Abstract: An object of the present invention is to provide novel apoptosis inhibitors and therapeutic agents for inner ear hearing impairment. As a pharmaceutical agent for this purpose, biguanide compounds represented by the following structural formula (I) or a rapamycin derivative represented by the following structural formula (II) as an active ingredient is provided: wherein R1 to R7 are each independently selected from a hydrogen atom, a halogen atom, or a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-10 aryl group, a 5- or 6-membered heteroaryl group, or a 5- or 6-membered non-aromatic heterocyclic group, each of which may have a substituent selected from a halogen atom, a cyano group, a C1-6 alkyl group, a C1-6 alkoxy group, a C1-6 alkoxy carbonyl group, a C3-8 cycloalkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, and a phenyl group; wherein R1 is a C1-6 alkyl or a C3-6 alkynyl, R2 is H, —CH2-OH or —CH2—CH2OH, and X is ?O, (H, H) or (H, OH).

Abstract: An object of the present invention is to provide novel apoptosis inhibitors and therapeutic agents for inner ear hearing impairment. As a pharmaceutical agent for this purpose, biguanide compounds represented by the following structural formula (I) or a rapamycin derivative represented by the following structural formula (II) as an active ingredient is provided: wherein R1 to R7 are each independently selected from a hydrogen atom, a halogen atom, or a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-10 aryl group, a 5- or 6-membered heteroaryl group, or a 5- or 6-membered non-aromatic heterocyclic group, each of which may have a substituent selected from a halogen atom, a cyano group, a C1-6 alkyl group, a C1-6 alkoxy group, a C1-6 alkoxy carbonyl group, a C3-8 cycloalkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, and a phenyl group; wherein R1 is a C1-6 alkyl or a C3-6 alkynyl, R2 is H, —CH2-OH or —CH2—CH2—OH, and X is ?O, (H, H) or (H, OH).

Abstract: An object of the present invention is to provide novel apoptosis inhibitors and therapeutic agents for inner ear hearing impairment. As a pharmaceutical agent for this purpose, biguanide compounds represented by the following structural formula (I) or a rapamycin derivative represented by the following structural formula (II) as an active ingredient is provided: wherein R1 to R7 are each independently selected from a hydrogen atom, a halogen atom, or a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-10 aryl group, a 5- or 6-membered heteroaryl group, or a 5- or 6-membered non-aromatic heterocyclic group, each of which may have a substituent selected from a halogen atom, a cyano group, a C1-6 alkyl group, a C1-6 alkoxy group, a C1-6 alkoxy carbonyl group, a C3-8 cycloalkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, and a phenyl group; wherein R1 is a C1-6 alkyl or a C3-6 alkynyl, R2 is H, —CH2-OH or —CH2—CH2OH, and X is ?O, (H, H) or (H, OH).

Abstract: An object of the present invention is to provide novel apoptosis inhibitors and therapeutic agents for inner ear hearing impairment. As a pharmaceutical agent for this purpose, biguanide compounds represented by the following structural formula (I) or a rapamycin derivative represented by the following structural formula (II) as an active ingredient is provided: wherein R1 to R7 are each independently selected from a hydrogen atom, a halogen atom, or a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-10 aryl group, a 5- or 6-membered heteroaryl group, or a 5- or 6-membered non-aromatic heterocyclic group, each of which may have a substituent selected from a halogen atom, a cyano group, a C1-6 alkyl group, a C1-6 alkoxy group, a C1-6 alkoxy carbonyl group, a C3-8 cycloalkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, and a phenyl group; wherein R1 is a C1-6 alkyl or a C3-6 alkynyl, R2 is H, —CH2—OH or —CH2—CH2—OH, and X is ?O, (H, H) or (H, OH).

Abstract: A water purification solid material of relatively low cost whose handling is easy, produced from a natural raw material only; and a method of water purification with the use of the same. There is provided a water purification solid material for use in water purification using a microbe, characterized in that it is obtained by working only a natural raw material whose main component is a polysaccharide. Further, there is provided a method of water purification with the use of the same.

Abstract: A water purification solid material of relatively low cost whose handling is easy, produced from a natural raw material only; and a method of water purification with the use of the same. There is provided a water purification solid material for use in water purification using a microbe, characterized in that it is obtained by working only a natural raw material whose main component is a polysaccharide. Further, there is provided a method of water purification with the use of the same.

Abstract: A system for making use of rainwater falling on houses and buildings, which comprises a means for removing a predetermined quantity of initial precipitation from the rainwater collected form the roof surface of the building; and a purifier receiving the subsequent rainwater from which the initial precipitation has been removed. The purifier includes a filtering tank, a sterilization tank, and a supply tank connected to the sterilization tank. The filtering tank has a physical filter and a pH adjusting agent, the sterilization tank contains a primary reactive catalyst for producing active oxygen species, and the supply tank supplies aqueous hydrogen peroxide to the primary reactive catalyst. The system also has a storage tank that stores the purified rainwater supplied from the purifier. The storage tank contains a secondary reactive catalyst for decomposing and eliminating residual active oxygen species remaining in the purified rainwater supplied from the purifier.

Abstract: A system for making use of rainwater falling on houses and buildings, which comprises a means for removing a predetermined quantity of initial precipitation from the rainwater collected form the roof surface of the building; and a purifier receiving the subsequent rainwater from which the initial precipitation has been removed. The purifier includes a filtering tank, a sterilization tank, and a supply tank connected to the sterilization tank. The filtering tank has a physical filter and a pH adjusting agent, the sterilization tank contains a primary reactive catalyst for producing active oxygen species, and the supply tank supplies aqueous hydrogen peroxide to the primary reactive catalyst. The system also has a storage tank that stores the purified rainwater supplied from the purifier. The storage tank contains a secondary reactive catalyst for decomposing and eliminating residual active oxygen species remaining in the purified rainwater supplied from the purifier.

Abstract: A system for making use of rainwater falling on houses and buildings, which comprises a means for removing a predetermined quantity of initial precipitation from the rainwater collected form the roof surface of the building; and a purifier receiving the subsequent rainwater from which the initial precipitation has been removed. The purifier includes a filtering tank, a sterilization tank, and a supply tank connected to the sterilization tank. The filtering tank has a physical filter and a pH adjusting agent, the sterilization tank contains a primary reactive catalyst for producing active oxygen species, and the supply tank supplies aqueous hydrogen peroxide to the primary reactive catalyst. The system also has a storage tank that stores the purified rainwater supplied from the purifier. The storage tank contains a secondary reactive catalyst for decomposing and eliminating residual active oxygen species remaining in the purified rainwater supplied from the purifier.

Abstract: A method for managing a water system habitat environment and a system for managing a water system habitat environment are provided in which oxides which accumulate in a relatively small-scale water environment are continuously and effectively reduction changed and released into the atmosphere, such that a balance between oxidation changing and reduction changing of solute can be achieved. Furthermore, building up to a balanced state can be carried out in a short period of time from creation of the water environment, and the balanced state can be maintained over a long period of time. Soil (22), in which an organic carbon source (21) is mixed-in in a predetermined amount with respect to an amount of water in a pond (10), is covered, to a predetermined thickness, on substantially an entire bottom of a depression (4) which is to become the pond (10) and whose bottom portion has been subjected to a waterproofing treatment (3).

Abstract: A method for managing a water system habitat environment and a system for managing a water system habitat environment are provided in which oxides which accumulate in a relatively small-scale water environment are continuously and effectively reduction changed and released into the atmosphere, such that a balance between oxidation changing and reduction changing of solute can be achieved. Furthermore, building up to a balanced state can be carried out in a short period of time from creation of the water environment, and the balanced state can be maintained over a long period of time. Soil (22), in which an organic carbon source (21) is mixed-in in a predetermined amount with respect to an amount of water in a pond (10), is covered, to a predetermined thickness, on substantially an entire bottom of a depression (4) which is to become the pond (10) and whose bottom portion has been subjected to a waterproofing treatment (3).

Abstract: A system for making use of rainwater falling on houses and buildings, which comprises a means for removing a predetermined quantity of initial precipitation from the rainwater collected form the roof surface of the building; and a purifier receiving the subsequent rainwater from which the initial precipitation has been removed. The purifier includes a filtering tank, a sterilization tank, and a supply tank connected to the sterilization tank. The filtering tank has a physical filter and a pH adjusting agent, the sterilization tank contains a primary reactive catalyst for producing active oxygen species, and the supply tank supplies aqueous hydrogen peroxide to the primary reactive catalyst. The system also has a storage tank that stores the purified rainwater supplied from the purifier. The storage tank contains a secondary reactive catalyst for decomposing and eliminating residual active oxygen species remaining in the purified rainwater supplied from the purifier.