Abstract: A terminal device includes a housing, a circuit board, and an interface component. An isolation groove is formed in an inner wall of the housing. The isolation groove has a first opening, and the first opening is exposed to the housing. The interface component is sealed in the isolation groove through a sealing kit. The interface component is electrically connected to the circuit board, and an interface end of the interface component is exposed to the first opening. Due to isolation of the sealing kit in the isolation groove, it is difficult for liquid to overflow to the circuit board through the isolation groove, to implement a good waterproof effect of the terminal device.

Abstract: The disclosure belongs to the technical field of synthetic adhesives, and discloses a bionic wet surface adhesion promoter and the preparation thereof, and a room temperature curable silicone sealant composition and the preparation thereof. A method for preparing a bionic wet surface adhesion promoter includes: reacting polyvinylpyrrolidone with 2-chloro-3?,4?-dihydroxyacetophenon; purifying the product obtained in the reaction step using n-hexane; drying the product obtained in the purification step using a vacuum drying process; and grinding the product obtained in the drying step into powder using a ball milling process; wherein the mass ratio of polyvinylpyrrolidone to 2-chloro-3?,4?-dihydroxyacetophenon is (0.8˜1.2):1.

Abstract: A notebook computer includes a control chip, a speaker, and the fan. The control chip and the fan are disposed inside a chassis of the notebook computer. The method includes: controlling, by the control chip, the speaker to send a first sound signal, where the first sound signal and a first noise signal that is generated by running of the fan have opposite phases and a same frequency. The first sound signal is used to cancel the first noise signal.

Abstract: The invention provides methods for detecting the presence of an aggregate in a sample by contacting the sample suspected of containing an aggregate with an aggregate-specific binding reagent under conditions that allow the binding of the reagent to the aggregate, if present; and detecting the presence of the aggregate, if any, in the sample by its binding to the reagent; where the aggregate-specific binding reagent typically has a net charge of at least about positive one at the pH at which the sample is contacted with the ASB reagent, is attached to a solid support at a charge density of at least about 60 nmol net charge per square meter, and binds preferentially with aggregates over monomers when attached to the solid support. Methods for detecting the presence of oligomer are also provided. Compositions for use in the methods are provided.

Abstract: The invention relates to peptoid reagents that interact preferentially with a pathogenic form of a conformational disease protein as compared to a nonpathogenic form of the conformational disease protein where the peptoid reagent comprises an amino-terminal region, a carboxy-terminal region, and at least one peptoid region between the amino-terminal region and the carboxy-terminal region where the peptoid region comprises 3 to about 30 N-substituted glycines, and optionally one or more amino acids. The invention also relates to methods of using the peptoids in detecting and isolating prions, and in the treatment and prevention of prion-related diseases.

Abstract: The invention provides methods for detecting the presence of a non-prion pathogenic conformer in a sample by contacting the sample suspected of containing a non-prion pathogenic conformer with a pathogenic conformer-specific binding reagent under conditions that allow the binding of the reagent to the pathogenic conformer, if present; and detecting the presence the pathogenic conformer, if any, in the sample by its binding to the reagent; where the pathogenic conformer-specific binding reagent is typically derived from a prion protein fragment and interacts preferentially with a pathogenic prion protein. Methods for diagnosis of conformational diseases are also provided.

Abstract: The invention relates to peptoid reagents that interact preferentially with a pathogenic form of a conformational disease protein as compared to a nonpathogenic form of the conformational disease protein where the peptoid reagent comprises an amino-terminal region, a carboxy-terminal region, and at least one peptoid region between the amino-terminal region and the carboxy-terminal region where the peptoid region comprises 3 to about 30 N-substituted glycines, and optionally one or more amino acids. The invention also relates to methods of using the peptoids in detecting and isolating prions, and in the treatment and prevention of prion-related diseases.

Abstract: Peptide reagents that interact preferentially with the PrPsc form of the prion protein are described for use in detecting PrPsc in biological samples. In particular, ELISA assays are described.

Abstract: Peptide reagents that interact preferentially with the PrPsc form of the prion protein are described. Methods of using the reagents for isolation and purification of the PrPsc isoform are described.

Abstract: The invention relates to peptoid reagents that interact preferentially with a pathogenic form of a conformational disease protein as compared to a nonpathogenic form of the conformational disease protein where the peptoid reagent comprises an amino-terminal region, a carboxy-terminal region, and at least one peptoid region between the amino-terminal region and the carboxy-terminal region where the peptoid region comprises 3 to about 30 N-substituted glycines, and optionally one or more amino acids. The invention also relates to methods of using the peptoids in detecting and isolating prions, and in the treatment and prevention of prion-related diseases.