Patents by Inventor Maija Dambrova

Maija Dambrova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of 3-carboxy-N-ethyl-N,N-dimethylpropan-1-aminium salts in the treatment of cardiovascular disease
    Patent number: 10351534
    Abstract: Salts of 3-carboxy-N-ethyl-N,N-dimethylpropan-1-aminium, method of preparation thereof and use in the treatment of cardiovascular disease.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: July 16, 2019
    Assignee: JSC GRINDEKS
    Inventors: Ivars Kalvins, Edgars Liepins, Einars Loza, Maija Dambrova, Ilmars Stonans, Daina Lola, Janis Kuka, Osvalds Pugovics, Reinis Vilskersts, Solveiga Grinberga
  • Use of 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetamide in the treatment of seizures
    Patent number: 10105348
    Abstract: Use of 2-(5S-Methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetamide or its pharmaceutically acceptable salt in manufacture of a medicament for prophylaxis and treatment of seizure.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: October 23, 2018
    Assignee: Latvian Institute of Organic Synthesis
    Inventors: Liga Zvejniece, Maija Dambrova, Baiba Svalbe, Edijs Vavers, Ivars Kalvins, Grigorijs Veinbergs, Ilmars Stonans, Ilga Misane, Maksims Vorona, Aleksandrs Cernobrovijs
  • Use of 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetamide in the Treatment of Seizures
    Publication number: 20180200227
    Abstract: Use of 2-(55-Methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetamide or its pharmaceutically acceptable salt in manufacture of a medicament for prophylaxis and treatment of seizure.
    Type: Application
    Filed: August 2, 2016
    Publication date: July 19, 2018
    Inventors: Liga Zvejniece, Maija Dambrova, Baiba Svalbe, Edijs Vavers, Ivars Kalvins, Grigorijs Veinbergs, Ilmars Stonans, Ilga Misane, Maksims Vorona, Aleksandrs Cernobrovijs
  • USE OF 3-CARBOXY-N-ETHYL-N,N-DIMETHYLPROPAN-1-AMINIUM SALTS IN THE TREATMENT OF CARDIOVASCULAR DISEASE
    Publication number: 20180079728
    Abstract: Salts of 3-carboxy-N-ethyl-N,N-dimethylpropan-1-aminium, method of preparation thereof and use in the treatment of cardiovascular disease.
    Type: Application
    Filed: December 1, 2017
    Publication date: March 22, 2018
    Inventors: Ivars KALVINS, Edgars LIEPINS, Einars LOZA, Maija DAMBROVA, IImars STONANS, Daina LOLA, Janis KUKA, Osvalds PUGOVICS, Reinis VILSKERSTS, Solveiga GRINBERGA
  • PHARMACEUTICAL COMPOSITION FOR THE PREVENTION AND TREATMENT OF DISEASES ASSOCIATED WITH ELEVATED INDUCIBLE NITRIC OXIDE SYNTHASE
    Publication number: 20180064687
    Abstract: The invention relates to the new medical use of (4R)-2-(4-phenyl-2-oxopyrrolidin-1-yl)acetamide for the treatment of pathological conditions, including sepsis and peripheral neuropathy, characterized by overexpression of iNOS gene.
    Type: Application
    Filed: May 14, 2015
    Publication date: March 8, 2018
    Inventors: Liga ZVEJNIECE, Maija DAMBROVA, Grigorijs VEINBERGS, Maksims VORONA, Ivars KALVINS
  • Use of 4-[ethyl(dimethyl)ammonio]butanoate in the treatment of cardiovascular disease
    Patent number: 9573882
    Abstract: New compound 4-[ethyl(dimethyl)ammonio]butanoate, method of preparation thereof and use in the treatment of cardiovascular disease.
    Type: Grant
    Filed: January 27, 2016
    Date of Patent: February 21, 2017
    Assignee: JSC GRINDEKS
    Inventors: Ivars Kalvins, Maija Dambrova, Edgars Liepins, Osvalds Pugovics, Reinis Vilskersts, Janis Kuka, Solveiga Grinberga, Einars Loza
  • PHARMACEUTICAL COMPOSITION FOR CONTROLLING BODY MASS GAIN COMPRISING S-PHENOTROPIL
    Publication number: 20160250185
    Abstract: The invention relates to medicine, in particular S-Phenotropil ((S)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide) containing pharmaceutical compositions and their use in control of body mass gain.
    Type: Application
    Filed: October 20, 2014
    Publication date: September 1, 2016
    Applicant: Latvian Institute of Organic Synthesis
    Inventors: Ivars KALVINS, Liga ZVEJNIECE, Larisa VARACEVA, Aleksandrs CERNOBROVIJS, Antons LEBEDEVS, Maija DAMBROVA, Baiba SVALBE, Edgars LIEPINS
  • N-carbamoylmethyl-4-(R)-phenyl-2-pyrrolidinone, method of its preparation and pharmaceutical use
    Patent number: 9382203
    Abstract: The invention relates to the R-enantiomer of N-carbamoylmethyl-4-phenyl-2-pyrrolidinone (R-Carphedon) of pharmacological value. The method of its preparation includes the N-alkylation of 4(R)-phenyl-2-pyrrolidinone with ethyl bromoacetate in the presence of a strong base and the treatment of intermediate N-ethoxycarbonylmethyl-4(R)-phenyl-2-pyrrolidinone with ammonia.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: July 5, 2016
    Assignee: JOINT STOCK COMPANY (JSC) “OLAINFARM”
    Inventors: Grigory Veinberg, Maksim Vorona, Liga Zvejniece, Aleksandrs Chernobrovijs, Ivars Kalvinsh, Ligita Karina, Maija Dambrova
  • USE OF 4-[ETHYL(DIMETHYL)AMMONIO]BUTANOATE IN THE TREATMENT OF CARDIOVASCULAR DISEASE
    Publication number: 20160137589
    Abstract: New compound 4-[ethyl(dimethyl)ammonio]butanoate, method of preparation thereof and use in the treatment of cardiovascular disease.
    Type: Application
    Filed: January 27, 2016
    Publication date: May 19, 2016
    Inventors: Ivars KALVINS, Maija DAMBROVA, Edgars LIEPINS, Osvalds PUGOVICS, Reinis VILSKERSTS, Janis KUKA, Solveiga GRINBERGA, Einars LOZA
  • Use of 4-[ethyl(dimethyl)ammonio]butanoate in the treatment of cardiovascular disease
    Patent number: 9278907
    Abstract: New compound 4-[ethyl(dimethyl)ammonio]butanoate, method of preparation thereof and use in the treatment of cardiovascular disease.
    Type: Grant
    Filed: October 22, 2010
    Date of Patent: March 8, 2016
    Assignee: JSC GRINDEKS
    Inventors: Ivars Kalvins, Maija Dambrova, Edgars Liepins, Osvalds Pugovics, Reinis Vilskersts, Janis Kuka, Solveiga Grinberga, Einars Loza
  • "Pharmaceutical composition for reducing the trimethylamine N-oxide level"
    Publication number: 20150313862
    Abstract: The invention discloses the use of pharmaceutical compositions containing 3-(2,2,2-trimethylhydrazinium)propionate dihydrate and pharmaceutically acceptable salts thereof for trimethylamine N-oxide level decrease in a body.
    Type: Application
    Filed: October 24, 2013
    Publication date: November 5, 2015
    Applicant: Latvian Institute of Organic Synthesis
    Inventors: Ivars KALVINS, Maija DAMBROVA, Edgars LIEPINS, Elina MAKAROVA, Osvalds PUGOVICS, Solveiga GRINBERGA, Eduards SEVOSTJANOVS
  • N-Carbamoylmethy1-4-(R)-phenyl-2-pyrrolidinone, method of its preparation and pharmaceutical use
    Patent number: 9102615
    Abstract: The invention relates to the R-enantiomer of N-carbamoylmethyl-4-phenyl-2-pyrrolidinone (R-Carphedon) of pharmacological value. The method of its preparation includes the N-alkylation of 4(R)-phenyl-2-pyrrolidinone with ethyl bromoacetate in the presence of a strong base and the treatment of intermediate N-ethoxycarbonylmethyl-4(R)-phenyl-2-pyrrolidinone with ammonia.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: August 11, 2015
    Assignee: Joint Stock Company (JSC) “OLAINFARM”
    Inventors: Grigory Veinberg, Maksim Vorona, Liga Zvejniece, Aleksandrs Chernobrovijs, Ivars Kalvinsh, Ligita Karina, Maija Dambrova
  • N-Carbamoylmethyl-4-(R)-Phenyl-2-Pyrrolidinone, Method of its Preparation and Pharmaceutical Use
    Publication number: 20150216846
    Abstract: The invention relates to the R-enantiomer of N-carbamoylmethyl-4-phenyl-2-pyrrolidinone (R-Carphedon) of pharmacological value. The method of its preparation includes the N-alkylation of 4(R)-phenyl-2-pyrrolidinone with ethyl bromoacetate in the presence of a strong base and the treatment of intermediate N-ethoxycarbonylmethyl-4(R)-phenyl-2-pyrrolidinone with ammonia.
    Type: Application
    Filed: April 16, 2015
    Publication date: August 6, 2015
    Inventors: Grigory Veinberg, Maksim Vorona, Liga Zvejniece, Aleksandrs Chernobrovijs, Ivars Kalvinsh, Ligita Karina, Maija Dambrova
  • 4-[(haloalkyl)(dimethyl)ammonio]butanoates and use thereof in the treatment of cardiovascular disease
    Patent number: 8940793
    Abstract: 4-[(Haloalkyl)(dimethyl)ammonio]butanoates of formula wherein Hal is Cl or F, n=1 or 2, method for preparing thereof and use thereof for treating cardiovascular disease.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: January 27, 2015
    Assignee: JSC Grindeks
    Inventors: Ivars Kalvins, Edgars Liepins, Einars Loza, Maija Dambrova, Ilmars Stonans, Daina Lola, Janis Kuka, Osvalds Pugovics, Viktors Andrianovs, Marina Makrecka, Daina Gustina, Solveiga Grinberga
  • 4R,5S-ENANTIOMER OF 2-(5-METHYL-2-OXO-4-PHENYL-PYRROLIDIN-1-YL)-ACETAMIDE WITH NOOTROPIC ACTIVITY
    Publication number: 20140296317
    Abstract: The invention relates to the 5S,4R-enantiomer of 2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide with cognition enhancing activity of high pharmacological value and to its preparation method which includes the synthesis of 5S-methyl-4R-phenylpyrrolidin-2-one, its N-alkylation with ethyl haloacetate and the treatment of intermediate ethyl 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetate with ammonia.
    Type: Application
    Filed: June 16, 2014
    Publication date: October 2, 2014
    Inventors: Ivars KALVINS, Antons LEBEDEVS, Aleksandrs CERNOBROVIJS, Maija DAMBROVA, Liga ZVEJNIECE, Maksims VORONA, Grigorijs VEINBERGS
  • 4,5-enantiomer of 2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide with nootropic activity
    Patent number: 8791273
    Abstract: The invention relates to the 5S,4R-enantiomer of 2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide with cognition enhancing activity of high pharmacological value and to its preparation method which includes the synthesis of 5S-methyl-4R-phenylpyrrolidin-2-one, its N-alkylation with ethyl haloacetate and the treatment of intermediate ethyl 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetate with ammonia.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: July 29, 2014
    Assignee: JSC Grindeks
    Inventors: Ivars Kalvins, Antons Lebedevs, Aleksandrs Cernobrovijs, Maija Dambrova, Liga Zvejniece, Maksims Vorona, Grigorijs Veinbergs
  • 4-[(haloalkyl)(dimethyl)ammonio]butanoates and use thereof in the treatment of cardiovascular disease
    Publication number: 20140107202
    Abstract: 4-[(Haloalkyl)(dimethyl)ammonio]butanoates of formula wherein Hal is Cl or F, n=1 or 2, method for preparing thereof and use thereof for treating cardiovascular disease.
    Type: Application
    Filed: April 27, 2012
    Publication date: April 17, 2014
    Applicant: JSC GRINDEKS
    Inventors: Ivars Kalvins, Edgars Liepins, Einars Loza, Maija Dambrova, Ilmars Stonans, Daina Lola, Janis Kuka, Osvalds Pugovics, Viktos Andrianovs, Marina Makrecka, Daina Gustina, Solveiga Grinberga
  • USE OF 3-CARBOXY-N-ETHYL-N,N-DIMETHYLPROPAN-1-AMINIUM SALTS IN THE TREATMENT OF CARDIOVASCULAR DISEASE
    Publication number: 20140088125
    Abstract: Salts of 3-carboxy-N-ethyl-N,N-dimethylpropan-1-aminium, method of preparation thereof and use in the treatment of cardiovascular disease.
    Type: Application
    Filed: April 27, 2012
    Publication date: March 27, 2014
    Applicant: JSC Grindeks
    Inventors: Ivars Kalvins, Edgars Liepins, Einars Loza, Maija Dambrova, Limars Stonans, Daina Lola, Janis Kuka, Osvalds Pugovics, Reinis Vilskersts, Solveiga Grinberga
  • USE OF 4-[ETHYL(DIMETHYL)AMMONIO]BUTANOATE IN THE TREATMENT OF CARDIOVASCULAR DISEASE
    Publication number: 20120220656
    Abstract: New compound 4-[ethyl(dimethyl)ammonio]butanoate, method of preparation thereof and use in the treatment of cardiovascular disease.
    Type: Application
    Filed: October 22, 2010
    Publication date: August 30, 2012
    Applicant: JSC GRINDEKS
    Inventors: Ivars Kalvins, Maija Dambrova, Edgars Liepins, Osvalds Pugovics, Reinis Vilskersts, Janis Kuka, Solveiga Grinberga, Einars Loza
  • 4R,5S-ENANTIOMER OF 2-(5-METHYL-2-OXO-4-PHENYL-PYRROLIDIN-1-YL)-ACETAMIDE WITH NOOTROPIC ACTIVITY
    Publication number: 20120215010
    Abstract: The invention relates to the 5S,4R-enantiomer of 2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide with cognition enhancing activity of high pharmacological value and to its preparation method which includes the synthesis of 5S-methyl-4R-phenylpyrrolidin-2-one, its N-alkylation with ethyl haloacetate and the treatment of intermediate ethyl 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetate with ammonia.
    Type: Application
    Filed: November 4, 2010
    Publication date: August 23, 2012
    Applicant: JSC Grindeks
    Inventors: Ivars Kalvins, Antons Lebedevs, Aleksandrs Cernobrovijs, Maija Dambrova, Liga Zvejniece, Maksims Vorona, Grigorijs Veinbergs