Patents by Inventor Makiko Fliss

Makiko Fliss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mitochondrial Dosimeter
    Publication number: 20090124795
    Abstract: Mitochondrial mutations occur as a product of contact of a person with an environmental pollutant. Mitochondrial mutations are readily detectable in body fluids. Measurement of mitochondrial mutations in body fluids can be used as a dosimeter to monitor exposure to the environmental pollutant. Mitochondrial mutations can also be detected in cancer patients. Probes and primers containing mutant mitochondrial sequences can be used to monitor patient condition.
    Type: Application
    Filed: April 10, 2008
    Publication date: May 14, 2009
    Applicant: JOHNS HOPKINS UNIVERSITY
    Inventors: Makiko Fliss, David Sidransky, Jin Jen, Kornelia Polyak, Bert Vogelstein, Kenneth W. Kinzler
  • Mitochondrial dosimeter
    Publication number: 20040018538
    Abstract: Mitochondrial mutations occur as a product of contact of a person with an environmental pollutant. Mitochondrial mutations are readily detectable in body fluids. Measurement of mitochondrial mutations in body fluids can be used as a dosimeter to monitor exposure to the environmental pollutant. Mitochondrial mutations can also be detected in cancer patients. Probes and primers containing mutant mitochondrial sequences can be used to monitor patient condition.
    Type: Application
    Filed: June 24, 2003
    Publication date: January 29, 2004
    Applicant: Johns Hopkins University
    Inventors: Makiko Fliss, David Sidransky, Jin Jen, Kornelia Polyak, Bert Vogelstein, Kenneth W. Kinzler
  • Mitochondrial dosimeter
    Patent number: 6605433
    Abstract: Mitochondrial mutations occur as a product of contact of a person with an environmental pollutant. Mitochondrial mutations are readily detectable in body fluids. Measurement of mitochondrial mutations in body fluids can be used as a dosimeter to monitor exposure to the environmental pollutant. Mitochondrial mutations can also be detected in cancer patients. Probes and primers containing mutant mitochondrial sequences can be used to monitor patient condition.
    Type: Grant
    Filed: March 15, 2000
    Date of Patent: August 12, 2003
    Assignee: The Johns Hopkins University
    Inventors: Makiko Fliss, David Sidransky, Jin Jen, Komelia Polyak, Bert Vogelstein, Kenneth W. Kinzler
  • Procedure for preparing gene expression libraries enriched for secretory protein genes
    Patent number: 6040144
    Abstract: The present invention relates to a method for producing a gene expression library enriched for a particular class of genes comprising (i) a nucleic acid preparation step and (ii) a polyclonal antiserum screening step, wherein both steps define the class of genes of interest. The method of the invention, using selection procedures directed not only at the underlying nucleic acid but also a functional attribute of the target class of proteins, may be used to produce gene expression libraries enriched for genes encoding a desired class of proteins, including, but not limited to, secretory proteins, cell cycle associated proteins, proteins defined by a particular subcellular location, tissue specific proteins, infection-related proteins, and non-infectious disease associated proteins.
    Type: Grant
    Filed: July 25, 1997
    Date of Patent: March 21, 2000
    Assignee: Mount Sinai School of Medicine
    Inventors: Frank Carter Bancroft, Makiko Fliss