Patents by Inventor Makoto Suematsu
Makoto Suematsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220365087Abstract: The present invention aims to provide a method of acquiring data for determination of, and a method of acquiring prediction data on the presence of cancer cells and/or the resistance to anticancer drugs, use of a marker for determining thereof, and a kit for determining thereof, in particular, to determine the resistance to anticancer drugs before administration of the anticancer drugs to patients. The resistance of cancer tissues of cancer patients to anticancer drugs can be determined by detecting polysulfide, which is a marker for the resistance to anticancer drugs, in the cancer tissues of the cancer patients before administration of the anticancer drugs.Type: ApplicationFiled: September 4, 2020Publication date: November 17, 2022Applicant: KEIO UNIVERSITYInventors: Takako HISHIKI, Makoto SUEMATSU
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Publication number: 20190117704Abstract: The present invention provides a method for producing adult oligodendrocyte progenitor cells from proliferative oligodendrocyte progenitor cells, and a pharmaceutical composition having for an active ingredient thereof adult OPC produced according to that method. The method for producing adult OPC of the present invention is characterized by inducing proliferating OPC to differentiate into adult OPC by culturing in the presence of a ligand of a thyroid hormone receptor or retinoic acid receptor in a low oxygen environment. The present invention further provides adult OPC produced according to the production method of the present invention, and a pharmaceutical composition having these adult OPC as an active ingredient thereof.Type: ApplicationFiled: December 18, 2018Publication date: April 25, 2019Applicant: Japan Science and Technology AgencyInventors: Makoto SUEMATSU, Yasuhito TOKUMOTO, Shinpei TAMAKI
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Patent number: 10202580Abstract: The present invention provides a method for producing adult oligodendrocyte progenitor cells from proliferative oligodendrocyte progenitor cells, and a pharmaceutical composition having for an active ingredient thereof adult OPC produced according to that method. The method for producing adult OPC of the present invention is characterized by inducing proliferating OPC to differentiate into adult OPC by culturing in the presence of a ligand of a thyroid hormone receptor or retinoic acid receptor in a low oxygen environment. The present invention further provides adult OPC produced according to the production method of the present invention, and a pharmaceutical composition having these adult OPC as an active ingredient thereof.Type: GrantFiled: January 21, 2015Date of Patent: February 12, 2019Assignee: JAPAN SCIENCE AND TECHNOLOGY AGENCYInventors: Makoto Suematsu, Yasuhito Tokumoto, Shinpei Tamaki
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Publication number: 20170294297Abstract: After a sample such as a biomedical tissue section is attached to an electrically-conductive slide glass (S1), the film layer of a matrix substance is appropriately formed by vapor deposition so as to cover the sample (S2). The crystal of the matrix substance in the film layer is very fine and uniform. Subsequently, the slide glass on which the matrix film layer is formed is placed in a vaporized solvent atmosphere, and the solvent infiltrates into the matrix film layer (S3). When the solvent sufficiently infiltrated is vaporized, a substance to be measured in the sample takes in the matrix and re-crystallized. Furthermore, the matrix film layer is formed again on the surface by the vapor deposition (S4). The added matrix film layer absorbs excessive energy of a laser beam during MALDI, which suppresses the denaturation of the substance to be measured and the like, so that high detection sensitivity can be achieved while high spatial resolution is maintained.Type: ApplicationFiled: June 23, 2017Publication date: October 12, 2017Applicants: SHIMADZU CORPORATIONInventors: Koretsugu OGATA, Kazuteru TAKAHASHI, Akiko KUBO, Makoto SUEMATSU, Takushi YAMAMOTO
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Patent number: 9728388Abstract: A metal film of a measurement device including a transparent dielectric substrate is irradiated with first light from a transparent dielectric substrate side, an optical electric field enhanced by an optical electric field enhancing effect of a localized plasmon induced to a surface of the metal film by the irradiation is generated, light emitted from the transparent dielectric substrate side is detected, a specimen installed on a surface of a metal fine concavo-convex structure layer and a matrix agent are irradiated with second light from a side opposite to the side of the irradiation with the first light in a state where a voltage is applied to the metal fine concavo-convex structure layer through a voltage application electrode, an analysis target substance for mass spectrometry in the specimen is desorbed from the surface by the irradiation, and the desorbed analysis target substance is detected.Type: GrantFiled: October 5, 2015Date of Patent: August 8, 2017Assignee: FUJIFILM CorporationInventors: Masayuki Naya, Shogo Yamazoe, Megumi Shiota, Makoto Suematsu
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Patent number: 9721776Abstract: After a sample such as a biomedical tissue section is attached to an electrically-conductive slide glass (S1), the film layer of a matrix substance is appropriately formed by vapor deposition so as to cover the sample (S2). The crystal of the matrix substance in the film layer is very fine and uniform. Subsequently, the slide glass on which the matrix film layer is formed is placed in a vaporized solvent atmosphere, and the solvent infiltrates into the matrix film layer (S3). When the solvent sufficiently infiltrated is vaporized, a substance to be measured in the sample takes in the matrix and re-crystallized. Furthermore, the matrix film layer is formed again on the surface by the vapor deposition (S4). The added matrix film layer absorbs excessive energy of a laser beam during MALDI, which suppresses the denaturation of the substance to be measured and the like, so that high detection sensitivity can be achieved while high spatial resolution is maintained.Type: GrantFiled: April 4, 2014Date of Patent: August 1, 2017Assignees: SHIMADZU CORPORATION, KEIO UNIVERSITYInventors: Koretsugu Ogata, Kazuteru Takahashi, Akiko Kubo, Makoto Suematsu, Takushi Yamamoto
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Publication number: 20170067020Abstract: The present invention provides a method for producing adult oligodendrocyte progenitor cells from proliferative oligodendrocyte progenitor cells, and a pharmaceutical composition having for an active ingredient thereof adult OPC produced according to that method. The method for producing adult OPC of the present invention is characterized by inducing proliferating OPC to differentiate into adult OPC by culturing in the presence of a ligand of a thyroid hormone receptor or retinoic acid receptor in a low oxygen environment. The present invention further provides adult OPC produced according to the production method of the present invention, and a pharmaceutical composition having these adult OPC as an active ingredient thereof.Type: ApplicationFiled: January 21, 2015Publication date: March 9, 2017Applicant: Japan Science and Technology AgencyInventors: Makoto SUEMATSU, Yasuhito TOKUMOTO, Shinpei TAMAKI
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Publication number: 20160035553Abstract: After a sample such as a biomedical tissue section is attached to an electrically-conductive slide glass (S1), the film layer of a matrix substance is appropriately formed by vapor deposition so as to cover the sample (S2). The crystal of the matrix substance in the film layer is very fine and uniform. Subsequently, the slide glass on which the matrix film layer is formed is placed in a vaporized solvent atmosphere, and the solvent infiltrates into the matrix film layer (S3). When the solvent sufficiently infiltrated is vaporized, a substance to be measured in the sample takes in the matrix and re-crystallized. Furthermore, the matrix film layer is formed again on the surface by the vapor deposition (S4). The added matrix film layer absorbs excessive energy of a laser beam during MALDI, which suppresses the denaturation of the substance to be measured and the like, so that high detection sensitivity can be achieved while high spatial resolution is maintained.Type: ApplicationFiled: April 4, 2014Publication date: February 4, 2016Applicants: KEIO UNIVERSITY, SHIMADZU CORPORATIONInventors: Koretsugu OGATA, Kazuteru TAKAHASHI, Akiko KUBO, Makoto SUEMATSU, Takuji YAMAMOTO
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Publication number: 20160027631Abstract: A metal film of a measurement device including a transparent dielectric substrate is irradiated with first light from a transparent dielectric substrate side, an optical electric field enhanced by an optical electric field enhancing effect of a localized plasmon induced to a surface of the metal film by the irradiation is generated, light emitted from the transparent dielectric substrate side is detected, a specimen installed on a surface of a metal fine concavo-convex structure layer and a matrix agent are irradiated with second light from a side opposite to the side of the irradiation with the first light in a state where a voltage is applied to the metal fine concavo-convex structure layer through a voltage application electrode, an analysis target substance for mass spectrometry in the specimen is desorbed from the surface by the irradiation, and the desorbed analysis target substance is detected.Type: ApplicationFiled: October 5, 2015Publication date: January 28, 2016Applicant: FUJIFILM CORPORATIONInventors: Masayuki NAYA, Shogo YAMAZOE, Megumi SHIOTA, Makoto SUEMATSU
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Publication number: 20140099385Abstract: An object of the present invention is to provide a composition for inhibiting fatty acid and cholesterol uptake in a living cell which is an inhibitor for fatty acid or cholesterol uptake by a living cell, comprising carbon monoxide (CO) or a compound capable of releasing CO in vivo.Type: ApplicationFiled: June 6, 2012Publication date: April 10, 2014Inventors: Makoto Suematsu, Yasuaki Kabe
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Publication number: 20130116148Abstract: Disclosed is a method for promptly identifying a liver disease. A normal person or a liver disease such as drug-induced liver injury, asymptomatic hepatitis B carrier, chronic hepatitis B, hepatitis C with persistently normal ALT, chronic hepatitis C, cirrhosis type C, hepatocellular carcinoma, simple steatosis, or non-alcoholic steatohepatitis is identified by measuring the concentration of a ?-Glu-X (wherein X represents an amino acid or an amine) peptide or the level of AST or ALT in blood and carrying out, for example, a multiple logistic regression based on the measured value.Type: ApplicationFiled: May 17, 2011Publication date: May 9, 2013Applicant: KEIO UNIVERSITYInventors: Tomoyoshi Soga, Masahiro Sugimoto, Makoto Suematsu, Takafumi Saito, Sumio Kawata
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Patent number: 8309056Abstract: Provided is a biomarker that enables easy and rapid detection of oxidative stress on a living organism and enables prevention of tissue damage or cell necrosis by drug administration, and which is a powerful marker for the study of toxicity and pharmacokinetics of various agents. Oxidative stress is determined by measuring blood concentration of ophthalmic acid, which is a substance that varies in blood depending on the variation of reduced glutathione (GSH) concentration in a biological sample with the use of an analyzer such as a capillary electrophoresis-mass spectrometer. Further, an anti-oxidative stress agent is screened by administering an anti-oxidative stress candidate agent to a non-human animal under oxidative stress conditions, measuring blood concentration of ophthalmic acid, and evaluating the degree of decrease in the ophthalmic acid concentration.Type: GrantFiled: April 22, 2011Date of Patent: November 13, 2012Assignee: Keio UniversityInventors: Tomoyoshi Soga, Makoto Suematsu
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Publication number: 20110259743Abstract: Provided is a biomarker that enables easy and rapid detection of oxidative stress on a living organism and enables prevention of tissue damage or cell necrosis by drug administration, and which is a powerful marker for the study of toxicity and pharmacokinetics of various agents. Oxidative stress is determined by measuring blood concentration of ophthalmic acid, which is a substance that varies in blood depending on the variation of reduced glutathione (GSH) concentration in a biological sample with the use of an analyzer such as a capillary electrophoresis-mass spectrometer. Further, an anti-oxidative stress agent is screened by administering an anti-oxidative stress candidate agent to a non-human animal under oxidative stress conditions, measuring blood concentration of ophthalmic acid, and evaluating the degree of decrease in the ophthalmic acid concentration.Type: ApplicationFiled: April 22, 2011Publication date: October 27, 2011Applicant: KEIO UNIVERSITYInventors: Tomoyoshi SOGA, Makoto Suematsu
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Publication number: 20110256561Abstract: A normal person (i.e. a control) and liver diseases such as drug induced liver injury, an asymptomatic hepatitis B carrier, an asymptomatic hepatitis C carrier, chronic hepatitis B, chronic hepatitis C, liver cancer, a nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and simple steatosis (SS) are identified by measuring the concentrations of ?-Glu-X (X represents an amino acid or an amine) peptides or the levels of AST or ALT in blood and carrying out, for example, a multiple logistic regression based on the measured value.Type: ApplicationFiled: November 26, 2009Publication date: October 20, 2011Applicants: THE UNIVERSITY OF TOKYO, KEIO UNIVERSITYInventors: Tomoyoshi Soga, Masahiro Sugimoto, Makoto Suematsu, Masashi Honma, Takehito Yamamoto, Hiroshi Suzuki
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Patent number: 7964177Abstract: Provided is a biomarker that enables easy and rapid detection of oxidative stress on a living organism and enables prevention of tissue damage or cell necrosis by drug administration, and which is a powerful marker for the study of toxicity and pharmacokinetics of various agents. Oxidative stress is determined by measuring blood concentration of ophthalmic acid, which is a substance that varies in blood depending on the variation of reduced glutathione (GSH) concentration in a biological sample with the use of an analyzer such as a capillary electrophoresis-mass spectrometer. Further, an anti-oxidative stress agent is screened by administering an anti-oxidative stress candidate agent to a non-human animal under oxidative stress conditions, measuring blood concentration of ophthalmic acid, and evaluating the degree of decrease in the ophthalmic acid concentration.Type: GrantFiled: January 16, 2007Date of Patent: June 21, 2011Assignee: Keio UniversityInventors: Tomoyoshi Soga, Makoto Suematsu
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Publication number: 20100010787Abstract: A platelet thrombus formation simulator, said simulator equipped with the following means: (a) a means that selects, from previously stored equations, an equation for the computation of adhesion force according to parallel activation grade; (b) a means that calculates the platelet adhesion force based on the equation depending on the activation grade of each platelet; and (c) a means that outputs the coagulation condition of platelets based on the calculated adhesion force of each platelet.Type: ApplicationFiled: September 14, 2007Publication date: January 14, 2010Inventors: Makoto Suematsu, Hitoshi Kawahara
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Publication number: 20090221496Abstract: The present invention provides: a pharmaceutical composition comprising an albumin conjugated with polyethylene glycol; and a method of treating a human thrombosis or a human ischemic disease, comprising intravenously administering an albumin conjugated with polyethylene glycol to a patient.Type: ApplicationFiled: March 1, 2007Publication date: September 3, 2009Applicant: KEIO UNIVERSITYInventors: Makoto Suematsu, Shintaro Mandai
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Publication number: 20090029409Abstract: Provided is a biomarker that enables easy and rapid detection of oxidative stress on a living organism and enables prevention of tissue damage or cell necrosis by drug administration, and which is a powerful marker for the study of toxicity and pharmacokinetics of various agents. Oxidative stress is determined by measuring blood concentration of ophthalmic acid, which is a substance that varies in blood depending on the variation of reduced glutathione (GSH) concentration in a biological sample with the use of an analyzer such as a capillary electrophoresis-mass spectrometer. Further, an anti-oxidative stress agent is screened by administering an anti-oxidative stress candidate agent to a non-human animal under oxidative stress conditions, measuring blood concentration of ophthalmic acid, and evaluating the degree of decrease in the ophthalmic acid concentration.Type: ApplicationFiled: January 16, 2007Publication date: January 29, 2009Applicant: KEIO UNIVERSITYInventors: Tomoyoshi Soga, Makoto Suematsu
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Publication number: 20080248012Abstract: A promoter of ATP release from red blood cells, comprising a substance capable of stabilizing the structure of hemoglobin in red blood cells in its T-state; and a method of releasing ATP from red blood cells with the use of the promoter. There are further provided an inhibitor of ATP release from red blood cells, comprising a substance capable of stabilizing the structure of hemoglobin in red blood cells in its R-state; and a method of inhibiting ATP release from red blood cells with the use of the inhibitor.Type: ApplicationFiled: July 1, 2004Publication date: October 9, 2008Applicant: KEIO UNIVERSITYInventor: Makoto Suematsu
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Publication number: 20080247949Abstract: The present invention relates to a biological tissue examination agent comprising hemoglobin labeled with 15O2 and a method for producing the same. More specifically, the present invention relates to a biological tissue examination agent for diagnosing a cause or condition of a disease by detecting oxygen metabolism in a biological tissue using hemoglobin labeled with 15O2, and a method for producing the same. The present invention also relates to a method for detecting oxygen metabolism in a biological tissue.Type: ApplicationFiled: November 18, 2005Publication date: October 9, 2008Applicant: Oxygenix Co., Ltd.Inventors: Yasuhisa Fujibashi, Tetsuya Mori, Makoto Suematsu, Katsuji Ohta