that is detrimental to the host. By disrupting microbial levels, microbial activity, microbial metabolism, or microbial diversity, the modulating agent described herein may be used to decrease the fitness of a variety of insects that carry vector-home pathogens that cause disease in humans.Type: ApplicationFiled: December 14, 2020Publication date: September 9, 2021Inventors: Ignacio MARTINEZ, Zachary Garo ARMEN, Christine CEZAR, Barry Andrew MARTIN, Maier Steve AVENDANO AMADO
-
Publication number: 20210254085Abstract: Disclosed herein are plant-modifying compositions including a plurality of plant messenger packs (PMPs) (e.g., including a plant extracellular vesicle (EV), or segment, portion, or extract thereof), wherein the PMPs include a plant-modifying agent, and wherein the plant-modifying agent comprising the heterologous RNA. The compositions herein are useful in methods for modifying plants such as to increase plant fitness, wherein the increase in plant fitness comprising an increase in development, growth, yield, resistance to abiotic stressors, or resistance to biotic stressors.Type: ApplicationFiled: August 24, 2019Publication date: August 19, 2021Inventors: Maria Helena Christine VAN ROOIJEN, Hok Hei TAM, Maier Steve AvendaƱo AMADO, Barry Andrew MARTIN, Ignacio MARTINEZ, Piotr Stanislaw KOWALSKI, Nataliya Vladimirovna NUKOLOVA, Yajie NIU
-
Publication number: 20210195917Abstract: Provided herein are agents, compositions, and methods for agricultural use, e.g., for altering the level, activity, or metabolism of one or more microorganisms resident in a host nematode or arthropod (e.g., honeybee or silkworm), the alteration resulting in an increase in the fitness of the host. The invention features a composition that includes an agent (e.g., phage, peptide, small molecule, antibiotic, or combinations thereof) that can alter the host's microbiota in a manner that is beneficial to the host. By promoting favorable microbial levels, microbial activity, microbial metabolism, and/or microbial diversity, the agents described herein may be used to increase the fitness of a variety of beneficial nematodes or arthropods, such as bees and silkworms, utilized in agriculture and commerce.Type: ApplicationFiled: July 27, 2020Publication date: July 1, 2021Inventors: Ignacio MARTINEZ, Zachary Garo ARMEN, Jonathan FRIEDLANDER, Christine CEZAR, Barry Andrew MARTIN, Maier Steve AVENDANO AMADO
-
Publication number: 20210196632Abstract: Disclosed herein are compositions including a plurality of plant messenger packs, (e.g., including a plant extracellular vesicle (EV), or segment, portion, or extract thereof), that are modified to have enhanced cell uptake (e.g., animal plant cell uptake, bacterial cell uptake, or fungal cell uptake), e.g., for use in a variety of agricultural or therapeutic methods.Type: ApplicationFiled: August 24, 2019Publication date: July 1, 2021Inventors: Maria Helena Christine VAN ROOIJEN, Hok Hei TAM, Maier Steve AVENDANO AMADO, Barry Andrew MARTIN, Ignacio MARTINEZ, Piotr Stanislaw KOWALSKI, Nataliya Vladimirovna NUKOLOVA, John Patrick CASEY, Jr.
-
Publication number: 20200261536Abstract: Provided herein are methods and compositions useful for human health, e.g., for targeting one or more microorganisms resident in a host insect (e.g., arthropod, e.g., insect, e.g., pathogen vector), the modulation resulting in a decrease in the fitness of the host. The invention features a composition that includes a modulating agent (e.g., phage, peptide, small molecule, antibiotic, or combinations thereof) that can alter the host's microbiota in a manner that is detrimental to the host. By disrupting microbial levels, microbial activity, microbial metabolism, or microbial diversity, the modulating agent described herein may be used to decrease the fitness of a variety of insects that carry vector-bore pathogens that cause disease in humans.Type: ApplicationFiled: March 23, 2020Publication date: August 20, 2020Inventors: Ignacio MARTINEZ, Zachary Garo ARMEN, Christine CEZAR, Barry Andrew MARTIN, Maier Steve AVENDANO AMADO
-
Publication number: 20200128856Abstract: Provided herein are methods and compositions for food and feed applications, e.g., for targeting one or more microorganisms resident in a host insect, the modulation resulting in an increase in the fitness of the host. The invention features a composition that includes a modulating agent (e.g., phage, peptide, small molecule, antibiotic, or combinations thereof) that can alter the host's microbiota in a manner that is beneficial to the host. By promoting favorable microbial levels, microbial activity, microbial metabolism, and/or microbial diversity, the modulating agent described herein may be used to increase the fitness of a variety of insects utilized in human food or animal feed industries.Type: ApplicationFiled: January 24, 2018Publication date: April 30, 2020Applicant: Flagship Pioneering Innovations V, Inc.Inventors: Ignacio MARTINEZ, Zachary Garo ARMEN, Christine CEZAR, Barry Andrew MARTIN, Maier Steve AVENDANO AMADO
-
Publication number: 20200129565Abstract: Provided herein are agents, compositions, and methods for agricultural use, e.g., for altering the level, activity, or metabolism of one or more microorganisms resident in a host nematode or arthropod (e.g., honeybee or silkworm), the alteration resulting in an increase in the fitness of the host. The invention features a composition that includes an agent (e.g., phage, peptide, small molecule, antibiotic, or combinations thereof) that can alter the host's microbiota in a manner that is beneficial to the host. By promoting favorable microbial levels, microbial activity, microbial metabolism, and/or microbial diversity, the agents described herein may be used to increase the fitness of a variety of beneficial nematodes or arthropods, such as bees and silkworms, utilized in agriculture and commerce.Type: ApplicationFiled: January 24, 2018Publication date: April 30, 2020Applicant: Flagship Pioneering Innovations V, Inc.Inventors: Ignacio MARTINEZ, Zachary Garo ARMEN, Jonathan FRIEDLANDER, Christine CEZAR, Barry Andrew MARTIN, Maier Steve AVENDANO AMADO
-
Publication number: 20200060286Abstract: Provided herein are agents, compositions, and methods useful for animal health, e.g., for altering the level, activity, or metabolism of one or more microorganisms resident in a host insect (e.g., arthropod, e.g., insect, e.g., pathogen vector), the alteration resulting in a decrease in the fitness of the host. The invention features a composition that includes an agent (e.g., phage, peptide, small molecule, antibiotic, or combinations thereof) that can alter the host's microbiota in a manner that is detrimental to the host. By disrupting microbial levels, microbial activity, microbial metabolism, or microbial diversity, the agents described herein may be used to decrease the fitness of a variety of insects that carry vector-borne pathogens that cause disease in animals.Type: ApplicationFiled: January 24, 2018Publication date: February 27, 2020Applicant: Flagship Pioneering Innovations V, Inc.Inventors: Ignacio MARTINEZ, Zachary Garo ARMEN, Barry Andrew MARTIN, Maier Steve AVENDANO AMADO
-
Publication number: 20190387748Abstract: Provided herein are agents, compositions, and methods for agricultural pest control, e.g., for altering the level, activity, or metabolism of one or more microorganisms resident in a host insect (e.g., agricultural pest), the alteration resulting in a decrease in the fitness of the host. The invention features a composition including an agent (e.g., phage, peptide, small molecule, antibiotic, or combinations thereof) that can alter the host's microbiota in a manner that is detrimental to the host. By disrupting microbial levels, microbial activity, microbial metabolism, and/or microbial diversity, the agents described herein may decrease the fitness of a variety of insects that are considered agricultural pests.Type: ApplicationFiled: January 24, 2018Publication date: December 26, 2019Inventors: Ignacio MARTINEZ, Zachary Garo ARMEN, Barry Andrew MARTIN, Maier Steve AVENDANO AMADO
-
Publication number: 20190365853Abstract: Provided herein are methods and compositions useful for human health, e.g., for targeting one or more microorganisms resident in a host insect (e.g., arthropod, e.g., insect, e.g., pathogen vector), the modulation resulting in a decrease in the fitness of the host. The invention features a composition that includes a modulating agent (e.g., phage, peptide, small molecule, antibiotic, or combinations thereof) that can alter the host's microbiota in a manner that is detrimental to the host. By disrupting microbial levels, microbial activity, microbial metabolism, or microbial diversity, the modulating agent described herein may be used to decrease the fitness of a variety of insects that carry vector-borne pathogens that cause disease in humans.Type: ApplicationFiled: January 24, 2018Publication date: December 5, 2019Inventors: Ignacio MARTINEZ, Zachary Garo ARMEN, Christine CEZAR, Barry Andrew MARTIN, Maier Steve AVENDANO AMADO