Abstract: A conjugate that can be used in photo-immunotherapy. A conjugate comprises an antibody specific to a vascular endothelial growth factor receptor (VEGFR) to which a photosensitizer having an absorption wavelength range overlapping with a wavelength range from a red beam of light to a near-infrared beam of light is bound. An antigen-antibody reaction causes the conjugate to bind to neovascularity located in an affected area, an excitation light having a wavelength of 660 to 740 nm irradiates the affected area to excite the photosensitizer, and the conjugate causes damage to the neovascularity by photosensitizing action.

Abstract: The present disclosure relates to compositions and methods of killing cells in vitro or in vivo. In particular examples, the method includes contacting a cell having a cell surface protein with a therapeutically effective amount of an antibody-IR700 molecule, wherein the antibody specifically binds to the cell surface protein. In particular examples the antibody recognizes a tumor-specific antigen on the surface of a tumor cell. The cell is subsequently irradiated, such as at a wavelength of 660 to 740 nm at a dose of at least 1 J cm?2, thereby killing the cell. Also provided are wearable devices that include an article of clothing, jewelry, or covering; and an NIR LED incorporated into the article, which can be used with the disclosed methods.

Abstract: The present disclosure relates to compositions and methods of killing cells in vitro or in vivo. In particular examples, the method includes contacting a cell having a cell surface protein with a therapeutically effective amount of an antibody-IR700 molecule, wherein the antibody specifically binds to the cell surface protein. In particular examples the antibody recognizes a tumor-specific antigen on the surface of a tumor cell. The cell is subsequently irradiated, such as at a wavelength of 660 to 740 nm at a dose of at least 1 J cm?2, thereby killing the cell. Also provided are wearable devices that include an article of clothing, jewelry, or covering; and an NIR LED incorporated into the article, which can be used with the disclosed methods.

Abstract: The present disclosure relates to compositions and methods of killing cells in vitro or in vivo. In particular examples, the method includes contacting a cell having a cell surface protein with a therapeutically effective amount of an antibody-IR700 molecule, wherein the antibody specifically binds to the cell surface protein. In particular examples the antibody recognizes a tumor-specific antigen on the surface of a tumor cell. The cell is subsequently irradiated, such as at a wavelength of 660 to 740 nm at a dose of at least 1 J cm?2, thereby killing the cell. Also provided are wearable devices that include an article of clothing, jewelry, or covering; and an NIR LED incorporated into the article, which can be used with the disclosed methods.

Abstract: A method for examining cancer cells by which examination of cancer cells may be carried out simply and efficiently without using an expensive apparatus, and a reagent therefor are disclosed. In the method for examining cancer cells according to the present invention, cancer cells separated from the body, which cells express SF-25 antigen on their surfaces, are bound to magnetic beads utilizing antigen-antibody reaction between the cancer cells and an anti-SF-25 antibody or antigen-binding fragment thereof, and then the magnetic beads are collected by magnetic force, and the cancer cells bound to the magnetic beads are examined.