Abstract: A skin care composition that contains a combination of a vitamin B3 compound, palmitoyl pentapeptide-4, acetyl tetrapeptide-11, and a dermatologically acceptable carrier. The combination of vitamin B3 compound, palmitoyl pentapeptide-4, and acetyl tetrapeptide-11 increases activation of a cell's Antioxidant Response Element (ARE), (e.g., synergistically) to improve a visible sign of skin aging.

Abstract: A skin care composition that includes a combination of palmitoyl dipeptide-7, acetyl tetrapeptide-11, other optional skin ingredients, and a dermatologically acceptable carrier. The combination of peptides synergistically improves cellular ATP level and/or upregulates the expression of peroxisome proliferator activated receptor alpha and/or methylsterol monooxygenase 1 to help provide improved skin health and appearance.

Abstract: A skin care composition that contains a combination of a vitamin B3 compound, palmitoyl pentapeptide-4, acetyl tetrapeptide-11, and a dermatologically acceptable carrier. The combination of vitamin B3 compound, palmitoyl pentapeptide-4, and acetyl tetrapeptide-11 increases activation of a cell's Antioxidant Response Element (ARE), (e.g., synergistically) to improve a visible sign of skin aging.

Abstract: A skin care composition that includes a combination of palmitoyl dipeptide-7, acetyl tetrapeptide-11, other optional skin ingredients, and a dermatologically acceptable carrier. The combination of peptides synergistically improves cellular ATP level and/or upregulates the expression of peroxisome proliferator activated receptor alpha and/or methylsterol monooxygenase 1 to help provide improved skin health and appearance.

Abstract: A skin care composition that includes a combination of palmitoyl dipeptide-7, acetyl tetrapeptide-11, other optional skin ingredients, and a dermatologic ally acceptable carrier. The combination of peptides synergistically improves cellular ATP level and/or upregulates the expression of peroxisome proliferator activated receptor alpha and/or methylsterol monooxygenase 1 to help provide improved skin health and appearance.

Abstract: A skin care composition that includes a combination of palmitoyl dipeptide-7, acetyl tetrapeptide-11, other optional skin ingredients, and a dermatologic ally acceptable carrier. The combination of peptides synergistically improves cellular ATP level and/or upregulates the expression of peroxisome proliferator activated receptor alpha and/or methylsterol monooxygenase 1 to help provide improved skin health and appearance.

Abstract: Multi-step cosmetic regimens are provided to improve the appearance of aging skin. A target portion of skin that exhibits a sign of skin aging is identified. A first formulation is topically applied, comprising at least one active possessing an ability to transcriptionally up-regulate an eigengene derived from a genetic co-expression module for one or more biological themes associated with skin cleansing and/or skin detoxification, and/or skin hydration to the target portion of skin. A second formulation is also topically applied, comprising at least one active possessing an ability to transcriptionally up-regulate an eigengene derived from a co-expression module for one or more biological themes associated with skin repair and/or rebuilding to the target portion of skin.

Abstract: Methods and systems for determining functional relationships between a skin-active agent and a skin condition of interest, and methods and systems for identifying cosmetic agents effective for treatment of dandruff, as well as the use of agents identified by such methods and systems for the preparation of cosmetic compositions, personal care products, or both are provided. Methods for developing in vitro models of skin disease and models for specific skin diseases are also provided.

Abstract: Provided are novel methods useful for the screening and generation of potential cosmetic agents that work in synchronization with the circadian rhythm of the skin for the treatment of aged skin. These novel methods allow for identification of new cosmetic agents that can be screened for their selective treatment of skin aging conditions and for the specific targeting of particular skin cell types, such as keratinocytes or fibroblasts.

Abstract: Multi-step cosmetic regimens are provided to improve the appearance of aging skin. A target portion of skin that exhibits a sign of skin aging is identified. A first formulation is topically applied, comprising at least one active possessing an ability to transcriptionally up-regulate an eigengene derived from a genetic co-expression module for one or more biological themes associated with skin cleansing and/or skin detoxification, and/or skin hydration to the target portion of skin. A second formulation is also topically applied, comprising at least one active possessing an ability to transcriptionally up-regulate an eigengene derived from a co-expression module for one or more biological themes associated with skin repair and/or rebuilding to the target portion of skin.

Abstract: Multi-step cosmetic regimens are provided to improve the appearance of aging skin. A target portion of skin that exhibits a sign of skin aging is identified. A first formulation is topically applied, comprising at least one active possessing an ability to transcriptionally up-regulate an eigengene derived from a genetic co-expression module for one or more biological themes associated with skin cleansing and/or skin detoxification, and/or skin hydration to the target portion of skin. A second formulation is also topically applied, comprising at least one active possessing an ability to transcriptionally up-regulate an eigengene derived from a co-expression module for one or more biological themes associated with skin repair and/or rebuilding to the target portion of skin.

Abstract: Provided are methods, systems and apparatus for identifying mechanisms of actions of agents with desired biological activity. Specifically, the methods, systems, and apparatus identify the target biological processes and pathways through which a beneficial treatment effect is accomplished by an ingredient or compound of interest. For each of a set of target biological processes and pathways, a treatment vector representing the difference in expression of the genes of the biological process or pathway when treated with the ingredient or compound of interest is compared to a clinical vector representing the difference in the expression of genes in the presence or absence of a clinical condition. Vector distance between the two vectors is compared to vector distances for other compounds and/or biological processes and pathways to determine the significance of the effect of the ingredient or compound of interest on the particular biological process or pathway.

Abstract: Methods and systems for determining functional relationships between a skin-active agent and a skin condition of interest, and methods and systems for identifying cosmetic agents effective for treatment of dandruff, as well as the use of agents identified by such methods and systems for the preparation of cosmetic compositions, personal care products, or both are provided. Methods for developing in vitro models of skin disease and models for specific skin diseases are also provided.

Abstract: A porous ion exchanger includes an open cell structure including interconnected macropores and mesopores whose average diameter is in a range of 1 to 1000 ?m existing on walls of the macropores. Moreover, a total pore volume is in a range of 1 to 50 ml/g, ion exchange groups are uniformly distributed, and an ion exchange capacity is not less than 0.5 mg equivalent/g of dry porous ion exchanger. The porous ion exchanger can be used as an ion exchanger filled into a deionization module of an electrodeionization water purification device, solid acid catalyst, adsorbent, and filler for chromatography.

Abstract: A porous ion exchanger includes an open cell structure including interconnected macropores and mesopores whose average diameter is in a range of 1 to 1000 ?m existing on walls of the macropores. Moreover, a total pore volume is in a range of 1 to 50 ml/g, ion exchange groups are uniformly distributed, and an ion exchange capacity is not less than 0.5 mg equivalent/g of dry porous ion exchanger. The porous ion exchanger can be used as an ion exchanger filled into a deionization module of an electrodeionization water purification device, solid acid catalyst, adsorbent, and filler for chromatography.

Abstract: A porous ion exchanger includes an open cell structure including interconnected macropores and mesopores whose average diameter is in a range of 1 to 1000 ?m existing on walls of the macropores. Moreover, a total pore volume is in a range of 1 to 50 ml/g, ion exchange groups are uniformly distributed, and an ion exchange capacity is not less than 0.5 mg equivalent/g of dry porous ion exchanger. The porous ion exchanger can be used as an ion exchanger filled into a deionization module of an electrodeionization water purification device, solid acid catalyst, adsorbent, and filler for chromatography.

Abstract: A porous ion exchanger includes an open cell structure including interconnected macropores and mesopores whose average diameter is in a range of 1 to 1000 ?m existing on walls of the macropores. Moreover, a total pore volume is in a range of 1 to 50 ml/g, ion exchange groups are uniformly distributed, and an ion exchange capacity is not less than 0.5 mg equivalent/g of dry porous ion exchanger. The porous ion exchanger can be used as an ion exchanger filled into a deionization module of an electrodeionization water purification device, solid acid catalyst, adsorbent, and filler for chromatography.

Abstract: A porous ion exchanger includes an open cell structure including interconnected macropores and mesopores whose average diameter is in a range of 1 to 1000 ?m existing on walls of the macropores. Moreover, a total pore volume is in a range of 1 to 50 ml/g, ion exchange groups are uniformly distributed, and an ion exchange capacity is not less than 0.5 mg equivalent/g of dry porous ion exchanger. The porous ion exchanger can be used as an ion exchanger filled into a deionization module of an electrodeionization water purification device, solid acid catalyst, adsorbent, and filler for chromatography.

Abstract: A porous ion exchanger includes an open cell structure including interconnected macropores and mesopores whose average diameter is in a range of 1 to 1000 ?m existing on walls of the macropores. Moreover, a total pore volume is in a range of 1 to 50 ml/g, ion exchange groups are uniformly distributed, and an ion exchange capacity is not less than 0.5 mg equivalent/g of dry porous ion exchanger. The porous ion exchanger can be used as an ion exchanger filled into a deionization module of an electrodeionization water purification device, solid acid catalyst, adsorbent, and filler for chromatography.

Abstract: A porous ion exchanger includes an open cell structure including interconnected macropores and mesopores whose average diameter is in a range of 1 to 1000 ?m existing on walls of the macropores. Moreover, a total pore volume is in a range of 1 to 50 ml/g, ion exchange groups are uniformly distributed, and an ion exchange capacity is not less than 0.5 mg equivalent/g of dry porous ion exchanger. The porous ion exchanger can be used as an ion exchanger filled into a deionization module of an electrodeionization water purification device, solid acid catalyst, adsorbent, and filler for chromatography.