Abstract: Provided herein are compounds of formula (1): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, Ry, Rz, R1, R2, R3, and R4 are as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.

Abstract: An image reading device includes a motor 3, a reading section 7 that reads an image on a medium 5, a first transporting roller 9 that transports the medium in a transport direction F by driving force of the motor and that is provided upstream of the reading section in the transport direction, a second transporting roller 11 that transports the medium in the transport direction by driving force of the motor and that is provided downstream of the reading section in the transport direction, and a measuring section 17, using an encoder sensor 15, configured to measure the rotational position of an encoder scale 13, wherein the encoder scale 13 is provided on a rotation shaft 19 of the second transporting roller 11.

Abstract: A control unit of an image reading device is configured to execute image correction control after performing a first reading operation of reading a medium while transporting the medium in a first direction, and the image correction control includes a second reading operation of reading the medium while transporting the medium in a second direction opposite to the first direction, and a combination process for combining a first area serving as a part of image data acquired through the first reading operation with a second area serving as a part of image data acquired through the second reading operation to acquire image data of one page.

Abstract: Provided herein are compounds of formula (I): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, Ry, Rz, R1, R2, R3, and R4 are as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.

Abstract: A shaft portion and a blade portion provided on a side surface of the shaft portion are included, and the blade portion includes cutting blades arranged in a plurality of lines on a side surface of the shaft portion along a peripheral direction, and arranged in a plurality of stages in an extending direction of a shaft center of the shaft portion in each line. Further, the cutting blade has a radial-direction clearance angle, a tip end-side clearance angle, and a base end-side clearance angle.

Abstract: A coating film removing apparatus includes: a substrate holding mechanism that holds a substrate; an end surface detection mechanism that detects an end surface of the substrate; an end portion removing mechanism that removes an end portion of the coating film applied on the substrate; and a moving mechanism that moves the substrate holding mechanism or the end portion removing mechanism, wherein the end portion removing mechanism removes the end portion of the coating film applied on the substrate while the moving mechanism is relatively moving the substrate holding mechanism and the end portion removing mechanism according to the end surface of the substrate detected by the end surface detection mechanism.

Abstract: A processing apparatus and a processing method which perform processing more accurately with a simple structure are provided. The processing apparatus includes an irradiation head 16 and a control device. The irradiation head 16 includes a laser turning unit 35 and a condensing optical system 37. The laser turning unit 35 includes a first prism 51, a second prism 52, a first rotating mechanism 53, and a second rotating mechanism 54. The control device adjusts the differences between rotation speeds and phase angles of the first prism 51 and the second prism 52 based on a relation between at least a heat affected layer of a workpiece and a turning speed of laser.

Abstract: When a catalyst temperature is lower than a predetermined temperature on a second or subsequent start of an engine since system activation of a vehicle, a catalyst warm-up request is output for the purpose of warming up a catalyst in a catalytic converter. An output limit Wout of a battery is not increased in response to a second or subsequent output of the catalyst warm-up request, while being increased in response to a first output of the catalyst warm-up request. Accordingly, the catalyst warm-up in response to the second or subsequent output of the catalyst warm-up request since the system activation suppresses excessive output of electric power from the battery and thereby suppresses deterioration of the battery. Catalyst warm-up is performed in response to the second or subsequent output of the catalyst warm-up request. This suppresses deterioration of emission.

Abstract: A shaft portion and a blade portion provided on a side surface of the shaft portion are included, and the blade portion includes cutting blades arranged in a plurality of lines on a side surface of the shaft portion along a peripheral direction, and arranged in a plurality of stages in an extending direction of a shaft center of the shaft portion in each line. Further, the cutting blade has a radial-direction clearance angle, a tip end-side clearance angle, and a base end-side clearance angle.

Abstract: Provided are a machining device and a machining method in which machining of higher precision can be performed with a simple configuration. The machining device has an irradiation head (16) and a controller; and the irradiation head (16) can be divided into a collimate optical system, a laser revolving unit (35), and a light collection optical system (37). The laser revolving unit (35) has a first prism (51), a second prism (52), a first rotation mechanism (53), and a second rotation mechanism (54). The controller controls the rotational speeds and the difference in phase angles of the first prism (51) and the second prism (52), on the basis of at least the relationship between a heat affected layer of a member to be machined and the revolving speed of the laser.

Abstract: When a catalyst temperature is lower than a predetermined temperature on a second or subsequent start of an engine since system activation of a vehicle, a catalyst warm-up request is output for the purpose of warming up a catalyst in a catalytic converter. An output limit Wout of a battery is not increased in response to a second or subsequent output of the catalyst warm-up request, while being increased in response to a first output of the catalyst warm-up request. Accordingly, the catalyst warm-up in response to the second or subsequent output of the catalyst warm-up request since the system activation suppresses excessive output of electric power from the battery and thereby suppresses deterioration of the battery. Catalyst warm-up is performed in response to the second or subsequent output of the catalyst warm-up request. This suppresses deterioration of emission.

Abstract: A processing apparatus and a processing method which perform processing more accurately with a simple structure are provided. The processing apparatus includes an irradiation head 16 and a control device. The irradiation head 16 includes a laser turning unit 35 and a condensing optical system 37. The laser turning unit 35 includes a first prism 51, a second prism 52, a first rotating mechanism 53, and a second rotating mechanism 54. The control device adjusts the differences between rotation speeds and phase angles of the first prism 51 and the second prism 52 based on a relation between at least a heat affected layer of a workpiece and a turning speed of laser.

Abstract: Provided are a machining device and a machining method in which machining of higher precision can be performed with a simple configuration. The machining device has an irradiation head (16) and a controller; and the irradiation head (16) can be divided into a collimate optical system, a laser revolving unit (35), and a light collection optical system (37). The laser revolving unit (35) has a first prism (51), a second prism (52), a first rotation mechanism (53), and a second rotation mechanism (54). The controller controls the rotational speeds and the difference in phase angles of the first prism (51) and the second prism (52), on the basis of at least the relationship between a heat affected layer of a member to be machined and the revolving speed of the laser.

Abstract: A three-dimensional laser processing machine performs high-precision laser processing on a workpiece (W) by setting the focal position of laser light to be condensed by a condensing lens at a predetermined distance from a portion to be processed of the workpiece (W), is provided with a three-dimensional shape measuring instrument (50) for measuring the three-dimensional shape of the workpiece (W), and sets the focal position of the laser light at the predetermined distance from the portion to be processed on the basis of three-dimensional shape data relating to the workpiece (W) measured by the three-dimensional shape measuring instrument (50).

Abstract: A coating film removing apparatus includes: a substrate holding mechanism that holds a substrate; an end surface detection mechanism that detects an end surface of the substrate; an end portion removing mechanism that removes an end portion of the coating film applied on the substrate; and a moving mechanism that moves the substrate holding mechanism or the end portion removing mechanism, wherein the end portion removing mechanism removes the end portion of the coating film applied on the substrate while the moving mechanism is relatively moving the substrate holding mechanism and the end portion removing mechanism according to the end surface of the substrate detected by the end surface detection mechanism.

Abstract: A refrigerated showcase is provided that can easily carry out a maintenance operation and the like of a cooling mechanism disposed in a machine chamber. A machine chamber 13 is defined on a side of a heat insulating box 16 defining a storage chamber 12 and also provided with a cooler to cool the storage chamber 12 to have a cooling mechanism 80 disposed therein to circularly supply a refrigerant to the cooler, and a front side of the storage chamber 12 and the machine chamber 13 is covered with a single front glass 14. Then, a side of the machine chamber 13 is defined by a detachable second side panel to configure the machine chamber 13 to open laterally in a state of removing the second side panel, and also the cooling mechanism 80 is placed on a unit base 38 drawable from the machine chamber 13 to configure to allow the unit base 38 to be drawn from the machine chamber 13 via a side opening of the machine chamber 13 opened by removing the second side panel.

Abstract: A refrigerated showcase is provided that can easily carry out a maintenance operation and the like of a cooling mechanism disposed in a machine chamber. A machine chamber 13 is defined on a side of a heat insulating box 16 defining a storage chamber 12 and also provided with a cooler to cool the storage chamber 12 to have a cooling mechanism 80 disposed therein to circularly supply a refrigerant to the cooler, and a front side of the storage chamber 12 and the machine chamber 13 is covered with a single front glass 14. Then, a side of the machine chamber 13 is defined by a detachable second side panel to configure the machine chamber 13 to open laterally in a state of removing the second side panel, and also the cooling mechanism 80 is placed on a unit base 38 drawable from the machine chamber 13 to configure to allow the unit base 38 to be drawn from the machine chamber 13 via a side opening of the machine chamber 13 opened by removing the second side panel.

Abstract: A 2-dimensional code reading apparatus includes a code position detector receiving an input image that is formed by optically reading 2-dimensional codes, and extracting a 2-dimensional codes from the input image. A data acquisition unit acquires identification information of a document page and positional information of the 2-dimensional codes on the document page, from the 2-dimensional codes. A data decoder performs decoding of the identification information and the positional information. The code position detector is provided with a code frame detector detecting a code frame which defines a fixed region of the 2-dimensional codes, and determining a dot of a target pixel as being a corner dot of the code frame.

Abstract: A paper identification information management system includes a client apparatus that handles a sheet of paper bearing prescribed information, and a management server connected to the client apparatus via a network to comprehensively manage information about the paper handled in the client apparatus. The client apparatus transmits a paper ID request and document information to the management server via the network when carrying out a printing operation. Based on the paper ID request and the document information, the management server assigns a paper ID to each sheet of paper handled by the client apparatus. The management server then transmits the paper IDs to the client apparatus, and simultaneously, records the assigned paper IDs in association with the document information.

Abstract: A method of managing a casual storage field comprises the steps of: receiving a plurality of information elements from one or more application programs, each information element including one or more data items; retaining the received information elements in the casual storage field; displaying a state of the casual storage field and the retained information elements; and handing over, in response to a user request, one or more of the retained information elements to an application program. The casual storage field can receive an information element from another application program, display the received information element in the display region of the casual storage field, and hand over in response to a user instruction, the information element to yet another application program.