Abstract: A manufacturing method for a micro-needle device includes following steps: a target tissue basic information obtaining step, a micro-needle template obtaining step, a micro-needle material adding step, a micro-needle semi-product obtaining step, and a micro-needle device obtaining step. The inner tissue distribution information is obtained by the application of optical coherence tomography. The micro-needle template is obtained according to the skin surface curvature information and the inner tissue distribution information. The micro-needle template has a plurality of areas and a plurality of mold holes. One or both of the diameter and the depth of the mold hole is determined by the inner tissue distribution information, and the curvature radius of the areas is determined by the skin surface curvature information. The manufacturing method for a micro-needle device is applicable to micro-needles with mixed configurations as well as micro-needles with syringe configurations.

Abstract: A micro-needle device is applicable for a target tissue with a first area having a first parameter and a second area having a second parameter. The micro-needle device includes a substrate and a micro-needle array connected to the substrate. The micro-needle array includes a first micro-needle corresponding to the first area and a second micro-needle corresponding to the second area. One of the surfaces of the substrate having the micro-needle array corresponds to the surface curvature of the target tissue. The first micro-needle has a first configuration corresponding to the first parameter, and the second micro-needle has a second configuration corresponding to the second parameter and different from the first configuration. The configuration includes at least one selected from a group consisting of length, distribution density, diameter, and medicine-carrying amount of micro-needle. A method for manufacturing a micro-needle device and a method for manufacturing a micro-needle mold are also provided.