Patents by Inventor Makoto Makino
Makoto Makino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11981644Abstract: Provided herein are compounds of formula (1): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, Ry, Rz, R1, R2, R3, and R4 are as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.Type: GrantFiled: November 5, 2021Date of Patent: May 14, 2024Assignee: CYTOKINETICS, INC.Inventors: Bradley P. Morgan, Chris Evans, Pu-Ping Lu, Makoto Yamasaki, Wenyue Wang, Scott Collibee, Takuya Makino, Kazuyuki Tsuchiya, Toshio Kurosaki, Susumu Yamaki, Eriko Honjo, Yuka Koizumi, Naoto Katoh, Ryuichi Sekioka, Ikumi Kuriwaki
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Patent number: 9982222Abstract: A detergent composition containing an ?-sulfo fatty acid alkyl ester salt and a fragrance composition, wherein the amount of the ?-sulfo fatty acid alkyl ester salt is from 1 to 30% by mass relative to the total mass of the detergent composition, the fragrance composition contains a fragrance (A) described below, and the amount of the fragrance (A) is from 0.07 to 0.5% by mass relative to the total mass of the detergent composition. Fragrance (A): a fragrance composed of at least one fragrance component selected from the group consisting of dihydromyrcenol, isobornyl acetate, ?-hexyl cinnamic aldehyde, lilial, tetrahydrolinalool, amyl salicylate, verdox, vertenex, tricyclodecenyl acetate, tricyclodecenyl propionate, Iso E Super and habanolide.Type: GrantFiled: June 12, 2014Date of Patent: May 29, 2018Assignee: Lion CorporationInventors: Makoto Makino, Atsushi Tsuda, Takuya Tsutsui
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Publication number: 20160122694Abstract: A detergent composition containing an ?-sulfo fatty acid alkyl ester salt and a fragrance composition, wherein the amount of the ?-sulfo fatty acid alkyl ester salt is from 1 to 30% by mass relative to the total mass of the detergent composition, the fragrance composition contains a fragrance (A) described below, and the amount of the fragrance (A) is from 0.07 to 0.5% by mass relative to the total mass of the detergent composition. Fragrance (A): a fragrance composed of at least one fragrance component selected from the group consisting of dihydromyrcenol, isobornyl acetate, ?-hexyl cinnamic aldehyde, lilial, tetrahydrolinalool, amyl salicylate, verdox, vertenex, tricyclodecenyl acetate, tricyclodecenyl propionate, Iso E Super and habanolide.Type: ApplicationFiled: June 12, 2014Publication date: May 5, 2016Inventors: Makoto MAKINO, Atsushi TSUDA, Takuya TSUTSUI
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Patent number: 6441093Abstract: A thermoplastic elastomer composition for calender-molding obtained by dynamically heat-treating a mixture comprising 40 to 95% by weight of (A) an oil-extended olefin copolymer rubber containing 100 parts by weight of an olefin copolymer rubber having a Mooney viscosity (ML1+4100° C.) of 120 to 350 and 20 to 150 parts by weight of mineral oil softening agent and 60 to 5% by weight of (B) a polypropylene resin, a process for producing a calendered sheet from the composition and a sheet obtained by the process.Type: GrantFiled: February 1, 2001Date of Patent: August 27, 2002Assignee: Sumitomo Chemical Company, LimitedInventors: Takeshi Tominaga, Nobuhiro Natsuyama, Hironobu Shigematsu, Tatsuo Hamanaka, Makoto Makino
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Publication number: 20010018475Abstract: A thermoplastic elastomer composition for calender-molding obtained by dynamically heat-treating a mixture comprising 40 to 95% by weight of (A) an oil-extended olefin copolymer rubber containing 100 parts by weight of an olefin copolymer rubber having a Mooney viscosity (ML1+4100° C.) of 120 to 350 and 20 to 150 parts by weight of mineral oil softening agent and 60 to 5% by weight of (B) a polypropylene resin, a process for producing a calendered sheet from the composition and a sheet obtained by the process.Type: ApplicationFiled: February 1, 2001Publication date: August 30, 2001Inventors: Takeshi Tominaga, Nobuhiro Natsuyama, Hironobu Shigematsu, Tatsuo Hamanaka, Makoto Makino
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Patent number: 5902674Abstract: A sheet including an olefin thermoplastic elastomer obtainable by dynamically heat-treating 100 parts by weight of a mixture of 40-90% by weight of (A) an olefin polymer rubber having a Mooney viscosity at 100.degree. C. (ML.sub.1+4 100.degree. C.) of 5-100 and substantially free from unconjugated diene and 60-10% by weight of (B) an olefin polymer in the presence of 0.005-0.5 part by weight of an organic peroxide and 0.05-4 parts by weight of N,N'-m-phenylenebismaleimide or divinylbenzene. Said sheet is excellent in light resistance and thermal aging resistance. A laminate including said sheet and a use thereof are also provided.Type: GrantFiled: May 6, 1997Date of Patent: May 11, 1999Assignee: Sumitomo Chemical Company, LimitedInventors: Makoto Makino, Tatsuo Hamanaka
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Patent number: 5415550Abstract: A riding simulation apparatus comprises a color picture image signal generating apparatus for outputting video image information of a forward field of view of the rider and video image information of the rear of the rider, a display apparatus for receiving the video image information outputted from the color picture image signal generating apparatus, masking a picture image based on the video image information of the rear of the rider and reflecting a video image based on the image information of the forward field of view of the rider on a flat screen provided at a position forwardly of the rider, and a pair of left and right liquid crystal television sets provided at the positions of back mirrors of the simulation motorcycle for receiving the video image information of the rear of the rider and displaying a picture image based on the video image information of the rear of the rider.Type: GrantFiled: July 20, 1993Date of Patent: May 16, 1995Assignee: Honda Giken Kogyo Kabushiki KaishaInventors: Katsuhito Aoki, Yukio Miyamaru, Makoto Makino, Takeshi Masaki
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Patent number: 5351486Abstract: A charging control apparatus including means for shortening a running-up period of the second turbocharger with an exhaust bypass valve when an instant engine speed is low, so that torque shock during the transition from one-turbocharger-operation to two-turbocharger-operation is decreased. During rapid acceleration at high engine speeds, an exhaust switching valve is opened at once. Further, the reference engine speed and the reference intake air quantity for switching to two-turbocharger-operation are varied in accordance with the gear shift position, so that an optimum switching to two-turbocharger-operation is obtained.Type: GrantFiled: January 6, 1994Date of Patent: October 4, 1994Assignee: Toyoto Jidosha Kabushiki KaishaInventors: Mamoru Yoshioka, Kunihiko Nakata, Akira Kotani, Makoto Makino
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Patent number: 5313798Abstract: A charging control apparatus including means for shortening a running-up period of the second turbocharger with an exhaust bypass valve when an instant engine speed is low, so that torque shock during the transition from one-turbocharger-operation to two-turbocharger-operation is decreased. During rapid acceleration at high engine speeds, an exhaust switching valve is opened at once. Further, the reference engine speed and the reference intake air quantity for switching to two-turbocharger-operation are varied in accordance with the shift gear position, so that an optimum switching to two-turbocharger-operation is obtained.Type: GrantFiled: July 31, 1992Date of Patent: May 24, 1994Assignee: Toyota Jidosha Kabushiki KaishaInventors: Mamoru Yoshioka, Kunihiko Nakata, Akira Kotani, Makoto Makino
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Patent number: 4941564Abstract: A motorcycle being assembled on an assembly line is transferred from a first line to a second line by gripping and lifting a front wheel of the motorcycle up to a prescribed height to support the motorcycle only through a rear wheel thereof, moving the motorcycle from the first line to the second line while rolling the rear wheel, clamping the rear wheel, and thereafter lowering the front wheel to move the motorcycle along the second line. The motorcycle can automatically be transferred reliably and efficiently, and various motorcycles of different types can easily be transferred by a single apparatus by only gripping front wheels thereof.Type: GrantFiled: April 6, 1989Date of Patent: July 17, 1990Assignee: Honda Giken Kogyo Kabushiki KaishaInventors: Hiroyuki Noguchi, Makoto Makino, David M. Nye